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Wang Y.,Yangzhou University | Guan B.,Yangzhou University | Tian T.,Yangzhou University | Peng X.,Childrens Hospital of Jiangxi | Xu L.,Yangzhou University
Oncology Letters | Year: 2015

The present study reports a rare case of a giant intrapetrous internal carotid aneurysm that compressed the internal jugular vein causing recurrent middle ear effusion in a 13-year-old female. Images obtained by computed tomography revealed middle ear effusion occupying the right side of the attic. Digital subtraction angiography (DSA) resulted in a diagnosis of a giant aneurysm of the right intrapetrous carotid artery, with a diameter of 25 mm and a neighboring area of compression of the internal jugular vein. The patient was treated successfully using coil embolization. The present study therefore indicates that DSA should be considered in the differential diagnosis of patients with middle ear effusion. Early treatment with coil embolization or other surgical treatments can be a life-saving therapeutic approach. © 2015, Spandidos Publications. All rights reserved. Source


Huang D.,Central South University | Wu X.,Central South University | Zheng W.,Childrens Hospital of Jiangxi | Peng X.,Childrens Hospital of Jiangxi | And 2 more authors.
Journal of Central South University (Medical Sciences) | Year: 2012

Objective: To analyze the podocalyxin (PCX) expression in the kidney and the number of urinary podocytes in different pathological grades of Henoch-Schönlein purpura nephritis (HSPN), and to determine whether the number of urinary podocytes reflects the renal damage in HSPN. Methods: Fifty-six children diagnosed with HSPN in our hospital were enrolled in the study and classified into 4 groups by renal pathology: grade II (Ila+IIb) (n=10), grade III (IIIa+HIb) (n=21), grade IV (n=16), and grade V (n=9). Four kidney autopsy specimens without histomorphologic lesions and 8 urine samples from healthy children served as controls. With immunofluorescence assay, the PCX expression in 4 normal renal tissues and in the renal tissues of the 56 HSPN children was detected and quantitatively analyzed. Positive rate and the number of urinary podocytes were detected in the 8 healthy children and 56 HSPN children. Results: In the renal tissues of the normal control group and grade II (Ila+IIb) HSPN group, the PCX expression was complete. The percentage of the PCX positive area out of the total glomerular area in the renal tissues of 2 groups had no significant difference (P>0.05). In the renal tissues of grade III (IIIa+IHb), IV, and V HSPN groups, the PCX expression showed various degrees of loss, decreasing in turn from grade II (Ila+IIb), III (IIIa+IHb), IV to V, with significant differences between each group (P<0.01). For HSPN with grade III (IIIa+IHb) or higher, positive PCX expression was found in the urine, suggesting the presence of enough podocytes in the urine. The percentage of fluorescence positive area out of the total glomerular area of PCX in the renal tissues was negatively correlated with the total number of urinary podocytes (r=-0.637, P<0.01). Conclusion: Podocyte injury plays a certain role in the pathological progression of HSPN. The urinary detection of podocytes can reflect the degrees of pathological damage in HSPN. Source

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