Tokyo, Japan

The Jikei University School of Medicine is a private university in Minato, Tokyo, Japan. Jikei means mercy and love in Japanese. Wikipedia.


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Araya J.,Jikei University School of Medicine | Nishimura S.L.,University of California at San Francisco
Annual Review of Pathology: Mechanisms of Disease | Year: 2010

Fibrogenic lung reactions occur as a common phenotype shared among disorders of heterogeneous etiologies. Even with a common etiology, the extent and pattern of fibrosis vary greatly among individuals, even within families, suggesting complex gene-environment interactions. The search for mechanisms shared among all fibrotic lung diseases would represent a major advance in the identification of therapeutic targets that could have a broad impact on lung health. Although it is difficult to grasp all of the complexities of the varied cell types and cytokine networks involved in lung fibrogenic responses, and to predict the biologic responses to the overexpression or deficiency of individual cytokines, a large body of evidence converges on a single common theme: the central importance of the transforming growth factor beta (TGF-?) pathway. Therapies that act upstream or downstream of TGF-? activation have the therapeutic potential to treat all fibrogenic responses in the lung. Copyright © 2010 by Annual Reviews.


Patent
Jikei University School of Medicine and Dowa Holding Co. | Date: 2013-09-10

There is provided a method of producing a radioactive cesium decontaminator, including: suspending magnetic particles in a solvent, and coating each magnetic particle with organic monomer or polymer, to thereby form a precursor; adding a ferrocyanide aqueous solution and an aqueous solution containing at least one kind of transition metal into a suspension liquid containing the precursor after coating while applying a strong shear force, to thereby generate a radioactive cesium decontaminator; and removing water content from a slurry containing the obtained radioactive cesium decontaminator.


Patent
Tokyo Women's Medical University, Jikei University School of Medicine and CellSeed | Date: 2013-07-24

The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cells in the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80C, wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.


Patent
Tokyo Women's Medical University, Jikei University School of Medicine and CellSeed | Date: 2016-04-14

The purpose of the present invention is to obtain an alternative to a substitute of the mucosa in the middle ear which is engrafted on the surface of the bone in the middle ear, hyperplasia of the granulation tissue and the bone and the development of the fibroblast cells in the middle ear are suppressed, and to obtain a middle ear mucosa-like cell sheet retaining cilia in the surface layer, comprising culturing nasal epithelium cells on a cell culture substrate coated with a polymer whose hydration force changes within a temperature range of 0 to 80 C., wherein the cells are cultured within a temperature range where the hydration force of the polymer is weak, and then changing the temperature to a temperature at which the hydration force is strong to recover the cultured cell sheet.


Patent
Otsuka Pharmaceutical Factory Inc., Jichi Medical University, Jikei University School of Medicine and Tokyo Women's Medical University | Date: 2014-12-09

The present invention provides an artificial kidney precursor containing a non-human mammalian metanephros separated out from a living body, wherein the metanephros has been subjected to freezing and thawing treatments outside a living body, and contains mammalian mesenchymal stem cells transferred outside a living body, and a method of production thereof.


Yokoyama M.,Jikei University School of Medicine
Journal of Drug Targeting | Year: 2014

In this review, polymeric micelles as drug-targeting carriers are concisely explained. In the first introduction part, I describe a brief history of polymer micelle's research for drug targeting, and then I explain this review's focus. Since most other review articles concerning polymeric micelle carriers explain only what was achieved in the polymeric micelle's research, I describe this review by focusing on what was not done. In the second part, I take up three characteristics of polymeric micelle carriers by comparing their advantages and disadvantages, what was done and what was not done in the past studies, and what is easily achieved and what is difficult to be achieved with polymeric micelles. In the last part, I discuss three common problems of nano-sized drug carrier systems including polymeric micelles, and then I add a few comments on these problems. © 2014 Informa UK Ltd.


Patent
Jikei University School of Medicine and Dowa Holdings Co. | Date: 2014-05-19

There is provided an aggregate of radioactive material removing particles in which two or more radioactive material removing particles having magnetic particles and a radioactive material adsorption component are assembled, wherein a pore volume in the aggregate is 0.5 mL/g or more and 5.0 mL/g or less, and the pore volume means a cumulative value obtained by a mercury press-in method.


Patent
Jikei University School of Medicine and Dowa Holdings Co. | Date: 2015-07-15

There is provided a method of producing a radioactive cesium decontaminator, including: suspending magnetic particles in a solvent, and coating each magnetic particle with organic monomer or polymer, to thereby form a precursor; adding a ferrocyanide aqueous solution and an aqueous solution containing at least one kind of transition metal into a suspension liquid containing the precursor after coating while applying a strong shear force, to thereby generate a radioactive cesium decontaminator; and removing water content from a slurry containing the obtained radioactive cesium decontaminator.


Provided is a radioactive substance collecting system and a radioactive substance collecting method which are capable of collecting radioactive substances with high efficiency. The radioactive substance collecting system according to the present invention removes radioactive substances (radioactive cesium 21) contained in a liquid (radioactive substancescontaminated water 20) and includes, as means for removing radioactive substances from the liquid, a radioactive substance trapping composite 1 including at least a magnetic particle 10 and a radioactive substance trapping compound 11 that traps radioactive substances, and magnetic accumulation means 30 for accumulating the radioactive substance trapping composite 1.


Patent
Japanese Foundation For Cancer Research and Jikei University School of Medicine | Date: 2014-06-30

A novel vaccine that can induce sufficiently high cell-mediated immunity is disclosed. The vaccine of the present invention contains, as an effective component, a polypeptide comprising a tandem repeat structure in which an MHC class I epitope region derived from an antigen protein and a spacer sequence are linked to each other alternately and repeatedly at least three times, or a recombinant vector which comprises a polynucleotide encoding said polypeptide and is capable of expressing said polypeptide in vivo. The spacer sequence is, for example, a sequence generated as an amino acid sequence inevitably encoded by a single base sequence which is designed such that the MHC class I epitope region derived from the antigen protein, an MHC class II epitope region derived from the antigen protein, and at least one higher-order-structure-stabilizing region are encoded by different reading frames in said single base sequence.

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