Jiangwan Hospital

Shanghai, China

Jiangwan Hospital

Shanghai, China
SEARCH FILTERS
Time filter
Source Type

Liang X.,Jiangwan Hospital | Wang B.,Jiangwan Hospital | Li F.,Shanghai JiaoTong University | Ma G.,Jiangwan Hospital | And 2 more authors.
Chinese Journal of Medical Imaging Technology | Year: 2016

Objective: To assess the severity of secondary hyperparathyroidism (SHPT) with conventional ultrasound. Methods: Fifty SHPT patients with parathyroid hyperplasia were divided into 4 groups according to the parathyroid hormone (PTH) level (group A, PTH<250 ng/L, n=8; group B, 250 ng/L≤PTH<600 ng/L, n=12; group C, 600 ng/L≤PTH<800 ng/L, n=18; group D, PTH≥800 ng/L, n=12). The shape, size, number, internal echo and blood flow of parathyroid glands were observed and compared among the 4 groups. The Results: of pathology of 21 patients underwent parathyroidectomy were corresponded with ultrasound features. Results: The differences of ultrasound features among the 4 groups were statistically significant (all P<0.05). With the increasing of PTH, the ultrasound features of parathyroid glands showed more irregular shape, larger volume, uneven internal echo and more abundant blood supply. But some ultrasound features had overlaps. The pathological accordant rates with the ultrasound features were 100% (12/12) in group D and 66.67% (6/9) in group C. Conclusion: Ultrasound can clearly show the morphologic and blood supply features in parathyroid glands. It has clinical value in assessing the severity of SHPT. However, some ultrasound features have overlaps, so it is necessary to combine other ultrasound technologies to improve the accuracy in assessing the severity of SHPT. Copyright © 2016 by the Press of Chinese Journal of Medical Imaging and Technology.


Liang X.-X.,Shanghai JiaoTong University | Liang X.-X.,Jiangwan Hospital | Wang B.-G.,Jiangwan Hospital | Du L.-F.,Shanghai JiaoTong University
Chinese Journal of Medical Imaging Technology | Year: 2015

Objective: To explore the relationship between primary hyperparathyroidism (PHPT) and recurrent urinary calculi with high frequency ultrasound parathyroid scaning. Methods: High frequency ultrasound parathyroid scaning was performed on 200 patients with urinary calculi (calculus group) and 200 physical examinees (control group) to observe the display rate and lesions. Those who with abnormal ultrasound features underwent the examines of serum parathyroid hormone (PTH), calcium and phosphorus. Results: In calculus group, parathyroid glands displayed in 136 cases (136/200, 68.00%) by high frequency ultrasound. Parathyroid tumor was found in 28 cases (28/200, 14.00%) and the volume of tumor was (588.93±15.25)mm3. In control group, parathyroid glands displayed in 90 cases (90/200, 45.00%) by high frequency ultrasound. Parathyroid tumor was found in 4 cases (4/200, 2.00%) and the volume of tumor was (84.74±12.51)mm3. The differences of display rate and the size of tumor were statistically significant between the two groups (both P<0.05). A total of 12 cases in calculus group were PHPT, while the serum PTH, calcium and phosphorus of another 16 cases in calculus group and 4 cases in control group were normal. There was statistical difference of PHPT incidence rate between the two groups (P<0.05). In calculus group, the PHPT incidence rate of urinary calculus occurred ≥3 times cases (7/53, 13.21%) was higher than that of urinary calculus occurred <3 times cases (5/147, 3.40%; P<0.05). Only single tumor was found by ultrasound in all of 12 PHPT cases. Among them, 7 cases underwent parathyroid resection with the pathology result as adenoma, 5 cases received medicine treatment. Conclusion: PHPT is an important and easily overlooked cause of recurrent urinary calculus, and high frequency ultrasound can be used as a routine method to screen parathyroid for recurrent urinary calculus patients. Copyright © 2015 by the Press of Chinese Journal of Medical Imaging and Technology.


Liang X.-X.,Jiangwan Hospital | Wang B.-G.,Jiangwan Hospital | Ma G.,Jiangwan Hospital | Meng X.-K.,Jiangwan Hospital
Chinese Journal of Medical Imaging Technology | Year: 2015

Objective: To explore the factors affecting the accuracy rate of transvaginal ultrasonography (TVS) in diagnosis of the early ectopic pregnancy (EP). Methods: The TVS features of 205 cases of 5600 suspected EP patients who had postmenopaused 4-6 weeks were analyzed, and the results were compared with that of laparoscopy. Results: The accurate rate of TVS in diagnosis of EP was 68.86% (115/167); The incidence of pregnancy of unknown location (PUL) was 38.54% (79/205). The proportion of patients who had no obvious clinical symptoms in the early pregnancy was 53.66% (110/205). The unruptured EP mainly appeared as tube ring mass (110/155, 70.97%) on ultrasonography. The less experienced physicians were more easy to misdiagnosis than the experienced physicians (P<0.05). Conclusion: The main factors affecting the accuracy rate of TVS in the early diagnosis of EP is the existence of PUL, the lack of clinical symptoms, the unruptured EP atypical ultrasound images and the experience and skills of ultrasound doctors. Copyright © 2015 by the Press of Chinese Journal of Medical Imaging and Technology.


Wang Y.,Jiangwan Hospital | Song J.,Jiangwan Hospital | Zhang J.,Jiangwan Hospital | Qian C.,Shanghai University | And 5 more authors.
Journal of Surgical Research | Year: 2013

Background Cell proliferation, renewal, and apoptosis factors are related to hemorrhagic shock (HS) survival. Objective Hepatic gene expression before and 24 h after induced HS were compared. Methods Male Sprague-Dawley rats aged 8-9 wk (n = 11) were subjected to blood loss, and HS was induced in 9 rats (blood loss <0.1 mL) by left lobular hepatectomy with fixed-volume blood loss (2.5 mL/100 g) for this self-controlled study. In 3 randomly selected rats surviving >24 h post-HS, hepatic tissue samples collected pre-HS (n = 3; group A) and 24 h post-HS (n = 3; group B) were used for microarray analysis (21,793 genes) of differentially expressed genes using pathway, gene ontology, and network analyses. Real-time reverse transcriptase polymerase chain reaction confirmed Aldh1a1, Aldh1a7, amine oxidase, copper containing 3, cytochrome P450 26A1, histidine decarboxylase 1, and epoxide hydrolase 2 expression using a beta-actin reference. Results Four rats survived 24 h after HS. Microarray revealed 562 upregulated and 634 downregulated genes in group A compared with group B. Gene ontology analysis revealed differentially expressed genes involved in cholesterol metabolic processes, extracellular stimuli response, sterol metabolic processes, hormonal stimuli response, steroid metabolic processes, endogenous stimulus response, oxidation and reduction reactions, organic substance response, and fatty acid metabolic processes. Conclusions HS pathogenesis involves numerous interrelated signaling pathways. Redox reaction and fatty acid metabolism pathway involvement in traumatic HS recovery, as well as other pathways, may provide novel targets for better understanding the pathology of HS and developing treatments to limit post-HS organ failure. © 2013 Elsevier Inc. All rights reserved.


PubMed | Shanghai JiaoTong University and Jiangwan Hospital
Type: | Journal: BioMed research international | Year: 2016

This study was to explore the significance of ultrasound in determining whether the patients with secondary hyperparathyroidism (SHPT) are sensitive to calcitriol treatment. According to the decrease value of parathyroid hormone (PTH), 42 SHPT patients were divided into two groups: drug susceptible group and drug insusceptible group. These 42 SHPT patients ultrasound images were retrospectively analyzed. The morphology, size, number, blood flow, elastic modulus, and perfusion of the parathyroid glands were correlated with drug therapeutic outcome (oral calcitriol). Most SHPT patients with drug susceptible showed volume <438.50mm(3) and number 2, with 0-1 structural and vascular patterns, associated with Relative Maximum Intensity (RIMAX) <1.59 and elastic modulus <18.8kPa, whereas most SHPT patients with drug insusceptible showed volume 438.50mm(3) and number 3, with 2-3 structural and vascular patterns, associated with Relative Maximum Intensity (RIMAX) 1.59 and elastic modulus 18.8kPa. Therefore, ultrasonography in SHPT allows an accurate definition of the morphology, size, number, blood flow, elastic modulus, and perfusion of the parathyroid glands and is useful in determining whether SHPT patients are sensitive to calcitriol treatment.


PubMed | Shanghai JiaoTong University and Jiangwan Hospital
Type: | Journal: BioMed research international | Year: 2017

Using the model and quantitative parameters of contrast-enhanced ultrasound (CEUS) to assess the severity of secondary hyperparathyroidism (SHPT) was proposed. 42 SHPT patients who underwent CEUS examination were divided into three groups, light, moderate, and heavy as per parathyroid hormone (PTH). The process of CEUS was divided into two phases, wash-in phase and wash-out phase. The three groups were analyzed with their enhancing model in the two phases. The quantitative parameters of CEUS such as Arrival Time (AT), Time to Peak (TTP), Mean Transit Time (MTT), and Maximum Intensity (IMAX) were measured by time-intensity curve (TIC) and compared among the three groups. The enhancing model of light SHPT, moderate SHPT, and heavy SHPT showed statistical significance in wash-in phase and wash-out phase (


Zhang H.-T.,Jiangwan Hospital | Gao X.-Y.,Fudan University | Xu Q.-S.,Jiangwan Hospital | Chen Y.-T.,Zhejiang Province Tumor Hospital | And 2 more authors.
OncoTargets and Therapy | Year: 2016

Objective: To evaluate the characteristics of enhancement of focal nodular hyperplasia (FNH) of the liver by analyzing the dynamic contrast-enhanced multislice computed tomography (MSCT) features and correlating them with pathological findings. Patients and methods: Nine males and 16 females with pathologically confirmed FNH and complete preoperative contrast-enhanced MSCT data were recruited for this study. The imaging features of FNH on the pre- and postcontrast MSCT were analyzed by two experienced radiologists by consensus. Results: Pathology showed central scars and abnormal blood vessels in 17 and 21 of 25 lesions, respectively, while MSCT with multiphase enhancement showed central scars in eight of the 17 lesions (47.1%) and abnormal arteries or draining veins in 13 of the 21 lesions (61.9%). Furthermore, abnormal draining veins in five lesions were found to be diagnostic, which is another important finding. Conclusion: Multiphase scanning can provide the panorama of FNH lesions and reveal their enhancement patterns and pathological characteristics. Abnormal blood vessels within or around the lesion are demonstrated more often than central scar, and both should be observed for FNH diagnosis. © 2016 Zhang et al.


Ma L.S.,Tongji University | Yan Q.,Jiangwan Hospital | Huang Y.,Jiangwan Hospital | Zhao W.,Jiangwan Hospital | Zhu Y.,Jiangwan Hospital
Oncology Letters | Year: 2015

The aim of the current study was to investigate the suppressive effects of pSilencer T7-human epidermal growth factor receptor 2 (HER2)-short hairpin RNA (shRNA) recom-binant plasmids on human SKOV3 ovarian cancer cell growth and sensitivity to carboplatin (CBP). Three different pairs of shRNAs (shRNAa, shRNAb and shRNAc), targeting the HER2 gene, were selected and transfected into human SKOV3 cells, respectively. The expression levels of HER2 were then detected by immunohistochemical (IHC), semi-quantitative reverse transcription-polymerase chain reaction and western blot analyses. In addition, cell cycle and cell growth were investigated using cell counting kit-8 (CCK-8). The results of the IHC and western blot analyses revealed that shRNAb significantly inhibited HER2 protein expression in SKOV3 cells. shRNAb exhibited an improved effect on HER2 expres-sion compared with shRNAa (P<0.01), while shRNAc did not affect HER2 expression. Nontransfected and nonspecific shRNA groups were used as the negative controls. Knockdown of HER2 expression by shRNA was initiated at 24 h following transfection, achieving an optimum effect at 48 h and lasting for at least 72 h after the treatment. The CCK-8 cell growth assay indicated that the knockdown of HER2 expression in the SKOV3 cell line resulted in significant growth suppression and cell cycle arrest. In addition, inhibition of HER2 significantly increased SKOV3 cell sensitivity to CBP treatment. In conclu-sion, pSilencer T7-HER2-shRNA significantly inhibited HER2 expression in human ovarian cancer cells in vitro and induced chemotherapeutic sensitivity to CBP. © 2015, Spandidos Publications. All rights reserved.


PubMed | Fudan University, Jiangwan Hospital and Zhejiang Province Tumor Hospital
Type: | Journal: OncoTargets and therapy | Year: 2016

To evaluate the characteristics of enhancement of focal nodular hyperplasia (FNH) of the liver by analyzing the dynamic contrast-enhanced multislice computed tomography (MSCT) features and correlating them with pathological findings.Nine males and 16 females with pathologically confirmed FNH and complete preoperative contrast-enhanced MSCT data were recruited for this study. The imaging features of FNH on the pre- and postcontrast MSCT were analyzed by two experienced radiologists by consensus.Pathology showed central scars and abnormal blood vessels in 17 and 21 of 25 lesions, respectively, while MSCT with multiphase enhancement showed central scars in eight of the 17 lesions (47.1%) and abnormal arteries or draining veins in 13 of the 21 lesions (61.9%). Furthermore, abnormal draining veins in five lesions were found to be diagnostic, which is another important finding.Multiphase scanning can provide the panorama of FNH lesions and reveal their enhancement patterns and pathological characteristics. Abnormal blood vessels within or around the lesion are demonstrated more often than central scar, and both should be observed for FNH diagnosis.


PubMed | Jiangwan Hospital
Type: Journal Article | Journal: Medical oncology (Northwood, London, England) | Year: 2014

Borealin/Dasra B, also called cell division cycle associated 8, is a member of the chromosomal passenger complex and plays a crucial role during mitosis and cell division. The expression of this gene has been investigated in several kinds of cancers, but its role in colorectal cancers (CRC) remains to be elucidated. In this study, our in silico analysis using the Oncomine database showed that Borealin was overexpressed in CRC tissues, which was further validated by immunohistochemistry in a cohort of 81 pairs of primary CRC and adjacent non-cancerous tissues. In CRC, Borealin expression was positively correlated with age (P = 0.0079), lymph node metastasis (P = 0.0086), and TNM stage (P = 0.0050). Significant difference in the overall survival time was seen between patients with high and low expression (P < 0.0001). Furthermore, high Borealin expression remained independently prognostic in multivariate analysis (HR 4.556, 95 % CI 1.964-10.567, P = 0.0004). Functional studies showed that suppression of Borealin expression with siRNA could significantly inhibit the growth and induce apoptosis in HCT-116 cells (P < 0.01). These results suggest that Borealin might act as an independent prognostic factor and a potential therapeutic target for patients with CRC.

Loading Jiangwan Hospital collaborators
Loading Jiangwan Hospital collaborators