Jiang E.-P.,Beihua University |
Jiang E.-P.,Guangdong Medical College |
Wang S.-Q.,Beihua University |
Wang Z.,Jilin Central General Hospital |
And 3 more authors.
Zhongguo Zhongyao Zazhi | Year: 2014
Objective: To observe the effect of Schisandra chinensis lignans(SCL) on neuronal apoptosis and PI3K/AKT signaling pathway of rats in the cerebral ischemia injury model, and study its possible mechanism. Method: Rats were orally administered SCL high, middle and low dose groups (100, 50, 25 mg·kg-1) for 14 days. The cerebral ischemia injury model was established by using the suture-occluded method to rate the neurological functions. The cerebral infarction area was observed by TTC staining. The pathological changes in brain tissues were determined by HE staining. Bcl-2 and Bax expressions were detected by immunohistochemical assay. The protein expressions of p-AKT and AKT were assayed by Western blotting. Result: Compared with the model group, SCL high, middle and low dose groups showed reduction in the cerebral infarction area to varying degrees, improve the pathological changes in brain tissues, promote the expression of apoptin Bcl-2 and p-AKT, and inhibit the expression of apoptin Bax. Conclusion: SCL shows a protective effect on rats with cerebral ischemia injury. Its mechanism may be related to the increase in p-AKT ability and anti-ischemic brain injury capacity and the inhibition of nerve cells.
Qiao S.,Jilin Central General Hospital |
Ye Q.,Jilin Central General Hospital |
Dou Y.,Jilin Central General Hospital |
Li M.,Jilin Central General Hospital |
And 4 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2013
Background and Objectives: Essential hypertension is the most common chronic disease. To provide a basis for developing the prevention and control strategies of hypertension by epidemiological investigation on factors related to hypertension in health examination population. Methods: Data of health examination population from Jilin municipal enterprise and public institutions during January 2011 and July 2012 were randomly selected, and statistical analysis was performed for the age, gender, body mass index, blood lipids, blood uric acid, serum creatinine, blood glucose and hypertension classification indexes. Results: 1859 patients were diagnosed as hypertension. The detection rate of hypertension, awareness rate, new discovery rate, treatment rate, control rate and rate of the patients with family history of hypertension were 21.0%, 27.5%, 72.5%, 19.1%, 6.0% and 26.7%, respectively. A statistically significant difference was found in serum creatinine, blood glucose, serum cholesterol, L-DLC, coronary disease, stroke and diabetes mellitus by the comparison among the different blood pressure grades. There was a difference in blood pressure, blood uric acid, blood creatinine, glucose, total cholesterol, triglycerides, H-DLC, L-DLC and other indexes between female and male. No difference was found in the family history of hypertension, renal damage, blood uric acid, triglycerides and H-DLC among the different blood pressure levels. Conclusions: The hypertension in health examination population has the features of high new discovery rate, low awareness rate and low treatment rate. The factors of age, gender, body mass index, serum creatinine, blood glucose, blood cholesterol, L-DLC, coronary heart disease, stroke and diabetes are associated closely with hypertension.