Jiaxing University

Zhejiang, China

Jiaxing University

Zhejiang, China
SEARCH FILTERS
Time filter
Source Type

News Article | December 1, 2016
Site: www.eurekalert.org

Previous studies identified the Hippo pathway kinases LATS1/2 as a tumor suppressor, but new research led by University of California San Diego School of Medicine scientists reveals a surprising role for these enzymes in subduing cancer immunity. The findings, published in Cell on December 1, could have a clinical role in improving efficiency of immunotherapy drugs. "Before our study, no one knew that the Hippo pathway was regulating immunogenicity," said first author Toshiro Moroishi, MD, PhD, postdoctoral researcher at UC San Diego Moores Cancer Center. "LATS1/2 deletion in cancer cells improves tumor immunogenicity, leading to the destruction of cancerous cells by enhancing anti-tumor immune responses." Hippo pathway signaling regulates organ size by moderating cell growth, apoptosis and stem cell renewal, but dysregulation contributes to cancer development. In vitro studies of Hippo pathway kinases LATS1/2 showed that the loss of these enzymes promoted cell proliferation and tumor survival. In vivo research using immune-compromised mouse models also supports a tumor suppressor function of the Hippo pathway. However, when Moroishi and team deleted LATS1/2 from mouse cancer cells and examined tumor growth in models with healthy immune systems researchers found that immunogenicity -- the ability to stimulate an immune response -- improved, destroying cancer cells. Researchers caution that immune systems of mouse models are different from the human immune system so the response might be different and further studies are needed. If the outcome proves to be the same, using a LATS1/2 inhibitor alone or in combination with an immune checkpoint inhibitor may stimulate the immune system of patients that previously did not respond to immunotherapy treatments. Currently, most immunotherapy research focuses on targeting the immune system, but the new findings reveal that tumor cells may also be vulnerable to inhibitors. "Inhibiting LATS1/2 could be an attractive approach to treat cancer," said Kun-Liang Guan, PhD, Distinguished Professor of Pharmacology at Moores Cancer Center and senior author of the study. "LATS is an ideal target because there are many kinase inhibitors that have been successfully developed as cancer drugs." This study focused on breast cancer, melanoma and squamous cell carcinoma but the same could be applied to other cancers, said Moroishi. Study co-authors include: Tomoko Hayashi, Yu Fujita, Dennis A. Carson, UC San Diego; Wei-Wei Pan, UC San Diego and Jiaxing University; Matthew V. Holt, and Jun Qin, Baylor College of Medicine. Disclosure: Kun-Liang Guan is co-founder of Vivace Therapeutics and holds equity interest.


Liu B.,Jiaxing University
Nonlinear Analysis: Real World Applications | Year: 2013

In this paper, we first investigate the existence of a unique equilibrium to general bidirectional associative memory neural networks with time-varying delays in the leakage terms by the fixed point theorem. Then, by constructing a Lyapunov functional, we establish some sufficient conditions on the global exponential stability of the equilibrium for such neural networks, which substantially extend and improve the main results of Gopalsamy [K. Gopalsamy, Leakage delays in BAM, J. Math. Anal. Appl. 325 (2007) 1117-1132]. © 2012 Published by Elsevier Ltd.


Li H.,Jiaxing University
Journal of Physics A: Mathematical and Theoretical | Year: 2011

The paper investigates the cluster synchronization stability problem for a class of complex dynamical networks with stochastic nonlinearities and probabilistic interval time-varying delays. The stochastic nonlinearities are considered here to reflect more realistic dynamical behaviors of complex networks; the delay in this paper is assumed to be random and its probability distribution is known a priori. Based on the stochastic analysis techniques and the properties of the Kronecker product, delay-dependent cluster synchronization stability criteria are derived in the form of linear matrix inequalities which can be readily solved by using the LMI toolbox in MATLAB; the solvability of derived conditions depends on not only the size of the delay but also the probability of the delay taking values in some intervals. Finally, a numerical example is given to illustrate the feasibility and effectiveness of the proposed method. © 2011 IOP Publishing Ltd.


Liu B.,Jiaxing University
Nonlinear Analysis: Real World Applications | Year: 2014

This paper is concerned with a non-autonomous delayed model of hematopoiesis which is defined on the non-negative function space. Based on the definition of an almost periodic function, we employ a novel argument to establish a delay-independent criteria ensuring the existence, uniqueness, and global exponential stability of positive almost periodic solutions of the model with almost periodic coefficients and delays. Moreover, an example and its numerical simulation are given to illustrate the theoretical results. © 2013 Elsevier Ltd. All rights reserved.


Zhang Y.,Jiaxing University
Journal of Magnetism and Magnetic Materials | Year: 2013

Based on first-principle calculations, we have studied the electronic and magnetic properties of AlP with aluminium vacancy and calcium doping. It was found that while Al vacancy and Ca impurity themselves are nonmagnetic, they generate holes residing in P 2p orbitals that lead to magnetic moments in AIR The coupling between two Al vacancies in AlP are always antiferromagnetic because of half-filled t2 level. However, the coupling becomes ferromagnetic with large magnetic energy when vacancies are replaced by nonmagnetic Ca atoms. Moreover, the presence of Ca dopants reduces the formation energy of Al vacancy. These results suggest that Ca-doped AlP is a promising room temperature ferromagnetic semiconductor free of magnetic precipitates, and it may find applications in the field of spintronics. © 2013 Elsevier BY. All rights reserved.


Yang M.,Jiaxing University
Nonlinear Analysis: Real World Applications | Year: 2011

This paper is concerned with the generalized Nicholson's blowflies model with multiple time-varying delays which is defined on the nonnegative function space. By using some differential inequalities, some new results are established to ensure that all solutions of the model converge exponentially to zero equilibrium point. Moreover, an example is given to illustrate our main results. © 2011 Elsevier Ltd. All rights reserved.


Li H.,Jiaxing University
International Journal of Innovative Computing, Information and Control | Year: 2011

The paper investigates the synchronization stability for discrete-time stochastic complex dynamical networks with probabilistic interval time-varying delays in the network coupling and in the dynamical nodes. Different from the common assumptions on the delay in the existing references, the delay in this letter is assumed to be random and its probability distribution is prior known. In terms of the probability distribution of the delays, the new type of system model with probability-distribution-dependent parameter matrices is proposed for the delay in the network coupling and in the dynamical nodes, the sufficient conditions for delay-dependent stochastic asymptotical synchronization stability are derived in the form of linear matrix inequalities, the solvability of derived conditions depends on not only the size of the delay, but also the probability of the delay taking values in some intervals. At last, a numerical example is given to illustrate the feasibility and effectiveness of the proposed method. ICIC International © 2011.


Liu B.,Jiaxing University
Nonlinear Analysis: Real World Applications | Year: 2011

This paper is concerned with a class of Nicholson blowfly systems with multiple time-varying delays. By applying the method of the Lyapunov functional, some criteria are established for the existence and uniqueness of positive periodic solutions of the system. Moreover, an example is given to illustrate the main results. © 2011 Elsevier Ltd. All rights reserved.


The paper investigates state estimation for complex dynamical networks with time-varying delay and stochastic sampling. Only two different sampling periods are considered which occurrence probabilities are given constants and satisfy Bernoulli distribution. By applying an input-delay approach, the probabilistic sampling state estimator is transformed into a continuous time-delay system with stochastic parameters in the system matrices, where the purpose is to design a state estimator to estimate the network states through available output measurements. Delay-dependent asymptotically stability condition is established for the system of the estimation error, which can be readily solved by using the LMI toolbox in MATLAB, the solvability of derived conditions depends on not only the size of the delay and the sampling period, but also the probability of taking values of the sampling period. Finally, a numerical example is provided to demonstrate the effectiveness of the obtained theoretical results. © 2014 Elsevier B.V.


A device and method for realizing blending and color mixing based on a triple-roving coupling drafting and twisting system, the device comprising a drafting and twisting system consisting of a set of rear rollers and a set of front rollers; the set of rear rollers comprises a combination rear leather roller (4) and a combination rear roller (5); the set of front rollers comprises a front leather roller (6) and a front roller (7); and the set of rear rollers is a combination rear roller having three degrees of rotational freedom and formed by sequentially positioning three sections of rings (8, 9, 10) with the same outer diameter on the same spindle. Each part of a drafting mechanism having three degrees of freedom is independently controlled for on-demand configuration of the blending ratio of the roving of different components or different colors and the configuration of the distributed length of the roving on yarns.

Loading Jiaxing University collaborators
Loading Jiaxing University collaborators