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Jilin, China

Jia X.-J.,Jilin University | Huang J.-Z.,Jilin Chemical Group
Asian Pacific Journal of Cancer Prevention | Year: 2015

Objective: To investigate short- and long-term treatment effects and side reactions of lobaplatin plus 5-Fu combined and concurrent radiotherapy in treating patients with inoperable middle-advanced stage esophageal cancer. Methods: Sixty patients with middle-advanced stage esophageal squamous cell cancer were retrospectively analyzed. All patients were administered lobaplatin (50 mg intravenously) for 2 h on day 1, and 5-Fu (500 mg/m2) injected intravenously from day 1 to 5 for 1 cycle, in an interval of 21 days for totally 4 cycles. At the same time, late-course accelerated hyperfractionated three-dimensional conformal radiotherapy was performed. Patients were firstly treated with conventional fractionated irradiation (1.8 Gy/d, 5 times/week, a total of 23 treatments, and DT41.4 Gy), and then treated with accelerated hyperfractionated irradiation (1.5 Gy, 2 times/d, a total of 27 Gy in 9 days, an entire course of 6-7 weeks, and DT 68.4Gy). Results: All patients completed treatment, including 10 complete response (CR), 41 partial response (PR), 7 stable disease (SD), and 2 progressive disease (PD). The total effective rate was 85.0% (51/60). Thirty-nine patients had an increased KPS score. One-, 2-, and 3-year survival rates were 85.3%, 57.5%, and 41.7%, respectively. The median survival time was 27 months. The adverse reactions included myelosuppression, which was mainly degree I and II. The occurrence rate of radiation esophagitis was 17.5%. No significant hepatic or renal toxicity was observed. Conclusion: Lobaplatin plus 5-Fu combined with concurrent radiotherapy is safe and effective in treating patients with middle-advanced stage esophageal cancer. However, this result warrants further evaluation by randomized clinical studies. Source

Song H.-D.,Jilin Chemical Group
Petrochemical Equipment | Year: 2012

The failure caused by insufficient heat supply and its basic performance happened in additive workshop. The actual total process heat load, fuel gas heat enthalpy, fuel gas flow rate, and other factors were considered and analyzed for insufficient heat supply and its cause. It was pointed out that volumetric flow rate was the main effect. The counter measure was taken and the heat supply was greatly increased, thus meet normal heat supply. The gas system reconstruction and dehydration were improved and total system performance was increased to meet the requirement of heat conduction oil furnace. Source

Wang K.-Y.,Jilin University | Wang K.-Y.,Beihua University | Ma J.,Beihua University | Zhang F.-X.,Beihua University | And 3 more authors.
IUBMB Life | Year: 2014

MicroRNAs (miRNAs) are small noncoding RNAs that participate in a variety of biological processes, and dysregulation of miRNAs is widely associated with cancer development and progression. MiR-378 is frequently downregulated in colorectal cancer (CRC) and colorectal cell lines; however, it has high serum levels. Bioinformatics analysis further deduced that CDC40 is a potential target of miR-378, and luciferase reporter assays confirmed the direct regulation of CDC40 by miR-378. CDC40 plays a key role in cell cycle progression through G1/S and G2/M and pre-mRNA splicing. Subsequently, we determined that miR-378 inhibits cell growth and the G1/S transition in CRC cells and that these effects were CDC40-dependent. Finally, miR-378 increased cell apoptosis induced by the chemotherapeutic drug l-OHP. Our data highlight the potential application of miR-378 as a tumor suppressor for CRC therapy and overcoming chemoresistance, and it may also be a potential tumor marker for CRC prognosis. © 2014 IUBMB Life, 66(9):645-654, 2014 © 2014 International Union of Biochemistry and Molecular Biology. Source

Lin Y.L.,Xuzhou Tumour Hospital | Li Z.G.,Jilin Chemical Group | He Z.K.,Tianjin Medical University | Guan T.Y.,Xuzhou Tumour Hospital | Ma J.Q.,Hebei Medical University
Journal of International Medical Research | Year: 2012

OBJECTIVE: To investigate the clinical and prognostic significance of protocadherin-10 (PCDH10) promoter methylation in serumderived DNA from patients with bladder cancer. METHODS: PCDH10 promoter methylation status was determined using methylation-specific polymerase chain reaction of DNA extracted from serum of patients with bladder cancer, and age- and sex-matched controls. Clinical and pathological details of bladder cancer were recorded. RESULTS: PCDH10 promoter methylation was detected in 59/117 (50.4%) of patients with bladder cancer, and none of 37 (0%) controls. Methylation was significantly associated with advanced stage (T2 - T4), high grade (G3), tumour recurrence and larger tumour size (> 3 cm). In addition, methylation was associated with significantly worse survival and was an independent predictor of overall survival. CONCLUSION: Serum-based analysis of PCDH10 promoter methylation may represent a useful noninvasive biomarker of malignant behaviour and outcome in bladder cancer. © SAGE Publications Ltd 2012. Source

Cheng Y.M.,Beihua University | Niu J.,Jilin Chemical Group | Sun T.J.,Beihua University
Applied Mechanics and Materials | Year: 2014

A Mobile Ad hoc network (MANET) is a network consisting of a set of wireless mobile nodes, in which nodes can communicate with each other without centralized control or established infrastructure. To obtain a better understanding of AODV (Ad hoc On-Demand Distance Vector Routing Protocol) and OLSR (Optimized Link State Routing Protocol) routing protocols, different performances are simulated and analyzed using OPNET modeler 14.5 with the various performance metrics, such as PDR (Packet Delivery Ratio), end-to-end delay and routing overhead. Only effect of mobility is analyzed in the paper. As a conclusion, in mobility case, routing overhead is not greatly affected by mobility speed in AODV and OLSR, and the PDR of OLSR is decreased as the node speed increased, while AODV is not changed. As to delay, AODV is always higher than OLSR in both static and mobility cases. © (2014) Trans Tech Publications, Switzerland. Source

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