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Wu R.-R.,Jiangxi Provincial Ganzhou Peoples Hospital | Xiao Z.-Y.,Jiangxi Provincial Ganzhou Peoples Hospital | Wang C.,Jiangxi Provincial Ganzhou Peoples Hospital | Liu H.-F.,Jiangxi Provincial Ganzhou Peoples Hospital | And 2 more authors.
Journal of B.U.ON. | Year: 2014

Purpose: The purpose of this study was to evaluate the short- and long-term efficacy and toxicity of the humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody h-R3 when combined with radiotherapy for the treatment of locally advanced nasopharyngeal carcinoma (NPC).. Methods: 35 patients with stage III-IVb NPC with moderate- or strong-intensity EGFR expression were randomly divided into either a radiotherapy alone group or a group receiving radiotherapy combined with h-R3. Results: The complete remission (CR) rates of the combination group at three time points were significantly higher (p<0.05) than those of the radiotherapy alone group. Overall survival, 3-year local control rate, and no distant metastasis rate did not differ between the two groups. No severe toxicity was noticed. Conclusion: h-R3 is an agent with good safety profile which could help enhance the radiation antitumor effect in locally advanced NPC, but it did not seem to exhibit significant long-term efficacy.

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