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Jinan, China

Liu X.-W.,Jinan 250031 | Kong X.-Y.,Shandong Guanlong Medic Utensils Co. | Zhong J.,National Engineering Research Center for Nanotechnology | Yang W.-Z.,Shandong Guanlong Medic Utensils Co. | And 5 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Percutaneous vertebroplasty and percutaneous kyphoplasty have become the mainstream clinical methods for the treatment of vertebral compression fractures. However, both of them have several shortcomings such as bone cement leakage, spinal stenosis, nerve compression, pulmonary embolism and other issues. OBJECTIVE: To verify the possibility of bone filling mesh container prepared by polyethylene terephthalate for the treatment of vertebral compression fractures. METHODS: The biological properties of bone filling mesh container were examined according to GB/T16886. After sample aging test, the tensile properties of the aged samples and the fresh prepared samples were compared. The expansion and bone cement leakage were evaluated by injecting bone cement into the bone filling mesh container and measuring the pressure. The initial strength and stiffness of the fresh pig vertebrae with calcium phosphate cement injection or with bone filling mesh container filled with calcium phosphate cement were compared. The in vivo bone tissue growth was periodically observed after the lumbar vertebra of 4-month-old pigs was implanted with the bone filling mesh container that was then full of bone cement. RESULTS AND CONCLUSION: The bone filling mesh container had good biocompatibility. Bone filling mesh containers after 2-year storage had the same tensile strength to the fresh bone filling mesh containers. At ambient conditions, after bone cement injection, bone filling mesh containers could be expanded at 5-10 atm and therefore could play the role of uplift; at 7-10 atm, bone cement could leak out from the bone filling mesh container and enter into the interspace between surrounding bone tissues, thus playing the role of adhesion and fixation. The vertebrae after bone cement injection with or without bone filling mesh containers had the same initial strength and stiffness and exhibited bigger initial strength and stiffness than untreated vertebrae. The in vivo animal experiments proved that bone filling mesh container had no obvious effect on the vertebrae. These findings indicate that the bone filling mesh container can be used to restore the height and strength of the fractured vertebrae. Moreover, it may eliminate bone cement leakage and therefore increase the surgery safety.


Liu X.-W.,Jinan 250031 | Zhong J.,National Engineering Research Center for Nanotechnology | Peng X.-T.,Jinan 250031 | Wei D.-X.,National Engineering Research Center for Nanotechnology | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2014

BACKGROUND: Vertebroplasty and kyphoplasty for osteoporotic vertebral compression fractures can result in many complications, such as bone cement leakage and adjacent-level fractures. OBJECTIVE: To verify the possibility of biodegradable mesh-like microporous polymer balloon for the treatment of osteoporotic vertebral compression fractures. METHODS: Biodegradable mesh-like microporous P(DLLA-CL) balloons were fabricated by electrospinning technique. Coated balloons with the same specification was fabricated by coating P(DLLA-CL) onto the same mould. Morphology of the balloons was observed by scanning electron microscopy. The balloon leakage was observed by eyes after the injection of water or cement. The initial strength and stiffness were measured by a universal testing machine. The proliferation of MC3T3-E1 cells on the balloons was determined by laser confocal microscope and cell counting kit-8 assays. The biodegradation of balloons in simulated body fluid, porcine pancreatic lipase, and fresh human serum was studied by residual weighing and scanning electron microscopy observation. Burst pressure of balloons was measured after the balloon was placed into a hole in the vertebral bone. For the in vitro calcium release tests, the balloons were filled with calcium cement, tied, placed into 6atm ultrapure water, and then the calcium concentration was regularly determined. RESULTS AND CONCLUSION: Mesh-like microporous balloons presented with good fiber morphology, thickness distribution, and the presence of pores; on the coated balloon surface, there was absence of specific morphology and porosity. Compared with the coated balloon, the mesh-like microporous balloon showed better mechanical properties, liquid permeability and burst pressure, to prevent leakage of bone cement and promote osteoblast adhesion and proliferation. In addition, the degradation of the mesh-like microporous balloons was more uniform and stable than the coated balloons, which may increase the calcium concentration in the injured vertebrae and will be beneficial to the new bone growth and fracture healing.

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