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Xia H.Y.,Nanchang University | Xia H.Y.,Jiangxi Provicial Institute for Drug and Food Control | Mai X.,Nanchang University | Mai B.,PingXiang College | And 4 more authors.
Asian Journal of Chemistry | Year: 2013

A series of benzyloxyurea and benzyloxyhydantoin derivatives were synthesized by substituting different benzyl groups on O-position and glucosamine, amino acid ester on N3-position of hydroxyurea. Their structures were elucidated by using spectrometry along with X-ray crystal structures analysis and in vitro antitumor activity against the human leukemia cell line K562 and murine leukemia cell line L1210 was evaluated by MTT assay. The L-phenylalanine ester substituent at N3-position was allowed with markedly increasing the activity against the tumor cells. The most promising compounds were 7e and 7b.

Xiao X.-W.,Jiangxi Provicial Institute for Drug and Food Control | Fu H.-Z.,Jiangxi Provicial Institute for Drug and Food Control | Luo Y.-H.,Jiangxi Provicial Institute for Drug and Food Control | Wei X.-Y.,CAS South China Botanical Garden
Journal of Asian Natural Products Research | Year: 2013

A new regioisomer of andrographolide, 17-hydro-9-dehydro-andrographolide (1), and five new sulfates of andrographolide (2-6) were isolated from Xiyanping, a China licensed anti-inflammatory drug derived from andrographolide through sulfation reaction. Their chemical structures were elucidated by spectroscopic and chemical methods. The inhibition effects of these compounds on angiogenesis were evaluated by rat aortic ring assay. Compounds 1 and 3 exhibited strong inhibitory activities on vascular endothelial cell tube formation in rat aorta ring at the concentration of 1 μM. Compounds 4 and 5 showed moderate suppression on angiogenesis at 10 μM. © 2013 Taylor & Francis Group, LLC.

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