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Changchun, China

Jilin University is a leading national research university under the direct jurisdiction of China's Ministry of Education.Located in Changchun, the capital city of Jilin Province in Northeast China, the university has seven campuses in six districts which are home to thirty-nine colleges covering thirteen academic disciplines, including philosophy, international relations, economics, law, literature, education, history, science, engineering, agriculture, medicine, management, and military science. The University has thirteen disciplinary areas, six national key laboratories, and seven national bases for the development of basic science. Other resources include five research bases for humanities and social science, eleven key laboratories sponsored by the Ministry of Education and eleven by other ministries of Chinese government.Jilin University is one of the most prestigious "Top 10" universities in China, and has several research projects in automobile engineering, chemistry, computer science, electrical engineering and biology. JLU also provides undergraduate and graduate programs in law, literature, philosophy, medicine and veterinary science. It is one of the key universities involved in China's Project 985, Project 211 and Project 2011.Jilin University is a comprehensive and national key university. JLU offers a variety of degree programs. It has now 115 undergraduate programs, 192 Master's degree program, 105 doctoral degree programs, and seventeen post-doctoral programs. In 2003 the university enrolled 59,000 full-time students, including more than 10,000 graduate students. At present there are 6,540 faculty members, with twenty members of Chinese Academy of science and Chinese Academy of Engineering, 1270 full professors, and 1652 associate professors. Wikipedia.

Guli M.,University of Bristol | Guli M.,Jilin University | Lambert E.M.,University of Bristol | Li M.,University of Bristol | Mann S.,University of Bristol
Angewandte Chemie - International Edition | Year: 2010

(Figure Presented) Redox reactions were utilized to deposit periodically arranged Ag and Au nano-structures within the solvent channels of cross-linked lysozyme crystals (see picture for Ag-doped lysozyme crystals). The ability to crystallize lysozyme in various polymorphic forms provides an opportunity to tailor the architecture of the metalized nanostructures through judicious choice of the protein lattice. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Suenaga D.,Nagoya University | He B.-R.,Nagoya University | Ma Y.-L.,Jilin University | Harada M.,Nagoya University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

We explore the mass splitting of heavy-light mesons with chiral partner structure in nuclear matter. In our calculation, we employed the heavy hadron chiral perturbation theory with chiral partner structure, and the nuclear matter is constructed by putting Skyrmions from the standard Skyrme model onto the face-centered cubic crystal and regarding the Skyrmion matter as nuclear matter. We find that, although the masses of heavy-light mesons with chiral partner structure are split in matter-free space and the Skyrmion phase, they are degenerated in the half-Skyrmion phase in which the chiral symmetry is restored globally. This observation suggests that the magnitude of the mass splitting of heavy-light mesons with chiral partner structure can be used as a probe of the phase structure of nuclear matter. © 2015 American Physical Society.

Xu H.,Jilin University | Yu B.,Beijing Institute of Technology
Expert Systems with Applications | Year: 2010

Email has become one of the fastest and most economical forms of communication. Email is also one of the most ubiquitous and pervasive applications used on a daily basis by millions of people worldwide. However, the increase in email users has resulted in a dramatic increase in spam emails during the past few years. This paper proposes a new spam filtering system using revised back propagation (RBP) neural network and automatic thesaurus construction. The conventional back propagation (BP) neural network has slow learning speed and is prone to trap into a local minimum, so it will lead to poor performance and efficiency. The authors present in this paper the RBP neural network to overcome the limitations of the conventional BP neural network. A well constructed thesaurus has been recognized as a valuable tool in the effective operation of text classification, it can also overcome the problems in keyword-based spam filters which ignore the relationship between words. The authors conduct the experiments on Ling-Spam corpus. Experimental results show that the proposed spam filtering system is able to achieve higher performance, especially for the combination of RBP neural network and automatic thesaurus construction. © 2009 Elsevier Ltd. All rights reserved.

Xue X.,Jilin University
Wei sheng wu xue bao = Acta microbiologica Sinica | Year: 2013

To sequence the complete genome of CVS-11 strain and establish a reverse genetic system of CVS-11 to further study its pathogenic mechanism, virulence genes and antigenic sites. We amplified12 fragments covering the complete genome of the CVS-11 strain by RT-PCR, and then cloned to pEASY-Blunt vector for sequencing the complete genome of CVS-11. We analyzed single restriction enzyme sites of the full length cDNA of the CVS-11 strain by DNAMAN and designed 4 pairs of specific primers. We amplified the full-length cDNA of CVS-11 by RT-PCR. We obtained four fragments and cloned into pcDNA3. 1. We named the full-length cDNA plasmid pcDNA3. 1-CVS-11. We also cloned helper plasmids pcDNA3.1-N, P, L and G expressing N, P, L and G protein of CVS-11 strain, respectively. We co-transfected NA cells with the full-length plasmid and four helper plasmids. We identified the supernatant of the transfected and then passaged NA cells by immunofluorescence staining and RT-PCR and found the recombinant virus rCVS-11 rescued successfully. Sequencing results showed that the complete genome of CVS-11 was composed of 11 927 nucleotides. The complete genome of CVS-11 encoded 5 structure proteins and gene array was the same as other reported rabies viruses. We successfully constructed a reverse genetic system of CVS-11, namely the full length plasmid pcDNA3. 1-CVS-11 and 4 help plasmids pcDNA3. 1-N, P, L, G and rescued the rCVS-11 from a full-length infectious cDNA clone. The reverse genetic system of the CVS-11 strain laid the foundation for future studies on rabies virus.

Sun J.,Jilin University | Sun J.,Ohio State University | Bhushan B.,Ohio State University
RSC Advances | Year: 2012

Insects of extremely small size have evolved to solve many problems. Their structure and mechanical properties information can be utilized to mimic them for industrial applications. Since beetle (Coleoptera, an order of insects) wings exhibit special functionalities, they have sparked worldwide research attention. Beetle wings are composed of a forewing (also known as elytron) and a hind wing. The elytra are rigid. A beetle's functional wings, which allow flying, are the hind wings. The elytra have an ingenious structure with superhydrophobic characteristics, a structural coloration and anti-adhesion characteristics. Their inner structure helps to provide light mass and high strength. The rotation angle and wing locking system of elytra are important features which increase beetles' ability to fly; they may furnish an insight for portable micro air vehicles (MAVs) and also provide inspiration for the design of bioinspired deployable systems. Studies of the structural and mechanical properties in biological systems may improve the understanding of natural solutions and advance the design of novel artificial materials. In this paper, the structure, mechanical properties and their relationship to function of beetle wings are discussed. Examples of bioinspired structures and materials are also presented. © 2012 The Royal Society of Chemistry.

He B.-R.,Nagoya University | Ma Y.-L.,Jilin University | Harada M.,Nagoya University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

We study the effects of light scalar mesons on the Skyrmion properties by constructing and examining a mesonic model including pion, rho meson, and omega meson fields as well as two-quark and four-quark scalar meson fields. In our model, the physical scalar mesons are defined as mixing states of the two- and four-quark fields. We first omit the four-quark scalar meson field from the model and find that when there is no direct coupling between the two-quark scalar meson and the vector mesons, the soliton mass is smaller and the soliton size is larger for lighter scalar mesons; when direct coupling is switched on, as the coupling strength increases, the soliton becomes heavy, and the radius of the baryon number density becomes large as the repulsive force arising from the ω meson becomes strong. We then include the four-quark scalar meson field in the model and find that mixing between the two-quark and four-quark components of the scalar meson fields also affects the properties of the soliton. When the two-quark component of the lighter scalar meson is increased, the soliton mass decreases and the soliton size increases. © 2015 American Physical Society. © 2015 American Physical Society.

Liu Y.,Jilin University
International journal of medical sciences | Year: 2012

Splenosis is not an uncommon disease. However, it is often misdiagnosed as malignant tumors, and then the patients underwent unnecessary operations. Unfortunately, it is very difficult to diagnose it prior to operation. We report a rare case of a 49-year-old female patient with liver and colon splenosis, misdiagnosed as liver and colon tumors, and summarize experience how to diagnose it preoperatively according to literatures. We come to conclusion that in patients who ever underwent splenectomy especially owning to trauma, and were found mass in abdomen, clinicians must consider the existence of splenosis, and take some measures, such as scintigraphy with (99m) Tc labelled heat-denatured erythrocyte rather than biopsy, to diagnose it correctly to prevent unnecessary operations.

Single-molecule force spectroscopy (SMFS) opens new avenues for elucidating the structures and functions of large coiled molecules such as synthetic and biopolymers at the single-molecule level. In addition, some of the features in the force-extension curves (i.e. force spectra) are closely related to primary/secondary structures of the molecules being stretched. For example, the long force plateau in the DNA stretching curve is related to the double-helix structure. These features can be regarded as the force fingerprints of individual macromolecules. These force fingerprints can therefore be used as indicators/criteria of single-molecule manipulation during the measurement of some unknown intra- or intermolecular interactions. By comparing the force spectra of a single polymer chain before and after interaction with other molecules, the mode/strength of such molecular interactions can be derived. This Review focuses on recent advances in AFM-based SMFS studies on molecular interactions in both synthetic and biopolymer systems using a single macromolecular chain as probe, including interactions between nucleic acids and proteins, mechanochemistry of covalent bonds, conformation-regulated enzymatic reactions, adsorption and desorption of biopolymers on a flat surface or from the nanopore of a carbon nanotube, and polymer interactions in the condensed state. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Liang Q.,Jilin University
Journal of Nanoparticle Research | Year: 2016

In this work, we show that compositionally controlled Cu2(Sn1–xGex)S3 nanocrystals can be successfully synthesized by the hot-injection method through careful tuning the Ge/(Sn+Ge) precursor ratio. The band gaps of the resultant nanocrystals are demonstrated to be linearly tuned from 1.45 to 2.33 eV by adjusting the composition parameter x of the Ge/(Sn+Ge) ratio from 0.0 to 1.0. The crystalline structures of the resultant NCs have been studied by the X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), select area electron diffraction (SAED), and Raman spectroscopy. A ligand exchange procedure is further performed to replace the native ligands on the surface of the NCs with sulfur ions. The photoresponsive behavior indicates the potential use of as-prepared Cu2(Sn1–xGex)S3 nanocrystals in solar energy conversion systems. The synthesis of compositionally controlled Cu2(Sn1–xGex)S3 nanocrystals reported herein provides a way for probing the effect of Ge inclusion in the Cu-Sn-S system thin films. © 2016, The Author(s).

Zhang H.,Shanghai Maritime University | Zhang H.,Ohio State University | Zhang X.,Jilin University | Wang J.,Ohio State University
Vehicle System Dynamics | Year: 2014

In this paper, we investigate the vehicle lateral dynamics stabilisation problem to enhance vehicle handling by considering time-varying longitudinal velocity. The longitudinal velocity is described by a polytope with finite vertices and a novel technique is proposed to reduce the number of vertices. Since the tyre dynamics is nonlinear, the cornering stiffness is represented via the norm-bounded uncertainty. Concerning the time-varying velocity and the nonlinear tyre model, a linear parameter-varying vehicle model is obtained. As the velocity and the states are measurable, a gain-scheduling state-feedback controller is introduced. In the lateral control, the sideslip angle is required to be as small as possible and the yaw rate is constrained to a certain level. Thus, the control objective is to minimise the sideslip angle while the yaw rate is under a prescribed level or constrain both the sideslip angle and the yaw rate to prescribed levels. To consider the transient response of the closed-loop system, the D-stability is also employed in the energy-to-peak control. The optimal controller can be obtained by solving a set of linear matrix inequalities. A nonlinear vehicle model is utilised to illustrate the design procedure and the effectiveness of the proposed design method. Finally, simulations and comparisons are carried out to show the significant advantage of the designed controller. Compared to the open-loop system, the closed-loop system with the designed controller can achieve much smaller sideslip angle and the yaw rate is closer to the desired yaw rate from a reference model. Therefore, the vehicle safety and the handling are both improved in our simulation cases. © 2014 © 2014 Taylor & Francis.

ABSTRACT: Study Design. Meta-analysisObjective. The purpose of this study was to answer the following questions: (1) Does heterotopic ossification (HO) negatively influence clinical outcomes following cervical total disc replacement (CTDR)? (2) Should patients be classified into HO and non-HO groups? (3) Is there a more rational classification?Summary of Background Data. HO has emerged as a common complication following CTDR and has been an important reason for reoperation, thus limiting the use of the surgery. However, the influence of HO on clinical outcomes following CTDR has not been well established.Methods. A meta-analysis was conducted with studies identified by searches of MEDLINE, EMBASE, and the Cochrane Library. We calculated the weighted mean differences (WMD) of the visual analog scale (VAS) pain, neck disability index (NDI) and range of motion (ROM). Patients were classified into two groups under three classifications based on the grade of HO. Results were pooled using a fixed effect model or a random effects model, according to the heterogeneity.Results. There were significant differences in ROM uner all three classifications. The VAS pain and NDI between the patients with and without HO showed no significant difference following CTDR. Significant differences in VAS pain were observed when patients were classified into a “high-grade HO” group (McAfee grades 3 or 4 HO) and a “low-grade HO” group (McAfee grade 0, 1, or 2 HO).Conclusions. The presence of HO is not associated with clinical outcomes following CTDR. However, the severity of HO actually impacts clinical outcomes in an inverse manner which needs further investigation. Itʼs inappropriate to classify patients based on the presence of heterotopic ossification, further studies of the classifications (ROM-affecting HO vs. ROM-preserving HO; high-grade HO vs. low-grade HO) and cervical stability following CTDR are needed. © 2015 by Lippincott Williams & Wilkins

Liu M.,Qingdao University of Science and Technology | Zhang J.,Qingdao University of Science and Technology | Liu J.,Nanjing University of Science and Technology | Yu W.W.,Jilin University
Journal of Catalysis | Year: 2011

Stable poly(N-vinyl-2-pyrrolidone)-stabilized Pt/Ru colloidal nanoparticles (PVP-Pt/Ru) were prepared via ethanol reduction of H2PtCl 66H2O and RuCl3nH2O. The average diameters of the nanoparticles with different molar ratio of Pt/Ru were in a range of 2.1-2.8 nm with narrow size distributions. X-ray photoelectron spectroscopy verified that both Pt and Ru were in the metallic state and Ru was rich on the surface. These nanoparticles were employed to selectively hydrogenate ortho-chloronitrobenzene at 298 K and 0.1 MPa hydrogen pressure. They showed high activity [TOF was in the range of 0.8-5.3 × 10 -2 molo-CNB/(molM,surface atom) s] and high selectivity (93-99%) to ortho-chloroaniline (o-CAN) for the reaction, which were composition-dependent. The selectivity to o-CAN monotonously increased, but the activity of the catalyst decreased with the increasing proportion of Ru in Pt/Ru colloidal catalysts. PVP-1Pt/4Ru nanoparticles exhibited the highest selectivity of 99.0% to o-CAN at a complete conversion. © 2010 Elsevier Inc. All rights reserved.

Fine N.M.,Mayo Medical School | Chen L.,Mayo Medical School | Chen L.,Jilin University | Bastiansen P.M.,Mayo Medical School | And 4 more authors.
Circulation: Cardiovascular Imaging | Year: 2013

Background-Although right ventricular (RV) dysfunction is a major determinant of outcome in patients with pulmonary hypertension (PH), the optimal measure of RV function is poorly defined. We hypothesized that RV strain measured by speckle-tracking echocardiography predicts outcome in PH over a broad range of pulmonary pressures. Methods and Results-Prospective peak RV longitudinal systolic strain measurement was performed on 575 patients (mean age, 56±18 years; 63% women) referred for echocardiography for known or suspected PH. Survival status was assessed over a median of 16.5 (interquartile range, 7.6-20.0) months. There were 406 patients with PH (71%) (74% group 1, 14% group 3, and 12% group 4) and 169 patients without evidence of PH (29%). Among patients with PH, 46% were World Health Organization functional class III-IV. The mean RV strain was -21.2±6.7% for all patients. RV strain declined with worse functional class, shorter 6-minute walk distances, higher N-terminal pro-B-type natriuretic peptide levels, and the presence of right heart failure. RV strain predicted outcome across pulmonary pressures and groups of PH. Eighteen-month survival was 92%, 88%, 85%, and 71% according to RV strain quartile (P<0.001), with a 1.46 higher risk of death (95% confidence interval, 1.05-2.12) per 6.7% decline in RV strain. RV strain predicted survival when adjusted for pulmonary pressure, pulmonary vascular resistance, and right atrial pressure and provided incremental prognostic value over conventional clinical and echocardiographic variables. Conclusions-Quantitative assessment of RV free-wall systolic strain is feasible and is a powerful predictor of the clinical outcome of patients with known or suspected PH. © 2013 American Heart Association, Inc.

Zeng T.,University of Waterloo | Li H.,Jilin University | Roy P.-N.,University of Waterloo
Journal of Physical Chemistry Letters | Year: 2013

We present the first simulation study of bosonic clusters doped with an asymmetric top molecule. The path-integral Monte Carlo method with the latest methodological advance in treating rigid-body rotation [Noya, E. G.; Vega, C.; McBride, C. J. Chem. Phys.2011, 134, 054117] is employed to study a para-water impurity in para-hydrogen clusters with up to 20 para-hydrogen molecules. The growth pattern of the doped clusters is similar in nature to that of pure clusters. The para-water molecule appears to rotate freely in the cluster. The presence of para-water substantially quenches the superfluid response of para-hydrogen with respect to the space-fixed frame. © 2012 American Chemical Society.

Ni J.-Y.,Sun Yat Sen University | Liu S.-S.,Jilin University | Xu L.-F.,Sun Yat Sen University | Sun H.-L.,Sun Yat Sen University | Chen Y.-T.,Sun Yat Sen University
World Journal of Gastroenterology | Year: 2013

AIM: To compare radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE) with RFA monotherapy in hepatocellular carcinoma (HCC). METHODS: We searched PubMed, Medline, Embase and Chinese databases (CBMdisc and Wanfang data) for randomized controlled trails comparing RFA plus TACE and RFA alone for treatment of HCC from January 2000 to December 2012. The overall survival rate, recurrence-free survival rate, tumor progression rate, and safety were analyzed and compared. The analysis was conducted on dichotomous outcomes and the standard meta-analytical techniques were used. Pooled odds ratios (ORs) with 95%CIs were calculated using either the fixed-effects or random-effects model. For each meta-analysis, the χ2 and I2 tests were first calculated to assess the heterogeneity of the included trials. For P < 0.05 and I2 > 50%, the assumption of homogeneity was deemed invalid, and the random-effects model was used; otherwise, data were assessed using the fixed-effects model. All statistical analysis was conducted using Review manager (version 4.2.2.) from the Cochrane collaboration. RESULTS: Eight randomized controlled trials were identified as eligible for inclusion in this analysis and included 598 patients with 306 treated with RFA plus TACE and 292 with RFA alone. Our data analysis indicated that RFA plus TACE was associated a significantly higher overall survival rate (OR1-year = 2.96, 95%CI: 1.84-7.74, P < 0.001; OR2-year = 3.72, 95%CI: 1.24-11.16, P = 0.02; OR3-year = 2.65, 95%CI: 1.81-3.86, P < 0.001) and recurrence-free survival rate (OR3-year = 3.00, 95%CI: 1.75-5.13, P < 0.001; OR5-year = 2.26, 95%CI: 1.43-3.57, P = 0.0004) vs that of RFA alone. The tumor progression rate in patients treated with RFA alone was higher than that of RFA plus TACE (OR = 0.60, 95%CI: 0.42-0.88, P = 0.008) and there was no significant difference on major complications between two different kinds of treatment (OR = 1.20, 95%CI: 0.31-4.62, P = 0.79). Additionally, the meta-analysis data of subgroups revealed that the survival rate was significantly higher in patients with intermediate- and large-size HCC underwent RFA plus TACE than in those underwent RFA monotherapy; however, there was no significant difference between RFA plus TACE and RFA on survival rate for small HCC. CONCLUSION: The combination of RFA with TACE has advantages in improving overall survival rate, and provides better prognosis for patients with intermediate-and large-size HCC. © 2013 Baishideng. All rights reserved.

Gao J.,Jilin University | Gao J.,University of Minnesota | Truhlar D.G.,University of Minnesota | Wang Y.,University of Minnesota | And 4 more authors.
Accounts of Chemical Research | Year: 2014

ConspectusMolecular mechanical force fields have been successfully used to model condensed-phase and biological systems for a half century. By means of careful parametrization, such classical force fields can be used to provide useful interpretations of experimental findings and predictions of certain properties. Yet, there is a need to further improve computational accuracy for the quantitative prediction of biomolecular interactions and to model properties that depend on the wave functions and not just the energy terms. A new strategy called explicit polarization (X-Pol) has been developed to construct the potential energy surface and wave functions for macromolecular and liquid-phase simulations on the basis of quantum mechanics rather than only using quantum mechanical results to fit analytic force fields. In this spirit, this approach is called a quantum mechanical force field (QMFF).X-Pol is a general fragment method for electronic structure calculations based on the partition of a condensed-phase or macromolecular system into subsystems ("fragments") to achieve computational efficiency. Here, intrafragment energy and the mutual electronic polarization of interfragment interactions are treated explicitly using quantum mechanics. X-Pol can be used as a general, multilevel electronic structure model for macromolecular systems, and it can also serve as a new-generation force field. As a quantum chemical model, a variational many-body (VMB) expansion approach is used to systematically improve interfragment interactions, including exchange repulsion, charge delocalization, dispersion, and other correlation energies. As a quantum mechanical force field, these energy terms are approximated by empirical functions in the spirit of conventional molecular mechanics. This Account first reviews the formulation of X-Pol, in the full variationally correct version, in the faster embedded version, and with systematic many-body improvements. We discuss illustrative examples involving water clusters (which show the power of two-body corrections), ethylmethylimidazolium acetate ionic liquids (which reveal that the amount of charge transfer between anion and cation is much smaller than what has been assumed in some classical simulations), and a solvated protein in aqueous solution (which shows that the average charge distribution of carbonyl groups along the polypeptide chain depends strongly on their position in the sequence, whereas they are fixed in most classical force fields). The development of QMFFs also offers an opportunity to extend the accuracy of biochemical simulations to areas where classical force fields are often insufficient, especially in the areas of spectroscopy, reactivity, and enzyme catalysis. © 2014 American Chemical Society.

Pei Y.-C.,Jilin University
International Journal of Mechanical Sciences | Year: 2012

A rotating flexible annular micro-disk under thermoelastic coupling is modeled to investigate the thermoelastic damping in the rotating micro-disk in Microdrives. Transverse deflection of the micro-disk is considered as a function of both disk radial and circumferential coordinates, and its thermoelastic temperature increment is modeled by simultaneously involving disk thickness, radial and circumferential coordinates. Heat convection boundaries are assumed at disk top and bottom surfaces. System governing equations with the centrifugal stresses of disk rotation and thermoelastic coupling terms are discretized along disk radial direction by an annular finite element, and a quadratic eigenvalue problem is yielded to determine the thermoelastic damping. Mode shapes of the transverse deflection and temperature increment are presented, effects of disk rotation, surface convection and ambient temperature on natural frequency, frequency shift and thermoelastic damping are investigated. The maximum thermoelastic damping is obtained by optimizing disk thickness, inner radius and radial width. © 2012 Elsevier Ltd. All rights reserved.

Liu Y.,Jilin University | Liu Y.,University of Texas at Austin | Fomel S.,University of Texas at Austin
Geophysical Prospecting | Year: 2013

Many natural phenomena, including geologic events and geophysical data, are fundamentally nonstationary - exhibiting statistical variation that changes in space and time. Time-frequency characterization is useful for analysing such data, seismic traces in particular. We present a novel time-frequency decomposition, which aims at depicting the nonstationary character of seismic data. The proposed decomposition uses a Fourier basis to match the target signal using regularized least-squares inversion. The decomposition is invertible, which makes it suitable for analysing nonstationary data. The proposed method can provide more flexible time-frequency representation than the classical S transform. Results of applying the method to both synthetic and field data examples demonstrate that the local time-frequency decomposition can characterize nonstationary variation of seismic data and be used in practical applications, such as seismic ground-roll noise attenuation and multicomponent data registration. © 2012 European Association of Geoscientists & Engineers.

Lin Q.,Jilin University
Applied Mechanics and Materials | Year: 2014

In this paper, a novel method which can identify error parameters of accelerometer accurately in the absence of high precision test turntable occasions is provided. The novel method makes use of artificial fish swarm algorithm(AFSA), permits to obtain an accurate identification by taking the acceleration norm as observation, and the standard variance of norm error as optimization index. The identification test is carried out on the platform of fiber optic gyro (FOG) strapdown inertial navigation system (SINS), and the 24-hours static navigation test is also executed. The validity of our method is verified by experiment results, which shows significant profit in practice. © (2014) Trans Tech Publications, Switzerland.

Zhang X.E.,Jilin University
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology | Year: 2012

To study the pathogen and characteristics of viral diarrhea in children in Changchun area. 460 stools specimens were collected from children with acute diarrhea cured in the childrens, hospital of Changchun in 2010. Rotavirus were detected by ELISA, caliceverus and astrovirus were detected by reverse transcription-polymerase chain reactions (RT-PCR), adenovirus were detected by polymerase chain reactions (PCR). A total of 460 specimens were detected. The detection rate of rotavirus, caliceverus, astrovious, adenovious respectively is 35.22%, 20.43%, 9.78%, 3.70%, the detectablerate of mixed infection is 7.61%, children under 2 years old were the major patient. The main genotypes of the virus: rotavirus (G3P[8]), caliceverus (GII-4), astrovious (type I), adenovious (Ad41). Rotavirus is the main pathogen in Changchun. Followed by caliceverus, astrovious, adenovious.

Yang H.,University of Colorado at Boulder | Liu Z.,Jilin University | Zhang W.,University of Colorado at Boulder
Advanced Synthesis and Catalysis | Year: 2013

A series of triphenolsilane-coordinated molybdenum(VI) propylidyne catalysts has been developed, which are resistant to small alkyne polymerization and compatible with various functional groups (including phenol substrates). The catalysts remain active in solution for days at room temperature (months at -30 °C). The catalysts are also compatible with 5 Å molecular sieves (small alkyne scavengers), and have enabled the homodimerization of small alkyne substrates at 40-70 °C in a closed system, with dimer products being obtained in 76-96% yields. A shape-persistent aryleneethynylene macrocycle (11) was also prepared on a gram scale with 0.5 mol% catalyst loading, in almost quantitative yield. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The existence of fundamental differences between lung adenocarcinoma (AC) and squamous cell carcinoma (SCC) in their underlying mechanisms motivated us to postulate that specific genes might exist relevant to prognosis of each histology subtype. To test on this research hypothesis, we previously proposed a simple Cox-regression model based feature selection algorithm and identified successfully some subtype-specific prognostic genes when applying this method to real-world data. In this article, we continue our effort on identification of subtype-specific prognostic genes for AC and SCC, and propose a novel embedded feature selection method by extending Threshold Gradient Descent Regularization (TGDR) algorithm and minimizing on a corresponding negative partial likelihood function. Using real-world datasets and simulated ones, we show these two proposed methods have comparable performance whereas the new proposal is superior in terms of model parsimony. Our analysis provides some evidence on the existence of such subtype-specific prognostic genes, more investigation is warranted. © 2015 Suyan Tian.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Chan J.G.Y.,University of Sydney | Bai X.,Jilin University | Traini D.,University of Sydney
Expert Opinion on Drug Delivery | Year: 2014

Introduction: Tuberculosis (TB) remains rampant throughout the world, in large part due to the lengthy treatment times of current therapeutic options. Rifapentine, a rifamycin antibiotic, is currently approved for intermittent dosing in the treatment of TB. Recent animal studies have shown that more frequent administration of rifapentine could shorten treatment times, for both latent and active TB infection. However, these results were not replicated in a subsequent human clinical trial. Areas covered: This review analyses the evidence for more frequent administration of rifapentine and the reasons for the apparent lack of efficacy in shortening treatment times in human patients. Inhaled delivery is discussed as a potential option to achieve the therapeutic effect of rifapentine by overcoming the barriers associated with oral administration of this drug. Avenues for developing an inhalable form of rifapentine are also presented. Expert opinion: Rifapentine is a promising active pharmaceutical ingredient with potential to accelerate treatment of TB if delivered by inhaled administration. Progression of current fundamental work on inhaled anti-tubercular therapies to human clinical trials is essential for determining their role in future treatment regimens. While the ultimate goal for global TB control is a vaccine, a short and effective treatment option is equally crucial. © 2014 Informa UK, Ltd.

Wu J.-H.,Jilin University | Horsley S.A.R.,University of Exeter | Artoni M.,European Laboratory for Nonlinear Spectroscopy | Artoni M.,CNR Institute of Acoustics and Sensors Orso Mario Corbino | La Rocca G.C.,Normal School of Pisa
Light: Science and Applications | Year: 2013

The typically tiny effect of radiation damping on a moving body can be amplified to a favorable extent by exploiting the sharp reflectivity slope at one edge of an optically induced stop-band in atoms loaded into an optical lattice. In this paper, this phenomenon is demonstrated for the periodically trapped and coherently driven cold 87Rb atoms, where radiation damping might be much larger than that anticipated in previous proposals and become comparable with radiation pressure. Such an enhancement could be observed even at speeds of only a few meters per second with less than 1.0% absorption, making radiation damping experimentally accessible. © 2013 CIOMP. All rights reserved.

Sun X.,Wayne State University | Wang Z.,Jilin University | Kadouh H.,Wayne State University | Zhou K.,Wayne State University
LWT - Food Science and Technology | Year: 2014

Chitosan films incorporated with various concentrations of gallic acid were prepared and investigated for antimicrobial, mechanical, physical and structural properties. Four bacterial strains that commonly contaminate food products were chosen as target bacteria to evaluate the antimicrobial activity of the prepared gallic acid-chitosan films. The incorporation of gallic acid significantly increased the antimicrobial activities of the films against Escherichia coli, Salmonella typhimurium, Listeria innocua and Bacillus subtilis. Chitosan films incorporated with 1.5 g/100 g gallic acid showed the strongest antimicrobial activity. It was also found that tensile strength (TS) of chitosan film was significantly increased when incorporating 0.5 g/100 g gallic acid. Inclusion of 0.5 g/100 g gallic acid also significantly decreased water vapor permeability (WVP) and oxygen permeability (OP). Microstructure of the films was investigated by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) and it was found that gallic acid was dispersed homogenously into the chitosan matrix. © 2013 Elsevier Ltd.

Jin R.,CAS Changchun Institute of Applied Chemistry | Bian Z.,CAS Changchun Institute of Applied Chemistry | Li J.,Jilin University | Ding M.,CAS Changchun Institute of Applied Chemistry | Gao L.,CAS Changchun Institute of Applied Chemistry
Dalton Transactions | Year: 2013

ZIF-8 crystal coatings were prepared by direct growth on different flexible polyimide substrates including a thin membrane and electrospun nanofiber mat. In SEM pictures, the ZIF-8 crystals exhibit a rhombic dodecahedron morphology. Owing to the flexible polyimide substrate, the MOF-polymer film may be moderately bent or easily tailored when not destroyed. The ZIF-8 coatings can be activated at high temperature owing to the excellent thermal resistance and low coefficient of thermal expansion of the polyimide. Furthermore, this material may be used as an efficient heterogeneous catalyst for the Knoevenagel reaction and can be easily recovered. The ZIF-8 coatings and 2-methylimidazole show similar catalytic behaviour as a weak base. This journal is © 2013 The Royal Society of Chemistry.

Du P.,Northeast Normal University | Yang Y.,Northeast Normal University | Yang J.,Northeast Normal University | Liu B.-K.,Jilin University | Ma J.-F.,Northeast Normal University
Dalton Transactions | Year: 2013

Four novel metal-organic frameworks (MOFs) based on high-nuclear metal carboxylate clusters, namely, [Zn4(L)2(μ3- OH)2(H2O)1.5]·2H2O (1), [Zn5Na(L)2(μ3-OH)4(CH 3CH2O)(H2O)2] (2), [Cd 4(L)2(BIME)0.5(μ3-OH) 2(H2O)1.5]·2H2O (3), and [Zn4(L)2(BET)0.5(μ3-OH) 2(H2O)] (4), where H3L = (3,5-dicarboxyl- phenyl)-(4-(2′-carboxyl-phenyl)-benzyl)ether, BET = 1,1′-(2′- oxybis(ethane-2,1-diyl))bis(1,2,4-triazol-1-yl), BIME = 1,2-bis(imidazol-1-yl) ethane, have been synthesized under hydrothermal conditions. In 1, each planar octanuclear zinc cluster [Zn8(μ3-OH) 8(CO2)12(H2O)3] is linked by twelve L anions to give an unusual (3,12)-connected framework with (4 3)2(420·628·8 18) topology. In 2, dodecanuclear heterometallic clusters [Zn 10Na2(μ3-OH)8(CO 2)12(CH3CH2O)2(H 2O)4] are surrounded by twelve L anions to form a (3,12)-connected net with the same topology as 1. However, 3 exhibits a rare (3,14)-connected (43)(324)(34·4 20·514·634·7 11·88) net based on octanuclear cadmium cluster [Cd8(BIME)2(μ3-OH)4(CO 2)12(H2O)4]·2H2O as a 14-connected node and H3L as a 3-connected node. In 4, each octanuclear zinc cluster [Zn8(BET)2(μ3-OH) 4(CO2)12(H2O)2] is linked by twelve L anions to furnish a (3,14)-connected net with the same topology as 3. The optical energy gaps and photoluminescence were investigated for the compounds. Moreover, compounds 1-4 exhibit good photocatalytic activities for degradation of methylene blue (MB) under UV irradiation and show good stability towards UV photocatalysis. In addition, 1 and 4 display a photocurrent density under several on-off cycles of illumination. © The Royal Society of Chemistry 2013.

Adekola K.A.,Jilin University
Agricultural Engineering International: CIGR Journal | Year: 2015

In this study, two-dimensional flow simulation in food extruder die for intermeshing co-rotating twin-screw extruder were performed by solving Navier-Stokes equation and continuity equation for non-Newtonian fluid using finite element computer package of ANSYS/FLOTRAN. The objective of the study is to determine the nature of flow, heat and pressure distribution in the die and to determine the effect of screw speed on process parameters such as temperature, pressure and flow rate in the die. Four different die geometries were used. The levels of temperature considered were 120°C, 140°C, 160°C and 180°C. The screw speeds (taken as inlet velocity for the die) were 120, 160, 200 and 240 rpm. The results are presented for the flow profile, pressure distribution, temperature distribution and flow rate. For all the velocities considered, temperature has no significant effect on the velocity vector. The concentration of the vectors increase as the cross-sectional area becomes smaller. The vectors are relatively linear and smooth in the transition section of the die and get concentrated towards the die exit. The flow rate increases with increase in inlet velocity. Extruder throughput has a significant effect on the flow rate as reflected in higher flow rate recorded for increased throughput. The pressure at the die exit is lower than the highest pressure obtained for all the experimental runs. As the dough gets to the die exit, the dough experienced pressure drop. A pressure drop of more than 0.8MPa between the entrance and exit of the die was obtained. Experimental results obtained for the die geometries statistically correlate with the simulation results. © 2015, Int. Comm. of Agricultural and Biosystems Engineering. All rights reserved.

Liu Q.-C.,CAS Changchun Institute of Applied Chemistry | Liu Q.-C.,Jilin University | Xu J.-J.,CAS Changchun Institute of Applied Chemistry | Chang Z.-W.,CAS Changchun Institute of Applied Chemistry | And 2 more authors.
Journal of Materials Chemistry A | Year: 2014

Cobalt oxide nanosheets (Co3O4 NSs) are grown on carbon paper (CP) by an efficient and facile electrodeposition method. When directly used as free-standing cathode for lithium-oxygen batteries, the Co 3O4 NSs/CP is found to be robust and shows enhanced specific capacity and cycling stability. This journal is © the Partner Organisations 2014.

Vantomme G.,CNRS Institute of Science and Supramolecular Engineering | Jiang S.,CNRS Institute of Science and Supramolecular Engineering | Jiang S.,Jilin University | Lehn J.-M.,CNRS Institute of Science and Supramolecular Engineering
Journal of the American Chemical Society | Year: 2014

Constitutional dynamic libraries of hydrazones aAbB and acylhydrazones aAcC undergo reorganization and adaptation in response to a chemical effector (metal cations) or a physical stimulus (light). The set of hydrazones [1A1B, 1A2B, 2A1B, 2A 2B] undergoes metalloselection on addition of zinc cations which drive the amplification of Zn(1A2B)2 by selection of the fittest component 1A2B. The set of acylhydrazones [E-1A1C, 1A2C, 2A1C, 2A2C] undergoes photoselection by irradiation of the system, which causes photoisomerization of E- 1A1C into Z-1A1C with amplification of the latter. The set of acyl hydrazones [E-1A1C, 1A3C, 2A1C, 2A 3C] undergoes a dual adaptation via component exchange and selection in response to two orthogonal external agents: a chemical effector, metal cations, and a physical stimulus, light irradiation. Metalloselection takes place on addition of zinc cations which drive the amplification of Zn( 1A3C)2 by selection of the fittest constituent 1A3C. Photoselection is obtained on irradiation of the acylhydrazones that leads to photoisomerization from E-1A 1C to Z-1A1C configuration with amplification of the latter. These changes may be represented by square constitutional dynamic networks that display up-regulation of the pairs of agonists ( 1A2B, 2A1B), (Z-1A 1C, 2A2C), (1A3C, 2A1C), (Z-1A1C, 2A 3C) and the simultaneous down-regulation of the pairs of antagonists (1A1B, 2A2B), (1A 2C, 2A1C), (E-1A1C, 2A3C), (1A3C, 2A 1C). The orthogonal dual adaptation undergone by the set of acylhydrazones amounts to a network switching process. © 2014 American Chemical Society.

Liu X.,Jilin University
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases | Year: 2013

To examine the effect of exposure to extremely low-frequency electromagnetic fields (ELF EMFs) on the liver function of workers. The workers in a factory were selected as subjects, and the recent physical examination data of these workers were collected. The workers aged 20∼40 years and with more than 2 years' working experience were included for analysis; considering the intensity of electromagnetic field, the workers exposed to less electromagnetic radiation were assigned to exposure I group (n = 123), those exposed to more electromagnetic radiation to exposure II group (n = 229), and those not exposed to electromagnetic radiation to control group (n = 212). There were no significant differences in sex, age, height, and body weight between the three groups (P > 0.05). Physical examination, including measurements of direct bilirubin (DBil), alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), γ-glutamyl transpeptidase (GGT), and albumin, was performed in a health examination center. The intensity of electromagnetic field was measured by EFA-300 power frequency electromagnetic field analyzer, and the intensity of noise by AWA5610D integrating sound level meter. The intensities of electric field and the magnetic field in exposure II group were significantly higher than those in the exposure I group. The levels of ALT, ALP, AST, GGT and albumin in exposure II group were significantly higher than those in exposure I group and control group. However, the level of direct bilirubin in exposure II group was significantly lower than that in exposure I group and control group. Occupational exposure to ELF EMFs may affect human liver function.

Zhao Y.,Jilin University | Zhao Y.,New York State Institute for Basic Research in Developmental Disabilities | Gong C.-X.,New York State Institute for Basic Research in Developmental Disabilities
Cellular and Molecular Neurobiology | Year: 2014

Chronic cerebral hypoperfusion (CCH) is a common consequence of various cerebral vascular disorders and hemodynamic and blood changes. Recent studies have revealed an important role of CCH in neurodegeneration and dementia, including vascular dementia and Alzheimer’s disease (AD). This article reviews the recent advances in understanding CCH-induced neurodegeneration and AD-related brain pathology and cognitive impairment. We discuss the causes and assessment of CCH, the possible mechanisms by which CCH promotes Alzheimer-like pathology and neurodegeneration, and animal models of CCH. It appears that CCH promotes neurodegeneration and AD through multiple mechanisms, including induction of oxidative stress, Aβ accumulation and aggravation, tau hyperphosphorylation, synaptic dysfunction, neuronal loss, white matter lesion, and neuroinflammation. Better understanding of the mechanisms of CCH will help develop therapeutic strategies for preventing and treating neurodegeneration, including sporadic AD and vascular dementia, caused by CCH. © 2014, Springer Science+Business Media New York.

Jiang J.,Jilin University
World journal of gastroenterology : WJG | Year: 2012

To investigate the role of expressions of Ki-67, p53, epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) in gastrointestinal stromal tumor (GIST) grading and prognosis. Tumor tissue was collected retrospectively from 96 patients with GIST. Antibodies against Ki-67, p53, EGFR and COX-2 were used for immunohistochemical staining. Tumor grading was designated according to a consensus system and the staining was quantified in 3 categories for each antibody in the statistical analysis. The Ki-67 expression in GISTs was significantly associated with the size of the tumors, mitotic rate and the risk of malignancy (χ(2) = 15.51, P = 0.02; χ(2) = 22.27, P < 0.001; χ(2) = 20.05; P < 0.001). The p53 expression was also significantly correlated with mitotic rate and the risk of malignancy (χ(2) = 9.92, P = 0.04; χ(2) = 9.97; P = 0.04). Over-expression of Ki-67 was strongly correlated with poor survival (χ(2) = 10.44, P = 0.006), but no correlation was found between the expression of p53, EGFR or COX-2 and survival. Multivariate analysis further demonstrated that Ki-67 expression (relative risk = 15.78, 95% CI: 4.25-59.37) could be used as an independent prognostic value for GIST patients. Adjuvant imatinib therapy could improve clinical outcomes in the patients with high risk and intermediate risk of recurrence after complete tumor resections (median survival time: 52 mo vs 37 mo, χ(2) = 7.618, P = 0.006). Our results indicated that the expression of Ki-67 could be used as an independent prognostic factor for GIST patients.

Sun P.D.,Jilin University
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2011

To study the feasibility and influence of vagus nerve preservation in radical operation for proximal gastric cancer. Thirty-two patients with early or T2 cardia cancer from May 2007 to May 2009 were enrolled and randomized into two groups, i.e. vagus nerve preservation group(n=16) and control group(n=16). Two groups were compared with regard to operative time, anastomotic fistula, digestive discomforts, body weight, survival rate, findings on gastroscope and abdominal ultrasonography. There were no statistically significant differences between the two groups in operative time (2.8 vs. 2.5 h), postoperative complications rate (25.0% vs. 31.3%). No recurrence or mortality was observed after one-year follow-up. However, patients who underwent vagus nerve preservation had less postprandial discomforts(3 vs. 12 cases), bile reflux(3 vs. 10 cases), atrophic gastritis(1 vs. 9 cases), gallstones(1 vs. 8 cases), body mass index, and diarrhea(P<0.05). For patients with early gastric cancer, preservation of the vagus nerve during radical gastrectomy results in less complications and does not compromise patient survival.

Lin L.,Dalian Polytechnic University | Zhai S.-R.,Dalian Polytechnic University | Xiao Z.-Y.,Dalian Polytechnic University | Song Y.,Dalian Polytechnic University | And 2 more authors.
Bioresource Technology | Year: 2013

In continuation of previous work on utilizing rice husks, this study aimed to prepare mesoporous activated carbons using residues of sodium hydroxide-pretreated RHs, and then examine their dye adsorption performance. The influences of the activation temperature and activation time on the surface area, pore volume, and pore radius of the activated carbon were investigated based on nitrogen adsorption/desorption isotherms and transmission electron microscopy. The adsorptive behavior of the mesoporous activated carbons obtained under optimum preparation conditions was evaluated using methyleneblue as the model adsorbate. The adsorption kinetics was studied by pseudo-first-and pseudo-second-order models, and the adsorption isotherms were studied by Langmuir and Freundlich models. The pseudo-second-order model and Langmuir isotherm were found to fit well the adsorption characteristics of the as-prepared mesoporous activated carbons. Thermodynamic data of the adsorption process were also obtained to elucidate the adsorption thermo-chemistry between the activated carbons produced from NaOH-pretreated RHs and MB molecules. © 2013 Elsevier Ltd.

Hu Z.,University of Maryland University College | Hu Z.,Jilin University | Weeks J.D.,University of Maryland University College
Physical Review Letters | Year: 2010

We use a new configuration-based version of linear response theory to efficiently solve self-consistent mean field equations relating an effective single particle potential to the induced density. The versatility and accuracy of the method is illustrated by applications to dewetting of a hard sphere solute in a Lennard-Jones fluid, the interplay between local hydrogen bond structure and electrostatics for water confined between two hydrophobic walls, and to ion pairing in ionic solutions. Simulation time has been reduced by more than an order of magnitude over previous methods. ©2010 The American Physical Society.

Li H.,University of Waterloo | Li H.,Jilin University | Le Roy R.J.,University of Waterloo | Roy P.-N.,University of Waterloo | McKellar A.R.W.,NRC Steacie Institute for Molecular Sciences
Physical Review Letters | Year: 2010

Clusters of para-hydrogen (pH2) have been predicted to exhibit superfluid behavior, but direct observation of this phenomenon has been elusive. Combining experiments and theoretical simulations, we have determined the size evolution of the superfluid response of pH2 clusters doped with carbon dioxide (CO2). Reduction of the effective inertia is observed when the dopant is surrounded by the pH2 solvent. This marks the onset of molecular superfluidity in pH2. The fractional occupation of solvation rings around CO2 correlates with enhanced superfluid response for certain cluster sizes. © 2010 The American Physical Society.

Li M.,Jilin University
Environmental technology | Year: 2011

The reductive degradation of nitrobenzene (NB) by iron-carbon micro-electrolysis packing was investigated. The influence of initial NB concentration, pH value and packing amount on the removal rate of NB were studied. The results showed that the reaction with packing followed the pseudo-first-order reaction. The optimum pH was 3.0 for the degradation of NB in the tested pH ranges of 3-9 and the optimum packing amount was 40 g/200 ml. The flow-through column packed with packing was designed to remove NB from simulated wastewater for approximately 68 days. The removal rate was over 90% within initial periods. It could be seen that after running for 68 days, the packing still had good performance after the long-term column experiment. In addition, the changes of the packing surfaces morphologies and matters before, during and after the column experiment were analysed by scanning electron microscopy in conjunction with energy-dispersion spectroscopy (EDS).

Xu H.L.,Jilin University | Chin S.L.,Laval University
Sensors | Year: 2011

Powerful femtosecond laser pulses propagating in transparent materials result in the formation of self-guided structures called filaments. Such filamentation in air can be controlled to occur at a distance as far as a few kilometers, making it ideally suited for remote sensing of pollutants in the atmosphere. On the one hand, the high intensity inside the filaments can induce the fragmentation of all matters in the path of filaments, resulting in the emission of characteristic fluorescence spectra (fingerprints) from the excited fragments, which can be used for the identification of various substances including chemical and biological species. On the other hand, along with the femtosecond laser filamentation, white-light supercontinuum emission in the infrared to UV range is generated, which can be used as an ideal light source for absorption Lidar. In this paper, we present an overview of recent progress concerning remote sensing of the atmosphere using femtosecond laser filamentation. © 2010 by the authors.

Wu B.,Jilin University
Archive of Applied Mechanics | Year: 2014

The half-power bandwidth method is commonly used to evaluate the system damping by using frequency response curves and assuming a small damping ratio. Preceding derivations obtain the third-order corrections to the classical formula but still show large errors when the damping ratio is high, especially for the acceleration case. In this note, new approximate formulas for damping ratio in terms of the half-power bandwidth are established using displacement and acceleration frequency response functions, respectively. The proposed formulas, third-order correction and classical approximations are compared by using relative errors of calculated damping ratios for both displacement and acceleration cases. The new formulas for damping ratio are brief and show excellent accuracy for small as well as high damping ratios. © 2014, Springer-Verlag Berlin Heidelberg.

Ma R.,Washington State University | Xu Y.,Jilin University | Zhang X.,Washington State University
ChemSusChem | Year: 2015

(Figure Presented). Transforming plant biomass to biofuel is one of the few solutions that can truly sustain mankind's long-term needs for liquid transportation fuel with minimized environmental impact. However, despite decades of effort, commercial development of biomass-to-biofuel conversion processes is still not an economically viable proposition. Identifying value-added co-products along with the production of biofuel provides a key solution to overcoming this economic barrier. Lignin is the second most abundant component next to cellulose in almost all plant biomass; the emerging biomass refinery industry will inevitably generate an enormous amount of lignin. Development of selective biorefinery lignin-to-bioproducts conversion processes will play a pivotal role in significantly improving the economic feasibility and sustainability of biofuel production from renewable biomass. The urgency and importance of this endeavor has been increasingly recognized in the last few years. This paper reviews state-of-the-art oxidative lignin depolymerization chemistries employed in the papermaking process and oxidative catalysts that can be applied to biorefinery lignin to produce platform chemicals including phenolic compounds, dicarboxylic acids, and quinones in high selectivity and yield. The potential synergies of integrating new catalysts with commercial delignification chemistries are discussed. We hope the information will build on the existing body of knowledge to provide new insights towards developing practical and commercially viable lignin conversion technologies, enabling sustainable biofuel production from lignocellulosic biomass to be competitive with fossil fuel. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA.

Ma Y.-L.,Jilin University | Harada M.,Nagoya University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2016

The spectroscopy of the doubly heavy baryons including different heavy quarks is studied based on the heavy quark symmetry of QCD. We point out that, when the two heavy quarks are in S-wave, these baryons with a certain spin jl of the light cloud can be classified into two sets: a heavy quark singlet with total spin of j=jl and a heavy quark multiplet with j=(jl+1), jl,.|jl-1|, all the baryons in these two sets have the same mass and, the baryons with the same quantum numbers in these two sets do not mix with each other. We finally point out that the strong decay of the first excited baryon with light spin jl=1/2 to the ground state and one-pion is determined by the mass splitting through the generalized Goldberger-Treiman relation. © 2016 The Authors.

Qi D.,Changan University | Leick M.,University of Illinois at Urbana - Champaign | Liu Y.,Jilin University | Lee C.-F.F.,University of Illinois at Urbana - Champaign
Fuel | Year: 2011

In this study, the effect of injection timing and EGR rate on the combustion and emissions of a Ford Lion V6 split injection strategy direct injection diesel engine has been experimentally investigated by using neat biodiesel produced from soybean oil. The results showed that, with the increasing of EGR rate, the brake specific fuel combustion (BSFC) and soot emission were slightly increased, and nitrogen oxide (NOx) emission was evidently decreased. Under higher EGR rate, the peak pressure was slightly lower, and the peak heat release rate kept almost identical at lower engine load, and was higher at higher engine load. With the main injection timing retarded, BSFC was slightly increased, NOx emission was evidently decreased, and soot emission hardly varied. The second peak pressure was evidently decreased and the heat release rate was slightly increased. © 2010 Elsevier Ltd. All rights reserved.

Song H.-W.,Jilin University
Faguang Xuebao/Chinese Journal of Luminescence | Year: 2013

The birth of the concept of photonic crystal (PC) makes the dream of manipulating photon become reality. Possessing spatial periodicity in their dielectric constant on the length scale of the optical wavelength, PCs behave with electromagnetic waves just like atomic crystals do with electrons. As an electronic band gap is created by the periodic arrangement of atoms in a semiconductor, the periodic electromagnetic modulation created by a PC can yield a photonic stop band (PSB), which has significant modification on the spontaneous radiative rate and emission intensity of the fluorescent guest implanted in the PCs. The modification of PCs on spontaneous emission is attracting current interests due to its considerable scientific and technological values. In this article, after highlight the international development on this field, on emphasis, we will introduce our recent results on the preparation of three-dimensional lanthanide oxide PCs through the self-assembly method and the modification of PCs on spontaneous emission of rare earth ions. Recently, we observed a number of interesting phenomena, such as the observation of Lamb shift, inhibited long-scale energy transfer (ET) and improvement of luminescent quantum yield in lanthanide oxide inverse opal PCs.

Yao K.,CAS Changchun Institute of Optics and Fine Mechanics and Physics | Yao K.,University of China Academy of Science | Wang J.,CAS Changchun Institute of Optics and Fine Mechanics and Physics | Liu X.,CAS Changchun Institute of Optics and Fine Mechanics and Physics | Liu W.,Jilin University
Optics Express | Year: 2014

We describe a closed-loop dynamic holographic adaptive optics system. This system can be realized via one liquid crystal spatial light modulator and one CCD camera. The liquid crystal spatial light modulator is used as the wavefront sensor and corrector, as well as imaging element. CCD detects the spots at holographic image plane and at focal plane of imaging channel simultaneously. The basic principle of the system is introduced first, and then the numerical analysis is presented. On this basis, we report a practical implementation of the dynamic holographic adaptive optics system. The results show that a rapid increase of Strehl ratio and improved image quality at focal plane for deliberately introduced aberrations can be achieved, verifying the feasibility of the system. © 2014 Optical Society of America.

Zhu S.,Jilin University
Complex Analysis and Operator Theory | Year: 2014

An operator (formula presented.) on a complex Hilbert space (formula presented.) is called skew symmetric if (formula presented.) can be represented as a skew symmetric matrix relative to some orthonormal basis for (formula presented.). In this paper, we study the approximation of skew symmetric operators and provide a (formula presented.)-algebra approach to skew symmetric operators. We classify up to approximate unitary equivalence those skew symmetric operators (formula presented.) satisfying (formula presented.). This is used to characterize when a unilateral weighted shift with nonzero weights is approximately unitarily equivalent to a skew symmetric operator. © 2014, Springer Basel.

Yu A.-Y.,Jilin University
Canadian Journal of Chemistry | Year: 2013

In this work, the reaction mechanism and kinetics of Cl + CH 2BrCH2Br → products are theoretically investigated for the first time. The optimized geometries and frequencies of all of the stationary points and selected points along the minimum-energy path for the three hydrogen abstraction channels and two bromine abstraction channels are calculated at the BH&H-LYP level with the 6-311G** basis set and the energy profiles are further calculated at the CCSD(T) level of theory. The rate constants are evaluated using the conventional transition-state theory, the canonical variational transition-state theory, and the canonical variational transition-state theory with a small-curvature tunneling correction over the temperature range 200-1000 K. The results show that reaction channel 3 is the primary channel and the calculated rate constants are in good agreement with available experimental values. The three-parameter Arrhenius expression for the total rate constants over 200-1000 K is provided. © 2013 Published by NRC Research Press.

Zhang Z.,Baicheng Normal College | Zhang Z.,Jilin University
Inorganic Chemistry Communications | Year: 2012

Silver atoms and strongly interlinking α-metatungstate units ensure the 3D structure of (NH 4) 5[Ag 5(L) 2(H 2O) 8(H 2W 12O 40)]•H 2O (L = pyridine-3,5-dicarboxylate dianion), which has been synthesized in aqueous solution and characterized by the normal physical methods as well as the single-crystal X-ray diffraction. This compound represents the first example that the α-metatungstate cluster as the structural motif is linked by transition metal complexes to yield unprecedented 3D framework with the highest eleven-connected number. © 2011 Elsevier B.V. All rights reserved.

Barisic N.,CEA Saclay Nuclear Research Center | Barisic N.,University of Minnesota | Barisic N.,Institute of Physics | Badoux S.,CNRS French National High Magnetic Field Laboratory | And 10 more authors.
Nature Physics | Year: 2013

The metallic state of the underdoped high- Tc cuprates has remained an enigma: how may seemingly disconnected Fermi-surface segments, observed in zero magnetic field as a result of the opening of a partial gap (the pseudogap), possess conventional quasiparticle properties? How do the small Fermi-surface pockets evidenced by the observation of quantum oscillations emerge as superconductivity is suppressed in high magnetic fields? Such quantum oscillations, discovered in underdoped YBa2Cu3O 6.5(Y123; ref.) and YBa2Cu4O8 (Y124; ref.), signify the existence of a conventional Fermi surface. However, owing to the complexity of the crystal structures of Y123 and Y124 (CuO2 double layers, CuO chains, low structural symmetry), it has remained unclear whether the quantum oscillations are specific to this particular family of cuprates. Numerous theoretical proposals have been put forward to explain the source of quantum oscillations, including materials-specific scenarios involving CuO chains and scenarios involving the quintessential CuO2 planes. Here we report the observation of quantum oscillations in underdoped HgBa 2CuO4+δ (Hg1201), a model cuprate superconductor with individual CuO2 layers, high tetragonal symmetry and no CuO chains. This observation proves that quantum oscillations are a universal property of the underdoped CuO2 planes, and it opens the door to quantitative future studies of the metallic state and of the Fermi-surface reconstruction phenomenon in this structurally simplest cuprate. © 2013 Macmillan Publishers Limited.

Cisplatin resistance is a difficult problem in clinical chemotherapy, and the mechanisms involved in cisplatin resistance require further study. In this study, we investigated the role of chloride channel-3 (ClC-3) in cisplatin resistance. Autophagy was demonstrated by accumulation of LC3-II, beclin 1 and Atg12-Atg5. The ultrastructure changes were observed under electron microscope. Chemical staining with acridine orange or MDC was used to detect acidic vesicular organelles. Quantification of apoptosis was detected by PI and Annexin V staining. The mechanisms involved in the Akt pathway and autophagy were studied by western blot analysis. Our results showed that Akt phosphorylation and autophagy were induced by cisplatin in human glioma U251 cells. Specific inhibition of ClC-3 by ClC-3 siRNA sensitized the apoptosis-resistant U251 cells to cisplatin-mediated cell death and downregulated phosphorylated Akt. Interestingly, ClC-3 suppression also inhibited induction of autophagy by cisplatin although the Akt/mTOR pathway was deregulated. Counteracting the autophagic process by 3-methylademine enhanced cytotoxicity of cisplatin, revealing that autophagy plays a key role in chemoresistance. Suppressing the Akt/mTOR pathway by the NADPH oxidase inhibitor diphenyl iodonium (DPI) indicated that cisplatin-induced activation of Akt/mTOR pathway requires generation of reactive oxygen species (ROS) through NADPH oxidase. Collectively, our results suggest that ClC-3 suppression causes the inhibition of Akt and autophagy, which can enhance the therapeutic benefit of cisplatin in U251 cells. Copyright © 2013 Wiley Periodicals, Inc.

Jiang T.,Ningbo University | Qin W.,Jilin University | Zhou J.,Ningbo University
Journal of Alloys and Compounds | Year: 2014

The synthesis of YbF3 and NaYbF4 crystals was successfully fulfilled by a facial hydrothermal method. The phase and morphology of the products were adjusted by changing the surfactant additive and fluorine source and tuning the pH value of the initial solution. The products with various morphologies range from octahedral nanoparticles, corn-like nanobundles, nanospheres, microrods, and hollow microprisms were prepared at different conditions. The growth mechanism of these products has been systematically studied. Impressively, relatively enhanced high order ultraviolet (UV) upconversion (UC) luminescence was observed in Tm3+ (Er3+) ions doped YbF3 nanocrystals (NCs) compared with NaYbF4 microcrystals under the excitation of 980 nm infrared laser. The investigation results reveal that the crystal symmetry of matrix has significant effect on the spectra and lifetimes of the doping lanthanide ions. The simply synthesized water soluble YbF3 NCs with efficient UV UC luminescence may find potential application in biochemistry. © 2014 Elsevier B.V. All rights reserved.

Liu Z.-Q.,Jilin University
Current Organic Chemistry | Year: 2014

High efficiency in the organic synthesis makes the multicomponent reaction (MCR) an attractive research field, in which some three-component reactions such as the Strecker (found in 1850), Hantzsch (1882), Biginelli (1891), Mannich (1912), and Passerini (1921) were widely spread, followed by the findings of some four-component reactions such as the Bucherer Bergs and Asinger reactions found in 1929 and 1956, respectively. However, the reaction among ketone, amine, isonitrile, and carboxylic acid to form bisamide found by Ivar K. Ugi in 1959 still takes the most important position in the MCRs because the Ugi four-component reaction (Ugi 4CR) occurs among four organic reagents in methanol or other popular solvents without the aid of any catalysts. Thus, Ugi 4CR represents a selfresembling process among organic reagents and therefore implies the possibility that an organic reaction may involve more than four reagents within one pot operation. Thus, Ugi 4CR can be regarded as the breakthrough in the research of MCRs. Many published reviews summarize the Ugi 4CR from different viewpoints, but the aim of the presented review on Ugi 4CR together with Passerini three-component reaction (Passerini 3CR) is to introduce a successful mode for the study on MCRs, in which the research on a MCR may involve four aspects including mechanism, substrate, catalyst, and application. The quantum calculation on the energy variation of Ugi 4CR reveals that the addition of isocyanide to imine controls the reaction rate of Ugi 4CR, and imine is generated via the reaction between the amine and ketone at the first step in Ugi 4CR. As a result, the investigation on the substrates of Ugi 4CR focuses on the formation of imine and the resources of carboxylic acid and ketone. Moreover, some catalysts are employed to induce the diastereoisomer ratio because a chiral center is involved in the product of Ugi 4CR. In addition, Lewis acid is used to activate the inert reagents or to drive the further reactions based on Ugi 4CR products. The application of Ugi 4CR is not the major concern in this review because many previous reviews have focused on this topic. Only some recently published results are documented herein. For example, Ugi 4CR can be used to construct macromolecules with complicated topological structure, to introduce medicinal molecule into nanoparticles, and to synthesize biological-related molecules. Finally, a successful model for the research on MCR can be summarized from the study on Ugi 4CR. Understanding mechanism is the basis for investigating MCR, followed by expanding the suitable substrates and exploring the chiral catalysts. As a result, the MCR can be widely applied to synthesize various molecules. © 2014 Bentham Science Publishers.

Su J.,Shanghai JiaoTong University | Zou X.,Jilin University | Chen J.-S.,Shanghai JiaoTong University
RSC Advances | Year: 2014

The defect chemistry of metal oxides is a very important research aspect of inorganic solid-state materials. This is because (i) a certain amount of defects or imperfections are always present in metal oxide materials; (ii) the presence of defects affects, and even sometimes determines, the physical and chemical properties of the materials; and (iii) more importantly, defects do not necessarily have adverse effects on the properties of materials, and judicious "defect engineering" can bring about improved properties desired in material systems, and even some new useful functionalities that are not available to the "perfect" material. In this review, we specially highlight the recent research efforts toward understanding the defect chemistry of titanium dioxide (also known as titania, TiO2), a widely-studied multifunctional metal oxide. In the discussion, particular attention is paid to the synthesis of Ti3+/oxygen vacancy self-modified TiO2 materials and the favorable effects of these defects on the materials' properties and applications. This review, focusing on a representative metal oxide (i.e., TiO2), is anticipated to provide some new insights into the general defect chemistry of metal oxides, and to give impetus to the development of the "defect engineering" of metal oxide materials. © 2014 The Royal Society of Chemistry.

Oxidative stress is widely implicated in the death of retinal ganglion cells associated with various optic neuropathies. Agonists of the dopamine D(1) receptor have recently been found to be potentially neuroprotective against oxidative stress-induced injury. The goal of this study was to investigate whether SKF83959, a next-generation high-affinity D(1) receptor agonist, could protect retinal ganglion cell 5 (RGC-5) cells from H(2)O(2)-induced damage and the molecular mechanism involved. We examined expression of the D(1) receptor in RGC-5 cells with reverse-transcription-PCR and immunoblotting and assessed neuroprotection using propidium iodide staining and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. In addition, we monitored the activation and involvement of members of mitogen-activated protein kinase family, extracellular signal-regulated kinase (ERK), p38 and c-Jun NH(2)-terminal kinase, with western blot and specific inhibitors. We found that the D(1) receptor was expressed in RGC-5 cells, but the sequence analysis suggested this cell line is from mouse and not rat origin. SKF83959 exhibited a remarkable neuroprotective effect on H(2)O(2)-damaged RGC-5 cells, which was blocked by the specific D(1) receptor antagonist, SCH23390. ERK and p38 were activated by SKF83959, and pretreatment with their inhibitors U0126 and SB203580, respectively, significantly blunted the SKF83959-induced cytoprotection. However, the specific c-Jun NH(2)-terminal kinase inhibitor, SP600125, had no effect on the SKF83959-induced protection. We conclude that SKF83959 attenuates hydrogen peroxide-induced injury in RGC-5 cells via a mechanism involving activation of the ERK and p38 pathways and the D(1) receptor is a potential molecular target for developing neuroprotective drugs.

Zhao Z.L.,Jilin University
Genetics and molecular research : GMR | Year: 2012

The mannan-binding lectin gene (MBL) participates as an opsonin in the innate immune system of mammals, and single nucleotide polymorphisms (SNPs) in MBL cause various immune dysfunctions. In this study, we detected SNPs in MBL2 at exon 1 using polymerase chain reaction single-strand conformation polymorphism analysis and DNA sequencing techniques in 825 Chinese Holstein cows. Four new SNPs with various allele frequencies were also found. The g.1164 G>A SNP was predicted to substitute arginine with glutamine at the N-terminus of the cysteine-rich domain. In the collagen-like domain, SNPs g.1197 C>A and g.1198 G>A changed proline to glutamine, whereas SNP g.1207 T>C was identified as a synonymous mutation. Correlation analysis showed that the g.1197 C>A marker was significantly correlated to somatic cell score (SCS), and the g.1164 G>A locus had significant effects on SCS, fat content, and protein content (P < 0.05), suggesting possible roles of these SNPs in the host response against mastitis. Nine haplotypes and nine haplotype pairs corresponding to the loci of the 4 novel SNPs were found in Chinese Holsteins. Haplotype pairs MM, MN, and BQ were correlated with the lowest SCS; MN with the highest protein yield; MM with the highest protein rate, and MN with the highest 305- day milk yield. Thus, MM, MN, and BQ are possible candidates for marker-assisted selection in dairy cattle breeding programs.

Lanthanide-doped core-shell upconversion nanocrystals (UCNCs) have tremendous potential for applications in many fields, especially in bio-imaging and medical therapy. As core-shell UCNCs are mostly synthesized in organic solvents, tedious organic-aqueous phase transfer processes are usually needed for their use in bio-applications. Herein, we demonstrate the first example of one-step synthesis of highly luminescent core-shell UCNCs in the "aqueous" phase under mild conditions using innocuous reagents. A microwave-assisted approach allowed for layer-by-layer epitaxial growth of a hydrophilic NaGdF4 shell on NaYF4:Yb, Er cores. During this process, surface defects of the nanocrystals could be gradually passivated by the homogeneous shell deposition, resulting in obvious enhancement in the overall upconversion emission efficiency. In addition, the up-down conversion dual-mode luminescent NaYF4:Yb, Er@NaGdF4:Ce, Ln (Eu, Tb, Sm, Dy) nanocrystals were also synthesized to further validate the successful formation of the core-shell structure. More significantly, based on their superior solubility and stability in water solution, high upconversion efficiency and Gd-doped predominant X-ray absorption, the as-prepared NaYF4:Yb, Er@NaGdF4 core-shell UCNCs exhibited high contrast in in vitro cell imaging and in vivo X-ray computed tomography (CT) imaging, demonstrating great potential as multiplexed luminescent biolabels and CT contrast agents.

Tan G.,University of Tennessee Health Science Center | Tan G.,Jilin University | Shi Y.,University of Tennessee Health Science Center | Wu Z.-H.,University of Tennessee Health Science Center
Biochemical and Biophysical Research Communications | Year: 2012

DNA damage response upon UV radiation involves a complex network of cellular events required for maintaining the homeostasis and restoring genomic stability of the cells. As a new class of players involved in DNA damage response, the regulation and function of microRNAs in response to UV remain poorly understood. Here we show that UV radiation induces a significant increase of miR-22 expression, which appears to be dependent on the activation of DNA damage responding kinase ATM (ataxia telangiectasia mutated). Increased miR-22 expression may result from enhanced miR-22 maturation in cells exposed to UV. We further found that tumor suppressor gene phosphatase and tensin homolog (PTEN) expression was inversely correlated with miR-22 induction and UV-induced PTEN repression was attenuated by overexpression of a miR-22 inhibitor. Moreover, increased miR-22 expression significantly inhibited the activation of caspase signaling cascade, leading to enhanced cell survival upon UV radiation. Collectively, these results indicate that miR-22 is an important player in the cellular stress response upon UV radiation, which may promote cell survival via the repression of PTEN expression. © 2011 Elsevier Inc..

Zhang J.,Jilin University | Lu Z.-Y.,CAS Changchun Institute of Applied Chemistry | Sun Z.-Y.,CAS Changchun Institute of Applied Chemistry
Soft Matter | Year: 2011

By using computer simulations, we propose a simple route to fabricate 7-17 nm particles with controllable patch symmetry via self-assembly of a polymer chain in one step. A single chain of polystyrene-polymethylmethacrylate (PS-PMMA) multiblock copolymer, which is intended to be a generic representative for common hydrophobic multiblock copolymers, is used to fabricate the patchy particles in a solvent that is poor for both components. Various kinds of patchy particles, such as one-patch (with C ∞v symmetry), two-patch (with D ∞h symmetry), three-patch (with D 3hsymmetry), four-patch (with T d symmetry), and cross-ribbon patchy particles, have been obtained. Our work demonstrates that a rational bottom-up design of patchy nanoparticles with controllable symmetry is possible by manipulating the block copolymer chain length and solvent quality. © 2011 The Royal Society of Chemistry.

He J.,Colorado State University | Zhang Y.,Colorado State University | Zhang Y.,Jilin University | Chen E.Y.-X.,Colorado State University
Synlett | Year: 2014

Reported herein is the first example of polymerization of polar vinyl monomers bearing the C=C-C=N functionality by Frustrated Lewis pairs (FLPs). In particular, FLPs based on Al(C6F5)3 and N-heterocyclic carbenes rapidly convert 2-vinyl pyridine and 2-isopropenyl-2-oxazoline into medium to high molecular weight, N-functionalized vinyl polymers. Activated monomer-alane adduct 1 and initiated zwitterionic intermediate 2 have been isolated and structurally characterized, providing strong evidence for the proposed bimolecular, activated monomer polymerization mechanism. © Georg Thieme Verlag Stuttgart New York.

Gao C.,Jilin University
Research Journal of Applied Sciences, Engineering and Technology | Year: 2013

From economic perspective, the form and function of big stadium becomes diversified. Its utility and density increase. The fire evacuation becomes the common safety problem we all have to face. It is also the core of fire fighting design for big stadiums. Current researches focus on the development of evacuation model and behaviors during the evacuation. With the technical development, smart evacuation command already has the basis for realization. This study, on basis of performance evacuation, fire safety evacuation judgment and clustering behaviors, proposes fire detection-alarming-smart evacuation system design. Its result, on one hand, provides references for current big stadium to make evacuation plans and build fitting facilities. One the other hand, it can provide thoughts for fire-fighting safety design. It has widespread applicant prospect and abundant theoretic and practical significances. © Maxwell Scientific Organization, 2013.

It is believed that a hot Jupiter (giant planet with a short period less than 10 days) forms in the outer region of a protoplanetary disk, then migrates inward to an orbit with a short period around 3 days, and stops there by a final stopping mechanism. The prominent problem is why hot Jupiters migrate inward to short-period orbits, while other extrasolar giant planets and Jovian planets in our solar system exist on long-period orbits. Here we show that this difference in orbital periods is caused by two populations of protoplanetary disks. One population experiences gravitational instability during some periods of their lifetime (GI disks), while the other does not (No-GI disks). In GI disks, planets can quickly migrate inward to short-period orbits to become hot Jupiters. In No-GI disks, the migration is so slow that planets can exist on long-period orbits. Protoplanetary disks are classified into the two populations because of the differences in properties of molecular cloud cores, from which disks from. We specifically compare our theory with observations. Our theory is supported by observations of extrasolar planets. We analyze the current status of our solar system and find that our solar nebula belongs to the population with a low migration rate. This is consistent with the observation that Jupiter and Saturn are indeed on long-period orbits. Our results further suggest that, in the future observations, a hot Jupiter cannot be found around a star with mass below a critical mass (0.14-0.28M⊙). © 2010. The American Astronomical Society. All rights reserved.

Dong L.,Jilin University
European journal of medical research | Year: 2014

Plasmablastic lymphoma (PBL) is an aggressive neoplasm exclusively occurring in AIDS patients. Recently, increasing cases of human immunodeficiency virus (HIV)-negative PBL have been reported. No standard therapy protocol is currently available since there is a great difference between PBL with and without HIV infection. Here, we present a rather rare case of HIV-negative PBL in the neck that dramatically responded to radiotherapy alone. Our case highlights the possibility of PBL in the neck and helps to expand our understanding of this separate lymphoma. The related literature review summarized the clinicopathological features and treatment status of HIV-negative PBL.

Abramavicius D.,Jilin University | Mukamel S.,University of California at Irvine
Journal of Chemical Physics | Year: 2011

We study the effects of correlated molecular transition energy fluctuations in molecular aggregates on the density matrix dynamics, and their signatures in the optical response. Correlated fluctuations do not affect single-exciton dynamics and can be described as a nonlocal contribution to the spectral broadening, which appears as a multiplicative factor in the time-domain response function. Intraband coherences are damped only by uncorrelated transition energy fluctuations. The signal can then be expressed as a spectral convolution of a local contribution of the uncorrelated fluctuations and the nonlocal contribution of the correlated fluctuations. © 2011 American Institute of Physics.

Zhang X.-B.,5 Building | Xi Z.,Jilin University
Physical Chemistry Chemical Physics | Year: 2011

A mechanism for the dehydrogenation reaction of 1,2,3,4-tetrahydroquinoline to quinoline derivatives, catalyzed by a Cp*Ir complex containing a 2-pyridonate ligand, is proposed and supported by theoretical calculations at the B3LYP level. The proposed mechanism involves two stages which are all thermodynamically unfavorable (endothermic by 36.3 kcal mol-1 and 18.4 kcal mol-1, respectively). The apparent activation energies of the first and second stages of the reaction are 30.8 kcal mol-1 and 34.0 kcal mol-1, respectively, and are considered overestimates of the entropy change of reaction. Owing to a decrease in the oxidative ability of iridium(III) coordinated to large electronegative nitrogen and chlorine, ligand promoted hydrogen abstraction is crucial at both stages of dehydrogenation, in which the oxidation state of iridium(III) does not change, and the ligand 2-pyridonate is converted to 2-hydroxypyridine. Cp*Ir(C5NH 4OH)ClH, an important intermediate, releases hydrogen through an energy barrier of 23.5 kcal mol-1. © the Owner Societies 2011.

Wang L.,Jilin University
Mathematical Problems in Engineering | Year: 2013

The problem of extracting knowledge from a relational database for probabilistic reasoning is still unsolved. On the basis of a three-phase learning framework, we propose the integration of a Bayesian network (BN) with the functional dependency (FD) discovery technique. Association rule analysis is employed to discover FDs and expert knowledge encoded within a BN; that is, key relationships between attributes are emphasized. Moreover, the BN can be updated by using an expert-driven annotation process wherein redundant nodes and edges are removed. Experimental results show the effectiveness and efficiency of the proposed approach. © 2013 LiMin Wang.

Liu Z.,Jilin University | Liu Z.,Harbin University
Nonlinear Analysis: Real World Applications | Year: 2013

In this paper, we obtain sufficient criteria for the existence of periodic solutions to deterministic SIR and SEIR epidemic models with modified saturation incidence rates by means of using the continuation theorem based on coincidence degree theory, and we show that the solution is unique and globally stable. Second, we discuss their corresponding stochastic epidemic models with random perturbation have a unique global positive solution respectively, and we utilize stochastic Lyapunov functions to investigate the asymptotic behavior of the solution. © 2012 Elsevier Ltd. All rights reserved.

Wang L.-Y.,Jilin University
National Medical Journal of China | Year: 2013

Objective: To explore the clinical efficacy and safety of MYCu intrauterine contraceptive device (TUD) containing indomethacin. Methods: From October 1 to December 31, 2004, women of child-bearing age requiring IUD for contraception were chosen from the Outpatient Departments of China-Japan Friendship Hospital of Jilin University, Peking University First Hospital, Peking University Third Hospital, Jilin University Second Hospital and Affiliated Shengjing Hospital of China Medical University. They were randomly inserted with MYCuIUD and control TCu380A IUD each for 1000 cases and followed up at 1, 3, 6, 12, 24, 36, 48 and 60 months post-insertion. Results: When MYCu TUD group and TCu380A group 60 months post-insertion were compared, the cumulative pregnancy rates with IUD in situ were 2.38/100 women per year and 2.84/100 women per year respectively. And the difference had no statistical significance (P>0.05); the cumulative expulsion rates, mostly of partial expulsion and downward movement, were 0.87/100 women per year and 2.94/100 women per year respectively. And the difference had statistical significance(P<0.05); the cumulative termination rates due to bleeding/pain were 3.57/100 women per year and 4.83/100 women per year respectively. And the difference had no statistical significance (P>0.05); Side effects in MYCu group were less pronounced than those in TCu group. And the inter-group differences had statistical significance (P<0.05). Conclusion: As a comparatively ideal medicated medical device, MYCu IUD has an excellent contraceptive efficacy, a low rate of expulsion and side effects and good reversibility. Particularly a low occurrence rate of bleeding and pain during early insertion is recommended. Its life expectancy is 15 years. And its contraceptive effectiveness and safety alter 5 years should be examined during further follow-ups. Copyright © 2013 by the Chinese Medical Association.

Yan H.,Jilin University
Jilin Daxue Xuebao (Diqiu Kexue Ban)/Journal of Jilin University (Earth Science Edition) | Year: 2014

The Russian geologists made a series of impotant progresses in the study on tectonics and metallogeny of the Central-Eastern Siberia and Russian Far East based on theory of plate-tectonic models and terrane analyses in the last 20 years. The progresses are collectively reflected in the research results of two international cooperation projects and two new monographes. The present paper recommends the tectonic evolution, the tectonic, metallogenic units and some important ore deposits with theirs main characteristics of the Central-Eastern Siberia and Russian Far East, and the some more important problems of geological evolution of the Russian Far East as the transform continental margins and the Mongolia-Okhotsk oeogenic belt, which can give the readers a very brief introduction to the concerned area of the Eastern Russian.

Wang Y.,CAS Nanjing Institute of Geology and Palaeontology | Huang C.,Sichuan University | Sun B.,Lanzhou University | Quan C.,Jilin University | And 3 more authors.
Earth-Science Reviews | Year: 2014

The Cretaceous was one of the most remarkable periods in geological history, with a "greenhouse" climate and several important geological events. Reconstructions of atmospheric CO2 using proxies are crucial for understanding the Cretaceous "greenhouse." In this paper we summarize the major approaches for reconstructing CO2 based on paleobotanical or geochemical data, and synthesize the CO2 variations throughout the Cretaceous. The results show that atmospheric CO2 levels remained relatively high throughout the Cretaceous, but were lower in the early Cretaceous, highest in the mid-Cretaceous and gradually declined during the late Cretaceous. However, this overall trend was interrupted by several rapid changes associated with ocean anoxic events (OAEs) and the end-Cretaceous catastrophic event. New data on paleo-CO2 levels from paleobotanical and paleosol evidences support not only the overall trends indicated by geochemical models, but provide more precise records of the short-term fluctuations related to brief episodes of climate change. Temporal resolution within the long quiet magnetic period in the middle Cretaceous is one of the obstacles preventing us from a more comprehensive understanding of the CO2 climate linkage. But new paleo-CO2 determinations and climatic data from stratigraphic sections of sediments intercalated with datable volcanic rocks will allow a better understanding of the relationships between fluctuations of atmospheric CO2, climate change, and geological events. © 2013 Elsevier B.V.

Liu S.,Northeastern University China | Su X.,Jilin University
RSC Advances | Year: 2014

As a novel nanomaterial, I-III-VI type quantum dots have been a major focus of research and development in the past decade, which can be attributed to their tunable fluorescence emission wavelengths, high photostability and low toxicity of chemical composition. In addition, I-III-VI type quantum dots have fluorescence emission wavelengths in the near-infrared regions, and thus have potential applications in bioimaging. In this review, several recent advances regarding I-III-VI type quantum dots are summarized, including synthetic methods, characteristics and some applications. Furthermore, we discuss the prospects and challenges related to this novel type of quantum dots. This journal is © the Partner Organisations 2014.

Man Y.-G.,Armed Forces Institute of Pathology and American Registry of Pathology | Man Y.-G.,Jilin University
Journal of Cancer | Year: 2010

This commentary proposes that budding tumor cell projections from focally disrupted tumor capsules represent a most effective target for early detection and intervention of prostate tumor invasion. The rationale, supporting data, and clinical applications of the hypothesis are discussed. © Ivyspring International Publisher.

He T.,Jilin University
Scientometrics | Year: 2013

Retraction is a self-cleaning activity done in the global science community. In this study, the retraction of global scientific publications from 2001 to 2010 was quantitatively analyzed by using the Science Citation Index Expanded. The results indicated that the number of retractions increased faster compared to the number of global scientific publications. Three very different patterns of retraction existed in each field. In the multi-disciplinary category and in the life sciences, retraction was relatively active. The impact factor strongly correlated with the number of retractions, but did not significantly correlate with the rate of retraction. Although the increases in the number of publications in China, India, and South Korea were faster, their retraction activities were higher than the worldwide average level. © 2012 Akadémiai Kiadó, Budapest, Hungary.

Qian Z.-H.,Jilin University | Wang Y.-J.,Changchun University of Science and Technology
Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology | Year: 2013

Based on analyzing overseas and domestic research status and technology readiness levels of wireless sensor networks (WSNs), the correlation between WSNs and Internet of Things (IoT) is described from a technical point. Key technologies required for WSNs implement, which include information acquisition system design, network services support and network communication protocol, are discussed in this paper. Development conceptions of future WSNs are presented based on summarizing challenges that WSNs must be solved.

Lu Z.,University of California at Riverside | Li C.,University of California at Riverside | Li C.,Jilin University | Yin Y.,University of California at Riverside
Journal of Materials Chemistry | Year: 2011

A convenient route for the preparation of thermochromic VO2 particles has been developed by combining solution-phase hydrolysis and a thermal reduction process. With this method, the particle size can be easily tuned from tens to hundreds of nanometres. The liquid dispersibility of these VO2 particles facilitates convenient observation and effective measurement of the temperature-dependent optical properties in the visible region. We observe a blue shift of the resonance peak of metal-phase VO 2 particles with decreasing size. The size effect also exists in the phase transition behavior: smaller VO2 particles exhibit a wider hysteresis curve during the semiconductor-to-metal transition. We also demonstrate that the VO2 particles in the form of a colloidal dispersion can be easily incorporated into thin plastic thermochromic films that may be used as smart windows for energy management. This journal is © The Royal Society of Chemistry.

Song Y.,University of Chinese Academy of Sciences | Chen Y.,Jilin University | Feng L.,University of Chinese Academy of Sciences | Ren J.,University of Chinese Academy of Sciences | Qu X.,University of Chinese Academy of Sciences
Chemical Communications | Year: 2011

We report here a folic acid conjugated graphene-hemin composite for selective, quantitative and fast colorimetric detection of cancer cells based on the peroxidase-like activity. © 2011 The Royal Society of Chemistry.

Liu L.,Jiangnan University | Li J.,Jilin University
Science China: Physics, Mechanics and Astronomy | Year: 2014

The magnetic moment of 2+ 1 state for 10Be are calculated and investigated in terms of single particle orbits for protons and neutrons under the framework of ab initio Monte Carlo shell model method in an emax = 3 model space. The reduced matrix elements of orbital and spin angular momentum are evaluated. It is found that the orientations of orbital angular momentum in different single particle orbits are consistent. Conversely, the orientations of spin in different single particle orbits tend to be chaotic. The nuclear magnetic moment of 2+ 1 state for 10Be is obtained as 1.006 μN and is discussed in regards to the contribution of orbital and spin angular momentum both for protons and neutrons. The corresponding g-factor is also given. © Science China Press and Springer-Verlag Berlin Heidelberg 2014.

Chen H.,Peking Union Medical College | Liu Y.,Peking Union Medical College | Jiang X.,Jilin University | Chen M.,Peking Union Medical College | Wang H.,Peking Union Medical College
Antimicrobial Agents and Chemotherapy | Year: 2010

The incidence of methicillin-resistant Staphylococcus aureus (MRSA) has been increasing yearly at Peking Union Medical College Hospital (PUMCH). In order to understand the molecular evolution of MRSA at PUMCH, a total of 466 nonduplicate S. aureus isolates, including 302 MRSA and 164 methicillin- susceptible (MSSA) isolates recovered from 1994 to 2008 were characterized by staphylococcal cassette chromosome mec (SCCmec) typing, spa typing, pulsed-field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). The 302 MRSA isolates were classified into 12 spa types and 9 sequence types (STs). During the years from 1994 to 2000, the most predominant MRSA clone was ST239-MRSA-III-spa t037. Since 2000, ST239-MRSA-III-spa t030 has rapidly replaced t037 and become the major clone. Another clone, ST5-MRSA-II-spa t002 emerged in 2002 and constantly existed at a low prevalence rate. The 164 MSSA isolates were classified into 62 spa types and 40 STs. ST398 was the most common MLST type for MSSA, followed by ST59, ST7, ST15, and ST1. Several MSSA genotypes, including ST398, ST1, ST121, and ST59, were identical to well-known epidemic communityacquired MRSA (CA-MRSA) isolates. MLST eBURST analysis revealed that the ST5, ST59, and ST965 clones coexisted in both MRSA and MSSA, which suggested that these MRSA clones might have evolved from MSSA by the acquisition of SCCmec. Two pvl-positive ST59-MRSA-IV isolates were identified as CA-MRSA according to the clinical data. Overall, our data showed that the ST239-MRSA-III-spa t037 clone was replaced by the emerging ST239-MRSA-III-spa t030 clone, indicating a rapid change of MRSA at a tertiary care hospital in China over a 15-year period. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

Liu F.,Shaoxing University | Kong W.,Shaoxing University | Qi C.,Shaoxing University | Zhu L.,Jilin University | Xiao F.-S.,Zhejiang University
ACS Catalysis | Year: 2012

Novel excellent hydrophobic- mesoporous- polymer-based solid acid catalysts have been successfully synthesized by copolymerization of divinylbenzene (DVB) with sodium p-styrene sulfonate (H-PDVB-x-SO 3H's) under solvothermal conditions. N 2 isotherms and TEM images showed that H-PDVB-x-SO 3H's have high BET surface areas, large pore volumes, and abundant mesoporosity; CHNS element analysis and acid-base titration technology showed that H-PDVB-x-SO 3H's have adjustable sulfur contents (0.31-2.36 mmol/g) and acidic concentrations (0.26-1.86 mmol/g); TG curves showed that H-PDVB-x-SO 3H's exhibited much higher stability of the active site (372 °C) than that of the acidic resin of Amberlyst 15 (312 °C); contact angle and water adsorption tests showed that H-PDVB-x-SO 3H's exhibited excellent hydrophobic properties. Catalytic tests in esterification of acetic acid with cyclohexanol, esterification of acetic acid with 1-butanol, and condensation of benzaldehyde with ethylene glycol showed that H-PDVB-x-SO 3H's were more active than those of Amberlyst 15, SO 3H-functionalized ordered mesoporous silicas, and beta and USY zeolites, which were even comparable with that of homogeneous H 2SO 4. The superior hydrophobicity of solid acid catalysts would be favorable for achieving excellent catalytic performance because water usually acts as a byproduct in various acid-catalyzed reactions, which can easily poison the acid sites and result in opposite reactions. Synthesis of porous solid acid catalysts with good hydrophobicity would be very important for their applications. © 2012 American Chemical Society.

Xue Y.,Jilin University | Matuszewski M.,Instytut Fizyki Polskiej Akademii Nauk
Physical Review Letters | Year: 2014

We predict the existence of a self-localized solution in a nonresonantly pumped exciton-polariton condensate. The solution has a shape resembling the well-known hyperbolic tangent profile of a dark soliton, but exhibits several distinct features. We find that it performs small oscillations, which are transformed into "soliton explosions" at lower pumping intensities. Moreover, after hundreds or thousands of picoseconds of apparently stable evolution the soliton decays abruptly, which is explained by the acceleration instability found previously in the Bekki-Nozaki hole solutions of the complex Ginzburg-Landau equation. We show that the soliton can be formed spontaneously from a small seed in the polariton field or by using spatial modulation of the pumping profile. © 2014 American Physical Society.

Weng C.-H.,I - Shou University | Lin Y.-T.,National Chung Hsing University | Chang C.-K.,I - Shou University | Liu N.,Jilin University
Ultrasonics Sonochemistry | Year: 2013

Decolourization of direct azo dye, direct blue 15 (DB15), by an advanced Fenton process coupled with ultrasonic irradiation (Fenton/US) was investigated. Zero-valent iron (ZVI) aggregates were used as the catalyst. A positive synergistic effect occurred when Fenton's reagent was combined with ultrasonic irradiation. Experimental results showed that the optimum conditions for decolourization were pH 3.0, Fe(0) 1 g/L, H2O2 5.15 × 10-3mol/L with ultrasound density of 120 W/L at 60 kHz. These conditions yielded 99% decolouration of 4.7 × 10-5 M DB15 (4130 ADMI) solution within 10 min. DB15 decolouration follows the first-order decolouration kinetics. Although the solutions containing H2CO 3, Cl-, ClO4-, NO3- and SO42- ions did not have a significant effect on the decolouration, the H2PO4- ion did decrease the decolouration rate. High ultrasonic input power accelerated the reaction and increased decolourization efficiency. The cost effectiveness of this process at high ultrasound density could be controlled despite the high electricity costs incurred by the process. ZVI aggregates were reusable; however, an increase in the number of times ZVI was recycled decreased the decolourization rate. This study demonstrates that a Fenton/US process can effectively decolour the direct azo dye DB15 in wastewater. © 2012 Elsevier B.V. All rights reserved.

Peng Q.,The University of Oklahoma Health Sciences Center | Peng Q.,Jilin University | O'Loughlin J.L.,The University of Oklahoma Health Sciences Center | Humphrey M.B.,The University of Oklahoma Health Sciences Center
PLoS ONE | Year: 2012

Innate immune activation via Toll-like receptors (TLRs), although critical for host defense against infection, must be regulated to prevent sustained cell activation that can lead to cell death. Cells repeatedly stimulated with lipopolysaccharide (LPS) develop endotoxin tolerance making the cells hypo-responsive to additional TLR stimulation. We show here that DOK3 is a negative regulator of TLR signaling by limiting LPS-induced ERK activation and cytokine responses in macrophages. LPS induces ubiquitin-mediated degradation of DOK3 leading to SOS1 degradation and inhibition of ERK activation. DOK3 mice are hypersensitive to sublethal doses of LPS and have altered cytokine responses in vivo. During endotoxin tolerance, DOK3 expression remains stable, and it negatively regulates the expression of SHIP1, IRAK-M, SOCS1, and SOS1. As such, DOK3-deficient macrophages are more sensitive to LPS-induced tolerance becoming tolerant at lower levels of LPS than wild type cells. Taken together, the absence of DOK3 increases LPS signaling, contributing to LPS-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naïve and endotoxin-induced tolerant conditions.

We investigated the frequency and types of Y-chromosome microdeletions and chromosomal anomalies in non-obstructive azoospermic and severely oligozoospermic infertile males in northeastern China. The sample consisted of 519 infertile males (456 azoospermic, 63 severely oligozoospermic). PCR assays for Y-chromosome microdeletions and chromosome analysis were performed on all patients and controls. Array-comparative genomic hybridization was performed for three patients with chromosomal anomalies. Fifty-nine of 519 patients (11.37%) had Y-chromosome microdeletions. Microdeletions were found in 11.18% (51/456) of the non-obstructive azoospermic patients and in 12.7% (8/63) of the severely oligozoospermic patients. Eleven of 51 non-obstructive azoospermic patients with Y-chromosome microdeletions had multiple segmental deletions in the AZFb+c regions; four of these patients had chromosomal anomalies. Our sample from northeastern China had a higher frequency of microdeletions among severely oligozoospermic than among non-obstructive azoospermic males.

Jin R.,Northeast Normal University | Yang Y.,Northeast Normal University | Zou Y.,Jilin University | Liu X.,Northeast Normal University | Xing Y.,Northeast Normal University
Chemistry - A European Journal | Year: 2014

Hollow mesoporous structures have recently aroused intense research interest owing to their unique structural features. Herein, an effective and precisely controlled synthesis of hollow rare-earth silicate spheres with mesoporous shells is reported for the first time, produced by a simple hydrothermal method, using silica spheres as the silica precursors. The as-prepared hollow rare-earth silicate spheres have large specific surface area, high pore volume, and controllable structure parameters. The results demonstrate that the selection of the chelating reagent plays critical roles in forming the hollow mesoporous structures. In addition, a simple and low-energy-consuming approach to synthesize highly stable and dispersive gold nanoparticle-yttrium silicate (AuNPs/YSiO) hollow nanocomposites has also been developed. The reduction of 4-nitrophenol with AuNPs/YSiO hollow nanocomposites as the catalyst has clearly demonstrated that the hollow rare-earth silicate spheres are good carriers for Au nanoparticles. This strategy can be extended as a general approach to prepare multifunctional yolk-shell structures with diverse compositions and morphologies simply by replacing silica spheres with silica-coated nanocomposites. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Sun L.,Heilongjiang University | Tian C.,Heilongjiang University | Fu Y.,Jilin University | Yang Y.,Heilongjiang University | And 3 more authors.
Chemistry - A European Journal | Year: 2014

An advanced supercapacitor material based on nitrogen- doped porous graphitic carbon (NPGC) with high a surface area was synthesized by means of a simple coordination- pyrolysis combination process, in which tetraethyl orthosilicate (TEOS), nickel nitrate, and glucose were adopted as porogent, graphitic catalyst precursor, and carbon source, respectively. In addition, melamine was selected as a nitrogen source owing to its nitrogen-enriched structure and the strong interaction between the amine groups and the glucose unit. A low-temperature treatment resulted in the formation of a NPGC precursor by combination of the catalytic precursor, hydrolyzed TEOS, and the melamine-glucose unit. Following pyrolysis and removal of the catalyst and porogent, the NPGC material showed excellent electrical conductivity owing to its high crystallinity, a large Brunauer- Emmett-Teller surface area (SBET=1027 m2g-1), and a high nitrogen level (7.72 wt%). The unusual microstructure of NPGC materials could provide electrochemical energy storage. The NPGC material, without the need for any conductive additives, showed excellent capacitive behavior (293 Fg-1 at 1 Ag-1), long-term cycling stability, and high coulombic efficiency (>99.9% over 5000 cycles) in KOH when used as an electrode. Notably, in a two-electrode symmetric supercapacitor, NPGC energy densities as high as 8.1 and 47.5 Whkg-1, at a high power density (10.5 kWkg-1), were achieved in 6m KOH and 1m Et4NBF4-PC electrolytes, respectively. Thus, the synthesized NPGC material could be a highly promising electrode material for advanced supercapacitors and other conversion devices. © 2014 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim.

Yu J.,Clemson University | Wu C.,Clemson University | Wu C.,Jilin University | Tian Z.,Clemson University | And 2 more authors.
Nano Letters | Year: 2012

The motion of individual charge carriers in organic nanostructures was tracked by fluorescence microscopy. A twinkling effect is observed in fluorescence microscopy of single conjugated polymer nanoparticles, that is, small displacements in the fluorescence spot of single nanoparticles of the conjugated polymer PFBT are observed over time. There is evidence that superquenching by the charge carrier induces a dark spot in the nanoparticle, which moves with the carrier, resulting in the observed displacements in the fluorescence. Zero-field mobilities of individual charge carriers consistent with highly trapped polarons were obtained from tracking experiments. © 2012 American Chemical Society.

Hoven C.V.,University of California at Santa Barbara | Wang H.,University of California at Santa Barbara | Wang H.,Jilin University | Elbing M.,University of California at Santa Barbara | And 3 more authors.
Nature Materials | Year: 2010

Widely used solid-state devices fabricated with inorganic semiconductors, including light-emitting diodes and solar cells, derive much of their function from the p-n junction. Such junctions lead to diode characteristics and are attained when p-doped and n-doped materials come into contact with each other. Achieving bilayer p-n junctions with semiconducting polymers has been hindered by difficulties in the deposition of thin films with independent p-doped and n-doped layers. Here we report on how to achieve permanently fixed organic p-n heterojunctions by using a cationic conjugated polyelectrolyte with fluoride counteranions and an underlayer composed of a neutral conjugated polymer bearing anion-trapping functional groups. Application of a bias leads to charge injection and fluoride migration into the neutral layer, where irreversible covalent bond formation takes place. After the initial charging and doping, one obtains devices with no delay in the turn on of light-emitting electrochemical behaviour and excellent current rectification. Such devices highlight how mobile ions in organic media can open opportunities to realize device structures in ways that do not have analogies in the world of silicon and promise new opportunities for integrating organic materials within technologies now dominated by inorganic semiconductors.

Liang D.,Jilin University | Liang D.,Purdue University | Yang H.,Purdue University | Finefrock S.W.,Purdue University | Wu Y.,Purdue University
Nano Letters | Year: 2012

Recent efforts on the development of nanostructured thermoelectric materials from nanowires (Boukai, A. I.; et al. Nature2008, 451, (7175), 168-171; Hochbaum, A. I.; et al. Nature2008, 451, (7175), 163-167) and nanocrystals (Kim, W.; et al. Phys. Rev. Lett.2006, 96, (4), 045901; Poudel, B.; et al. Science2008, 320, (5876), 634-638; Scheele, M.; et al. Adv. Funct. Mater.2009, 19, (21), 3476-3483; Wang, R. Y.; et al. Nano Lett.2008, 8, (8), 2283-2288) show the comparable or superior performance to the bulk crystals possessing the same chemical compositions because of the dramatically reduced thermal conductivity due to phonon scattering at nanoscale surface and interface. Up to date, the majority of the thermoelectric devices made from these inorganic nanostructures are fabricated into rigid configuration. The explorations of truly flexible composite-based flexible thermoelectric devices (See, K. C.; et al. Nano Lett.2010, 10, (11), 4664-4667) have thus far achieved much less progress, which in principle could significantly benefit the conversion of waste heat into electricity or the solid-state cooling by applying the devices to any kind of objects with any kind of shapes. Here we report an example using a scalable solution-phase deposition method to coat thermoelectric nanocrystals onto the surface of flexible glass fibers. Our investigation of the thermoelectric properties yields high performance comparable to the state of the art from the bulk crystals and proof-of-concept demonstration also suggests the potential of wrapping the thermoelectric fibers on the industrial pipes to improve the energy efficiency. © 2012 American Chemical Society.

Douville R.,Johns Hopkins University | Liu J.,Johns Hopkins University | Liu J.,Jilin University | Rothstein J.,Johns Hopkins University | Nath A.,Johns Hopkins University
Annals of Neurology | Year: 2011

Objective: Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons, of unknown etiology. Previous studies showed reverse transcriptase in serum of ALS patients at levels comparable to human immunodeficiency virus-infected patients; however, the source and significance of the retroviral elements is uncertain. Methods Expression of a human endogenous retrovirus (HERV-K) was determined in autopsy brain tissue of patients with ALS and compared to control populations by real-time polymerase chain reaction followed by sequencing of the amplified genes and confirmed by immunostaining. Results HERV-K pol transcripts were increased in patients with ALS compared to those with chronic systemic illness, but could not be detected in Parkinson disease or in the accidental death controls. Sequencing revealed several actively transcribed loci in the HML-2 and 3 subfamilies of HERV-K, with a specific pattern of expression including intact open reading frames and the transcription of a unique locus in ALS. The frequency of intact pol transcripts was highest in the motor cortex, and the reverse transcriptase protein was localized to cortical neurons of ALS patients. HERV-K expression strongly correlated with TDP-43, a multifunctional protein known to be dysregulated in ALS. Interpretation We have identified a specific pattern of HERV-K expression in ALS, which may potentially define the pathophysiology of ALS. Targeting of activated genome-encoded retroviral elements may open new prospects for the treatment of ALS. © 2011 American Neurological Association.

Han X.X.,Kwansei Gakuin University | Ozaki Y.,Kwansei Gakuin University | Zhao B.,Jilin University
TrAC - Trends in Analytical Chemistry | Year: 2012

Surface-enhanced Raman scattering (SERS) is currently undergoing rapid development as an ultra-sensitive analytical technique in the biological field. Label-free and extrinsic SERS labeling are two independent approaches that are commonly used to detect biomolecules directly and indirectly. The label-free detection method is a direct, convenient method for the detection of biomolecules and is more reliable than extrinsic SERS labeling, but its major limitations are poor selectivity in some complex mixtures and poor sensitivity at relatively low sample concentrations.However, label-free, highly sensitive, selective detection of biomolecules based on SERS is possible. With the development of novel SERS-active substrates, Raman instruments, and methods for sample pretreatment, the label-free protocol is becoming increasingly powerful and promising.This review highlights recent developments in label-free SERS-based techniques for bimolecular detection, including direct biomolecule identification, biomolecule-ligand recognition via spectral differences among molecular bridges, and indirect phenolic molecule detection based on azo couplings. © 2012 Elsevier Ltd.

Hensel Z.,Johns Hopkins University | Feng H.,State University of New York at Stony Brook | Han B.,State University of New York at Stony Brook | Hatem C.,Johns Hopkins University | And 4 more authors.
Nature Structural and Molecular Biology | Year: 2012

Gene expression is inherently stochastic; precise gene regulation by transcription factors is important for cell-fate determination. Many transcription factors regulate their own expression, suggesting that autoregulation counters intrinsic stochasticity in gene expression. Using a new strategy, cotranslational activation by cleavage (CoTrAC), we probed the stochastic expression dynamics of cI, which encodes the bacteriophage Î repressor CI, a fate-determining transcription factor. CI concentration fluctuations influence both lysogenic stability and induction of bacteriophage Î. We found that the intrinsic stochasticity in cI expression was largely determined by CI expression level irrespective of autoregulation. Furthermore, extrinsic, cell-to-cell variation was primarily responsible for CI concentration fluctuations, and negative autoregulation minimized CI concentration heterogeneity by counteracting extrinsic noise and introducing memory. This quantitative study of transcription factor expression dynamics sheds light on the mechanisms cells use to control noise in gene regulatory networks. © 2012 Nature America, Inc. All rights reserved.

Wang X.,Tianjin Medical University | Zhang Z.,Dalian Central Hospital | Yao C.,Jilin University
Cancer Investigation | Year: 2011

The pathophysiology of multiple myeloma-induced angiogenesis is complex and involves both direct production of angiogenic cytokines by plasma cells and their induction within the microenvironment. In this research, we investigated whether mesenchymal stem cells participated in inducing the angiogenic response in multiple myeloma, and explored the mechanism by which MSCs influence myeloma angiogenesis. We detected the concentration of angiogenic factors (bFGF, HGF, and VEGF) in the conditioned medium of mesenchymal stem cells and the capillary formation ability of mesenchymal stem cells in vitro. We found that conditioned medium of MSCs derived from MM significantly promoted the proliferation, chemotaxis, and capillary formation of human umbilical vein endothelial cells compared with that from normal donors. ELISA and RT-PCR were used to detect the mRNA and protein levels of angiogenic factors (bFGF, HGF, and VEGF) in the conditioned medium. We found that mRNA and protein levels of angiogenic factors were elevated in MSCs from multiple myeloma compared with normal donors. © 2011 Informa Healthcare USA, Inc.

Dong W.,University of Wuppertal | Fei T.,Jilin University | Palma-Cando A.,University of Wuppertal | Scherf U.,University of Wuppertal
Polymer Chemistry | Year: 2014

Novel conjugated polymers based on 3,6-carbazole repeat units were synthesized by nickel-catalyzed Yamamoto coupling under microwave heating. The resulting poly(3,6-carbazole)s contain tetraphenylethylene (TPE) units in their side chains. The resultant polymers show aggregation induced emission (AIE) behavior. Hereby, the photoluminescence (PL) intensity of PCzTPE0.5 in 90% water-THF is 35 times higher than that in pure THF, connected to the introduction of TPE side chains. The ability of polymer PCzTPE0.5 for explosive sensing was also studied. A maximum Stern-Volmer quenching constant of 1.26 × 106 M-1 was observed for PL quenching of PCzTPE0.5 aggregates by trinitrobenzene (TNB). A solid state paper strip test based on PCzTPE0.5 and PCzTPE also demonstrates effective PL quenching towards both TNB vapor and solution. This journal is © 2014 the Partner Organisations.

Wang T.,University of Florida | Lamontagne D.,University of Florida | Lynch J.,Lawrence Berkeley National Laboratory | Zhuang J.,Jilin University | Cao Y.C.,University of Florida
Chemical Society Reviews | Year: 2013

Colloidal superparticles are size- and shape-controlled nanoparticle assemblies in the form of colloidal particles. Because these superparticles can exhibit physical and chemical properties different from both individual nanoparticles and their bulk assemblies, the development of superparticle synthesis has attracted significant research attention and is emerging as a new frontier in the field of nanotechnology. In this review, we discuss theoretical considerations on the nucleation and growth of colloidal superparticles. We then present recent progress in the synthesis and characterization of monodispersed colloidal superparticles, which are important for applications such as biomedical diagnosis, biological separation, and light emitting devices. © 2013 The Royal Society of Chemistry.

Gao J.-M.,Northwest University, China | Yang S.-X.,Zhejiang Agriculture And forestry University | Qin J.-C.,Jilin University
Chemical Reviews | Year: 2013

Researchers survey the chemical and biological literature regarding the isolation, structure elucidation, biological activities, biosynthesis, and chemical synthesis of azaphilone derivatives from nature. The general methods for the synthesis of some natural azaphilone-like scaffolds are also discussed. Citrinin produced by several fungal species of genera Penicillium, Monascus, and Aspergillus, is widely considered as a hazardous contaminant of foods and feeds. A number of various derivatives of the citrinin family have been isolated from different P. citrinum strains and two Aspergillus species. The derivatives can be classified into four different categories on the basis of the degree of polymerization of the citrinin core, including monomeric citrinin congeners 2-6 and decarboxydihydrocitrinin.

Yang Z.,Ohio State University | Sun W.,Ohio State University | Sun W.,Jilin University | Hu K.,Ohio State University
Biochimica et Biophysica Acta - Molecular Cell Research | Year: 2012

Activation of protein kinase C (PKC) via adenosine receptors is known to be involved in the cardioprotection of ischemic preconditioning (IPC). Specifically, activation of PKCε is critical for cardioprotection. There is ample evidence that PKCε resides in cardiac mitochondria. However, the signals that promote translocation of PKCε are largely unknown. The present study was designed to determine whether and how adenosine receptor activation induces translocation of PKCε to mitochondria. Freshly isolated adult rat cardiac myocytes and rat heart-derived H9c2 were used in the study. Immunofluorescence imaging of isolated mitochondria showed that PKCε but not PKCδ was localized in mitochondria and this mitochondrial localization of PKCε was significantly increased by adenosine treatment. The adenosine-induced increase in PKCε-positive mitochondria was largely prevented not only by PKC inhibitor chelerythrine, but also by the HSP90 inhibitor geldanamycin and by siRNA targeting HSP90. Immunoblot analysis from percoll-purified mitochondria further demonstrated that adenosine mediated a significant increase in mitochondrial PKCε[U+F020] but not PKCδ. This effect was blocked by inhibiting PKC activity with chelerythrine and bisindolylmaleimide. Furthermore, co-immunoprecipitation data showed that PKCε but not PKCδ was associated with TOM70 and HSP90, and this association was enhanced by adenosine treatment. Moreover, adenosine-induced association of PKCε with TOM70 was reduced by suppressing HSP90 expression with siRNA. In conclusion, we demonstrate that adenosine induces HSP90-dependent translocation of PKCε to mitochondria, possibly through mitochondrial import machinery TOM70. These results point out a novel mechanism in regulating PKC in mitochondria and suggest an important implication in ischemic preconditioning or postconditioning. © 2011 Elsevier B.V..

Wu C.,University of Washington | Wu C.,Jilin University | Chiu D.T.,University of Washington
Angewandte Chemie - International Edition | Year: 2013

In recent years, semiconducting polymer nanoparticles have attracted considerable attention because of their outstanding characteristics as fluorescent probes. These nanoparticles, which primarily consist of π-conjugated polymers and are called polymer dots (Pdots) when they exhibit small particle size and high brightness, have demonstrated utility in a wide range of applications such as fluorescence imaging and biosensing. In this review, we summarize recent findings of the photophysical properties of Pdots which speak to the merits of these entities as fluorescent labels. This review also highlights the surface functionalization and biomolecular conjugation of Pdots, and their applications in cellular labeling, in vivo imaging, single-particle tracking, biosensing, and drug delivery. We discuss the relationship between the physical properties and performance, and evaluate the merits and limitations of the Pdot probes for certain imaging tasks and fluorescence assays. We also tackle the current challenges of Pdots and share our perspective on the future directions of the field. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Talalay P.G.,Jilin University
Cold Regions Science and Technology | Year: 2013

Drilling to till and bedrock of ice sheets and glaciers offers unique opportunities for examining processes acting at the bed. Samples of basal and subglacial material contain important paleo-climatic and paleo-environmental records and provide a unique habitat for life, give significant information on sediment deformation beneath glaciers and its coupling to the subglacial hydraulic system, subglacial geology, and tectonics. Retrieving bedrock samples under ice sheets and glaciers is a very difficult task. Drilling operations are complicated by extremely low temperature at the surface of, and within glaciers, and by glacier flow, the absence of roads and infrastructures, storms, winds, snowfalls, etc. Nevertheless, borehole drilling might be considered as the optimal method to access beds of the glaciers and to sample subglacial material. Four types of subglacial drilling technologies are considered: (1) non-rotary sampling; (2) non-core penetrating; (3) pipe-string rotary drilling; (4) electromechanical cable-suspended drilling. The most simple and effective systems for sampling in subglacial soft sediments or unfrozen till from pre-drilled access holes are non-rotary devices like gravity corer and piston corer. The maximal thickness of ice is determined by the length of wire rope attached to the corer and could possibly be more than 4000. m. Potentially, piston sampling can reach a maximal depth of 25. m in soft subglacial lake sediments. In stiffer sediments a hammer corer or vibrocorer should be used. To install different sensors and markers into the soft till beneath glaciers and to measure basal sliding, different types of sediment non-core penetrators were used. Typically the boreholes are pre-drilled by hot-water systems as well. To recover core of the true bedrock the rotary drilling systems are used. The experience of pipe-string rotary drilling in subglacial environment showed that drilling operations were very unstable, and the recovery of subglacial sediment was generally poor. Commercial drilling rigs for drilling up to the depth of 3000. m or more tend to be very heavy and require a large logistical load to move and support. They also require more equipment for the circulation system. Taking into account that they are not adapted for extremely unfavorable conditions in Polar Regions and also need high power consumption, these drill rigs were not considered for subglacial exploration. Electromechanical cable-suspended systems are widely used for core drilling in pure and debris-containing ice. The main feature of these systems is that an armored cable with a winch is used instead of a pipe-string to provide power to the down-hole motor system and to retrieve the down-hole unit. The use of armored cable allows a significant reduction in power and material consumption, a decrease in the time of round-trip operations, and a simplification in the cleaning of the hole from the cuttings. To penetrate frozen till and bedrock the electomechanical drills can be adapted for coring bedrock. This was confirmed by four successful penetrations into the bedrock carried out by U.S. and Russian specialists. The procedure of till and bedrock drilling and the geological description of retrieved debris-containing ice and bedrock cores are given. © 2012 Elsevier B.V.

Han X.X.,Kwansei Gakuin University | Pienpinijtham P.,Chulalongkorn University | Zhao B.,Jilin University | Ozaki Y.,Kwansei Gakuin University
Analytical Chemistry | Year: 2011

Studies have shown that many adverse health effects are associated with human exposure to dietary or environmental estrogens. Therefore, the development of rapid and highly sensitive detection methods for estrogens is very important and necessary to maintain hormonal concentration below the safety limit. Herein, we demonstrate a simple and rapid approach to detect trace amounts of phenolic estrogen based on surface-enhanced resonance Raman scattering (SERRS). Because of a coupling reaction between diazonium ions and the phenolic estrogens, azo compounds are formed with strong SERRS activity, which allows phenolic estrogen recognition at subnanomolar levels in solution. The proposed protocol has multiplexing capability, because each SERRS fingerprint of the azo dyes specifically corresponds to the related estrogen. Moreover, it is universal and highly selective, not only for phenolic estrogens but also for other phenolic molecules, even in complex systems. © 2011 American Chemical Society.

Bai Z.K.,Jilin University
Journal of molecular histology | Year: 2013

The aim of this study was to investigate the differential expression and regulation of Runt-related transcription factor 3 (Runx3) in mouse uterus during early pregnancy and its regulation by steroid hormones using in situ hybridization. There was a low level of the Runx3 mRNA expression in the mouse uterus on days 1-4 of pregnancy. On day 5 when embryo implanted, Runx3 mRNA signal was obviously observed in the stromal cells surrounding the implanting blastocyst. From day 6 to 8 of pregnancy, Runx3 mRNA was highly expressed in the decidual cells and mesometrial decidual beds. Similarly, Runx3 mRNA was strongly expressed in decidualized cells under artificial decidualization. Compared with the delayed uterus, a high level of Runx3 mRNA signal was detected in the uterus with activated implantation. In the ovariectomized mouse uterus, estrogen could induce the expression of Runx3, while progesterone had no effects. These results suggest that Runx3 may play an important role during mouse implantation and decidualization. Estrogen can induce the expression of Runx3 in the ovariectomized mouse uterus.

In this work, I take into consideration the Pauli exclusion principle (PEP) in the quasiparticle random-phase approximation (QRPA) calculations for the deformed systems by replacing the traditional quasiboson approximation (QBA) with the renormalized one. With this new formalism, the parametrization of QRPA calculations has been changed and the collapse of QRPA solutions could be avoid for realistic GPP values. I further find that the necessity of the renormalization parameter of particle-particle residual interaction GPP in QRPA calculations is due to the exclusion of PEP. So with the inclusion of PEP, I could easily extend the deformed QRPA calculations to the less-explored region where lack of experimental data prevent effective parametrization of GPP for QRPA methods. With this theoretical improvement, I give predictions of weak decay rates for even-even isotopes in the rare-earth region and compare the results with existing calculations. © 2016 American Physical Society.

Wu Z.-Y.,Jilin University
Communications in Theoretical Physics | Year: 2016

Based on a general variational principle, Einstein-Hilbert action and sound facts from geometry, it is shown that the long existing pseudotensor, non-localizability problem of gravitational energy-momentum is a result of mistaking different geometrical, physical objects as one and the same. It is also pointed out that in a curved spacetime, the sum vector of matter energy-momentum over a finite hyper-surface can not be defined. In curvilinear coordinate systems conservation of matter energy-momentum is not the continuity equations for its components. Conservation of matter energy-momentum is the vanishing of the covariant divergence of its density-flux tensor field. Introducing gravitational energy-momentum to save the law of conservation of energy-momentum is unnecessary and improper. After reasonably defining "change of a particle's energy-momentum", we show that gravitational field does not exchange energy-momentum with particles. And it does not exchange energy-momentum with matter fields either. Therefore, the gravitational field does not carry energy-momentum, it is not a force field and gravity is not a natural force. © 2016 Chinese Physical Society and IOP Publishing Ltd.

Sun H.-B.,Jilin University
Science China: Physics, Mechanics and Astronomy | Year: 2016

Catenary is the curve that a free-hanging chain assumes under its own weight, which is thought to be a true mathematical and mechanical form in architecture. Pu and colleagues recently demonstrated that nanostructured catenaries could be used to construct ultrathin and lightweight optical devices, which are the key of the next-generation integrated photonic systems. Similar to the catenary of equal strength, the phase gradient of the optical catenary is equal everywhere, which is a direct outcome of its special geometric shape. Besides the catenary shapes, gammadion shape has also been used for the design of metasurface. By purposely changing the relative split positions at certain arms to selective excitation of different resonance modes in the gammadion metamaterials, THz wave amplitude manipulation, as well as broadband static resonance tunability at the resonance frequency, can be theoretically and experimentally achieved.

Yang Y.,Changchun University of Technology | Liu Y.,Jilin University
Journal of Materials Science and Technology | Year: 2010

To improve the surface corrosion resistance of the alumina films fabricated by micro-arc oxidation (MAO), Al2O3 coatings at different current densities (5, 7 and 10 A/dm2) were produced on aluminum alloys by adding SiC nano-particles into electrolyte during MAO process. The morphology and phase composition of the coatings were investigated by scanning electron microscopy (SEM) and X-ray diffraction (XRD), respectively. Furthermore, the corrosion performance of the coatings was evaluated via a three-electrode system in a 3.5 wt pct NaCl solution. From the obtained morphology of alumina coatings, it was believed that the Al2O3 coatings embedded with SiC nano-particles were formed. The electrochemical impedance spectroscopy (EIS) plots and potentiodynamic polarization plots of the Al2O3 coatings with and without SiC nano-particles at different current densities reveal that the Al2O3 coatings with SiC nano-particles formed at 10 A/dm2 showed the better corrosion resistance than the other coatings produced at 5 and 7 A/dm2. © 2010 The Chinese Society for Metals.

Liang S.,Changchun Normal University | Liang S.,Jilin University | Zhang J.,Nanjing Normal University
Nonlinear Analysis: Real World Applications | Year: 2014

In this paper, we consider the existence and multiplicity of solutions of Kirchhoff type problems with critical nonlinearity in R3:- ε2(a+b∫R3|u|2dx) Δu+V(x)u=K(x)|u|4u+h(x,u), (t,x) â̂̂R×R3. Under suitable assumptions, we prove that this has at least one solution and for any mâ̂̂N, it has at least m pairs of solutions. © 2013 Elsevier Ltd. All rights reserved.

Yu J.H.,Jilin University
International journal of medical sciences | Year: 2013

Dracorhodin perchlorate (DP) was a synthetic analogue of the antimicrobial anthocyanin red pigment dracorhodin. It was reported that DP could induce apoptosis in human prostate cancer, human gastric tumor cells and human melanoma, but the cytotoxic effect of DP on human breast cancer was not investigated. This study would investigate whether DP was a candidate chemical of anti-human breast cancer. The MTT assay reflected the number of viable cells through measuring the activity of cellular enzymes. Phase contrast microscopy visualized cell morphology. Fluorescence microscopy detected nuclear fragmentation after Hoechst 33258 staining. Flowcytometric analysis of Annexin V-PI staining and Rodamine 123 staining was used to detect cell apoptosis and mitochondrial membrane potential (MMP). Real time PCR detected mRNA level. Western blot examined protein expression. DP dose and time-dependently inhibited the growth of MCF-7 cells. DP inhibited MCF-7 cell growth through apoptosis. DP regulated the expression of Bcl-2 and Bax, which were mitochondrial pathway proteins, to decrease MMP, and DP promoted the transcription of Bax and inhibited Bcl-2. Apoptosis-inducing factor (AIF) and cytochrome c which localized in mitochondrial in physiological condition were released into cytoplasm when MMP was decreased. DP activated caspase-9, which was the downstream of mitochondrial pathway. Therefore DP decreased MMP to release AIF and cytochrome c into cytoplasm, further activating caspase 9, lastly led to apoptosis. Therefore DP was a candidate for anti-breast cancer, DP induced apoptosis of MCF-7 through mitochondrial pathway.

Lee C.-H.,Chihlee Institute of Technology | Liao C.-J.,National Taiwan University of Science and Technology | Chung T.-P.,Jilin University
International Journal of Production Economics | Year: 2014

This paper considers a real-life identical parallel scheduling problem originating from the manufacturing plant producing polyvinyl chloride leather products. In the considered scheduling problem, each job has some attributes and each attribute has several different levels. Because there is at least one different level of attribute between two adjacent jobs, it is necessary to make a setup adjustment whenever there is a switch from processing a job to a different job on each machine. The problem can be classified as a scheduling problem to minimize the makespan on two identical parallel machines with multi-attribute setup times. A constructive heuristic, named COIT, is first proposed for the problem and evaluated by comparing with the current scheduling method used by the case plant. To further improve the solution, a variable neighborhood search (VNS) metaheuristic is presented and compared with a mixed integer programming model. The computational results show that the COIT heuristic outperforms the current scheduling method with a significant improvement, and the VNS can further improve the solution. © 2014 Elsevier B.V. All rights reserved.

Gao W.,University of Ulm | Mueller J.E.,University of Ulm | Jiang Q.,Jilin University | Jacob T.,University of Ulm
Angewandte Chemie - International Edition | Year: 2012

Synergy with potential: Analysis of relevant mechanistic pathways by density functional theory, reveals the synergistic role of co-adsorbed CO and OH in promoting HCOOH electrooxidation on Pt(111). Kinetic models derived from these studies show the atomistic surface phenomena underlying the experimental CV observation in the potential range between 0.0 and 1.2 V (see picture). © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Qu S.,CAS Changchun Institute of Optics and Fine Mechanics and Physics | Wang X.,Jilin University | Lu Q.,CAS Changchun Institute of Optics and Fine Mechanics and Physics | Liu X.,CAS Changchun Institute of Optics and Fine Mechanics and Physics | Wang L.,CAS Changchun Institute of Optics and Fine Mechanics and Physics
Angewandte Chemie - International Edition | Year: 2012

C-dots on hand: Luminescent carbon nanodots were synthesized and were shown to be biocompatible, have low toxicity, and distinctive photoluminescence properties. These C-dots are inexpensive to synthesize and could potentially be used for versatile applications, such as anticounterfeiting, information encryption, and information storage. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Yu J.,Jilin University | Jackson R.,West Virginia University
Growth and Change | Year: 2011

In this paper, we present a critical assessment of recent economic development policy directions centered on the concept of regional innovation clusters. We begin by investigating the rationale underlying the Obama administration's promotion of regional innovation clusters (RICs) and their introduction to the policy arena in its Strategy for American Innovation. The connections among RICs and existing research and policies in industry and occupational clusters, regional innovation systems and regional economic development are identified and analyzed to highlight those most critical challenges to conceptualizing and theorizing RICs. While we applaud the long overdue focus of economic development policies on sub-national regions, we identify several major conceptual shortcomings and programmatic difficulties associated with RICs as a centerpiece for economic development strategies. © 2011 Wiley Periodicals, Inc.

Zhao L.,Jilin University
Cytogenetic and Genome Research | Year: 2015

Fluorine is reported to affect embryonic development, but the underlining mechanism is unclear. The modification of DNA methylation of the H19 and Peg3 genes is important in embryonic development. Therefore, the effect of fluorine on methylation of H19 and Peg3 during early mouse embryos was studied. It was shown that the H19 gene was significantly downmethylated in E2.5, E3.5, and E4.5 embryos from pregnant mice treated with 120 mg/l NaF in drinking water for 48 h. But methylation of both H19 and Peg3 genes was disrupted when the parent male mice were treated with NaF for 35 days. H19 DNA methylation decreased significantly, while Peg3 was almost completely methylated. However, when pregnant mice, mated with NaF-treated male mice, were again treated with NaF for 48 h, either H19 or Peg3 methylation in the embryos decreased significantly. In addition, the mRNA level of H19 considerably increased in E3.5 and E4.5 embryos from NaF-treated pregnant mice. Further, the expression of DNMT1 decreased significantly after NaF treatment. Conclusively, we demonstrated that fluorine may adversely affect early embryonic development by disrupting the methylation of H19 and Peg3 through downregulation of DNMT1. © 2015 S. Karger AG, Basel Copyright © 2015, S. Karger AG. All rights reserved.

Du Z.-J.,CAS Changchun Institute of Applied Chemistry | Du Z.-J.,University of Chinese Academy of Sciences | Gao L.-X.,CAS Changchun Institute of Applied Chemistry | Lin Y.-J.,Jilin University | Han F.-S.,CAS Changchun Institute of Applied Chemistry
ChemCatChem | Year: 2014

A protocol for the copper-mediated direct aryl C - H halogenation is presented. Highly selective mono- and di-halogenations are achieved by using acyl hypohalites, generated in situ from the readily available carboxylic acid and N-halosuccinimides (NXS; X=Br and Cl) as powerful halogenating reagents. The correct choice of carboxylic acid additives and solvents is essential for both high yield and selectivity. Consequently, the use of inexpensive Cu catalyst and the new strategy for the in situ generation of acyl hypohalite halogenating reagents from the readily affordable and easily-to-handle carboxylic acid and NXS (X=Br and Cl) offers advantages for practical application. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Zhong R.-L.,Northeast Normal University | Xu H.-L.,Northeast Normal University | Li Z.-R.,Jilin University | Su Z.-M.,Northeast Normal University
Journal of Physical Chemistry Letters | Year: 2015

The excess electron is a kind of special anion with dispersivity, loosely bounding and with other fascinating features, which plays a pivotal role (promote to about 106 times in (H2O)3{e}) in the large first hyperpolarizabilities (?0) of dipole-bound electron clusters. This discovery opens a new perspective on the design of novel nonlinear optical (NLO) molecular materials for electro-optic device application. Significantly, doping alkali metal atoms in suitable complexants was proposed as an effective approach to obtain electride and alkalide molecules with excess electron and large NLO responses. The first hyperpolarizability is related to the characteristics of complexants and the excess electron binding states. Subsequently, a series of new strategies for enhancing NLO response and electronic stability of electride and alkalide molecules are exhibited by using various complexants. These strategies include not only the behaviors of pushed and pulled electron, size, shape, and number of coordination sites of complexants but also the number and spin state of excess electrons in these unusual NLO molecules. © 2015 American Chemical Society.

Yu T.,Jilin University | Yu T.,Heilongjiang University
Systems and Control Letters | Year: 2011

This paper deals with the transmission problem in simultaneous stabilization of time-varying linear systems. We establish two criteria for the transitivity in simultaneous stabilization. In particular, we give a necessary and sufficient condition for certain linear systems to satisfy a strengthened version of transitivity. © 2010 Elsevier B.V. All rights reserved.

Li Z.-W.,CAS Changchun Institute of Applied Chemistry | Lu Z.-Y.,Jilin University | Sun Z.-Y.,CAS Changchun Institute of Applied Chemistry | An L.-J.,CAS Changchun Institute of Applied Chemistry
Soft Matter | Year: 2012

Janus particles exhibit interesting self-assembly behavior and functional performances. In particular, soft and deformable Janus particles, as diverse as Janus micelles, Janus microgels, and Janus dendrimers, should receive more attention due to their unique chemical and physical properties and enormous potential applications. Gaining control over precise and predictable self-assembled structures and understanding the fundamental details of self-assembly remain a formidable challenge. Here we present a novel mesoscale model for soft Janus particles, which successfully reflects their physical nature by directly mapping onto experimentally measurable particle properties. By properly tuning Janus balance and the strength of attraction between attractive patches, soft Janus particles can reversibly self-assemble into a number of fascinating hierarchical superstructures in dilute solutions, such as micelles, wormlike strings, single helices, double helices, bilayers, tetragonal bilayers, and complex supermicelles. Our work demonstrates that soft Janus particles with deformable and non-centrosymmetric characteristics hide many surprises in the design and fabrication of hierarchically self-assembled superstructures. © 2012 The Royal Society of Chemistry.

Fan X.,Jilin University | Fan X.,Nanyang Technological University | Shen Z.,Nanyang Technological University | Liu A.Q.,Nanyang Technological University | Kuo J.-L.,Academia Sinica, Taiwan
Nanoscale | Year: 2012

Boron nitride (BN) domains are easily formed in the basal plane of graphene due to phase separation. With first-principles calculations, it is demonstrated theoretically that the band gap of graphene can be opened effectively around K (or K′) points by introducing small BN domains. It is also found that random doping with boron or nitrogen is possible to open a small gap in the Dirac points, except for the modulation of the Fermi level. The surface charges which belong to the π states near Dirac points are found to be redistributed locally. The charge redistribution is attributed to the change of localized potential due to doping effects. The band opening induced by the doped BN domain is found to be due to the breaking of localized symmetry of the potential. Therefore, doping graphene with BN domains is an effective method to open a band gap for carbon-based next-generation microelectronic devices. This journal is © The Royal Society of Chemistry 2012.

Zhou F.,University of Georgia | Xu Y.,University of Georgia | Xu Y.,Jilin University
Bioinformatics | Year: 2010

Summary: Huge amount of metagenomic sequence data have been produced as a result of the rapidly increasing efforts worldwide in studying microbial communities as a whole. Most, if not all, sequenced metagenomes are complex mixtures of chromosomal and plasmid sequence fragments from multiple organisms, possibly from different kingdoms. Computational methods for prediction of genomic elements such as genes are significantly different for chromosomes and plasmids, hence raising the need for separation of chromosomal from plasmid sequences in a metagenome. We present a program for classification of a metagenome set into chromosomal and plasmid sequences, based on their distinguishing pentamer frequencies. On a large training set consisting of all the sequenced prokaryotic chromosomes and plasmids, the program achieves ~92% in classification accuracy. On a large set of simulated metagenomes with sequence lengths ranging from 300 bp to 100 kbp, the program has classification accuracy from 64.45% to 88.75%. On a large independent test set, the program achieves 88.29% classification accuracy. © The Author(s) 2010. Published by Oxford University Press.

Wang J.,Jilin University | Zhu J.,CAS Qingdao Institute of Bioenergy and Bioprocess Technology | Zhu J.,Chinese Academy of Sciences | Bennett G.N.,Rice University | San K.-Y.,Rice University
Metabolic Engineering | Year: 2011

Succinic acid has drawn much interest as a precursor of many industrially important chemicals. Using a variety of feedstocks for the bio-production of succinic acid would be economically beneficial to future industrial processes. Escherichia coli SBS550MG is able to grow on both glucose and fructose, but not on sucrose. Therefore, we derived a SBS550MG strain bearing both the pHL413 plasmid, which contains Lactococcus lactis pycA gene, and the pUR400 plasmid, which contains the scrK, Y, A, B, and R genes for sucrose uptake and catalyzation. Succinic acid production by this modified strain and the SBS550pHL413 strain was tested on fructose, sucrose, a mixture of glucose and fructose, a mixture of glucose, fructose and sucrose, and sucrose hydrolysis solution. The modified strain can produce succinic acid efficiently from all combinations of different carbon sources tested with minimal byproduct formation and with high molar succinate yields close to that of the maximum theoretic values. The molar succinic acid yield from fructose was the highest among the carbon sources tested. Using the mixture of glucose and fructose as the carbon source resulted in slightly lower yields and much higher productivity than using fructose alone. Fermenting sucrose mixed with fructose and glucose gave a 1.76-fold higher productivity than that when sucrose was used as the sole carbon source. Using sucrose pretreated with sulfuric acid as carbon source resulted in a similar succinic acid yield and productivity as that when using the mixture of sucrose, fructose, and glucose. The results of the effect of agitation rate in aerobic phase on succinate production showed that supplying large amount of oxygen in aerobic phase resulted in higher productions of formate and acetate, and therefore lower succinate yield. This study suggests that fructose, sucrose, mixture of glucose and fructose, mixture of glucose, fructose and sucrose, or sucrose hydrolysis solution could be used for the economical and efficient production of succinic acid by our metabolic engineered E. coli strain. © 2011 Elsevier Inc.

Lu Z.Y.,Jilin University
Methods in molecular biology (Clifton, N.J.) | Year: 2013

Dissipative particle dynamics (DPD) is a particle-based mesoscopic simulation method, which facilitates the studies of thermodynamic and dynamic properties of soft matter systems at physically interesting length and time scales. In this method, molecule groups are clustered into the dissipative beads, and this coarse-graining procedure is a very important aspect of DPD as it allows significant computational speed-up. In this chapter, we introduce the DPD methodology, including its theoretical foundation and its parameterization. With this simulation technique, we can study complex behaviors of biological systems, such as the formation of vesicles and their fusion and fission processes, and the phase behavior of lipid membranes.

Meng Z.,Jilin University
Journal of Applied Geophysics | Year: 2016

We present a new method dedicated to the interpretation of full gravity gradient tensor data, based on SL0 sparse recovery inversion. The SL0 sparse recovery method aims to find out the minimum value of the objective function to fit the data function and to solve the non-zero solution to the objective function. Based on continuous iteration, we can easily obtain the final global minimum (namely the property and space attribute of the inversion target). We consider which type of tensor data combination produces the best inversion results based on the inversion results of different full gravity gradient tensor data combinations (separate tensor data and combined tensor data). We compare the recovered models obtained by inverting the different combinations of different gravity gradient tensor components to understand how different component combinations contribute to the resolution of the recovered model. Based on the comparison between the SL0 sparse recovery inversion results and the smoothest and focusing inversion results of the full gravity gradient tensor data, we show that SL0 sparse recovery inversion can obtain more stable and efficient inversion results with relatively sharp edge information, and that this method can also produce a stable solution of the inverse problem for complex geological structures. This new method to resolve very large full gravity gradient tensor datasets has the considerable advantage of being highly efficient; the full gravity gradient tensor inversion requires very little time. This new method is very effective in explaining the full gravity tensor which is very sensitive to small changes in local anomaly. The numerical simulation and inversion results of the compositional model indicates that including multiple components for inversion increases the resolution of the recovered density model and improves the structure delineation. We apply our inversion method to invert the gravity gradient tensor survey data from the Vinton salt dome, Louisiana. The results of inversion are in good agreement with the known formation in the region, which supports the validity of our method. © 2016 Elsevier B.V.

Earlier studies have demonstrated that Deuterohaemin-AlaHisThrValGluLys (DhHP-6), a novel porphyrin-peptide, increases lifespan and enhances stress resistance of Caenorhabditis elegans. To explore the possible mechanisms, in this study we investigated the roles of SIR-2.1 and DAF-16 in DhHP-6's function using wild-type and various other mutant strains of C. elegans. DhHP-6's effect was dependent upon DAF-16, and it did not extend the lifespan of the loss-of-function daf-16 mutant strain (daf-16(mu86) I). DhHP-6 enhanced DAF-16 translocation from cytoplasm to nuclei; and it increased DAF-16's transcriptional activity, likely by activating the SIR-2.1/DAF-16 complex. DhHP-6's effect was also dependent upon SIR-2.1, and it did not increase the lifespan of the worms with SIR-2.1 deacetylase activity inhibited by niacin amide (SIR-2.1 inhibitor) and SIR-2.1 RNA interference (RNAi). Niacin amide and RNAi increased DAF-16's nuclear localization; but they decreased DAF-16's transcriptional activity, likely by preventing the formation of the SIR-2.1/DAF-16 complex. These results suggest that DhHP-6 extends the lifespan of C. elegans via SIR 2.1 and DAF-16, and they provide new insights into the molecular mechanisms of aging.

Jiang G.Y.,Jilin University
Applied Mechanics and Materials | Year: 2014

With the continues improving of people's living standards, more and more people work out in all kinds of sports fields beyond the busy work. On the other hand, the development of the modern competitive sports also requires that the sports experts should not only strive for the scientific training, but should also pay much attention on the improvement and development of the sports equipment at the same time, which makes the sports equipment market have achieved unprecedented prosperity. This paper introduces the application of the fiber reinforced composite materials in the field of sports equipment, which is described mainly from the advantages of the fiber reinforced composite materials used in sports equipment areas, and from the aspects of the principles of material selection, the product varieties, the application examples and the status. © (2014) Trans Tech Publications, Switzerland.

Chen X.H.,Jilin University
Zhonghua xin xue guan bing za zhi | Year: 2010

To evaluate the impacts of Helicobacter pylori (H. pylori) infection on atherosclerosis and plasma lipid levels in high-cholesterol diet fed C57BL/6 mice. Female C57BL/6 mice were randomly divided into 4 groups (n = 12 each): fed with normal chow diet (A), infected with H. pylori (B), fed with high-cholesterol diet (C) and infected with H. pylori and fed with high-cholesterol diet (D). After 52 weeks, plasma levels of lipids were measured and aortic atherosclerosis was observed. The ureA, ureC, cagA and vacA DNA were also detected by PCR in the aortic arteries. (1) Prevalence of atherosclerosis was similar between group C and D (91.6% vs. 100%, P > 0.05) while there was no atherosclerosis in group A and B. H. pylori infected mice showed more obvious inflammation in gastric mucosa than mice without H. pylori infection. (2) The plasma levels of triglyceride, total cholesterol and LDL were higher and HDL was lower in group B, C and D than those in group A and in group D than in group C (all P < 0.05). (3) Roberts & Thompson scores and number of foam cells in plaques were significantly higher in group D compared with those in group C (all P < 0.05). (4) ureC DNA was detected in 5 out of 12 aortic arteries of mice in group D but not in group A, B and C. Our results suggested that H. pylori infection might enhance the atherosclerotic lesion formation in this mouse model.

Ma F.,Huaibei Normal University | Zhou Z.-J.,Jilin University | Liu Y.-T.,Ningxia University
ChemPhysChem | Year: 2012

The geometries and electronic properties of tubiform [n] boron nitride clusters entrapping Li 2 (Li 2@BN-cluster(n,0); n=4-8), obtained by doping BN-cluster(n,0) with Li 2 molecules, are investigated by means of DFT. The effects of tube diameter n on the dipole moment μ 0, static polarizability α 0, and first hyperpolarizability β 0 are elucidated. Both the dipole moment and polarizability increase with increasing tube diameter, whereas variation of the static first hyperpolarizability with tube diameter is not monotonic; β 0 follows the order 1612 (n=4)<3112 (n=5)<5534 (n=7)<8244 (n=6)<12 282 a.u. (n=8). In addition, the natural bond orbital (NBO) charges show that charge transfer takes place from the Li 2 molecule to the BN cluster, except for BN-cluster(8,0) with larger tube diameter. Since the large-diameter tubular BN-cluster(8,0) can trap the excess electrons of the Li 2 molecule, Li 2@BN-cluster(8,0) can be considered to be a novel electride compound. Novel tubiform electride Li 2@BN-cluster(8,0), in which the excess electrons are localized in the cavity of the large-diameter tube (see picture), exhibits a large NLO response. It was discovered during DFT calculations of the structures and electronic properties of tubiform [n] boron nitride clusters entrapping Li 2 (Li 2@BN-cluster(n,0); n= 4-8). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Alia S.M.,University of California at Riverside | Zhang G.,Jilin University | Kisailus D.,University of California at Riverside | Li D.,University of California at Riverside | And 3 more authors.
Advanced Functional Materials | Year: 2010

Porous platinum nanotubes (PtNTs) with a all thickness of 5 nm, an outer diameter of 60 nm, and a length of 520 μm are synthesized by galvanic displacement with silver nanowires, which are formed by the ethylene glycol reduction of silver nitrate. Oxygen reduction reaction (ORR) and durability experiments are conducted for PtNTs, Pt nanoparticles supported on carbon (Pt/C), and bulk polycrystalline Pt (BP-Pt) electrocatalysts to evaluate their catalytic properties for use as cathode catalysts in proton exchange membrane fuel cells. PtNTs demonstrate improved mass and specific activity for ORR and durability to Pt/C. Following durability testing, PtNTs exhibit specific ORR activity approaching that of BP-Pt. Catalyst activity for the methanol oxidation reaction (MOR) is characterized through cyclic voltammetry and chronoamperometry techniques to evaluate the materials for use as anode catalysts in direct methanol fuel cells. The PtNTs show improved specific activity for MOR and chronoamperometry characteristics over Pt/C and BP-Pt catalysts. This study focuses on the use of porous platinum nanotubes (PtNTs) with a thickness of 5 nm, an outer diameter of 60 nm, and a length of 520 μm as fuel cell catalysts. PtNTs demonstrate higher mass and specific activity for oxygen reduction and durability than the conventional platinum supported on carbon catalyst (Pt/C). PtNTs further illustrate greater specific activity and poison resistance for methanol oxidation than Pt/C and bulk platinum. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The new polymeric compounds (NH 4) 8[Cu(H 2O) 2H 2W 12O 42]-10H 2O (1) and (NH 4) 4[Co(H 2O)) 2][Co(H 2O) 4] 2[H 2W 12O 42]·8H 2O (2) have been synthesized in aqueous solution and characterized by elemental analysis, TG analysis. Single crystal X-ray diffraction revealed that the [H 2W 12O 42] 10- (named paratungstate-B) units act as tetradentate and octadentate ligands, respectively. In compound 1, two neighboring paratungstate-B clusters are linked by [Cu(H 2O) 2] 2+ units leading to the formation of 1D chain. In crystal of 2, each cobalt ion links two paratungstate-B clusters, while each [H 2W 12O 42] 10- block is surrounded by two [Co(H 2O) 2] 2+ and four [Co(H 2O) 4] 2+ bridging cations resulting a 2D sheet formed parallel to the [101] plane. © Springer Science+Business Media, LLC 2011.

Meng C.D.,Jilin University
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2012

To test the immunoglobulin free light chain (FLC) from nasal secretion(s) and serum of patients with allergic rhinitis and non-allergic rhinitis for the purpose of exploring the possible immunological mechanism. Sixty consecutive patients were selected between September and December in 2009, involving 30 patients with allergic rhinitis and 30 patients with non-allergic rhinitis, diagnosed by symptoms, signs, SPT and sIgE. Thirty volunteers was chosen as health control (HC). ELISA was used to detect the total IgE, eosinophil cationic protein (ECP), mast cell tryptase (MCT), κFLC, λFLC in nasal secretion and serum. The data was statistically analyzed by SPSS 17.0 software. According to the VAS scores, the nasal symptoms of AR and NAR, including sneeze, nasal discharge, nasal obstruction and nasal itching were compared. There was no statistical difference (t value was 1.189, 0.741, 0.758, 0.797, respectively, P < 0.5); In serum, κFLC, λFLC, IgE, ECP & MCT were increased in NAR compared to HC (P < 0.05); λFLC was increased in NAR compared to AR group (P < 0.05), κFLC and ECP were increased in AR. There was no significant difference between AR and NAR (P < 0.05); In nasal secretion, κFLC, λFLC, IgE, ECP and MCT were increased in AR and NAR compared to HC, and the ECP and IgE were significantly increased in AR compared to NAR (P < 0.05). ; In nasal secretion, the FLCs revealed a significantly higher correlation with MCT (r value was 0.518 and 0.484, P < 0.01), and in serum revealed a significant correlation with ECP (r value was 0.343 and 0.342, P < 0.01). Immunoglobulin free light chain takes part in the path of physiological process of allergic rhinitis and non-allergic rhinitis with the immunological mechanism.

Wang P.,Jilin University
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2010

To detect the expression of microRNAs (miRNAs) in laryngeal carcinoma and adjacent normal tissue using microarray, and to discuss the relationship between miRNAs and laryngeal carcinoma. miRNA were extracted from 8 cases of laryngeal cancer tissue and its adjacent normal tissue. miRNA identification were performed by microarray of miRNA hybridization and cluster analysis was used with Significance Analysis of Microarrays (SAM, version 2.1) and Cluster 3.0 software. miRNA were confirmed by real time quantification RT-PCR with RNA-tailing and primer extension. Totally 47 different miRNAs were found expressed in laryngeal cancer, with 23 of miRNA expression were up-regulated and 24 of miRNA expression were down-regulated. The expression of miR-1, miR-486-5p, miR-206, miR-487a,miR-375, miR-422a, miR-144, miR-384, miR-378, miR-133a were down-regulated by 5 multiple and while expression of miR-93, miR-31, miR-20b were up-regulated by 3 multiple. There are 5 miRNA clusters with coexpression in laryngeal cancer tissue and located on chromosome 8, 13, 14, 18 and X. Moreover, RT-PCR analysis demonstrated that there was no significantly difference of miRNA expression between microarray and RT-PCR. The different expression of miRNA may play an important role in the pathogenesis and development of laryngeal cancer.

Tu X.,Agency for Science, Technology and Research Singapore | Liow T.-Y.,Agency for Science, Technology and Research Singapore | Song J.,Agency for Science, Technology and Research Singapore | Song J.,Jilin University | And 4 more authors.
Optics Express | Year: 2013

We demonstrate silicon Mach-Zehnder Interferometer (MZI) optical modulator with 50.1-Gb/s data rate and 5.56 dB dynamic extinction ratios. The phase shifter is composed by a 4 mm-long reverse-biased p-n junction with a modulation efficiency (Vπ·Lπ) of ∼26.7 V·mm and phase shifter loss of ∼1.04 dB/mm at Vbias = -6 V. The measured electro-optic bandwidth reaches 25.6 GHz at Vbias = -5 V. Compensation doping method and low loss traveling-wave electrodes are utilized to improve the modulator performance. Measurement result demonstrates that reasonable choosing of working point and doping profile of the silicon optical modulator is critical in order to match the performance requirement of the real application. © 2013 Optical Society of America.

Man Y.-G.,Armed Forces Institute of Pathology and American Registry of Pathology | Man Y.-G.,Jilin University
International Journal of Biological Sciences | Year: 2010

Our previous studies revealed that leukocyte infiltration could trigger breast and prostate tumor invasion through physical disruption of tumor capsules. Our current study, involving multiple types of human tumors, further suggests that leukocyte infiltration also triggers metastasis through the following pathways: 1) the physical movement into the epithelium disrupts inter-cellular junctions and surface adhesion molecules, which cause the disassociation of tumor cells from tumor cores, 2) some of these tumor cells subsequently form tight junctions with the plasma membranes of leukocytes creating tumor cell-leukocyte chimeras (TLCs), and 3) the leukocytes of TLCs impart migratory capacity to associated tumor cell partners. Our findings suggest a novel pathway for tumor cell dissemination from primary sites and journey to new sites. © Ivyspring International Publisher.

Wang X.,Jilin University | Li Y.,North China Electrical Power University
Journal of Hazardous Materials | Year: 2011

Clay minerals in surficial sediment samples, collected from the Songhua River in China, were separated via sedimentation after removal of Fe/Mn oxides and organic materials; Cu and Zn adsorption onto the sediment components was then evaluated. Clay minerals were examined via X-ray diffraction and scanning electron microscopy. Clay minerals were found to consist mainly of illite, kaolinite, chlorite and an illite/smectite mixed layer. Non-clay minerals were dominated by quartz and orthoclase. The retention of Cu and Zn by clay minerals was 1.6 and 2.5 times, respectively, greater than that of the whole, untreated surficial sediment. Compared to the other critical components in sediments related to metal sorption (Mn oxides, Fe oxides and organic materials), the adsorption capacity of clay minerals was found to be relatively lower on a unit mass basis. These data suggest that, although clay minerals may be important in the adsorption of heavy metals to aquatic sediments, their role is less significant than Fe/Mn oxides and organic materials. © 2011 Elsevier B.V.

Chen C.,Jilin University | Song M.,University of Toledo | Xin C.,Old Dominion University | Backens J.,Christopher Newport University
IEEE Network | Year: 2013

Cognitive radio networks are a promising solution to the spectrum scarcity issue. However, cognitive radio networks are vulnerable to various kinds of security attacks, among which the jamming attack has attracted great attention as it can significantly degrade spectrum utilization. In this article we model the jamming and anti-jamming process as a Markov decision process. With this approach, secondary users are able to avoid the jamming attack launched by external attackers and therefore maximize the payoff function. We first use a policy iteration method to solve the problem. However, this approach is computationally intensive. To decrease the computation complexity, Q-function is used as an alternate method. Furthermore, we propose an algorithm to solve the Q-function. The simulation results indicate that our approach can achieve better performance than existing approaches to defend against the jamming attack. © 1986-2012 IEEE.

Kan Y.,Jilin University
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2010

To introduce recent progress on diagnosis and treatment of benign symmetric lipomatosis (BSL). Detailed clinical data of 6 patients with BSL were reviewed and analyzed. We present a summary of the clinical symptoms, physical sign, diagnosis and therapeutic methods of BSL. And related literatures were discussed together. All of 6 patients have excessive subcutaneous fat deposit predominantly around neck. One patients had upper extremity localizations. Six patients had the complication of left ventricular diastolic function changes, glucose intolerance or diabetes mellitus, chronic hepatopathy, hyperuricemia and sleep apnea syndrome in one or more. One patients with several symptoms occur simultaneously, another one female patient was accompanied by all symptoms but chronic hepatopathy. Five male patient were alcohol abusers. Total neck lipectomy and abstinence from alcohol were performed on 5 patients. One patient refused treatment. During a follow-up of 3 months to 4 years, one patients was relapsed again, and no recurrence was seen in another 4 patients. All patho logical results were nonencapsulated fat. BSL is a lipodystrophy caused by diffuse fatty tissue, symmetry deposition in the neck and shoulder subcutaneous fascia space or deep fascial space. The highest incidence favors to middle-aged man who is alcoholic. Chronic alcohol addiction and typical clinical symptoms help to diagnosis BSL. Lipectomy represents a successful procedure in treating BSL.

Cheng M.,Jilin University
Mathematical Methods in the Applied Sciences | Year: 2014

In the present paper, we consider the dissipative coupled fractional Schrödinger equations. The global well-posedness by the contraction mapping principle is obtained. We study the long time behavior of solutions for the Cauchy problem. We prove the existence of global attractor. Copyright © 2013 John Wiley & Sons, Ltd.

Zhao D.,Tohoku University | Tian Y.,Tohoku University | Tian Y.,Jilin University
Geophysical Journal International | Year: 2013

The origin of intraplate volcanoes in Northeast Asia is considered to be associated with upwelling of hot and wet asthenospheric materials in the big mantle wedge above the stagnant Pacific slab in the mantle transition zone. Among these intraplate volcanoes, Changbai is the largest and most active one, and very deep earthquakes (500-650 km depths) in the Pacific slab under East Asia occur ̃300 km to the east of the Changbai volcano. Integrating the findings of geophysical, geochemical and petrologic studies so far, we suggest a link between Changbai volcanism and the deep earthquakes in the Pacific slab. Many large shallow earthquakes occurred in the Pacific Plate in the outer-rise areas close to the oceanic trench, and sea water may enter down to a deep portion of the oceanic lithosphere through the active normal faults which generated the large outer-rise earthquakes. Sea water or fluids may be preserved in the active faults even after the Pacific Plate subducts into the mantle.Many large deep earthquakes are observed that took place in the subducting Pacific slab under the Japan Sea and the East Asian margin. At least some of the large deep earthquakes are caused by the reactivation of faults preserved in the subducting slab, and the fluids preserved in the faults within the slab may cause the observed non-double-couple components of the deep earthquake faulting. Fluids preserved in the slab may be released to the overlying mantle wedge through large deep earthquakes. Because large deep earthquakes occur frequently in the vicinity of the Changbai volcano, many more fluids could be supplied to this volcano than in other areas in Northeast Asia, making Changbai the largest and most active intraplate volcano in the region. © The Authors 2013. Published by Oxford University Press on behalf of The Royal Astronomical Society.

Tian Y.,Jilin University | Tian Y.,Tohoku University | Zhao D.,Tohoku University
Geophysical Journal International | Year: 2013

We determined the first 3-D P-wave anisotropic tomography beneath the North China Craton (NCC) using a large number of high-quality arrival-time data from local earthquakes and teleseismic events, which reveals depth-dependent azimuthal anisotropy in the crust and upper mantle down to 600 km depth. In the NCC western block, the fast velocity direction (FVD) varies from east-west in the southern part to northeast-southwest in the northern part, which may reflect either the interaction between the Yangtze block and NCC or fossil lithospheric fabrics in the craton. Under the NCC eastern block, a uniform northwest-southeast FVD is revealed in the lower part of the upper mantle (300-410 km depths) and the mantle transition zone (410-660 km depths), which may reflect horizontal and upwelling flows in the big mantle wedge (BMW) above the stagnant Pacific slab in the mantle transition zone. The NCC central block exhibits a northeast-southwest FVD, consistent with the surface tectonic orientation there, suggesting that the cold and thick (>300 km) cratonic root of the NCC western block may obstruct the northwest-southeast trending mantle flow induced by the Pacific Plate subduction, resulting in a northeast-southwest trending mantle flow under the central block. Our present results indicate that the corner flow in the BMW associated with the deep subduction of the Pacific Plate is the main cause of NCC reactivation and mantle dynamics under East China. © The Authors 2013. Published by Oxford University Press on behalf of The Royal Astronomical Society.

The horizontal gradient ratio has been widely used to enhance the linear features of potential field data. I explore a combination of the horizontal gradient ratio and Euler method to interpret gridded potential field data, called HGR-EUL method. A linear equation derived for the Euler equation and expressing the fields as horizontal gradient ratio can be used to estimate the horizontal location and the depth of the source without any priori information about the nature (structural index) of the source. After obtaining the source location parameters, the nature of the source can be determined. The HGR-EUL method is tested on synthetic magnetic anomalies, and the inversion results show that the method can accurately provide the location parameters for noise-free data, and also obtain reasonable results for noise-corrupted data by applying a low pass filter to smooth the data. I also applied the HGR-EUL method to real magnetic data, and the results are compared with results from the standard Euler deconvolution method. The results obtained by the HGR-EUL method show less unjustified variability and are more useful for geologists. © 2013 Society of Exploration Geophysicists.

Chen X.,Jiangsu University | Wang L.,Jilin University
Computers and Mathematics with Applications | Year: 2010

In this paper, the variational iteration method is applied to neutral functional-differential equations with proportional delays. Illustrative examples are given to show the efficiency of the method. We also compare the performance of the method with that of a particular Runge-Kutta method and a one-leg θ-method. © 2010 Elsevier Ltd. All rights reserved.

Chen M.,Jilin University
Journal of Dynamical and Control Systems | Year: 2015

In this paper, we consider a coupled system of two Korteweg-de Vries equations on a bounded domain. We establish the null controllability of this system from the left Dirichlet boundary conditions. Combining the analysis of a linearized system and a fixed point argument, this controllability result is reduced to prove the null controllability of a linearized system with two distributed controls. © 2015 Springer Science+Business Media New York

Zhang L.,Northeast Normal University | Wang T.,Changchun University of Science and Technology | Li L.,Northeast Normal University | Wang C.,Northeast Normal University | And 2 more authors.
Chemical Communications | Year: 2012

A facile, mild, environmentally friendly and reproducible strategy was used to fabricate the multifunctional fluorescent-magnetic polyethyleneimine functionalized Fe3O4-mesoporous silica yolk-shell nanocapsules for simultaneous fluorescent tracking and magnetically guided small interfering RNA delivery. © 2012 The Royal Society of Chemistry.

Sun Y.,Civil Aviation University of China | Ma F.,Jilin University
Inverse Problems in Science and Engineering | Year: 2015

In this paper, we are concerned with the inverse boundary determination problem from the Cauchy data connected with the Laplace equation in (Formula presented.). We proposed a numerical method based on the method of fundamental solution. The major advantage of the invariant method of fundamental solution is keeping a very basic natural property under an invariant condition, i.e. the invariance under trivial coordinate changes in the problem description. This method combines the Tikhonov regularization method with Morozov discrepancy principle to solve an inverse problem. Some examples are given for numerical verification on the efficiency of the proposed method. It is shown that the proposed method is effective and stable even for the data with relatively high noise levels. © 2014 Taylor & Francis.

Wang H.,Jilin University
European Journal of Gastroenterology and Hepatology | Year: 2016

AIMS: We aimed to develop new simple predictive models for significant fibrosis and inflammation in chronic hepatitis patients using routine laboratory parameters. METHODS: A total of 218 patients who had undergone liver biopsy were enrolled in our study. Among these, 116 had chronic hepatitis B, 65 had primary biliary cirrhosis, and 37 had autoimmune hepatitis. Patients were divided into two groups: absent–mild (S0–S1, G0–G1) and moderate–severe (S2–S4, G2–G4) according to the histologic severity of liver fibrosis and inflammation. All common demographics and routine laboratory parameters were analyzed. RESULTS: Red blood cell distribution width (RDW) and globulin values increased with progressive liver fibrosis and inflammation. After adjustment for other potent predictors, liver fibrosis was associated independently with RDW and platelet (odds ratio=0.976 and 1.487, respectively), whereas significant inflammation was associated independently with globulin, alanine aminotransferase, red blood cell, and platelet (odds ratio=1.153, 1.017, 0.392, and 1.487, respectively). The sensitivity and specificity of model A were 73.4 and 79.1% for the detection of significant liver fibrosis [area under the receiver-operating characteristic curve (AUROC)=0.81, P<0.001]. The sensitivity and specificity of model B were 75.9 and 88.9% for predicting advanced liver inflammation (AUROC=0.89, P<0.001). Compared with pre-existing indicators, model A achieved the highest AUROC (0.81, P<0.001) for liver fibrosis, whereas model B showed the highest AUROC (0.89, P<0.001) for liver inflammation. CONCLUSION: RDW may provide a useful clinical value for predicting liver fibrosis; meanwhile, globulin may provide a useful clinical value for predicting liver inflammation in chronic hepatitis patients with other markers. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

Li Y.,Nankai University | Zhou Z.,Nankai University | Yu G.,Jilin University | Chen W.,University of Puerto Rico at San Juan | Chen Z.,University of Puerto Rico at San Juan
Journal of Physical Chemistry C | Year: 2010

The catalytic oxidation of CO on Fe-embedded graphene was investigated by means of first-principles computations. Fe atom can be constrained at a vacancy site of graphene with a high diffusion barrier (6.78 eV), and effectively activate the adsorbed O2 molecule. The reactions between the adsorbed O2 with CO via both Langmuir-Hinshelwood (LH) and Eley-Rideal (ER) mechanisms were comparably studied. The Fe-embedded graphene shows good catalytic activity for the CO oxidation via the more favorable ER mechanism with a two-step route. © 2010 American Chemical Society.

Richter A.P.,MCI Management Center Innsbruck | Lombardi J.R.,City College of New York | Zhao B.,Jilin University
Journal of Physical Chemistry C | Year: 2010

By use of surface-enhanced Raman spectroscopy, we observe the degree of charge-transfer for Ag/PATP/ ZnO sandwich compounds as a function of both ZnO nanoparticle size and as a function of excitation wavelength. We show that there are several likely charge-transfer resonances. The most obvious is the resonance at particle diameter of 27.7 nm for all wavelengths. In a theoretical study it has been suggested that when there is an electron acceptor on the nanoparticle surface it may form a complex with the semiconductor exciton and that this is most likely the origin of the size-dependent resonance. At the smallest size (18.2 nm) studied here, there is an increase in degree of charge-transfer (relative to adjacent sizes), indicating the possibility of another, lower-lying charge-transfer state, which also could be caused by the acceptor-exciton complex. The other resonance suggested by our data is to higher excitation energy for all particle sizes. It can be seen that the degree of charge-transfer is rising as the excitation wavelength is shortened, indicating an additional charge-transfer resonance in the ultraviolet. Copyright © 2010 American Chemical Society.

Cancers have a multifactorial etiology a part of which is genetic. Recent data indicate that expression of the tight junction claudin proteins is involved in the etiology and progression of cancer. To explore the correlations of the tight junction proteins claudin-2,-6, and -11 in the pathogenesis and clinical behavior of gastric cancer, 40 gastric cancer tissues and 28 samples of non-neoplastic tissues adjacent to the tumors were examined for expression of claudin-2,-6, and -11 by streptavidin-perosidase immunohistochemical staining method. The positive expression rates of claudin-2 in gastric cancer tissues and adjacent tissues were 25% and 68% respectively (P<0.001). The positive expression rates of claudin-6 in gastric cancer tissues and adjacent tissues were 55% and 79% respectively (P=0.045<0.05). In contrast, the positive expression rates of claudin-11 in gastric cancer tissues and gastric cancer adjacent tissues were 80% and 46% (P=0.004<0.01). Thus in our study, the expression of claudin-2, and claudin-6 was down regulated in gastric cancer tissue while the expression of claudin-11 was up regulated. Correlations between claudin expression and clinical behavior were not observed. Our study provides the first evidence that claudin-2,-6, and -11 protein expression varies between human gastric cancers and adjacent non-neoplastic tissues. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5470513569630744.

Li Q.-M.,Jilin University
Chemical Research in Chinese Universities | Year: 2013

Polyacrylonitrile(PAN)-based activated carbon fiber(PACF) supporting nano-ZnO(PACF/nano-ZnO) was prepared by spin, pretreatment, carbonization, and KOH chemical activation at an activation temperature of 950 °C for 40 min. Nano-ZnO content, distribution and antibacterial properties of the PACF/nano-ZnO were studied. The pore structure and surface properties of the PACF/nano-ZnO were studied by Brunauer-Emmett-Teller(BET), N2/77 K isothermal adsorption. The specific surface area increased markedly after the activation process and it was several hundred times greater than that before the process. The PACF/nano-ZnO shows a strong adsorption for Staphylococcus aureus(S. aureus) and Escherichia coli(E. coli) and antibacterial activity against them. As an experimental result, antibacterial properties of PACF/nano-ZnO increased with increasing the concentration of nano-ZnO particles, which suggests it is a promising antibacterial material. © 2013 Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH.

Gao W.,University of Ulm | Mueller J.E.,University of Ulm | Anton J.,University of Ulm | Jiang Q.,Jilin University | And 2 more authors.
Angewandte Chemie - International Edition | Year: 2013

Watching the defectives: DFT studies on the growth of nickel clusters on different graphene substrates shows that graphene defects essentially determine the morphology of the clusters. Defects greatly improve the catalytic reactivity of the larger clusters Nin (5≤n≤10). Smaller clusters Ni n (n<4) efficiently open the band gap of defective graphene, allowing a way to modulate the electronic properties of the graphene. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Song W.,Jilin University
Nanoscale | Year: 2014

A gecko-foot inspired nanocupule surface prepared by an AAO template covering method was composed of poly(N-isopropylacrylamide) and polystyrene blend. Both superhydrophobicity and high adhesion force were exhibited on the PNIPAm/PS film at room temperature. Moreover, by controlling the temperature, the wettability of the film could be switched between 138.1 ± 5.5°and 150.6 ± 1.5°, and the adhesion force could also be correspondingly tuned accurately by temperature. This reversibility in both wettability and adhesion force could be used to construct smart devices for fine selection of water droplets. The proof-of-concept was demonstrated by the selective catching of precise weight controlled water droplets at different temperatures. This work could help us to design new type of devices for blood bioanalysis or lossless drug transportation. This journal is © The Royal Society of Chemistry.

In this study, the problem of spatio-temporal-polarisation filtering based on hypercomplex processes is considered for an electromagnetic (EM) vector-sensor array. The quaternion domain facilitates modelling and processing of four-dimensional real signals (or two-dimensional complex signals). Based on the quaternion model of linear symmetric array with twocomponents EM vector-sensors, an interference and noise canceller (INC) is presented for polarised signals. Then, the output signal to interference-plus-noise ratio (SINR) expression of INC is derived and its performance is analysed. The performance analysis reveal explicitly the fact that even though no separation between the direction of arrival (DOAs) of the desired signal and interference, the maximum value of output SINR can be obtained employing the orthogonality between the polarisations of the desired signal and interference. Simulation results show that if sample size N is large enough, the INC has larger output SINR and better robustness against the DOA mismatch.

Chen J.-G.,Taizhou University | Zeng S.-L.,CAS Beijing Institute of Applied Physics And Computational Mathematics | Yang Y.-J.,Jilin University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2010

We theoretically propose a method of producing single attosecond pulse by high-order harmonic generation with a two-color multicycle driver laser field. It is shown that this scheme can modulate the quantum paths by adjusting the relative phase. In the case of the short quantum path control, a broadband supercontinuum spectrum with a 93 eV spectral width can be produced which directly generates an isolated 46 as pulse without phase compensation. When the long quantum path is picked out, a harmonic continuum spectrum with a bandwidth of 101 eV appears, an intense isolated 39 as pulse with high-signal-to-noise ratio is generated successfully by superposing some properly selected harmonics, the phases of which are locked. In both cases, our simulations show that the value of the time delay between two lasers can be varied between -0.2 fs and 0.2 fs to keep the isolated sub-50-as pulse generation. In particular, these results are analyzed by using both classical and three-dimensional quantum-mechanical approaches. © 2010 The American Physical Society.

We analyzed genetic diversity and population genetic structure of four artificial populations of wild barley (Hordeum brevisubulatum); 96 plants collected from the Songnen Prairie in northeastern China were analyzed using amplified fragment length polymorphism (AFLP), specific-sequence amplified polymorphism (SSAP) and methylation-sensitive amplified polymorphism (MSAP) markers. Indices of (epi-)genetic diversity, (epi-)genetic distance, gene flow, genotype frequency, cluster analysis, PCA analysis and AMOVA analysis generated from MSAP, AFLP and SSAP markers had the same trend. We found a high level of correlation in the artificial populations between MSAP, SSAP and AFLP markers by the Mantel test (r > 0.8). This is incongruent with previous findings showing that there is virtually no correlation between DNA methylation polymorphism and classical genetic variation; the high level of genetic polymorphism could be a result of epigenetic regulation. We compared our results with data from natural populations. The population diversity of the artificial populations was lower. However, different from what was found using AFLP and SSAP, based on MSAP results the methylation polymorphism of the artificial populations was not significantly reduced. This leads us to suggest that the DNA methylation pattern change in H. brevisubulatum populations is not only related to DNA sequence variation, but is also regulated by other controlling systems.

Liu Y.,CAS Changchun Institute of Applied Chemistry | Liu Y.,Chinese Academy of Sciences | Ai K.,CAS Changchun Institute of Applied Chemistry | Yuan Q.,Jilin University | Lu L.,CAS Changchun Institute of Applied Chemistry
Biomaterials | Year: 2011

We report here the development of Gd-doped ZnO quantum dots (QDs) as dual modal fluorescence and magnetic resonance imaging nanoprobes. They are fabricated in a simple, versatile and environmentally friendly method, not only decreasing the difficulty and complexity, but also avoiding the increase of particle's size brought about by silica coating procedure in the synthesis of nanoprobes reported previously. These nanoprobes, with exceptionally small size and enhanced fluorescence resulting from the Gd doping, can label successfully the HeLa cells in short time and present no evidence of toxicity or adverse affect on cell growth even at the concentration up to 1 mm. These results show that such nanoprobes have low toxicity, especially in comparison with the traditional PEGylated CdSe/ZnS or CdSe/CdS QDs. In MRI studies, they exert strong positive contrast effect with a large longitudinal relaxivity (r 1) of water proton of 16 mm -1 s -1. Their capability of imaging HeLa cells with MRI implies that they have great potential as MRI contrast agents. Combining the high sensitivity of fluorescence imaging with high spatial resolution of MRI, We expect that the as-prepared Gd-doped Zno QDs can provide a better reliability of the collected data and find promising applications in biological, medical and other fields. © 2010 Elsevier Ltd.

Liu Z.-M.,Jilin University
Chinese Critical Care Medicine | Year: 2013

Objective: To observe the effects of Shenmai injection on post-cardiac arrest syndrome (PCAS) in rabbit and to discuss the underlying mechanism. Methods: Seventy-three rabbits were divided into sham operation group (n= 10), model group (n=21), high and low dosage Shenmai group (each n = 21) by random number table method. The animal model of cardiac arrest was reproduced by clamping the endotracheal tube. The rabbits in sham operation group were only given anesthesia and tracheostomy without producing asphyxia by clamping the trachea to produce asphyxia. Serum creatine kinase isoenzyme (CK-MB), alanine aminotransferase (ALT), creatinine (Cr), troponin I (cTnI), tumor necrosis factor-α (TNF-α), interleukin (IL-1β, IL-6) and nuclear transcription factors-κB (NF-κB) levels were determined before asphyxia and 3, 6, 12, 24, 48 hours after restoration of spontaneous circulation (ROSC), and dynamic changes in various parameters were determined in each group. Results: All the indexes in model group and Shenmai groups were gradually increased after ROSC. IL-6 peaked at 6 hours, 1L-1β peaked at 12 hours, CK-MB, cTnI, TNF-α and NF-κB peaked at 24 hours, ALT and Cr peaked at 48 hours. CK-MB, ALT, cTnI levels in high dosage Shenmai group were significantly lower than those in the model group 6 hours after ROSC [CK-MB (U/L): 571.69 ± 24.39 vs. 587.98 ± 22.38, ALT (U/L): 74.88 ± 8.71 vs. 81.49 ± 5.79, cTnI (μg/L): 7.82 ± 1.52 vs. 8.97 ± 1.87], serum levels of TNF-α and NF-κB 12 hours after ROSC [TNF-α(ng/L): 120.36 ± 12.38 vs. 135.23 ± 20.13, NF-κB (ng/L): 2.18 ± 0.17 vs. 2.29 ± 0.15], and the serum levels of IL-1β and IL-6 24 hours after ROSC in high dose Shenmai group were significantly lower than those in the model group [IL-1β (ng/L): 1.49 ± 0.13 vs. 1.62 ± 0.17, IL-6 (ng/L): 72.01 ± 5.02 vs. 79.35 ± 11.28], however, serum Cr in high dosage Shenmai group was significandy lower than in the model group at 24 hours after ROSC (μmol/L: 158.73 ± 4.40 vs. 162.97 ± 5.02, P<0.05 or P<0.01). In low dosage Shenmai group, the serum level of CK-MB, Cr, cTnI were significantly lower than those in the model group 24 hours after ROSC [CK-MB (U/L): 1 769.00 ± 19.73 vs. 2 120.96 ± 24.15, Cr (μmol/L): 159.32 ± 3.02 vs. 162.97 ± 5.02, cTnI (μg/L): 12.17 ± 3.04 vs. 14.89 ± 3.09,P<0.05 or P<0.01). But after ROSC, ALT, TNF-α, IL-1β, IL-6 and NF-κB showed no significant change as compared with model group. In high dosage Shenmai group, serum levels of CK-MB and cTnI at 6, 12 hours and TNF-α and IL-6 at 24 hours after ROSC were significandy lower than those in the low dosage Shenmai group (all P<0.05). Conclusions: Severity of injury of different organs in rabbit cardiac arrest model showed positive correlation with the alterations in serum TNF-α, IL-1β, IL-6, NF-κB after cardiopulmonary resuscitation. Early use of Shenmai injection after cardiopulmonary resuscitation can retard the development of PCAS, especially in the protection of ischemia and hypoxia of myocardium after cardiopulmonary resuscitation.

Wu H.,Jilin University
Wei sheng wu xue bao = Acta microbiologica Sinica | Year: 2012

A sigma factor is an important component of RNA polymerase complex and is essential for initiation of RNA synthesis. The sigma factors fall into 2 categories: primary sigma factor is essential for bacterial growth and the alterative sigma factor is activated under different environmental conditions. Sigma F (SigF) is one of the sigma factors of Mycobacterium tuberculosis, affecting its virulence and pathogenesis. In contrast, the ortholog of the non-virulent, fast growing strain Mycobacterium smegmatis has been suggested without similar physiology roles. Here, we studied the functions of M. smegmatis SigF. sigF knockout Mycobacterium smegmatis strain was constructed by specialized transduction. The wild type, knockout and complementary stains were challenged by oxidative stress and antibiotics. The knockout sigF stain was susceptible oxidative stress, compared to wild type. Furthermore, there was no defect in resistance to antibiotics including isoniazid between the knockout sigF strain and wild type strain. In addition, SigF is required for carotenoid pigment production in M. smegmatis. Our data suggested that SigF is important to detoxify the reactive oxygen species, probably through photo-oxidative stress response pathway, which is independent on the pathway that is required for the isoniazid activation.

Wu Y.,Jilin University
Genetics and molecular research : GMR | Year: 2012

Aralia elata is an important medicinal plant in China; it produces large amounts of oleanane type triterpene saponins. A full-length cDNA encoding β-amyrin synthase (designated as AeAS) was isolated from young leaves of A. elata by reverse transcription-PCR. The full-length cDNA of AeAS was found to have a 2292-bp open reading frame, encoding a protein with 763 amino acid residues. The deduced amino acid sequence of AeAS showed the highest identity (97%) to Panax ginseng β-amyrin synthase. When AeAS cDNA was expressed in Escherichia coli, an 87.8-kDa recombinant protein was detected by SDS-PAGE and Western blotting. The sequence was also heterologously expressed in the yeast Pichia pastoris, and production of β-amyrin was detected by HPLC. Tissue expression pattern analysis by real-time reverse transcription-PCR revealed that AeAS is strongly expressed in leaves and stems, and weakly expressed in roots and flowers.

Feng L.,University of Chinese Academy of Sciences | Chen Y.,Jilin University | Ren J.,University of Chinese Academy of Sciences | Qu X.,University of Chinese Academy of Sciences
Biomaterials | Year: 2011

Here we report an electrochemical sensor that can realize label-free cancer cell detection using the first clinical trial II used aptamer AS1411 and functionalized graphene. By taking advantages of AS1411 high binding affinity and specificity to the overexpressed nucleolin on the cancer cell surface, our developed electrochemical aptasensor can distinguish cancer cells and normal ones and detect as low as one thousand cells. With DNA hybridization technique, this E-DNA sensor can be regenerated and reusable for cancer cell detection. Our work gives a good example for label-free cancer cell detection based on aptamer and graphene-modified electrode. © 2011 Elsevier Ltd.

Liu W.,Jilin University
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2011

Spinal cord injury is a difficult medical problem and current therapeutic methods could not obtain satisfactory results. Recent 20 years, stem cell technology developed rapidly, embryonic stem cells and adult stem cells were used for treating neurological disease and nerve injury of animal models and the clinical results were confirmed. It provided a new prospect for the treatment of nerve injury at the cellular level. However,due to technical and ethical problems, it is difficult to obtain the appropriate cells that can be applied to the human being. Recently, induced pluripotent stem cells were developed as a new method for the treatment of spinal cord injuries by the autologous transplantation. Starting from this work, the purpose of this review is to assess the differentiate ability of induced pluripotent stem cells into neurocyte and review the latest developments in this area.

Wang H.,CAS National Center for Nanoscience and Technology | Zhao Y.,CAS National Center for Nanoscience and Technology | Wu Y.,CAS National Center for Nanoscience and Technology | Hu Y.-L.,Jilin University | And 3 more authors.
Biomaterials | Year: 2011

The use of single chemotherapeutic drug has shown some limitations in anti-tumor treatment, such as development of drug resistance, high toxicity and limited regime of clinical uses. The combination of two or more therapeutic drugs is feasible means to overcome the limitations. Co-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. Attempts have been made to deliver chemotherapeutic drugs simultaneously using drug carriers, such as micelles, liposomes, and inorganic nanoparticles (NPs). Here we reported core-shell NPs that were doubly emulsified from an amphiphilic copolymer methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA). These NPs offered advantages over other nanocarriers, as they were easy to fabricate by improved double emulsion method, biocompatible, and showed high loading efficacy. More importantly, these NPs could co-deliver hydrophilic doxorubicin (DOX) and hydrophobic paclitaxel (TAX). The drug-loaded NPs possessed a better polydispersity, indicating that they are more readily subject to controlled size distribution. Studies on drug release and cellular uptake of the co-delivery system demonstrated that both drugs were effectively taken up by the cells and released simultaneously. Furthermore, the co-delivery nanocarrier suppressed tumor cells growth more efficiently than the delivery of either DOX or TAX at the same concentrations, indicating a synergistic effect. Moreover, the NPs loading drugs with a DOX/TAX concentration ratio of 2:1 showed the highest anti-tumor activity to three different types of tumor cells. This nanocarrier might have important potential in clinical implications for co-delivery of multiple anti-tumor drugs with different properties. © 2011 Elsevier Ltd.

Li S.,Sun Yat Sen University | Jiang Q.,Jilin University | Yang G.W.,Sun Yat Sen University
Applied Physics Letters | Year: 2010

Influence of the uniaxial strain on the electronic structures of ZnO nanowires (NWs) and nanotubes (NTs) has been studied using the density functional theory. It was found that the uniaxial compress strain can lead to a band gap transition from direct to indirect band for both ZnO NWs and NTs. Under the same strain, the phase transition of the thick NW is easier than that of the thin one, and the phase transition of NWs seems easier than that of NTs. These results suggested the uniaxial strain can be used to tune the band structures of ZnO nanostructures, which may be help for design of ZnO-based nanodevices. © 2010 American Institute of Physics.

Wu J.-H.,Jilin University | Artoni M.,CNR Institute of Acoustics and Sensors Orso Mario Corbino | Artoni M.,CNR Institute of Applied Physics Nello Carrara | La Rocca G.C.,Normal School of Pisa
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2010

We develop a general scheme for studying the optical response of ultracold atoms driven into a regime of standing-wave electromagnetically induced transparency. We rely on full numerical solutions of the Maxwell-Liouville equations without invoking secular and adiabatic approximations and arbitrary initial state assumptions. These approximations and assumptions can conceal, e.g., significant loss and diffusion responsible for the decay of stationary light pulses in cold atomic samples. The complex decay dynamics of a stationary light pulse is here analyzed in terms of higher-order spin and optical coherences that arise from nonlinear interactions of the stationary light pulse with the two counterpropagating components of a standing-wave driving field. Specific results for stationary light pulses in cold Rb87 atoms have been discussed for temperature regimes where the residual Doppler broadening is negligible. © 2010 The American Physical Society.

Chang C.-H.,National Taiwan University | Chang C.-H.,Academia Sinica, Taiwan | Fan X.,Jilin University | Lin S.-H.,Academia Sinica, Taiwan | Kuo J.-L.,Academia Sinica, Taiwan
Physical Review B - Condensed Matter and Materials Physics | Year: 2013

Structures, electronic properties, and phonon dispersions of monolayer MX2 (M= Mo, W; X= S, Se) under various types of mechanical strains are investigated with density functional calculations. By analyzing the orbitals near band gaps, we demonstrate that the X-M-X bond angle, together with the X-X distances, plays one of the most important roles in determining band gaps, as it is directly related to the coupling of d orbitals of the M atoms and p orbitals of the X atoms. It is found that the band gaps of monolayer MX 2 are more sensitive to biaxial strains. This notion can be attributed to the fact that, under biaxial strains, MX2 tends to be stretched more significantly along the out-of-plane direction, resulting in greater changes in bond lengths/angles than uniaxial strains. While most theoretical reports suggested systematic reduction of band gaps under mechanical strains, we found that the direct band gaps can be robustly widened by applying compressive biaxial strains. Our results are of immediate importance for the recent experimental advances in applying compressive strains, which was not applicable before. On the other hand, the anisotropy of X-M-X bond angles induced by uniaxial strains leads to splitting in the phonon dispersion, and is directly relevant to recent Raman spectroscopy results. As most transition-metal dichalcogenides share the same structural characters, we expect that the notions derived here are applicable to other layered transition-metal oxides/chalcogenides and open up new venues to engineer their properties. © 2013 American Physical Society.

Wang Y.,CAS Changchun Institute of Applied Chemistry | Song S.,CAS Changchun Institute of Applied Chemistry | Liu J.,Jilin University | Liu D.,CAS Changchun Institute of Applied Chemistry | Zhang H.,CAS Changchun Institute of Applied Chemistry
Angewandte Chemie - International Edition | Year: 2015

Limited therapeutic efficiency and severe side effects in patients are two major issues existing in current chemotherapy of cancers in clinic. To design a proper theranostic platform seems thus quite needed to target cancer cells accurately by bioimaging and simultaneously release drugs on demand without premature leakage. A novel ZnO-functionalized upconverting nanotheranostic platform has been fabricated for clear multi-modality bioimaging (upconversion luminescence (UCL), computed tomography (CT), and magnetic resonance imaging (MRI)) and specific pH-triggered on-demand drug release. In our theranostic platform multi-modality imaging provides much more detailed and exact information for cancer diagnosis than single-modality imaging. In addition, ZnO can play the role of a "gatekeeper" to efficiently block the drug in the mesopores of the as-prepared agents until it is dissolved in the acidic environment around tumors to realize sustained release of the drug. More importantly, the biodegradable ZnO, which is non-toxic against normal tissues, endows the as-prepared agents with high therapeutic effectiveness but very low side effects. These findings are of great interests and will inspire us much to develop novel effective imaging-guided on-demand chemotherapies in cancer treatment. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA.

Shen W.Z.,Jilin University
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2012

This study was purposed to clarify the difference of microRNA (miRNA) expression in the peripheral blood cells of patients with primary immune thrombocytopenia (ITP) and normal controls. Exqion miRCURY(TM) microarray was used to investigate differentially expressed miRNA of peripheral blood cells obtained from affected ITP patients and the healthy controls. Cluster analysis was used to identify miRNA expression profile between the ITP patients and the healthy controls. Real-time PCR was used for validation. The results showed that a total of 159 miRNA were found to be differentially expressed in ITP patients compared to the controls, with 79 up-regulated and 80 down-regulated. Based on these differentially expressed miRNA, a tree with clear distinction between the controls and ITP patients was generated by cluster analysis. Real-time PCR confirmed microarray analysis results. It is concluded that differentially expressed miRNA were found in the peripheral blood cells from ITP patients, which may be potential novel biomarkers for ITP as well as help to elucidate pathogenic mechanisms of ITP.

Wang L.,Peking University | Wang L.,Jilin University | Du Y.,Key Laboratory of Carcinogenesis and Translational Research | Lu M.,Peking University | Li T.,Peking University
Nucleic Acids Research | Year: 2012

Protein lysine acetylation plays an important role in the normal functioning of cells, including gene expression regulation, protein stability and metabolism regulation. Although large amounts of lysine acetylation sites have been identified via large-scale mass spectrometry or traditional experimental methods, the lysine (K)-acetyl-transferase (KAT) responsible for the acetylation of a given protein or lysine site remains largely unknown due to the experimental limitations of KAT substrate identification. Hence, the in silico prediction of KAT-specific acetylation sites may provide direction for further experiments. In our previous study, we developed the acetylation set enrichment based (ASEB) computer program to predict which KAT-families are responsible for the acetylation of a given protein or lysine site. In this article, we provide KAT-specific acetylation site prediction as a web service. This web server not only provides the online tool and R package for the method in our previous study, but several useful services are also included, such as the integration of protein-protein interaction information to enhance prediction accuracy. This web server can be freely accessed at http://cmbi.bjmu.edu.cn/ huac. © 2012 The Author(s).

Mao X.,University of Georgia | Zhang H.,University of Georgia | Zhang H.,Nankai University | Yin Y.,University of Georgia | And 2 more authors.
Nucleic Acids Research | Year: 2012

The majority of bacterial genes are located on the leading strand, and the percentage of such genes has a large variation across different bacteria. Although some explanations have been proposed, these are at most partial explanations as they cover only small percentages of the genes and do not even consider the ones biased toward the lagging strand. We have carried out a computational study on 725 bacterial genomes, aiming to elucidate other factors that may have influenced the strand location of genes in a bacterium. Our analyses suggest that (i) genes of some functional categories such as ribosome have higher preferences to be on the leading strands; (ii) genes of some functional categories such as transcription factor have higher preferences on the lagging strands; (iii) there is a balancing force that tends to keep genes from all moving to the leading and more efficient strand and (iv) the percentage of leading-strand genes in an bacterium can be accurately explained based on the numbers of genes in the functional categories outlined in (i) and (ii), genome size and gene density, indicating that these numbers implicitly contain the information about the percentage of genes on the leading versus lagging strand in a genome. © 2012 The Author(s).

Yang X.,University of Nottingham | Yan Y.Y.,University of Nottingham | Yan Y.Y.,Jilin University | Mullen D.,Thermacore
Applied Thermal Engineering | Year: 2012

Heat pipes, known as "super thermal conductors" have been widely used in many areas for more than 50 years. Currently, due to the various requirements put on cooling systems, such as lightweight, better heat transfer performance, and optimised appearance, heat pipes have been improved significantly in the past decades. This paper summarises the recent developments of lightweight, high performance heat pipes. Various methods or approaches to achieve the requirements of lightweight and high performance are introduced. The applications of lightweight materials can help reduce by up to 80% the weight of conventional copper heat pipes; however the lightweight material often has problems of corrosion. Although improving the design of wick structures and changing the size of conventional heat pipe assemblies can help to reduce weight and achieve high heat flux, there are still some limitations to the applications of lightweight materials such as magnesium due to its incompatibility with some working fluids. © 2011 Elsevier Ltd. All rights reserved.

Li W.,University of Texas at Austin | Manthiram A.,University of Texas at Austin | Guiver M.D.,Hanyang University | Liu B.,Jilin University
Electrochemistry Communications | Year: 2010

Novel acid-base blend membranes consisting of acidic sulfophenylated poly(ether ether ketone ketone) (Ph-SPEEKK) and various amounts of basic polysulfone tethered with 5-amino-benzotriazole (PSf-BTraz) have been prepared and characterized. The blend membranes show higher proton conductivity and lower liquid uptake and dimensional swelling compared to plain Ph-SPEEKK and sulfonated poly(ether ether ketone) (SPEEK) membranes. The Ph-SPEEKK/PSf-BTraz blend membranes with optimized basic polymer contents exhibit lower methanol crossover and higher performance with improved stability in direct methanol fuel cells (DMFC) at various methanol concentrations (1-10 M) than plain Ph-SPEEK and Nafion-115 membranes. © 2010 Elsevier B.V. All rights reserved.

Liu Y.,Jilin University | Liu S.,CAS Changchun Institute of Applied Chemistry | Liu Z.,CAS Changchun Institute of Applied Chemistry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | Year: 2013

Xanthine oxidase (XOD) inhibitors play an important role in the treatment of gout and many other diseases related to the superoxide anion metabolism. In this study, an ultrafiltration-liquid chromatography-mass spectrometry (UF-LC-MS) method was developed for the screening and identification of potential XOD inhibitors from Radix Salviae Miltiorrhizae extract. Eleven lipophilic diterpenoid quinines were identified as XOD inhibitors from the extract. The relationship between the structure and activity of the detected compounds was estimated on the basis of the UF-LC-MS data. The results demonstrate that the 1,2-naphthoquinone group is necessary for the XOD inhibitory activity of the compounds, and that furan and hydroxyl on the alicyclic ring could enhance the activity of the compounds at different levels. These results may explain and support the medical use of the extract of Radix S. Miltiorrhizae for the prevention and treatment of hyperuricemia and gout. © 2013 Elsevier B.V.

Li S.J.,Jilin University
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2011

To investigate the expression of translationally controlled tumor protein (TCTP) in human breast cancer tissues and its clinical significances. The expression of TCTP in 94 human breast cancer and the corresponding adjacent normal mammary tissues were detected using immunohistochemistry. The expression rate of TCTP was 64.89% in human breast cancer tissues, significantly higher than that in normal benign mammary tissues (39.36%, P<0.001). TCTP overexpression was positively correlated to the tumor size, clinical stage, lymph node metastasis and histological grade of breast cancer (P<0.05). Patients with positive TCTP expression had a significantly shorter mean survival time than those with negative expression (P<0.001). TCTP may play an important role in the tumorigenesis and development of breast cancer, and can be an important prognostic factor for this malignancy.

Liu X.,Japan Institute for Molecular Science | Liu X.,Jilin University | Xu Y.,Japan Institute for Molecular Science | Jiang D.,Japan Institute for Molecular Science
Journal of the American Chemical Society | Year: 2012

Conjugated polymers are attractive materials for the detection of chemicals because of their remarkable π-conjugation and photoluminescence properties. In this article, we report a new strategy for the construction of molecular detection systems with conjugated microporous polymers (CMPs). The condensation of a carbazole derivative, TCB, leads to the synthesis of a conjugated microporous polymer (TCB-CMP) that exhibits blue luminescence and possesses a large surface area. Compared with a linear polymer analogue, TCB-CMP showed enhanced detection sensitivity and allowed for the rapid detection of arenes upon exposure to their vapors. TCB-CMP displayed prominent fluorescence enhancement in the presence of electron-rich arene vapors and drastic fluorescence quenching in the presence of electron-deficient arene vapors, and it could be reused without a loss of sensitivity and responsiveness. These characteristics are attributed to the microporous conjugated network of the material. Specifically, the micropores absorb arene molecules into the confined space of the polymer, the skeleton possesses a large surface area and provides a broad interface for arenes, and the network architecture facilitates exciton migration over the framework. These structural features function cooperatively, enhancing the signaling activity of TCB-CMP in fluorescence-on and fluorescence-off detection. © 2012 American Chemical Society.

Li Z.,University of Nebraska - Lincoln | Li Z.,Jilin University | Dzenis Y.,University of Nebraska - Lincoln
Talanta | Year: 2011

Pristine and Co-doped In2O3 nanowires were synthesized via electrospinning with subsequent calcination. Scanning electron microscopy, X-ray diffraction, and energy-dispersive X-ray spectroscopy were used to characterize nanowire morphology and structure. Ethanol sensing performance analyzed in the range of temperatures and concentrations showed that Co-doped In2O3 nanowires exhibited significantly enhanced sensitivity and rate of performance with the response and recovery times of 2 s and 3 s, respectively. Combined with excellent selectivity and linearity, these properties make the fabricated nanowires a good candidate for practical ethanol sensing. Further performance improvements are possible with utilization of nanofiber continuity intrinsic of the used top-down nanowire nanomanufacturing process. © 2011 Elsevier B.V. All rights reserved.

Liu N.-N.,Harbin University of Commerce | Gao S.-M.,Northeast Petroleum University | Ding Y.-H.,Jilin University
Dalton Transactions | Year: 2015

The inverse sandwich Ca-C8H8-Ca is predicted to be an open-shell singlet state. Since the C8H8 ligand prevents the spin-up and spin-down electrons of different calcium atoms from forming Ca-Ca bonds, the spin-coupling electrons lead to a singlet diradical character. The metal-ligand interaction contributes to the stability of Ca-C8H8-Ca against dissociation and isomerization. For the coordination complex (DME)3Ca-C8H8-Ca(DME)3, the open-shell singlet state is unavailable, while the closed-shell singlet state with direct Ca-Ca bonds is more favorable, because dimethyl ether molecules could push the spin-paired electrons of different calcium atoms to migrate towards the direction of Ca-Ca bonding. For Ca-C4H4-Ca, the ground state is an open-shell singlet state, of which the diradical character is very similar to that of Ca-C8H8-Ca. For (DME)3Ca-C4H4-Ca(DME)3, the lowest energy is the triplet state. This journal is © The Royal Society of Chemistry.

Jin F.,Jilin University | Jin F.,University of Duisburg - Essen | Brockmeier U.,University of Duisburg - Essen | Otterbach F.,University of Duisburg - Essen | Metzen E.,University of Duisburg - Essen
Molecular Cancer Research | Year: 2012

The SDF-1/CXCR4 axis has been implicated in breast cancer metastasis. In contrast to its well-established role in organ-specific homing and colonization of tumor cells, the involvement in intravasation, especially in a hypoxic environment, is still poorly understood. Initially, we detected both, the chemokine SDF-1 and its receptor CXCR4 in microvessels in invasive ductal cancer samples. To elucidate the role of the SDF-1/CXCR4 axis in vascular endothelium for tumor intravasation, we evaluated the effects of CXCR4 activation in human umbilical vein and dermal microvascular endothelial cells (HUVEC and HDMEC) and in cultured mammary carcinoma cells (MDA MB231, and MCF7). We observed an upregulation of SDF-1 and CXCR4 in HUVECs in hypoxia, which led to proliferation, migration, and tube formation. Hypoxia induced adhesion of tumor cells to endothelial cells and stimulated transendothelial migration. The effects of hypoxia were dependent on the activity of the transcription factor hypoxia-inducible factor. Adhesion to and migration through a HUVEC monolayer were significantly reduced by lentiviral inhibition of CXCR4 in breast carcinoma cells or treatment of endothelial cells with an anti-SDF-1 neutralizing antibody. These data show that the interaction of SDF-1 secreted by ECs with tumor cell CXCR4 is sufficient to stimulate transendothelial migration of the tumor cells. Our results suggest that the SDF-1/ CXCR4 axis is important in angiogenesis and tumor cell intravasation. Because both proteins were readily identifiable in a significant fraction of human breast cancer samples by immunohistochemistry, CXCR4 may constitute a molecular target for therapy when both, SDF-1, and CXCR4 are expressed. ©2012 AACR.

Chen W.,University of Puerto Rico at San Juan | Li Y.,Nankai University | Yu G.,Jilin University | Li C.-Z.,Florida International University | And 3 more authors.
Journal of the American Chemical Society | Year: 2010

The intriguing electronic and magnetic properties of fully and partially hydrogenated boron nitride nanoribbons (BNNRs) were investigated by means of first-principles computations. Independent of ribbon width, fully hydrogenated armchair BNNRs are nonmagnetic semiconductors, while the zigzag counterparts are magnetic and metallic. The partially hydrogenated zigzag BNNRs (using hydrogenated BNNRs and pristine BNNRs as building units) exhibit diverse electronic and magnetic properties: they are nonmagnetic semiconductors when the percentage of hydrogenated BNNR blocks is minor, while a semiconductor→ half-metal→metal transition occurs, accompanied by a nonmagnetic→ magnetic transfer, when the hydrogenated part is dominant. Although the half-metallic property is not robust when the hydrogenation ratio is large, this behavior is sustained for partially hydrogenated zigzag BNNRs with a smaller degree of hydrogenation. Thus, controlling the hydrogenation ratio can precisely modulate the electronic and magnetic properties of zigzag BNNRs, which endows BN nanomaterials many potential applications in the novel integrated functional nanodevices. © 2010 American Chemical Society.

Gao G.,Southwest University | Xu J.,Jilin University
Critical Reviews in Eukaryotic Gene Expression | Year: 2013

Brucellosis caused by Brucella spp. is a common zoonosis in many parts of the world. Humans are infected through contact with infected animals or their dirty products. Many mechanisms are needed for this successful infection, although the mechanisms are still unclear. Host immune response and some signaling molecules play an important role in the infection event. Bacterial pathogens operate by attacking crucial intracellular pathways or some important molecules in each of these pathways for survival in their hosts. The crucial components (molecules) of immunity or pathway play a critical role in the whole process of Brucella infection. Here we summarize the findings of the Brucella-host interactions' immune system and signaling molecular cascades involved in the TLR-initiated immune response to Brucella spp. infection. The paper serves to deepen our understanding of this complex process and to provide some clues regarding the discovery of drug targets for prevention and control. © 2013 Begell House, Inc.

Liu R.Z.,Jilin University
Zhonghua nan ke xue = National journal of andrology | Year: 2012

The Y chromosome contains genes closely related to male gonadal development and spermatogenesis. The azoospermia factor (AZF) is a gene on the long arm of the Y chromosome that regulates spermatogenesis, and its deletion can induce spermatogenic arrest and consequently male infertility. Most researchers subdivide AZF into AZFa, AZFb and AZFc, and some believe there to be another region, AZFd, between AZFa and AZFb. Different AZF deletions lead to different phenotypes. AZFc deletion, as the commonest type that attracts widespread attention of researchers, includes complete AZF deletion and partial AZF deletion, and the latter mainly consists of gr/gr deletion and b2/b3 deletion. The gr/gr deletion can cause infertility in some areas or in human species. The influence of b2/b3 deletion on spermatogenesis has not been confirmed, but its wide spread in haplogroup N has distribution scientists' attention. This review outlines the structures, candidate genes and deletions of AZF, especially AZFc, along with their relationship with spermatogenesis, so as to provide a theoretical basis for clinical prenatal diagnosis and treatment of infertility.

Han Y.,King Abdullah University of Science and Technology | Zhang D.,Jilin University
Current Opinion in Chemical Engineering | Year: 2012

Periodically ordered mesoporous silicas constitute one of the most important branches of porous materials that are extensively employed in various chemical engineering applications including adsorption, separation and catalysis. This short review gives an introduction to recently developed mesoporous silicas with emphasis on their complicated structures and synthesis mechanisms. In addition, two powerful techniques for solving complex mesoporous structures, electron crystallography and electron tomography, are compared to elucidate their respective strength and limitations. Some critical issues and challenges regarding the development of novel mesoporous structures as well as their applications are also discussed. © 2011 Elsevier Ltd.

Kolk A.,University of Amsterdam | Hong P.,Jilin University | van Dolen W.,University of Amsterdam
Business Strategy and the Environment | Year: 2010

In the past decade, a sizeable body of literature has built up on the concept and characteristics of corporate social responsibility (CSR) in Western countries, where it has also been referred to as sustainability. More recently, attention has grown for CSR in emerging countries. Remarkably, China has hardly been studied so far. This paper aims to help fill this gap by considering, against this background, the CSR notion in China, through an exploration of a small sample of large retailers in China, both Chinese and non-Chinese companies. The analysis of CSR/sustainability dimensions, as communicated by these large retailers in both the Chinese and the English language, shows substantial differences between the Chinese and international contexts. Interestingly, the largest divergence can be found for international retailers between their Chinese and corporate attention for CSR (so home versus host settings), most notably in the case of Carrefour, and to a lesser extent Wal-Mart. In the Chinese context, there are differences between the Chinese and international retailers as well (so domestic versus foreign firms), with the former reporting more on economic dimensions, including philanthropy, and the latter more on product responsibility - contentious labour issues and the environment receive relatively limited attention in both groups in China. The paper concludes with a discussion of the implications for research and practice. Copyright © 2008 John Wiley & Sons, Ltd and ERP Environment.

Meng Q.,Jilin University
Zeitschrift fur Angewandte Mathematik und Physik | Year: 2015

In this paper, we study the time-discretized compressible magnetohydrodynamic equations posed in a bounded domain of R3 and equipped with boundary conditions. We prove the existence of generalized solutions for the adiabatic exponent γ > 1. © 2014, Springer Basel.

Brown B.A.,Michigan State University | Fang D.L.,Jilin University | Horoi M.,Central Michigan University
Physical Review C - Nuclear Physics | Year: 2015

The nuclear matrix elements for two-neutrino double-β and zero-neutrino double-β decay of Ge76 are evaluated in terms of the configuration-interaction (CI), quasiparticle random-phase approximation (QRPA), and interacting boson model methods. We point out deficiencies in all of these models and suggest ways that some of them can be corrected. The final results are obtained from the CI method corrected for configuration admixtures involving orbitals outside of the CI configuration space by using results from QRPA, many-body-perturbation theory, and the connections to related observables. The CI two-neutrino matrix element is reduced due to the inclusion of spin-orbit partners and to many-body correlations connected with Gamow-Teller β decay. The CI zero-neutrino matrix element for the heavy neutrino is enhanced due to particle-particle correlations that are connected with the odd-even oscillations in the nuclear masses. The CI zero-neutrino matrix element for the light neutrino contains both types of correlations that approximately cancel each other. The uncertainty from short-range correlations is also considered. © 2015 American Physical Society.

Yang S.,Jilin University | Wang J.,Jilin Agricultural University
Cell Biochemistry and Biophysics | Year: 2015

Our previous studies suggested that Estrogen inhibits cytokine-induced expression of VCAM-1 and ICAM-1 in cultured human endothelial cells via AMP-activated protein kinase (AMPK) activation. Here, we sought to delineate the mechanisms underlying estrogen activation of AMPK. AMPK can be considered a ‘fuel gauge’ of cellular energy status in response to metabolic stress. It is controlled by upstream kinases such as Ca2+/calmodulin-dependent protein kinase kinase β (CaMKKβ) or LKB1. The present study of human endothelial cells demonstrates that AMPK is activated by estradiol (E2) through a Ca2+-dependent mechanism involving the estrogen receptor-β (ERβ) activation. Inhibition of CaMKK with STO-609, a specific inhibitor of CaMKKα and CaMKKβ, attenuated E2-induced AMPK activation, suggesting that CaMKKβ was the responsible AMPK kinase. Conversely, down-regulation of LKB1 did not affect E2-induced AMPK activation. E2 stimulation caused phosphorylation of acetyl coenzyme A carboxylase (ACC) and endothelial nitric oxide synthase (eNOS), two main targets of AMPK. Inhibition or down-regulation of CaMKKβ eliminated phosphorylation of ACC and eNOS in response to E2. Together, our data highlight the role of Ca2+ as a regulator of AMPK activation in response to E2 stimulation. We demonstrate that E2 activates AMPK via an ERβ/Ca2+/CaMKKβ-dependent pathway in endothelial cells. © 2015, Springer Science+Business Media New York.

Liu L.,University of Connecticut | Liu S.,Jilin University
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing | Year: 2014

The stepped-frequency continuous wave (SFCW) radar technique was used to detect cardio-respiratory signals as the vital sign from a human subject positioned behind obstacles under laboratory conditions. The experiments were organized with a number of detection scenarios by collecting data from a group of human subjects. The experiments also investigated the effect of varying thickness of the obstacles, human subject postures, status of breathing, position of radar antenna relative to human subject's chest, as well as the length of survey times. The experimental results have shown that respiration as the primary vital sign can be detected with very high confidence and should be highlighted in developing radar systems for search and rescue for earthquake disaster survivors. Among the four human subject postures of face up, face down, face left, and face right, detection of the cardiologic signals can solely be achieved possibly when the subject was facing up. When the radar antennas to be placed at certain offset, not directly above the human subject's chest, it is still possible for good detection of the breathing signal. The minimum recording time for extracting respiration signal can be as short as 5 s. Even be conservative, a period of 30 s should be long enough for catching the respiratory signal with high signal to noise ratio. © 2008-2012 IEEE.

Wei Y.,Jilin University | Yang M.,Zhejiang Normal University
Zeitschrift fur Angewandte Mathematik und Physik | Year: 2014

In this paper, we consider the existence and multiplicity of homoclinic type solutions to a system of diffusion equations with spectrum point zero. By using some recent critical point theorems for strongly indefinite problems, we obtain at least one nontrivial solution and also infinitely many solutions. © 2013 Springer Basel.

Wu H.,Nanyang Technological University | Fan X.,Jilin University | Kuo J.-L.,Academia Sinica, Taiwan
International Journal of Hydrogen Energy | Year: 2012

By the incorporation of C into (BN)12 fullerene, our theoretical investigation shows that the hydrogenation reaction on carbon doped B 11N12C cluster is both thermodynamically favored and kinetically feasible under ambient conditions. Without using the metal catalyst, the C atom can work as an activation center to dissociate H2 molecule and provide the free H atom for further hydrogenation on the B 11N12C fullerene, which saves the materials cost in practical applications for hydrogen storage. Moreover, the material curvature also plays an important role in reducing the activation barrier for the hydrogen dissociation on the BN fullerenes. © 2012, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.

Zhang L.,University of Colorado at Boulder | Zhang L.,Jilin University | Zunger A.,University of Colorado at Boulder
Nano Letters | Year: 2015

Layered group-VIB transition metal dichalcogenides (with the formula of MX2) are known to show a transition from an indirect band gap in the thick n-monolayer stack (MX2)n to a direct band gap at the n = 1 monolayer limit, thus converting the system into an optically active material suitable for a variety of optoelectronic applications. The origin of this transition has been attributed predominantly to quantum confinement effect at reduced n. Our analysis of the evolution of band-edge energies and wave functions as a function of n using ab initio density functional calculations including the long-range dispersion interaction reveals (i) the indirect-to-direct band gap transformation is triggered not only by (kinetic-energy controlled) quantum confinement but also by (potential-energy controlled) band repulsion and localization. On its own, neither of the two effects can explain by itself the energy evolution of the band-edge states relevant to the transformation; (ii) when n decreased, there emerge distinct regimes with characteristic localization prototypes of band-edge states deciding the optical response of the system. They are distinguished by the real-space direct/indirect in combination with momentum-space direct/indirect nature of electron and hole states and give rise to distinct types of charge distribution of the photoexcited carriers that control excitonic behaviors; (iii) the various regimes associated with different localization prototypes are predicted to change with modification of cations and anions in the complete MX2 (M = Cr, Mo, W and X = S, Se, Te) series. These results offer new insight into understanding the excitonic properties (e.g., binding energy, lifetime etc.) of multiple layered MX2 and their heterostructures. © 2015 American Chemical Society.

Chang X.,Jilin University | Wang Z.-Q.,Nankai University | Wang Z.-Q.,Utah State University
Nonlinearity | Year: 2013

This paper focuses on the following scalar field equation involving a fractional Laplacian:(δ) αu = g(u) in ℝN, where N ≥ 2, α ∈ (0, 1), (?δ) α stands for the fractional Laplacian. Using some minimax arguments, we obtain a positive ground state under the general BerestyckiLions type assumptions. © 2013 IOP Publishing Ltd & London Mathematical Society.

Chung T.-P.,Jilin University | Liao C.-J.,National Taiwan University of Science and Technology
Applied Soft Computing Journal | Year: 2013

We consider the n-job, k-stage problem in a hybrid flow shop (HFS) with the objective of minimizing the maximum completion time, or makespan, which is an NP-hard problem. An immunoglobulin-based artificial immune system algorithm, called IAIS algorithm, is developed to search for the best sequence. IAIS, which is better fit the natural immune system, improves the existing AIS by the process before/after encounter with antigens. Before encounter with antigens, a new method of somatic recombination is presented; after encounter with antigens, an isotype switching is proposed. The isotype switching is a new approach in artificial immune system, and its purpose is to produce antibodies with the same protection but different function to defense the antigen. To verify IAIS, comparisons with the existing immune-based algorithms and other non-immune-based algorithms are made. Computational results show that IAIS is very competitive for the hybrid flow shop scheduling problem. © 2013 Elsevier B.V. All rights reserved.

Li C.,Tianjin University of Technology | Yang Y.-W.,Jilin University | Liang Z.-X.,Tianjin University of Technology | Wu G.-L.,Nankai University | Gao H.,Tianjin University of Technology
Polymer Chemistry | Year: 2013

Thiourea has been shown to interact actively with phosphate groups of DNA. To this end, linear and five-arm poly(glycidyl methacrylate)s (PGMA)s are post-modified with 1,2-ethanediamine (E), 1,4-butanediamine (B) and diethylenetriamine (D) via ring opening reactions to obtain various amino poly(glycidyl methacrylate)s (PGOHMAs), namely L-E, S5-E, S5-B, L-B, and L-D (L represents linear polymer, S5 represents five-arm polymer, E is short for 1,2-ethanediamine, B is short for 1,4-butanediamine, and D is short for diethylenetriamine). These amino PGOHMAs are further functionalized with methyl isothiocyanate (M) to give thiourea-modified PGOHMAs (TPGOHMAs), L-EM, S5-EM, L-DM, L-BM, S5-BM, L-EM and S5-EM, with propyl isothiocyanate (P) to give L-BP. Both the amino PGOHMAs and TPGOHMAs are used as gene vectors. The mean hydrodynamic diameter of amino PGOHMA/plasmid DNA (pDNA) and TPGMP/pDNA complexes is in the range of 65-195 nm, as determined by dynamic light scattering, and decreases with increasing nitrogen-to-phosphate (N/P) ratio. At the same N/P ratio, TPGOHMA/pDNA complexes exhibit lower values of zeta potentials than its amino PGOHMA counterpart when zeta potentials turned into positive. Gel electrophoresis indicates that TPGOHMA polymers can condense pDNA at lower N/P ratios than amino PGOHMAs. MTT assay suggests that TPGOHMAs have obviously lower cytotoxicity than amino PGOHMAs against Huh-7 cells. Subsequently, in vitro gene transfection studies against Huh-7 cells show that TPGOHMA/pDNA exhibits lower transfection efficiency than amino PGOHMAs, except for L-DM/pDNA complexes. Confocal laser scanning microscopy reveals that L-DM/pDNA complexes achieve endosomal escape more effectively than L-D/pDNA complexes. This study revealed the effect of thiourea-modification of amino PGOHMA on its gene transfection properties. L-DM, with enhanced transfection efficiency and reduced cytotoxicity, is an interesting material for further investigation as a nucleic acid delivery vehicle. © 2013 The Royal Society of Chemistry.

Feng X.,Curtin University Australia | Zhang S.,Jilin University | Lou X.,Curtin University Australia
Colloids and Surfaces B: Biointerfaces | Year: 2013

Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy. In this paper, core-shell structured titanium dioxide-silica (TiO2-SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicity and photo-killing ability of the TiO2 nanoparticles was investigated. Silica coating reduced the photocatalytic reactivity but improved the cytocompatibility of the TiO2 nanoparticles. This effect was amplified with increasing silica shell thickness. When the silica thickness was about 5.5nm, the coated TiO2 not only retained a high level photodynamic reactivity, comparable to the non-coated TiO2 nanoparticles, but also demonstrated an improved cell compatibility and effective photo-killing ability upon the mouse fibroblast cells (L929). © 2013 Elsevier B.V.

Zhang Z.,CAS Changchun Institute of Applied Chemistry | Xu F.,CAS Changchun Institute of Applied Chemistry | Yang W.,CAS Changchun Institute of Applied Chemistry | Guo M.,Jilin University | And 3 more authors.
Chemical Communications | Year: 2011

Ag-graphene composite nanosheets (AGCN) with adjustable size and well-controlled densities of Ag nanoparticles (Ag NPs) using Poly(N-vinyl-2-pyrrolidone) (PVP) as a reductant and stabilizer are reported. The obtained AGCN substrate is extremely suitable for surface-enhanced Raman spectroscopy (SERS). © 2011 The Royal Society of Chemistry.

Wang G.,Hong Kong University of Science and Technology | Wang G.,Jilin University | Zhang T.-Y.,Hong Kong University of Science and Technology
Journal of Colloid and Interface Science | Year: 2012

Hierarchical nanostructured CuO surface was embellished to amplify the wettability. The pristine superhydrophilic CuO surface spontaneously transited to be superhydrophobic after exposed in air at room temperature for about 3. weeks. The wettability change is attributed to the adsorption of oxygen molecules on the topmost layer according to the surface chemical analysis. The adsorbed oxygen molecules could be removed by dipping the sample into l-Ascorbic acid solution for 10. s, leading to the recovery of the pristine superhydrophilicity. © 2012 Elsevier Inc..

Fang F.,Jilin University
Zhonghua nan ke xue = National journal of andrology | Year: 2012

To explore the correlation of low-dose radiation with endoplasmic reticulum stress and the activation of the PERK-CHOP signaling pathway in mouse testicular cells. Healthy Kunming mice were randomly assigned to time-effect (0, 3, 6, 12 and 24 h of irradiation at 75 mGy) and dose-effect (12 h of irradiation at 0, 50, 75, 100 and 200 mGy) groups. The contents of H202 and MDA were measured by colorimetry with the agent kits, the expressions of GRP78, PERK and CHOP mRNA detected by quantitative RT-PCR, and the levels of GRP7B, PERK, phosphorylated PERK (pho-PERK) and CHOP proteins determined by Western blotting and image analysis. After whole-body irradiation of the mice with 75 mGy, the content of H2 02 in the testis tissue was increased with time prolongation, while that of MDA decreased slightly at 3 and 6 h and then increased with the lengthening of time, both increased significantly at 12 and 24 h as compared with those at 0 h (P < 0. 05, P < 0. 01). Apart from reduced levels of GRP78 mRNA at 3 and 24 h and GRP78 protein at 6 h after irradiation, significant increases were found in the mRNA expressions of GRP78 at 12 h, PERK at 3,6, 12 and 24 hand CHOP at 12 and 24 h (P < 0.05, P < 0.01), as well as in the protein levels of GRP78 at 12 and 24 h, pho-PERK at 3, 12 and 24 h and CHOP at 3, 6, 12 and 24 h in comparison with those at 0 h (P < 0. 05, P < 0. 01). No obvious regularity was observed in the change of the PERK protein expression. After 12 h of whole-body irradiation, the content of H202 was increased at 50, 75 and 100 mGy, but decreased slightly at 200 mGy, while that of MDA was increased with dose increasing, with significant increases in the content of H2 02 at 75 and 100 mCy and in that of MDA at 75, 100 and 200 mGy as compared with the 0 mGy group. Apart from the reduced levels of GRP78 mRNA at 50 and 200 mCy, significant increases were found in the mRNA expressions of PERK at 75, 100 and 200 mGy and CHOP at 50, 75, 100 and 200 (P c 0. 05, P < 0.01) as well as in the protein levels of GRP78 at 100 and 200 mGy, pho-PERK at 50, 100 and 200 mGy and CHOP at 50, 75, 100 and 200 mCy as compared with those at 0 mGy (P < 0. 05, P < 0. 01). There were differences in the changes of different protein expressions, but no obvious regularity was seen in the change of the PERK protein expression. Low-dose radiation can induce endoplasmic reticulum stress in mouse testicular cells, and activate the PERK-CHOP signaling pathway.

Wang Q.,Jilin University
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2011

To report a case of follicular dendritic cell sarcoma (FDCS) of tonsil,analyze its clinical and pathological features, as well as the diagnosis and differential diagnosis. Tonsillectomy of low temperature coblation were done with general anesthesia. Histopathology, immunohistochemistry, electron microscope were used to analyzed the features of FDCS. The clinical character and treatment were reported. There was no evidence of recurrence in two years. A correct diagnosis of FDCS was difficult to make , and immunohistochemical and ultrastructural studies are useful to FDCS's diagnosis. Low temperature coblation used in FDCS need more experience.

Zhang W.,Ikerbasque | Zheng W.,Jilin University
Advanced Functional Materials | Year: 2016

The emerging single-atom field spans single-atom catalysis in chemistry and single-atom manipulation in physics up to the state-of-the-art characterization via imaging and spectroscopy. These interdisciplinary progresses have been interacted closely with the development of materials science, underscoring the principle that the single atom excels as the smallest functional material. This simple concept not only permits to reinvent our understanding of the nature of materials, but also promises unambiguously to have a great impact on other physical sciences. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Gu C.H.,Jilin University
Zhonghua nan ke xue = National journal of andrology | Year: 2013

Recurrent spontaneous abortion (RSA) has various complicated causes, and more and more researches are focused on its etiology. Genetic factors are the most common risk factors of RSA; immune factors, infection factors, male factors and female factors play an important role; environmental pollution and some other unknown factors may also be conspirators. This article presents an overview on the possible risk factors of RSA.

Fang D.-L.,Jilin University | Faessler A.,University of Tubingen | Simkovic F.,Comenius University
Physical Review C - Nuclear Physics | Year: 2015

In this work, we calculate the matrix elements for the 0νββ decay of Nd150 using the deformed quasiparticle random-phase approximation (pn-QRPA) method. We adopted the approach introduced by Rodin and Faessler [Phys. Rev. C 84, 014322 (2011)PRVCAN0556-281310.1103/PhysRevC.84.014322] and Simkovic et al. [Phys. Rev. C 87, 045501 (2013)PRVCAN0556-281310.1103/PhysRevC.87.045501] to restore the isospin symmetry by enforcing MF2ν=0. We found that with this restoration, the Fermi matrix elements are reduced in the strongly deformed Nd150 by about 15 to 20%, while the more important Gamow-Teller matrix elements remain the same. The results of an enlarged model space are also presented. This enlargement increases the total (Fermi plus Gamow-Teller) matrix elements by less than 10%. © 2015 American Physical Society.

Stromal cell-derived factor-1 is a dominant chemokine in bone marrow that is known to be involved in inflammatory diseases, including rheumatoid arthritis. Its role in bone repair has recently been demonstrated. The purpose of this study was to investigate the role of extraneous stromal cell-derived factor-1 in fracture healing. Copyright 2011, SLACK Incorporated.

To investigate the expression of vitronectin (VN) in placental basal plate and its relationship with the pathogenesis of severe preeclampsia. From March 2010 to December 2011, 17 patients with early-onset severe preeclampsia who delivered in the Second Hospital of Jilin University were recruited as the early-onset severe preeclampsia group; and 16 women were recruited as the late-onset severe preeclampsia group. Meanwhile, 15 healthy pregnant women who delivered before 34 weeks were defined as the early control group (termination of pregnancy was carried out because of fetal heart malformations), and 15 healthy pregnant women delivered after 34 weeks were defined as the late control group. Immunohistochemistry and semi-quantitative reverse transcription (RT)-PCR were used to investigate the expression of VN protein and mRNA in the placental infarct center and its surrounding tissue of placental basal plate. The levels of serum prothrombin time (PT), part thromboplastin time (APTT) and fibrinogen (FIb) were detected and the international normalized ratio (INR) was calculated. The correlation of abnormal coagulation markers and VN expression levels in the early-onset severe preeclampsia group and the early control group was studied. (1) VN protein was detected in all placental basal plate of the four groups. It was highly expressed in the necrotic tissue of placental infarct center and weakly expressed in the tissue far from the infarcted area. (2) The mean levels of VN protein expression in placental basal plate of the early-onset severe preeclampsia group, the late-onset severe preeclampsia group, the late control group and the early control group were 0.152 ± 0.019, 0.113 ± 0.023, 0.095 ± 0.014 and 0.055 ± 0.010, respectively. And the differences between the groups were statistically significant (P < 0.01). The VN protein expression in placental infarct center, infarct edge, peri-infarct tissue and tissue far from the infarcted area gradually reduced, and the differences were statistically significant (P < 0.01). Compared with the same areas of each group, the differences were not statistically significant (P > 0.05). (3) VN mRNA were detectable in infarct center, infarct edge, per-infarct tissue and tissue far from the infarcted area of placental basal plate. In the early-onset severe preeclampsia group and the early control group, it was statistically higher in infarct center than in tissue far from the infarcted area (P < 0.05). (4) PT of the early-onset severe preeclampsia group was (9.45 ± 0.63) s, significantly shorter than that of the early control group [(9.88 ± 0.17) s, P < 0.05]. While there was no statistically significant difference in APTT, FIB and INR among the four groups (P > 0.05). (5) In the early-onset severe preeclampsia group, VN expression level and PT were significantly negative correlated (r = -0.612, P < 0.05); while in the early control group there was no correlation (r = 0.489, P > 0.05). VN was highly expressed in placental basal plate of the early-onset severe preeclampsia group, which caused the imbalance of coagulation and fibrinolysis system and the pathogenesis of severe preeclampsia.

Wu T.,Harvard University | Merbl Y.,Harvard University | Huo Y.,Jilin University | Gallop J.L.,Harvard University | And 2 more authors.
Proceedings of the National Academy of Sciences of the United States of America | Year: 2010

The Anaphase-Promoting Complex (APC) is an E3 ubiquitin ligase that regulates mitosis and G1 by sequentially targeting cell-cycle regulators for ubiquitination and proteasomal degradation. The mechanism of ubiquitin chain formation by APC and the resultant chain topology remains controversial. By using a single-lysine APC substrate to dissect the topology of ubiquitinated substrates, we find that APC-catalyzed ubiquitination has an intrinsic preference for the K11 linkage of ubiquitin that is essential for substrate degradation. K11 specificity is determined by an E2 enzyme, UBE2S/E2-EPF, that elongates ubiquitin chains after the substrates are pre-ubiquitinated by UbcH10 or UbcH5. UBE2S copurifies with APC; dominant-negative Ube2S slows down APC substrate degradation in functional cell-cycle extracts. We propose that Ube2S is a critical, unique component of the APC ubiquitination pathway.

Wang D.G.,Jilin University
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2012

To investigate the efficacy of laparoscope complete mesocolic excision (CME) for right colon cancer. The clinical data of 49 cases of right colon cancer without metastasis and intestinal obstruction who underwent elective laparoscope CME by the same group of surgeons between October 2009 and June 2011 at the First Hospital of Jilin University were analyzed retrospectively. Among the 49 cases with CME, the median number of total lymph node retrieved was 22. The positive rate of lymph node in patients with stage III disease was 16.3%. The median operative time of all the cases was 145 min. The mean intraoperative blood loss was 75 ml. The median time to flatus passage and defecation was 3 days and 6 days respectively. The median hospital stay was 12 days. The overall postoperative complication rate was 12.2% (6/49). Laparoscope complete mesocolic excision for right colon cancer is safe and feasible.

Lu S.Y.,Jilin University
Environmental science and pollution research international | Year: 2011

Okadaic acid (OA) and analogues of dinophysistoxin (DTX) are key diarrheic shellfish poisoning (DSP) toxins, which possibly arouse DSP symptoms by consuming the contaminated shellfish. Because of the stable toxicity in high temperature and the long-term carcinogenicity, the outbreaks of DSP related to consumption of bivalve mollusks contaminated by DSP toxins pose a hazard to public health. Therefore, it is worth developing a fast and reliable analytical method for the detection of OA and analogues in shellfish. In this paper, an indirect competitive enzyme-linked immunosorbent assay (ELISA) (icELISA) for detecting OA and DTX-1 in seafood was developed based on monoclonal antibody (McAb). The OA was conjugated to human immunoglobulin G (IgG) and bovine serum albumin (BSA) by the active ester method as the immune antigen and the detective antigen. The spleen cells from BALB/c mice immunized with OA-IgG were fused with SP2/0 myeloma cells. A hybridoma cell line, which secreted McAb against OA, was selected by "limiting dilution" cloning. An icELISA was developed based on immobilized conjugate (OA-BSA) competing the McAb with the free OA in seafood sample. A hybridoma cell line, which secreted IgG1 subclass monoclonal antibody (McAb) against OA, was selected. The IC(50) of the McAb for OA and dinophytoxin-1 (DTX-1) were 4.40 and 3.89 ng/mL, respectively. Based on the McAb, an indirect competitive ELISA for detection of OA and DTX-1 in seafood was developed. The regression equation was y = 54.713x - 25.879 with a coefficient correlation of R (2) = 0.9729. The linear range and the limit of detection were 0.4-12.5 and 0.45 ng/mL, respectively. The average recovery of OA and DTX-1 spiked shellfish was 82.29% with the coefficient of variation of 7.67%. The developed icELISA is a fast, sensitive, and convenient assay for detecting of total amount of OA and DTX-1 in seafood.

Zhu X.,Jilin University
Journal Wuhan University of Technology, Materials Science Edition | Year: 2012

Cuprous oxides with different morphologies were formed on F-doped tin oxide (FTO) covered glass substrates by potentiostatic deposition of cupric acetate. The effects of CTAB and Cl- on the crystal morphologies of cuprous oxide were studied. Different crystal morphologies of cuprous oxides were obtained by the change of the concentrations of CTAB and Cl. The flowerlike and cubic morphologies of Cu2O crystals were obtained when using higher concentration of CTAB and KCl, respectively. Photoelectrochemical properties of the Cu2O thin films prepared in the system were also studied. © 2012 Wuhan University of Technology and Springer-Verlag Berlin Heidelberg.

Hu Z.,Jilin University
Chemical Communications | Year: 2014

We derive an instantaneous symmetry-preserving mean field equation relating the long-ranged component of the intermolecular interaction to an effective single particle potential. We verify the efficiency and accuracy of the symmetry-preserving mean field approach to treat complex nonuniform electrostatics and foresee its application to study self-assembly and disassembly processes at interfaces in many computer simulations. This journal is © the Partner Organisations 2014.

Zhao J.B.,Jilin University
Applied Mechanics and Materials | Year: 2014

In this paper, the principle of solar assisted heat pump and ground source heat pump was introduced, the comprehensive utilization of solar assisted heat pump and ground source heat pump was discussed in severe cold region, the article illustrated the advantages and matters of the system to which need pay attention, and pointed out that the comprehensive utilization of the combination solar assisted heat pump and ground source heat pump had a substantial economic and environmental benefits in severe cold region. © (2014) Trans Tech Publications, Switzerland.

Sun C.Q.,Nanyang Technological University | Sun C.Q.,Xiangtan University | Sun C.Q.,Jilin University
Nanoscale | Year: 2010

Although they exist ubiquitously in human bodies and our surroundings, the impact of nonbonding lone electrons and lone electron pairs has long been underestimated. Recent progress demonstrates that: (i) in addition to the shorter and stronger bonds between under-coordinated atoms that initiate the size trends of the otherwise constant bulk properties when a substance turns into the nanoscale, the presence of lone electrons near to broken bonds generates fascinating phenomena that bulk materials do not demonstrate; (ii) the lone electron pairs and the lone pair-induced dipoles associated with C, N, O, and F tetrahedral coordination bonding form functional groups in biological, organic, and inorganic specimens. By taking examples of surface vacancy, atomic chain end and terrace edge states, catalytic enhancement, conducting-insulating transitions of metal clusters, defect magnetism, Coulomb repulsion at nanoscale contacts, Cu3C2H2 and Cu3O 2 surface dipole formation, lone pair neutralized interface stress, etc, this article will focus on the development and applications of theory regarding the energetics and dynamics of nonbonding electrons, aiming to raise the awareness of their revolutionary impact to the society. Discussion will also extend to the prospective impacts of nonbonding electrons on mysteries such as catalytic enhancement and catalysts design, the density anomalies of ice and negative thermal expansion, high critical temperature superconductivity induced by B, C, N, O, and F, the molecular structures and functionalities of CF 4 in anti-coagulation of synthetic blood, NO signaling, and enzyme telomeres, etc. Meanwhile, an emphasis is placed on the necessity and effectiveness of understanding the properties of substances from the perspective of bond and nonbond formation, dissociation, relaxation and vibration, and the associated energetics and dynamics of charge repopulation, polarization, densification, and localization. Finding and grasping the factors controlling the nonbonding states and making them of use in functional materials design and identifying their limitations will form, in the near future, a subject area of "nonbonding electronics and energetics", which could be even more challenging, fascinating, promising, and rewarding than dealing with core or valence electrons alone. © The Royal Society of Chemistry 2010.

Guo H.,CAS Changchun Institute of Applied Chemistry | Zhu Y.,Lichtenbergstrasse 4 | Qiu S.,Jilin University | Lercher A.J.,Lichtenbergstrasse 4 | Zhang H.,CAS Changchun Institute of Applied Chemistry
Advanced Materials | Year: 2010

Strategies for synthesizing of nanoscale single or bimetallic lanthanide metal-organic framework (MOF) materials and their transformation into Eu 1-xTbx-MOF thin films are reported. The thin films prepared via spin coating deposition method are smooth, dense and mechanically stable. They also exhibit marked luminescent properties and efficient Tb 3+-to-Eu3+ energy transferability. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chen J.-G.,Taizhou University | Yang Y.-J.,Jilin University | Zeng S.-L.,CAS Beijing Institute of Applied Physics And Computational Mathematics | Liang H.-Q.,Taizhou University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2011

We theoretically investigate high-order