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Gong S.S.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

Four deoxynucleoside 5′-phosphoromorpholidates were prepared from carboxybenzylprotected 2′-deoxyribonucleosides. The synthetic route involved three consecutive steps including phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling reactions. © (2014) Trans Tech Publications, Switzerland. Source


Gong S.S.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Li X.J.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

A series of d4T 5′-selenophosphoramidates were prepared in good yields from d4T 5′-H-phosphonamidates. H-Phosphonamidates were silylated with TMSCl, and then oxidized with selenium in the presence of DBU to afford d4T 5′-selenophosphoramidates. Due to the lowered electron density on the P atom of H-phosphonamidates, these intermediates were less prone to be oxidized than their P-O counterparts. © (2014) Trans Tech Publications, Switzerland. Source


Gong S.S.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Yang Q.K.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

A novel and efficient strategy has been developed for the synthesis of FA-Gly-Leu-NH2 (FAGLA), a furylacryloyl dipeptide substrate for the thermolysin from Bacillus thermoproteolyticus. © (2014) Trans Tech Publications, Switzerland. Source


Liu G.D.,Jiangxi Provincial Colleges and Universities | Gong S.S.,Jiangxi Science and Technology Normal University | Yang Q.K.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

A general method for the synthesis of nucleoside 5′-H-phosphonothioates are described in this paper. The synthetic strategy involves the coupling of 2′,3′-O-isopropylidene-protected nucleosides with triethylammonium phosphinate in the presence of pivaloyl chloride, oxidation with elemental sulfur, and final deprotection of 2′,3′-O-isopropylidene group with 50% aqueous solution of trifluoroacetic acid. © (2014) Trans Tech Publications, Switzerland. Source


Wang C.G.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Gong S.S.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

A study on the reaction paths of the reduction of bis(2-(benzoylamino)phenyl)disulfide revealed that both intramolecular cyclization and intermolecular substitution reactions happened upon cleavage of the disulfide bond by triphenylphosphine under acidic condition. © (2014) Trans Tech Publications, Switzerland. Source

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