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Chen Z.-Z.,National Institutes for Food and Drug Control | Chen Z.-Z.,China Pharmaceutical University | Chen Z.-Z.,Jiangxi Provincial Institute for Food and Drug Control | Zhang D.-S.,National Institutes for Food and Drug Control | And 3 more authors.
Yaoxue Xuebao | Year: 2012

A novel qualitative analytical method by using two-dimensional chromatographic correlation spectroscopy techniques for recognizing impurity peaks of HPLC methods of quality control and LC-MS chromatographic system was established. The structures of major degradation products of ceftizoxime and cefdinir were identified by LC-MS and MassWorks application; the standard chromatographic and spectral data of the degradation impurities were obtained by high-performance liquid chromatography with diode array detection. The impurity peaks of two-dimensional chromatography were matched by comparison of spectra and calculating correlation coefficients. Peaks in chromatography can be identified accurately and rapidly in different chromatographic systems such as column and mobile phase changed. The method provides a new way and thought to identify the peaks in quality control of impurities without reference impurity substances. Source


Zeng L.,University of Sichuan | Zeng L.,Provincial Key Laboratory for Food Safety Monitoring and Risk Assessment of Sichuan | Li Y.,University of Sichuan | Li Y.,Provincial Key Laboratory for Food Safety Monitoring and Risk Assessment of Sichuan | And 7 more authors.
Journal of Chromatographic Science | Year: 2015

Consumption of functional foods based on extracts from selected herbs to alleviate hypertension is an increasingly common practice in China. Adulteration of these foods with pharmaceuticals can significantly impact a consumer's health. To control the quality of the functional foods effectively, a method for the simultaneous determination of 10 common adulterants including chlortalidone, hydrochlorothiazide, indapamide, metoprolol, nifedipine, nimodipine, nitrendipine, reserpine, triamterene and valsartan in antihypertensive functional foods was developed. The target chemicals in samples were ultrasonically extracted with acetonitrile, and then cleaned-up with multi-walled carbon natotubes-dispersive solid-phase extraction. Finally, the analytes were separated with a C18 column using binary mobile phases consisting of acetonitrile and 0.03 mol/L KH2PO4 solutions (pH 3.0). The flow rate of the mobile phase was 0.80 mL/min, and the column temperature was 35°C. The detection wavelength was set at 220 nm. The limits of detection and quantification of the method ranged from 0.014 to 0.053 and 0.047 to 0.178 μg/mL, respectively. The recoveries of the method were in the range of 80.1-98.1% with relative standard deviations <9.53%. The method was successfully applied to the determination of the target chemicals in real samples and simulated samples, and respirine was detected in one tonic wine sample with a concentration of 56.8 ± 1.2 mg/L. © The Author 2015. Published by Oxford University Press. Source


Lu D.,University of Sichuan | Yang Y.,University of Sichuan | Wu X.,Jiangxi Provincial Institute for Food and Drug Control | Zeng L.,University of Sichuan | And 4 more authors.
Analytical Methods | Year: 2015

A rapid and efficient gas chromatography-mass spectrometry (GC-MS) has been developed for determination of eight VE isomers including α-, β-, γ-, δ-tocopherols and tocotrienols, as well as α-tocopherol acetate in functional foods and nutritional supplements. The vitamin E isomers in samples were directly extracted without saponification with mixed solvents of methanol and hexane (7 : 3,v/v). Good separation was achieved using a VF-5MS column (30 m × 0.25 mm, 0.25 μm) within 13 min. The mass spectrometer was operated in both full scan mode and SIM mode using electron impact ionization. Qualitative detection was based on characteristic ion pairs and retention time. Dibenzanthracene was used as an internal standard for quantification measurement. The linear ranges of the method were from 0.1 to 40 μg mL-1 with the correlation coefficients greater than 0.997. The detection limits ranged from 0.09 ng mL-1 to 0.46 ng mL-1, and the quantification limits were from 0.29 ng mL-1 to 1.52 ng mL-1. The intra-day and inter-day relative standard deviations (RSDs) of the method (for 1 μg mL-1 standard solution) were in the range of 4.9% to 8.0% and 2.1% to 4.9%, respectively. The average recoveries of the method ranged from 83.2% to 107%, with the RSDs from 1.1% to 8.4%. The method has been applied for the determination of VE isomers and α-tocopherol acetate in functional foods and nutritional supplements with satisfactory results. This journal is © The Royal Society of Chemistry. Source


Liao Y.-Y.,Jiangxi Provincial Institute for Food and Drug Control | Liao Y.-Y.,Jiangxi University of Traditional Chinese Medicine | Zhou G.-P.,Jiangxi Provincial Institute for Food and Drug Control | Wu G.-J.,Jiangxi Provincial Institute for Food and Drug Control | And 4 more authors.
Chinese Traditional and Herbal Drugs | Year: 2014

Objective: To study the chemical constituents from the leaves of Salix matsudana. Methods: The chemical constitunents were isolated by various column chromatographic methods. The structures of the compounds were elucidated on the basis of physiochemical properties and spectral analyses. Results: Six compounds were named as 5-β-D-glucosyloxy-7-hydroxychromone (1), 5, 7-dihydroxychromone (2), (2-hydroxyphenzyl)-O-β-D-glucopyranoside (3), vanillic acid-4-O-β-D-glucoside (4), cyclo (val-pro) (5), and gallic acid (6). Conclusion: Compound 1 is a new compound named matsudoside A, compounds 2-6 are obtained from this plant for the first time. ©, 2014, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved. Source


Zeng L.,University of Sichuan | Wu X.,Jiangxi Provincial Institute for Food and Drug Control | Li Y.,University of Sichuan | Li Y.,Provincial Key Laboratory for Food Safety Monitoring and Risk Assessment of Sichuan | And 3 more authors.
Analytical Methods | Year: 2015

A novel, simple and accurate high performance capillary electrophoresis method after multiwalled carbon nanotube-dispersive solid-phase extraction was developed for simultaneous determination of hydrochlorothiazide (HCT), chlortalidone (CTD), indapamide (IDP), reserpine (RSP), nifedipine (NDP) and valsartan (VST) in antihypertensive functional foods. After the analytes were ultrasonically extracted with acetonitrile, they were adsorbed on multiwalled carbon nanotubes (MWCNTs). Then the MWCNTs were separated through centrifugation and the analytes on the MWCNTs were desorbed with methanol. The eluent was removed through rotary evaporation and the residue was dissolved in acetonitrile-water (50 : 50, v/v) for CE analysis. The electrophoresis separation was carried out on an uncoated fused-silica capillary (57.0 cm total length and 50.0 cm effective length, 75.0 μm i.d.) by applying a voltage of 30 kV and the running buffer consisting of 10 mM borax buffer, 20 mM SDS and 30% acetonitrile (pH 9.7) with PDA detection at 220 nm. The capillary column temperature was set at 30 °C. The method showed good linearity in the ranges of 1-50 μg mL-1 with LODs of 0.058-0.157 μg mL-1. The proposed method was successfully applied to the analysis of antihypertensive functional foods with different matrices. Reserpine was detected in a sample with the content of 55.1 ± 0.9 μg mL-1 while other chemicals were not detected in all samples. The results of the proposed method were compared with those obtained by HPLC and there were no significant differences in the performance of the methods regarding accuracy and precision. This journal is © The Royal Society of Chemistry. Source

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