Nanchang, China

Jiangxi University of Traditional Chinese Medicine , designated as a Medical University in Nanchang, Jiangxi, is an institution of higher learning under the leadership of Jiangxi Provincial Government. Wikipedia.


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Zhu M.F.,Jiangxi University of Traditional Chinese Medicine | Du J.Q.,Jiangxi University of Traditional Chinese Medicine
Applied Mechanics and Materials | Year: 2014

Tongue image extraction is a fundamental step in objective diagnoses and quantitive checking of tongues. The accuracy of tongue image extraction can directly influence the results of the succedent checking in objective diagnoses of tongues. In this paper, we improved random walk image segmentation algorithm and applied it to tongue image extraction. Firstly, we utilized toboggan algorithm which adopted new classification rules to segment initial regions. Secondly, a weighted-graph was built according to initial regions in which only those adjacent regions were connected. Thirdly, random walk algorithm was applied to make the final segmentation in which a new weight function was designed for calculating the weights between the nodes of adjacent regions. Fourthly, mathematical morphology operations, i. e. inflations and erosions, were carried out on the segmentation result of the third step in order to fill small holes on the tongue region. In the experiment, we compared our method with traditional random walk algorithm. As the experiment results show, our method achieved much better segmentation effects. © (2014) Trans Tech Publications, Switzerland.


Zhang Z.L.,Jiangxi University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2010

To investigate effects of Valeriana amurensis Smir. ex Kom. on the inflammation reaction of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rat's brain. The model of Alzheimer's disease was established with multiple factors and the expressions of iNOS, COX-2, IkappaB-alpha of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rats' brain were observed by electron lens using immunohistochemistry method. The extracts of Valeriana amurensis could reduce the expressions of iNOS, COX-2 and IkappaB-alpha of cortical neurons and hippocampus neuronsin in a dose-dependent manner. The effects of 50% ethanol extracts of macroporous resin group were more significant than other groups. The 50% ethanol extract of macroporous resin group from Valeriana amurensis can improve the ability of spatial exploratory and effectively control the inflammation reaction, the mechanism maybe relevant to it's effect of decreasing the expressions of iNOS, COX-2 and IkappaB-alpha of cortical neurons and hippocampus neuronsin to inhibit the activity of glia cell and inflammatory injury of cortical neurons and hippocampus neuronsin in Alzheimer's disease model rat's brain.


Zuo Y.M.,Jiangxi University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2010

To investigate the effects of Valeriana amurensis on the expressions of P-APP,A4,1 and Caspase-3 of cortical neurons and hippocampus neurons in in Alzheimer's disease model rats' brain. Established the model with multiple factors, observed the expressions of beta-APP, Abeta(1-40) and Caspase-3 of cortical neurons and Hippocampus neurons in in Alzheimer's disease model rats' brain by electron lens using immunohistochemistry method. The extracts of the roots and rhizomes of Valeriana amurensis decreased the expressions of beta-APP, Abeta(1-40) and Caspase-3 of cortical neurons and hippocampus neurons in in a dose-dependent manner. The effects of high dose of 50% ethanol extract of macroporous resin group were more significant than the other groups'. The 50% ethanol extracts of macroporous resin group from the roots and rhizomes of Valeriana amurensis can decrease the expressions of beta-APP, Abeta(1-40), and Caspase-3, to inhibit the formation of senile plaques and neurofibrillary tangles in Alzheimer's disease model rats' brain, and decrease cell fate of cortical neurons and hippocampus neurons in in Alzheimer's disease model rats' brain.


Zhang J.,Jiangxi University of Traditional Chinese Medicine | Li X.,Jiangxi University of Traditional Chinese Medicine | Huang L.,University of North Carolina at Chapel Hill
Journal of Controlled Release | Year: 2014

Breast cancer is the most frequently diagnosed malignancy in American women. While significant progress has been made in the development of modern diagnostic tools and surgical treatments, only marginal improvements have been achieved with relapsed metastatic breast cancer. Small interfering RNAs (siRNAs) mediate gene silencing of a target protein by disrupting messenger RNAs in an efficient and sequence-specific manner. One application of this technology is the knockdown of genes responsible for tumorigenesis, including those driving oncogenesis, survival, proliferation and death of cells, angiogenesis, invasion and metastasis, and resistance to treatment. Non-viral nanocarriers have attracted attention based on their potential for targeted delivery of siRNA and efficient gene silencing without toxicity. Here, we review promising, non-viral delivery strategies employing liposomes, nanoparticles and inorganic materials in breast cancer. © 2014 Elsevier B.V.


Zhang K.,Jiangxi University of Traditional Chinese Medicine | Shen X.,Henan University
Analyst | Year: 2013

Cancer antigen 125 (CA 125) is a useful tumor marker with a threshold value of 35 U mL-1 expressed by more than 80% of patients with non-mucinous epithelial ovarian cancer. In this work, a novel strategy for the analysis of CA 125 using the plasmon resonance scattering (PRS) properties of gold nanorods was proposed. The gold nanorod (GNR)-anti-CA 125 conjugates were prepared first. The immunoreaction between the GNR modified CA 125 antibody and CA 125 took place in aqueous solution after the addition of CA 125. The target protein concentration was determined by analyzing the level of GNR aggregation caused by CA 125 antibody-antigen interactions using PRS. At a concentration of 1.0-80 U mL-1, CA 125 could be determined with a detection limit of 0.4 U mL-1. The PRS immunosensor showed high sensitivity, selectivity, and reproducibility. Determination of CA 125 in serum samples showed good recovery. This journal is © The Royal Society of Chemistry.


Chen G.,Jiangxi University of Traditional Chinese Medicine
Applied Mechanics and Materials | Year: 2013

The emergence of Web 2.0 concept means that new media development of Internet has entered a new stage. With the continue update of network technology, there are more and more people contact network. With the improvement of economic condition, there are more and more people contact network. The dependence on network is growing. The network hides huge market. Through network research and mathematical statistics, this paper finds that the expected invest of online advertising of U.S. in 2013 is up to 82%. So for the web digital marketing theory there is great significance. This paper establishes the marketing profit maximization model based on profit and Internet marketing investment theory of the web. It also introduces a simple case of marketing advertising through the form of web programming. It also concludes the influence of web network on different consumer groups in the market by case analysis. © (2013) Trans Tech Publications, Switzerland.


Zuo Y.M.,Jiangxi University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2013

To investigate the chemical components of Gardenia jasminoides. Various column chromatography were used in the isolation and purification. Physiochemical constant determination and spectral analysis were adopted to determine the chemical structures. Ten compounds were isolated and elucidated as syringic acid (1), syringaldehyde (2), vanillic acid (3), 3-hydroxy-vanillic acid (4), 3, 4, 5-trimethoxy-phenol (5), 4-hydroxy-3,5-dimethoxy-phenol (6), 4-methoxy-benzaldehyde (7), 7-hydroxy-5-methoxy-chromone (8), crocin-1 (9), crocin-2 (10). Compounds 2, 4 - 8 are first isolated from this plant.


STUDY DESIGN.: A retrospective study. OBJECTIVE.: The purpose of this study was to identify the rates and reasons, also the risk factors for unplanned reoperation of lumbar spinal surgery during the primary admission in terms of a multicenter and a large patient population study. SUMMARY OF BACKGROUND DATA.: Unplanned reoperation is suggested to be a useful quality indicator for spinal surgery. However, the rates of unplanned reoperation in patients underwent lumbar spinal surgery during the primary admission are not well established. METHODS.: This study was performed to review all the patients who underwent lumbar spinal surgery at three institutions from January 2010 to April 2015. Patients with unplanned reoperations after primary surgery during the same admission were included in this study. The demographics, diagnosis, surgical procedure and complications of patients were reviewed and statistical analysis was performed to investigate the incidences and risk factors of unplanned revision. RESULTS.: A total of 3936 patients who underwent lumbar spinal surgery from three institutions were reviewed, and 82 (2.08%) required unplanned reoperation during the primary admission because of wound infection (0.94%), screw misplacement (0.53%), cerebrospinal fluid leakage (0.27%), wound hematoma (0.18%) and neurologic deficit (0.15%). For the diagnosis, patients with lumbar spinal spondylolisthesis had a much higher rate of reoperation (4.3%) than those of lumbar stenosis (2.3%), vertebral tumor (2.2%), vertebral fracture (1.2%) and disc herniation (1.1%) with a significant difference (P?


Liu D.Y.,Jiangxi University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2012

To study the regulation effect of Scorpio and Scolopendra on CD4 + CD25 + FoxP3 + Treg Cell in peripheral blood from rats with collagen-induced arthritis. Sixty female Wistar rats were randomly divided into 6 groups, normal control group, model control group, low-dose, middle-dose and high-dose Scorpio and Scolopendra group,and the type II collagen group. Rats' arthritis was induced by collagen. The number of CD4 + CD25 + FoxP3 + Treg cell in peripheral blood was tested by flow cytometry, and the level of IL-2 in serum was detected by enzyme linked immunosorbent assay. Compared with the model groups,the levels of CD4 + CD25 + Treg cell and CD4 + CD25 + FoxP3 + Treg cell were increased obviously in the high and low dose of Scorpio and Scolopendra groups (P < 0.05 or P < 0.01), while the level of IL-2 in serum was decreased remarkably in the middle and low dose of Scorpio and Scolopendra groups (P < 0.05 or P < 0.01). It is realized that Scorpio and Scolopendra effectively treat RA by regulating the level of CD4 + CD25 + FoxP3 + Treg cell to restore immunological tolerance.


Liu J.Q.,Jiangxi University of Traditional Chinese Medicine
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2013

To study the diterpenoids of Tripterygium wilfordii by electrospray ionization tandem (ESI) and electron impact (EI) mass spectrometry and establish the methods for quickly and on line identification of these diterpenoids. The diterpenoids were analyzed by ESI-MS and EI-MS under positive ion model. In ESI-Trap-MS (+) model, the quasi-molecular ions [M + H] + of the diterpenoids took place bond cleavage and generally lost neutral molecules such as H2O, CH2CHCH3, CO and CH2CO, then generated characteristic fragment ion series (m/z 197, 183, 169). In ESI-TOF-MS (+) model, the quasi-molecular ions [M + H] + of the diterpenoids took place bond cleavage and generally lost neutral molecules such as H2O, CO, then generated characteristic fragment ion series (m/z 277, 185, 93). In EI-MS model, the molecular ions of the diterpenoids took place bond cleavage and generally lost neutral molecules such as H2O, CO, CH4, and isopropyl radical, then generated characteristic fragment ion series (m/z 149, 105, 91, 71, 55, 43). The ESI-MS and EI-MS characteristics of diterpenoids of Tripterygium wilfordii are reported for the first time. Based on these characteristics, the methods for quickly and on line identification of diterpenoids are established.

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