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Tianzhu Z.,Changchun University of Chinese Medicine | Shihai Y.,Jilin Agricultural University | Juan D.,Peking University
Inflammation | Year: 2014

In previous study, the anti-inflammatory effect of morin had been found. In this study, we investigated anti-inflammatory effects of morin on acute lung injury using lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. The cell counting in the bronchoalveolar lavage fluid (BALF) was measured. The animal lung edema degree was evaluated by wet/dry weight (W/D) ratio. The superoxidase dismutase (SOD) activity and myeloperoxidase (MPO) activity were assayed by SOD and MPO kits, respectively. The levels of inflammatory mediators including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-18, and IL-6 were assayed by enzyme-linked immunosorbent assay method. Pathological changes of lung tissues were observed by hematoxylin and eosin (HE) staining. The protein level of lung NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome was measured by Western blotting. The data showed that treatment with the morin markedly attenuated inflammatory cell numbers in the BALF, decreased lung NLRP3 inflammasome protein level, and improved SOD activity and inhibited MPO activity. Histological studies demonstrated that morin substantially inhibited LPS-induced neutrophils in lung tissue compared with model group. The results indicated that the morin had a protective effect on LPS-induced ALI in mice. © 2014, Springer Science+Business Media New York. Source


Si Y.,Jilin Agricultural University | Yang G.,Northeast Normal University
Journal of Materials Chemistry C | Year: 2013

The electronic circular dichroism (CD), UV-Vis absorption and emission spectra, charge transport, and nonlinear optical properties of the novel azaboradibenzo[6]helicene have been investigated by density functional theory (DFT) for the first time. The calculated absorption and emission energies are in good agreement with the experimental ones. The simulated CD spectra nicely reproduce the experimental CD spectra in both excitation energy and rotational strength without any shift or scaling, which can be used to assign its absolute configuration (AC) with high confidence. The electronic transition properties have been assigned and analyzed. The observed CD bands mainly result from exciton-coupling of the ortho-fused aromatic rings. The adiabatic potential energy surface method was used to calculate reorganization energy of the studied compound. The hole reorganization energy is slightly smaller than that of the electron reorganization energy. The largest bond-length changes upon reduction and oxidation are mainly localized on the rings containing B-N bonds. It is found that the photophysical properties of azaboradibenzo[6]helicene can be effectively tuned upon substitution. In view of the second-order polarizability value and intrinsic non-centrosymmetric electronic structure, the studied compounds have the possibility to be excellent second-order nonlinear optical materials. © 2013 The Royal Society of Chemistry. Source


Liu Q.,Chinese Academy of Agricultural Sciences | Liu Q.,Academy of Military Medical Science | He B.,Academy of Military Medical Science | Huang S.-Y.,Chinese Academy of Agricultural Sciences | And 2 more authors.
The Lancet Infectious Diseases | Year: 2014

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging haemorrhagic fever that was first described in rural areas of China. The causative agent, SFTS virus (SFTSV), is a novel phlebovirus in the Bunyaviridae family. Since the first report in 2010, SFTS has been found in 11 provinces of China, with about 2500 reported cases, and an average case-fatality rate of 7·3%. The disease was also reported in Japan and Korea in 2012; Heartland virus, another phlebovirus genetically closely related to SFTSV, was isolated from two patients in the USA. The disease has become a substantial risk to public health, not only in China, but also in other parts of the world. The virus could undergo rapid evolution by gene mutation, reassortment, and homologous recombination in tick vectors and vertebrate reservoir hosts. No specific treatment of SFTS is available, and avoiding tick bites is an important measure to prevent the infection and transmission of SFTSV. This Review provides information on the molecular characteristics and ecology of this emerging tick-borne virus and describes the epidemiology, clinical signs, pathogenesis, diagnosis, treatment, and prevention of human infection with SFTSV. © 2014 Elsevier Ltd. Source


Si Y.,Jilin Agricultural University | Yang G.,Northeast Normal University
RSC Advances | Year: 2013

The chiroptical, linear, and second-order nonlinear optical (NLO) properties of chiral mononuclear and dinuclear zinc complexes have been investigated for the first time at density functional theory level. The calculated electron absorption energies and oscillator strengths are in reasonable agreement with the experimental ones. The good agreement between the experimental and the simulated CD spectra shows that TDDFT calculations can be used to assign the absolute configurations (ACs) of chiral zinc complexes with high confidence. Based on these calculated results, the electron transition property and chiroptical origin have been analyzed and assigned. The results show that the coordinated Zn atoms have certain effects on the chiroptical property. The larger nonlinear optical response mainly results from interligand and intraligand charge transfer. The studied complexes have a possibility to be excellent second-order nonlinear optical material from the standpoint of first hyperpolarizability value, transparency and intrinsic non-centrosymmetric electronic structure. © 2013 The Royal Society of Chemistry. Source


Zhou Y.L.,Jilin Agricultural University
Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban | Year: 2011

By the method of water culture, the root exudates of Cangshan garlic and Caijiapo garlic were collected to study their allelopathic effects on the seed germination and seedling growth of lettuce, and on the development of pathogens Fusarium oxysporum f. sp. cucumerinum and F. oxysporium f. sp. niveum. The root exudates of the two garlic cultivars promoted the lettuce seed germination and seedling growth at low concentrations (0.1 and 0.2 g x mL(-1)), but showed inhibitory effects at high concentrations (0.4 and 0.6 g x mL(-1)), with the inhibitory effects being stronger for the root exudates of Caijiapo garlic. The two garlic cultivars' root exudates also had inhibitory effects on the mycelia growth and spore germination of the pathogens, and the effects increased with increasing concentration of the exudates, being stronger for Caijiapo garlic than for Cangshan garlic. F. oxysporum f. sp. cucumerinum was more sensitive to the inhibitory effects of the root exudates of the two garlic cultivars, as compared to F. oxysporium f. sp. niveum. Source

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