Liao J.,Nanchang University |
Wu S.-Y.,Maternal and Child Health Hospital of Jiangxi
Chinese Journal of Cancer Prevention and Treatment | Year: 2011
OBJECTIVE: To detect the expression of mRNA of E-cadherin (E-cad) in normal ovarian tissues, beningn ovarian tumor tissues and epithelial ovarian tumor, and the correlation between E-cad and epithelial ovarian tumor, and provide theoretical basis to clinical diagnosis and therapy. METHODS: The mRNA levels of E-cad were analyzed by FQ-PCR (Fish real time quantitative-polymerase chain reaction) in the fresh normal ovarian tissues, beningn ovarian tumor tissues, and epithelial ovarian carcinoma tissues. RESULTS: The expression of the mRNA of E-cad in normal ovarian surface epithelium, benign epithelial ovarian tumors and epithelial ovarian carcinomas was respectively 0, (0.2617±0.1382) and (0.0127±0.0181), and the expression rates were 0, 100% and 50%. There was statistical significance between benign epithelial ovarian tumors and epithelial ovarian carcinomas groups (χ2 = 30.924, P<0.05). There was a negative correlation between clinical stage and the expression of mRNA of E-cad Cr= -0.873, P<0.05). There was a positive correlation between the duration of survival and the expression of mRNA of E-cad (r = 0.602, P<0.05). There was not statistical significance between histologic type and the expression of mRNA of E-cad (χ2 = 3.811, P>0.05). There was not statistical significance between pathological grade and the expression of mRNA of E-cad (χ2 = 3.458, P>0.05). CONCLUSIONS: E-cad may be one of the indexes as progression and prognostic indicators of epithelial oarian cancer. E-cad can provide a thinking for molecular target therapy of epithelial ovarian.