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Ai W.-W.,Jiangxi Peoples Hospital | Zhang M.,Jiangxi Peoples Hospital | Wu S.,Jiangxi Peoples Hospital | Huang Q.,Jiangxi Peoples Hospital | And 2 more authors.
Journal of Dalian Medical University | Year: 2015

Objective: To study the correlation between N - terminal brain natriuretic peptide (NT - proBNP) and left ventricular end diastolic pressure (LVEDP) and pulmonary capillary wedge pressure (PCWP) in diastolic heart failure (DHF) patients as well as the diagnostic value for patients with varying degrees of diastolic heart failure. Methods: The 30 hospitalized patients with normal cardiac function were classified into normal group. The 60 hospitalized patients with abnormal cardiac function were classified into abnormal group. Besides, based on NYHA cardiac functional grading (grade I to III), the 60 patients were divided into 3 subgroups with 20 patients in each subgroup. LVEDP was measured with 6F pigtail catheter, and PCWP was measured with Swan - ganz catheter. Electrochemical luminescence device RocheElecsys 2010 was applied to determine NT - proBNP. Correlation between NT - proBNP and LVEDP and PCWP was analyzed. Results: With the progress in cardiac function grade, the levels of NT - proBNP, LVEDP and PCWP increased significantly (P <0.01). According to linear correlation and regression analysis, there was significant positive correlation between LogNT - proBNP and LVEDP (r = 0. 793, P < 0.01) and between LogNT - proBNP and PCWP (r = 0. 657, P < 0. 01). Conclusions: Serum NT - proBNP quantitative detection is a sensitive indicator of impaired left ventricular diastolic function. NT - proBNP has definite diagnostic value for the severity of diastolic heart failure.

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