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Liu G.D.,Jiangxi Provincial Colleges and Universities | Gong S.S.,Jiangxi Science and Technology Normal University | Yang Q.K.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

A general method for the synthesis of nucleoside 5′-H-phosphonothioates are described in this paper. The synthetic strategy involves the coupling of 2′,3′-O-isopropylidene-protected nucleosides with triethylammonium phosphinate in the presence of pivaloyl chloride, oxidation with elemental sulfur, and final deprotection of 2′,3′-O-isopropylidene group with 50% aqueous solution of trifluoroacetic acid. © (2014) Trans Tech Publications, Switzerland.


Gong S.S.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Yang Q.K.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

A novel and efficient strategy has been developed for the synthesis of FA-Gly-Leu-NH2 (FAGLA), a furylacryloyl dipeptide substrate for the thermolysin from Bacillus thermoproteolyticus. © (2014) Trans Tech Publications, Switzerland.


Wang C.G.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Gong S.S.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

A study on the reaction paths of the reduction of bis(2-(benzoylamino)phenyl)disulfide revealed that both intramolecular cyclization and intermolecular substitution reactions happened upon cleavage of the disulfide bond by triphenylphosphine under acidic condition. © (2014) Trans Tech Publications, Switzerland.


Sun Q.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Provincial Colleges and Universities | Li X.,Jiangxi Science and Technology Normal University | Sun J.,Jiangxi Science and Technology Normal University | And 3 more authors.
Tetrahedron | Year: 2014

Four nucleoside diphosphate 6-deoxy-l-sugars have been efficiently synthesized by coupling sugar-1-phosphates prepared from the H-phosphonate precursors with nucleoside 5′-phosphoropiperidates in the presence of 4,5-dicyanoimidazole (DCI) as the activator. Compared to the conventional 1H-tetrazole-promoted phosphoromorpholidate method, the new phosphoropiperidate/ DCI system significantly shortened the reaction time and afforded nucleoside diphosphate sugars in excellent isolated yields. © 2013 Elsevier Ltd. All rights reserved.


Sun Q.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Provincial Colleges and Universities | Gong S.-S.,Jiangxi Science and Technology Normal University | Liu S.,Jiangxi Science and Technology Normal University | And 3 more authors.
Tetrahedron | Year: 2014

A general and efficient P(V)-N activation method for the preparation of symmetrical and asymmetrical dinucleoside polyphosphates (NpnN′ s, n=2-4) and P2,P3-CX2-dinucleoside tetraphosphates (X=H, F, and Cl) has been established. Twenty-two dinucleoside polyphosphates and their phosphonate analogs were synthesized from nucleoside 5′-phosphoropiperidates with 4,5-dicyanoimidazole as the activator in good to high yields. © 2014 Elsevier Ltd. All rights reserved.


Gong S.S.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Li X.J.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

A series of d4T 5′-selenophosphoramidates were prepared in good yields from d4T 5′-H-phosphonamidates. H-Phosphonamidates were silylated with TMSCl, and then oxidized with selenium in the presence of DBU to afford d4T 5′-selenophosphoramidates. Due to the lowered electron density on the P atom of H-phosphonamidates, these intermediates were less prone to be oxidized than their P-O counterparts. © (2014) Trans Tech Publications, Switzerland.


Sun Q.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Provincial Colleges and Universities | Gong S.,Jiangxi Science and Technology Normal University | Sun J.,Jiangxi Science and Technology Normal University | And 4 more authors.
Tetrahedron Letters | Year: 2014

Thirteen nucleoside 5′-triphosphates (NTPs) and their β,γ-bridging oxygen-modified analogs (β,γ-CX 2-NTPs, X = H, F, Cl, and Br) have been efficiently synthesized from nucleoside 5′-phosphoropiperidates with 4,5-dicyanoimidazole as the activator. A high-yielding and chromatography-free protocol for the preparation of both natural and base-modified nucleoside 5′-phosphoropiperidates from the corresponding nucleoside 5′-phosphates was also developed. © 2013 Published by Elsevier Ltd.


Wang Q.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Gong S.S.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

Treatment of protected furanoses with FeCl3·6H2O in acetonitrile with microwave irradiation provides an efficient and mild protocol for regioselective removal of anomeric O-acetyl group. This method features cost efficient reagents, simple procedures, and high yields. The experimental results proved that microwave irradiation could notably shorten the reaction time and increase the product yield compared to the conventional thermal heating condition.


Gong S.S.,Jiangxi Science and Technology Normal University | Liu G.D.,Jiangxi Provincial Colleges and Universities | Sun Q.,Jiangxi Science and Technology Normal University
Advanced Materials Research | Year: 2014

Four deoxynucleoside 5′-phosphoromorpholidates were prepared from carboxybenzylprotected 2′-deoxyribonucleosides. The synthetic route involved three consecutive steps including phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling reactions. © (2014) Trans Tech Publications, Switzerland.


Sun Q.,Jiangxi Science and Technology Normal University | Sun Q.,Jiangxi Provincial Colleges and Universities | Liu S.,Jiangxi Science and Technology Normal University | Sun J.,Jiangxi Science and Technology Normal University | And 5 more authors.
Tetrahedron Letters | Year: 2013

Six symmetrical P1,P2-dinucleoside-5′- diphosphates (Np2Ns) have been synthesized from nucleoside-5′- H-phosphonate monoesters via a one-pot reaction in high yields. The key sequential hydrolysis protocol was developed based on the observation of reactive P1,P2,P3-trinucleoside-5′- triphosphate intermediate on 31P NMR. © 2013 Elsevier Ltd. All rights reserved.

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