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Nanchang, China

Jiangxi University of Traditional Chinese Medicine , designated as a Medical University in Nanchang, Jiangxi, is an institution of higher learning under the leadership of Jiangxi Provincial Government. Wikipedia.


Zhang K.,Jiangxi University of Traditional Chinese Medicine | Shen X.,Henan University
Analyst | Year: 2013

Cancer antigen 125 (CA 125) is a useful tumor marker with a threshold value of 35 U mL-1 expressed by more than 80% of patients with non-mucinous epithelial ovarian cancer. In this work, a novel strategy for the analysis of CA 125 using the plasmon resonance scattering (PRS) properties of gold nanorods was proposed. The gold nanorod (GNR)-anti-CA 125 conjugates were prepared first. The immunoreaction between the GNR modified CA 125 antibody and CA 125 took place in aqueous solution after the addition of CA 125. The target protein concentration was determined by analyzing the level of GNR aggregation caused by CA 125 antibody-antigen interactions using PRS. At a concentration of 1.0-80 U mL-1, CA 125 could be determined with a detection limit of 0.4 U mL-1. The PRS immunosensor showed high sensitivity, selectivity, and reproducibility. Determination of CA 125 in serum samples showed good recovery. This journal is © The Royal Society of Chemistry. Source


Zuo Y.M.,Jiangxi University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2010

To investigate the effects of Valeriana amurensis on the expressions of P-APP,A4,1 and Caspase-3 of cortical neurons and hippocampus neurons in in Alzheimer's disease model rats' brain. Established the model with multiple factors, observed the expressions of beta-APP, Abeta(1-40) and Caspase-3 of cortical neurons and Hippocampus neurons in in Alzheimer's disease model rats' brain by electron lens using immunohistochemistry method. The extracts of the roots and rhizomes of Valeriana amurensis decreased the expressions of beta-APP, Abeta(1-40) and Caspase-3 of cortical neurons and hippocampus neurons in in a dose-dependent manner. The effects of high dose of 50% ethanol extract of macroporous resin group were more significant than the other groups'. The 50% ethanol extracts of macroporous resin group from the roots and rhizomes of Valeriana amurensis can decrease the expressions of beta-APP, Abeta(1-40), and Caspase-3, to inhibit the formation of senile plaques and neurofibrillary tangles in Alzheimer's disease model rats' brain, and decrease cell fate of cortical neurons and hippocampus neurons in in Alzheimer's disease model rats' brain. Source


Miao L.,University of North Carolina at Chapel Hill | Guo S.,University of North Carolina at Chapel Hill | Zhang J.,Jiangxi University of Traditional Chinese Medicine | Kimb W.Y.,University of North Carolina at Chapel Hill | Huang L.,University of North Carolina at Chapel Hill
Advanced Functional Materials | Year: 2014

Combination chemotherapy is a common practice in clinical management of malignancy. Synergistic therapeutic outcome is only achieved when tumor cells are exposed to cells in an optimal ratio. However, due to diverse physicochemical properties of drugs, no free drug cocktails or nanomaterials are capable of co-loading and co-delivering drugs at an optimal ratio. Herein, we develop a novel nano-platform with precise ratiometric co-loading and co-delivery of two hydrophilic drugs for synergistic anti-tumor effects. Based on previous work, we utilize a solvent displacement method to ratiometrically load dioleoyl phosphatidic acid (DOPA)-gemcitabine monophosphate (GMP) and DOPA coated cisplatin-precipitate nanocores into the same PLGA NP. These cores are designed to have similar hydrophobic surface properties. GMP and cisplatin are engineered into PLGA NP at an optimal synergistic ratio (5:1, mol:mol) with over 70% encapsulation efficiency and were ratiometrically taken up by tumor cells in vitro and in vivo. These PLGA NP exhibit synergistic anti-cancer effects in a stroma-rich bladder tumor model. A single injection of dual drugs in PLGA NP can significantly inhibit tumor growth. This nanomaterial-system solves problems related to ratiometric co-loading and co-delivery of different hydrophilic moieties and provides possibilities for co-loading hydrophilic drugs with hydrophobic drugs for combination therapy. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Zhang Z.L.,Jiangxi University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2010

To investigate effects of Valeriana amurensis Smir. ex Kom. on the inflammation reaction of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rat's brain. The model of Alzheimer's disease was established with multiple factors and the expressions of iNOS, COX-2, IkappaB-alpha of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rats' brain were observed by electron lens using immunohistochemistry method. The extracts of Valeriana amurensis could reduce the expressions of iNOS, COX-2 and IkappaB-alpha of cortical neurons and hippocampus neuronsin in a dose-dependent manner. The effects of 50% ethanol extracts of macroporous resin group were more significant than other groups. The 50% ethanol extract of macroporous resin group from Valeriana amurensis can improve the ability of spatial exploratory and effectively control the inflammation reaction, the mechanism maybe relevant to it's effect of decreasing the expressions of iNOS, COX-2 and IkappaB-alpha of cortical neurons and hippocampus neuronsin to inhibit the activity of glia cell and inflammatory injury of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rat's brain. Source


Chen G.,Jiangxi University of Traditional Chinese Medicine
Applied Mechanics and Materials | Year: 2013

The emergence of Web 2.0 concept means that new media development of Internet has entered a new stage. With the continue update of network technology, there are more and more people contact network. With the improvement of economic condition, there are more and more people contact network. The dependence on network is growing. The network hides huge market. Through network research and mathematical statistics, this paper finds that the expected invest of online advertising of U.S. in 2013 is up to 82%. So for the web digital marketing theory there is great significance. This paper establishes the marketing profit maximization model based on profit and Internet marketing investment theory of the web. It also introduces a simple case of marketing advertising through the form of web programming. It also concludes the influence of web network on different consumer groups in the market by case analysis. © (2013) Trans Tech Publications, Switzerland. Source

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