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Liu E.,Shandong University | Li Z.,Shandong University | Wang N.,Shandong Provinical Institute of Dermatology and Venereology | Yan H.,Shandong University of Traditional Chinese Medicine | And 8 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2016

Background: Since the advent of four-port laparoscopic cholecystectomy (LC), many modifications have been made that aimed to improve cosmesis and patient prognosis. Here we compared a variety of surgical outcomes such as quality of life three months after surgery between three-port LC and conventional four-port LC. Methods: This study presents an analysis of 245 patients with cholelithiasis who were between 31 and 78 years of age and who underwent elective LC between May 2013 and December 2014. Patients were randomized to undergo either the three-port LC or four-port LC surgery. Operation and hospitalization details were collected. Cosmetic outcome and quality of life of patients were assessed by the validated Patient Scar Questionnaire and MOS-24 questionnaire, respectively, 3 months after surgery. Results: 245 patients were included, and a complete follow-up was possible for 216 patients (88%). The average length of hospital stay, as well as time needed for return to normal activity and work, was significantly shorter in the three-port group than in the four-port group. No significant differences were observed for operating time and bleeding volume. The average hospitalization cost was lower, and, more importantly, patients had a significantly better cosmetic outcome and quality of life scores at 3 months in the three-port group. Conclusion: Three-port LC was as effective as the conventional four-port LC, and it shortened hospital stay, reduced hospitalization cost, and accelerated patient recovery. Moreover, the cosmetic outcome and quality of life were better. © 2016, E-Century Publishing Corporation. All rights reserved.

Jiang C.-L.,Jiangxi Provincial Tumor Hospital | Ye X.-Q.,Jiangxi Provincial Tumor Hospital | Li J.-G.,Jiangxi Provincial Tumor Hospital
Journal of Practical Oncology | Year: 2011

Objective: To investigate the relationship between primary tumor regression rate and long-term outcome in nasopharyngeal carcinoma. Methods: Ninty patients with primary nasopharyngeal carcinoma were treated with radiotherapy. Contrast-enhanced CT scan was performed before radiotherapy and in the middle of the course (36-40 Gy). The tumor volume was calculated with square meter sum. The primary tumor volume was defined as V 0 before radiotherapy and as V 36 during the course. The rate of regression was defined as R = (V 0-V 36)/V 0 x 100%. Results: The overall 4-year local control rate (LCR), distant metastases-free survival (DMFS), disease-free survival (DFS) and overall survival (OS) were 90.3%, 81.2%, 71.5% and 81.6%, respectively. The 4-year LCR, DMFS, DFS and OS were 84.1%, 78.6%, 63.4% and 82.2% in HSG; 97.5%, 83.3%, 79.4% and 86.6% in MSG; and 90.4%, 82.2%, 71.5% and 77.6% in LSG. There were no significant differences in the 4-year LCR, DMFS, DFS and OS among the three groups (All P > 0.05). Conclusion: There is no significant correlation between tumor regression rate and prognosis in patients with nasopharyngeal carcinoma receiving radiotherapy.

Wang M.,Jiangxi Provincial Tumor Hospital | Wang Y.,Jiangxi Provincial Tumor Hospital | Zhong J.,Jiangxi Provincial Tumor Hospital
Molecular Medicine Reports | Year: 2015

Several studies have demonstrated that the isolated side population (SP) cells from solid tumors exhibit cancer stem cell-like properties, and are responsible for drug resistance during chemotherapy and tumor recurrence. In the current study, cancer stem cell-like SP cells were isolated in the MDU-22 breast cancer cell line using the Hoechst-33342 dye exclusion technique. It was observed that SP cells accounted for 3.8% of cells in the MDU-22 cell line, which was reduced to 0.6% in the presence of verapamil, an inhibitor of the ABC transporter. The sorted SP cells showed an elevated expression of stem cell markers, including ABCG2, OCT-4 and EpCAM. Furthermore, it was demonstrated that the isolated SP cells undergo rapid proliferation and have a high survival rate. These results indicate that the coexpression of adenosine triphosphatase binding cassette transporters and stem cell surface markers in SP cells may contribute to chemoresistance, tumor recurrence, metastasis and invasion. Therefore, the isolation and characterization of SP cells may provide novel insights for the development of alternative therapeutic agents to target cancer stem cells.

Feng L.,Nanchang University | He Y.-Q.,Nanchang University | Xu G.-H.,Jiangxi Provincial Tumor Hospital | Hu H.,Peking University | And 2 more authors.
Analytical Letters | Year: 2014

A simple, rapid, and economical method is reported for the determination of 3,4-dihydroxyphenylalanine, tyrosine, 4-hydroxyphenyllactic acid, 4-hydroxyphenylacetic acid, 4-hydroxyphenethylamine, and 3-(4-hydroxyphenyl)propionic acid in human serum by ultra-performance liquid chromatography coupled with fluorescence detection. Separation was achieved on a C18 column with isocratic elution using 95:5 (v/v) 50 mM ammonium formate buffer at pH 5.8 and acetonitrile. Fluorescence detection was performed with excitation and emission wavelengths of 277 and 316 nm, respectively. Under the optimized conditions, all compounds were eluted within 10 min. The effectiveness of various protein precipitants was investigated for the pretreatment of serum samples and 5% perchloric acid was selected as optimal. The calibration curves were linear (correlation coefficients > 0.9996), and the limits of detection and quantification for tyrosine and its metabolites ranged from 0.016 to 0.032 mg/L and 0.040 to 0.080 mg/L, respectively. Recoveries of tyrosine and its metabolites in normal subjects and cancer patients were in the range of 86.5-102.5% and 88.3-107.3%, respectively, with RSDS of 0.3-5.7% and 0.5-4.3%. Significant differences in serum concentrations of tyrosine and 4-hydroxyphenyllactic acid were found between normal individuals and cancer patients. © 2014 Taylor & Francis Group, LLC.

Chen Y.,Nanchang University | Zeng G.,Nanchang University | Tan J.,Chinese PLA General Hospital | Tang J.,Jiangxi Provincial Tumor Hospital | And 2 more authors.
Diabetes/Metabolism Research and Reviews | Year: 2015

Our aim is to clarify the features of complete type 2 diabetes mellitus (T2DM) remission in patients who undergo Roux-en Y gastric bypass surgery, to better determine factors affecting the outcome of T2DM surgery. A search was conducted for original studies on Medline, PubMed and Elsevier from inception until October 28, 2014. All of the articles included in this study were assessed with the application of predetermined selection criteria and were divided into two groups: Roux-en Y gastric bypass surgery for T2DM patients in remission or non-remission. The meta-analysis results demonstrated that fasting C-peptide values were significantly associated with increased remission (C-peptide: 95%CI=0.2-1.0) whereas T2DM duration, patient age, preoperative insulin use, preoperative fasting blood glucose values and preoperative glycosylated haemoglobin values were significantly associated with reduced remission (T2DM duration: 95%CI=-1.2 - -0.7; age: 95%CI=-0.5 - -0.1; percentage of preoperative insulin users: odd ratio=0.10, 95%CI=0.07-0.15; preoperative fasting blood glucose: 95%CI=-0.9 - -0.5; preoperative glycosylated haemoglobin: 95%CI=-1.1 - -0.4). However, the results demonstrated that body mass index was not statistically different (body mass index: 95%CI=-0.2-0.6). The results of the systematic review demonstrated that smaller waist circumference; lower total cholesterol, triglycerides and low-density lipoprotein levels, increased higher high-density lipoprotein levels, shorter cardiovascular disease history and less preoperative prevalence of hypertension contribute to the increased postoperative remission rate. Better results are obtained in younger patients with less severe diabetes, a smaller waist circumference, higher preoperative high-density lipoprotein, lower preoperative total cholesterol, triglycerides and low-density lipoprotein levels and fewer other complications of shorter durations. © 2015 John Wiley & Sons, Ltd.

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