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Jiangsu University is a provincial university located in Zhenjiang, Jiangsu province, People's Republic of China . Wikipedia.


Hong Z.-S.,Nanjing Southeast University | Yin J.,Hohai University | Yin J.,Jiangsu University | Cui Y.-J.,ParisTech National School of Bridges and Roads
Geotechnique | Year: 2010

Oedometer tests starting from a very small effective vertical stress of 0.5 kPa were performed on three reconstituted clays with different liquid limits. The soils were prepared at various initial water contents, ranging from 0.7 to 2.0 times their corresponding liquid limits. It is observed that the e-log v compression curves show an inverse 'S' shape due to suction pressure resisting deformation, similar to that of soft natural clays caused by consolidation yield stress. The suction pressure s of the reconstituted clays can be correlated with the ratio of initial void ratio to void ratio at liquid limit e0/eL. The suction pressure curve defined by a unique relationship between suction pressure s and the normalised void ratio at suction pressure es/eL is also proposed to distin- guish between the pre-suction and the post-suction states. In addition, Burland's concept of the intrinsic compres- sion line is adopted for correlating the compression curves of various reconstituted clays at high initial water contents. It has been found that the void index is a powerful parameter for normalising the compression curves in the post-suction state. Nevertheless, it seems that Burland's intrinsic compression line slightly under- estimates the void index at the low stresses considered in this study. An extended intrinsic compression line is then derived in order to better fit the data for stresses lower than 25 kPa.


Wang P.,Sun Yat Sen University | Wang P.,Jiangsu University | Wu H.,Sun Yat Sen University | Dai Z.,Sun Yat Sen University | Zou X.,Sun Yat Sen University
Chemical Communications | Year: 2012

An efficient electrochemical approach is developed for ultrasensitive profiling of the methylation status of the p53 tumor suppressor gene based on a label-free biosensor in combination with bisulfite conversion. © 2012 The Royal Society of Chemistry.


Li Y.,Jiangsu University
Chemical Engineering Transactions | Year: 2015

Since the aerobics is introduced into the college and university, it becomes popular in teachers and students. In order to develop the aerobics better and improve the level of the aerobics, it is necessary to predict the aerobics performance. Support vector machine method is one of the frequently-used prediction methods. In order to improve the performance of traditional LS-SVM, we put forward an improved LS-SVM algorithm. It is inertia weight LS-SVM (IWLS-SVM) algorithm. According to improving the inertia weight, the algorithm can enhance the performance of the traditional LS-VSM. In the numerical experiments, we apply the algorithm to predict the performance of the aerobics. The experimental results show that the prediction method has better feasible and effective. Copyright © 2015, AIDIC Servizi S. r. l.,.


Cao J.,CAS Kunming Institute of Botany | Cao J.,Jiangsu University | Huang J.,East Carolina University | Yang Y.,CAS Kunming Institute of Botany | Hu X.,CAS Kunming Institute of Botany
BMC Genomics | Year: 2011

Background: Oligopeptide transporters (OPTs) are a group of membrane-localized proteins that have a broad range of substrate transport capabilities and that are thought to contribute to many biological processes. The OPT proteins belong to a small gene family in plants, which includes about 25 members in Arabidopsis and rice. However, no comprehensive study incorporating phylogeny, chromosomal location, gene structure, expression profiling, functional divergence and selective pressure analysis has been reported thus far for Populus and Vitis.Results: In the present study, a comprehensive analysis of the OPT gene family in Populus (P. trichocarpa) and Vitis (V. vinifera) was performed. A total of 20 and 18 full-length OPT genes have been identified in Populus and Vitis, respectively. Phylogenetic analyses indicate that these OPT genes consist of two classes that can be further subdivided into 11 groups. Gene structures are considerably conserved among the groups. The distribution of OPT genes was found to be non-random across chromosomes. A high proportion of the genes are preferentially clustered, indicating that tandem duplications may have contributed significantly to the expansion of the OPT gene family. Expression patterns based on our analyses of microarray data suggest that many OPT genes may be important in stress response and functional development of plants. Further analyses of functional divergence and adaptive evolution show that, while purifying selection may have been the main force driving the evolution of the OPTs, some of critical sites responsible for the functional divergence may have been under positive selection.Conclusions: Overall, the data obtained from our investigation contribute to a better understanding of the complexity of the Populus and Vitis OPT gene family and of the function and evolution of the OPT gene family in higher plants. © 2011 Cao et al; licensee BioMed Central Ltd.


Wang Y.,Jiangsu University | Kroon J.K.M.,Durham University | Slabas A.R.,Durham University | Chivasa S.,Durham University
Proteomics | Year: 2013

Light plays an important role in plant growth, development, and response to environmental stresses. To investigate the effects of light on the plant responses to cadmium (Cd) stress, we performed a comparative physiological and proteomic analysis of light- and dark-grown Arabidopsis cells after exposure to Cd. Treatment with different concentrations of Cd resulted in stress-related phenotypes such as cell growth inhibition and decline of cell viability. Notably, light-grown cells were more sensitive to heavy metal toxicity than dark-grown cells, and the basis for this appears to be the elevated Cd accumulation, which is twice as much under light than dark growth conditions. Protein profiles analyzed by 2D DIGE revealed a total of 162 protein spots significantly changing in abundance in response to Cd under at least one of these two growing conditions. One hundred and ten of these differentially expressed protein spots were positively identified by MS/MS and they are involved in multiple cellular responses and metabolic pathways. Sulfur metabolism-related proteins increased in relative abundance both in light- and dark-grown cells after exposure to Cd. Proteins involved in carbohydrate metabolism, redox homeostasis, and anti-oxidative processes were decreased both in light- and dark-grown cells, with the decrease being lower in the latter case. Remarkably, proteins associated with cell wall biosynthesis, protein folding, and degradation showed a light-dependent response to Cd stress, with the expression level increased in darkness but suppressed in light. The possible biological importance of these changes is discussed. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Yin C.,Jiangsu University
Energy Education Science and Technology Part A: Energy Science and Research | Year: 2014

This research provides a scientific clarification of the concept and connotation of Performance and Educational Equipment’s Performance, taking life cycle cost of the Educational Equipment as a starting point and adopting widely used the important method of Performance Evaluation which is widely used—the balanced score card launched research about every matter factor of educational equipment evaluation, It also puts forward the specific measuring ways and standards of each part’s key points of the Educational Equipment, thus providing theoretical references for the use of Performance Evaluation of the Educational Equipment. © Sila Science. All Rights Reserved.


Balakrishnan N.,McMaster University | Balakrishnan N.,King Abdulaziz University | Zhao P.,Jiangsu University
Probability in the Engineering and Informational Sciences | Year: 2013

In this paper, we review some recent results on the stochastic comparison of order statistics and related statistics from independent and heterogeneous proportional hazard rates models, gamma variables, geometric variables, and negative binomial variables. We highlight the close connections that exist between some classical stochastic orders and majorization-type orders. © Cambridge University Press 2013.


In response to the fact that the physical education evaluation is unitary in evaluation content, has unclear target, fails to address comprehensive indexes and reaches general conclusion, this paper discusses the multiple evaluation of physical education in general colleges and universities. Firstly, based on the multiple intelligence theory, this paper analyzes the evaluation process of physical education and proposes a new evaluation index system for physical education in general colleges and universities. Secondly, by dealing with different indexes under the system and based on the fuzzy system theory, this paper constructs a multiple fuzzy evaluation model and obtains the fuzzy distance and fuzzy similarity between measured values of indexes and their corresponding classic domains, thus knowing the physical education ability and level in general colleges and universities. Last but not the least, a case involving physical education in a given university is discussed to verify the efficacy of the model. Copyright © 2015, AIDIC Servizi S.r.l.


Pan Y.,Nanyang Technological University | Zhou Y.,North China University of Water Conservancy and Electric Power | Sun T.,Jiangsu University | Er M.J.,Nanyang Technological University
Neurocomputing | Year: 2013

In the H ∞ tracking-based adaptive fuzzy controllers (HAFCs) of perturbed uncertain nonlinear systems, additional H ∞ control terms would greatly degrade fuzzy approximation abilities, which violates the original intention of using fuzzy logic systems. To solve this problem, a composite HAFC (CHAFC), which combines the HAFC with composite adaptation technique, is proposed in this paper. Outside of the approximation region, a robust stabilization controller is developed to achieve semi-global stability of the closed-loop system. Within the approximation region, a series-parallel identification model is introduced into an indirect HAFC to construct a CHAFC that can simultaneously achieve fuzzy identification and H ∞ tracking control. It is proved that the closed-loop system obtains H ∞ tracking performance in the sense that both tracking and modeling errors converge to small neighborhoods of zero. Simulated applications of aircraft wing rock suppression and inverted pendulum tracking demonstrate that the proposed approach not only effectively solves the aforementioned approximation problem, but also obviously outperforms previous approaches. © 2012 Elsevier B.V.


Zhou Y.,Jiangsu University | Meng X.,New York Medical College | Zhang S.,New York Medical College | Lee E.Y.C.,New York Medical College | Lee M.Y.W.T.,New York Medical College
PLoS ONE | Year: 2012

Mammalian DNA polymerase δ (Pol δ), a four-subunit enzyme, plays a crucial and versatile role in DNA replication and DNA repair processes. We have reconstituted human Pol δ complexes in insect cells infected with a single baculovirus into which one or more subunits were assembled. This system allowed for the efficient expression of the tetrameric Pol δ holoenzyme, the p125/p50 core dimer, the core+p68 trimer and the core+p12 trimer, as well as the p125 catalytic subunit. These were isolated in milligram amounts with reproducible purity and specific activities by a highly standardized protocol. We have systematically compared their activities in order to gain insights into the roles of the p12 and p68 subunits, as well as their responses to PCNA. The relative specific activities (apparent kcat) of the Pol δ holoenzyme, core+p68, core+p12 and p125/p50 core were 100, 109, 40, and 29. The corresponding apparent Kd's for PCNA were 7.1, 8.7, 9.3 and 73 nM. Our results support the hypothesis that Pol δ interacts with PCNA through multiple interactions, and that there may be a redundancy in binding interactions that may permit Pol δ to adopt flexible configurations with PCNA. The abilities of the Pol δ complexes to fully extend singly primed M13 DNA were examined. All the subassemblies except the core+p68 were defective in their abilities to completely extend the primer, showing that the p68 subunit has an important function in synthesis of long stretches of DNA in this assay. The core+p68 trimer could be reconstituted by addition of p12. © 2012 Zhou et al.


Zhan L.P.,Jiangsu University
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Year: 2011

To investigate the effect of Ad-ING4 on proliferation and migration of glioma cells and explore its probable mechanism. U251 were infected with Ad-ING4. ING4 gene expression was evaluated by RT-PCR. MTT assay was adopted to evaluate the effect of ING4 on proliferation of U251; Boyden chamber assay was used to check the effect of ING4 on the migration of U251. In ING4 transfected U251, Western blot was used for detecting NGF and TrkA expression; Pull-down assay was used for detecting active RhoA expression. ING4 was overexpressed in Ad-ING4 transfected U251 cells. ING4 inhibited proliferation and migration of U251 significantly. Moreover, overexpression of ING4 result in depression of NGF, TrkA and active RhoA. ING4 mediated inhibition of the proliferation and migration of human glioma cells by down regulating NGF, TrkA and active RhoA expression.


The aim of this work is to make a bibliometric analysis of anticancer research literature based on the data from the Web of Science. Anticancer drug research references published from 2000 to 2014 were used. Citespace software was employed to generate the knowledge maps of country/institution, cited authors, cited journals, co-words and cited references related with anticancer drug research. Results of this analysis indicated that the USA is the most productive country and the Chinese Acad. Sci. is the most productive institution in this field. Maeda H is the most influential author, leading the highest citation author group. “CANCER RES” is the most cited journal in which the most influential anticancer drug research articles were published. Mosmann’s (1983) paper is a representative and symbolic reference with the highest co-citation of number of 146 (centrality 0.29). The five hot anticancer drug research topics were also disclosed; they are: (1) chemotherapy drugs, (2) drug delivery, (3) bioscreening, (4) drug resistance research, and (5) enzyme inhibitor studies. Research frontiers identified included drug delivery with nanoparticles, controlled release, metabolism and so on. These analyses will be valuable for the reader to grasp an overall picture of anticancer research and research trends during these years. © 2015 Akadémiai Kiadó, Budapest, Hungary


Zhu X.L.,Jiangsu University
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2011

This study was purposed to explore the mechanisms of preventive effect of tetrandrine (TTD) on doxorubicin (ADM)-induced multidrug resistance (MDR) in human leukemia cell line K562 from two aspects of the transcription control of MDR1 gene and cell apoptosis. The experiment was divided into 3 groups: group I-blank control; group II-ADM-induced drug-resistance; group III-ADM-induced drug-resistance after pretreatment with TTD. Reverse transcription-PCR (RT-PCR) was used to detect the mRNA expression levels of c-Jun, YB-1 and Survivin genes. Western blot was used to determine the nuclear protein expression levels of c-Jun and YB-1. Flow cytometry was used to assay the apoptosis of cells. The results showed that as compared with group I, the expression levels of c-Jun mRNA and nuclear protein decreased (p < 0.05), as well as the expression levels of YB-1 mRNA and nuclear protein increased in group II (p < 0.05). However, the expression of Survivin mRNA had no change (p > 0.05); the apoptosis rate of cells was 8.31%. As compared with group II, the expression levels of c-Jun mRNA and nuclear protein increased (p < 0.05), expression levels of YB-1 mRNA and nuclear protein as well as Survivin mRNA decreased in group III (p < 0.05). The apoptosis of cells was 97.2%. It is concluded that TTD can inhibit the expression of YB-1 and up-regulate the expression of c-Jun, thus inhibit the expression of MDR1 gene. TTD can also inhibit the expression of Survivin and increase the apoptosis of cells induced by ADM.


Pan T.H.,Jiangsu University
Zhonghua wai ke za zhi [Chinese journal of surgery] | Year: 2011

To investigate the function and possible mechanisms of PIAS3 expression on the invasion of TJ905 cells. PIAS3 overexpression vectors were constructed and PIAS3 siRNA were chemically synthesized, which were separately transfected into TJ905 cells for upregulation or downregulation of PIAS3 expression levels in TJ905 cells. After that, the invasive effects of TJ905 cells were measured by Transwell assay, and the expression of PIAS3, tissue inhibitor of metalloproteinases (TIMP)3, matrix metalloprotease (MMP)-2, and MMP-9 were identified by Western blot. In vitro transfection efficiency of plasmids and oligonucleotides were separately 85.3% ± 3.1% and 95.1% ± 2.9%. PIAS3 overexpression plasmid transfection in vitro could effectively improve the expression of PIAS3 protein in TJ905 cells and inhibit the invasion of TJ905 cells (P < 0.05), and cell penetration ratio reduced from 87.9% ± 9.3% to 37.3% ± 7.9% compared with control group, while it upregulated TIMP3 and downregulated MMP-2, MMP-9 protein expression (P < 0.05); PIAS3 siRNA transfection could inhibit the PIAS3 protein expression of TJ905 cells and promote the invasion of TJ905 cells (P < 0.05), and cell penetration ratio increased from 83.9% ± 7.1% to 93.2% ± 3.1% compared with control group, while it downregulated TIMP3 and upregulated MMP-2, MMP-9 protein expression (P < 0.05). PIAS3 expression is closely related to the invasion properties of glioma TJ905 cells.


Wang S.-M.,Jiangsu University
Synthetic Communications | Year: 2015

A facile, economical, and practical method for the preparation of (S)-3-(4-fluorophenyl)morpholin-2-one [(S)-9] has been developed from ethyl 2-(4-fluorophenyl)-2-oxoacetate (7) in three steps through cyclization, hydrogenation, and resolution, providing a new and convenient access to the key intermediate of antiemetic drug aprepitant. © 2015 Taylor & Francis Group, LLC.


The large deflection problem of a bending circular plate is reduced to a nonlinear ordinary differential equation, and a type of pseudo-linearization is used to obtain the final solution. An innovative iteration technique is suggested. The initial iteration values of some functions for a given loading are adopted from the previous solution for a lower loading. This will significantly extend the range of solution for the non-dimensional loading. Previously, the solution for the non-dimensional loading Q = 100 was obtained. However, in this paper the solution for the non-dimensional loading Q = 1000 is achieved. © 2012 Elsevier Ltd. All rights reserved.


Chen Y.Z.,Jiangsu University
International Journal of Solids and Structures | Year: 2012

This paper studies the boundary value problem for a finite plate containing two dissimilar inclusions. The matrix and the two inclusions have different elastic properties. The loadings applied along the outer boundary are in equilibrium. The mentioned problem is decomposed into three boundary value problems (BVPs). Two of them are interior BVP for the elastic inclusions, while the other is a BVP for the triply-connected region. Three problems are connected together through the common displacements and tractions along the interface boundaries. Explicit form for the complex variable boundary integral equation (CVBIE) is derived. After discretization of relevant BIEs, the solutions are evaluated numerically. Three numerical examples for different elastic constant combinations are provided. © 2012 Elsevier Ltd. All rights reserved.


Ji X.,Jiangsu University | Ji X.,University of Newcastle | Su H.,Zhejiang University
Automatica | Year: 2015

Jensen's inequality and extended Jensen's inequality are two important integral inequalities when problems of stability analysis and controller synthesis for time-delay systems are considered. The extended Jensen's inequality introduces two additional free matrices and is generally regarded to be less conservative than Jensen's inequality. The equivalence between Jensen's inequality and extended Jensen's inequality in bounding the quadratic term -hâ«t-htẋT(s)Zẋ(s)ds in Lyapunov functional of time-delay systems is presented and theoretically proved. It is shown that the extended Jensen's inequality does not decrease the lower bound of this quadratic term obtained using Jensen's inequality, and then it does not reduce the conservativeness though two additional free matrices M1 and M2 are involved. © 2014 Elsevier Ltd. All rights reserved.


Dai J.,Jiangsu University | Mai F.,University of Hong Kong
Signal Processing | Year: 2012

This paper presents a novel algorithm for the initial configuration to the model selection problem in the two-class support vector machine (SVM) classification when fitting the entire path of SVM solutions for every value of the regularization parameter. Instead of using quadratic programming for initialization in the conventional two-class SVM regularization path fitting methods, we propose a piecewise linear method which reduces the computational cost significantly. Furthermore, an efficient treatment is provided to deal with the singular case where the data set contains linearly dependent points, duplicate points or nearly duplicate points. The performance of the proposed algorithm in terms of computational complexity and the ability to handle singular cases are backed by strict mathematical analysis and proof, and verified by the experimental results. © 2011 Elsevier B.V. All rights reserved.


You Q.,Huaiyin Institute of Technology | You Q.,Jiangsu Key Laboratory for Biomass based Energy and Enzyme Technology | Yin X.,Huaiyin Institute of Technology | Yin X.,Jiangsu University | Zhao Y.,Huaiyin Institute of Technology
Carbohydrate Polymers | Year: 2013

Process of enzyme assisted extraction (EAE) of polysaccharides from Cornus officinalis was optimized by response surface methodology (RSM). The influence of four different factors on the yield of C. officinalis polysaccharides (COP) was studied. Results showed that the optimal conditions were compound enzyme amount of 2.15%, extraction pH of 4.2, extraction temperature of 55 °C and extraction time of 97 min. Under these conditions, the COP yield was 9.29 ± 0.31%, which was well in agreement with the value predicted by the model. The three methods, EAE, hot water extraction (HWE), ultrasound-assisted extraction (UAE) for extracting COP by RSM were further compared. Results showed that EAE had the largest yield of polysaccharides with lower equipment cost. © 2013 Elsevier Ltd. All rights reserved.


Ma J.-Q.,University of Sichuan | Ding J.,University of Sichuan | Xiao Z.-H.,University of Sichuan | Liu C.-M.,Jiangsu University
International Immunopharmacology | Year: 2014

Ursolic acid (UA), a common pentacyclic triterpenoid compound, has been reported to have many benefits and medicinal properties. However, its protective effects against carbon tetrachloride (CCl4) induced injury in kidneys are not yet clear. In the current report, we investigated whether UA inhibited the oxidative stress and inflammation in the kidneys of CCl 4 treated mice. Male ICR mice were injected with CCl4 with or without UA co-administration (25 and 50 mg/kg intragastrically once daily) for six weeks. Our data showed that UA significantly prevented CCl 4-induced nephrotoxicity in a dose-dependent manner, indicated by both diagnostic indicators of kidney damage and histopathological analysis. Moreover, CCl4-induced profound elevation of ROS and oxidative stress, as evidenced by the increase of lipid peroxidation level and the depletion of the total antioxidant capacity (TAC) level in the kidney, was suppressed by treatment with UA. UA also decreased 8-hydroxy-2-deoxyguanosine (one product of oxidative DNA damage) levels. Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney. In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys. In conclusion, these results suggested that the inhibition of CCl4-induced inflammation by UA is due at least in part to its anti-oxidant activity and its ability to modulate the STAT3 and NF-κB signaling pathways. © 2014 Elsevier B.V.


Wu L.,Tsinghua University | Zhu J.,Jiangsu University | Xie H.,Tsinghua University
Journal of Thermal Spray Technology | Year: 2014

Thermal barrier coating (TBC) system is widely used in modern gas turbines to protect the internals and enable them to service in higher temperature environment. Residual stress in the TBC system can be induced during its production procedure, such as air plasma spraying (APS) process, and affect its performance to a large extent. The temperature history and the evolution of residual stress in the TBC system during APS process were studied in this paper by finite element simulation and hole-drilling experiment. A five-layered TBC specimen model was established, and a thermo-mechanical-coupled analysis was conducted in the simulation. The "modified element birth-death technique" was used to represent the formation of TBC. In addition, experimental validation of the simulation result was carried out on a TBC specimen using hole-drilling technique combined with moiré interferometry. The experimental data agreed well with the simulation results and the study of this paper could provide a reference for the production of the TBC system. © 2014 ASM International.


Chen Y.Z.,Jiangsu University
Smart Structures and Systems | Year: 2015

This paper provides a novel solution for thick-walled cylinders made of functionally graded materials (FGMs). In the formulation, the cylinder is divided into N layers. On the individual layer, the Young's modulus is assumed to be a constant. For an individual layer, two undetermined constants are involved in the elastic solution. Those undetermined coefficients can be evaluated from the continuation condition along interfaces of layers and the boundary conditions at the inner surface and outer surface of cylinder. Finally, the solution for thick-walled cylinders made of functionally graded materials is obtainable. This paper provides several numerical examples which are useful for engineer to design a cylinder made of FGMs. Copyright © 2015 Techno-Press, Ltd.


Errea I.,Donostia International Physics Center | Errea I.,Ikerbasque | Calandra M.,French National Center for Scientific Research | Pickard C.J.,University College London | And 7 more authors.
Physical Review Letters | Year: 2015

We use first-principles calculations to study structural, vibrational, and superconducting properties of H2S at pressures P≥200GPa. The inclusion of zero-point energy leads to two different possible dissociations of H2S, namely 3H2S→2H3S+S and 5H2S→3H3S+HS2, where both H3S and HS2 are metallic. For H3S, we perform nonperturbative calculations of anharmonic effects within the self-consistent harmonic approximation and show that the harmonic approximation strongly overestimates the electron-phonon interaction (λ≈2.64 at 200 GPa) and Tc. Anharmonicity hardens HS bond-stretching modes and softens HS bond-bending modes. As a result, the electron-phonon coupling is suppressed by 30% (λ≈1.84 at 200 GPa). Moreover, while at the harmonic level Tc decreases with increasing pressure, the inclusion of anharmonicity leads to a Tc that is almost independent of pressure. High-pressure hydrogen sulfide is a strongly anharmonic superconductor. © 2015 American Physical Society.


Zou D.,Jiangsu University | Wu J.,Northeastern University China | Gao L.,Northeastern University China | Li S.,University of South Australia
Neurocomputing | Year: 2013

A modified differential evolution algorithm (MDE) is proposed to solve unconstrained optimization problems in this paper. Gauss distribution and uniform distribution have one thing in common, that is randomness or indeterminateness. Due to this characteristic, MDE employs both distributions to adjust scale factor and crossover rate, which is useful to increase the diversity of the entire population. To guarantee the quality of the swarm, MDE uses an external archive, and some solutions of high quality in this external archive can be selected for candidate solutions. MDE adopts two common mutation strategies to produce new solutions, and the information of global best solution is more likely to be utilized for the mutation during late evolution process, which is beneficial to improving the convergence of the proposed algorithm. In addition, a central solution is generated in terms of all the other candidate solutions, and it can provide a potential searing direction. Experimental results show that MDE algorithm can yield better objective function values than the other six DE algorithms for some unconstrained optimization problems, thus it is an efficient alternative on solving unconstrained optimization problems. © 2013 Elsevier B.V.


Chen Y.,Jiangsu University
Proceedings - 2010 3rd International Congress on Image and Signal Processing, CISP 2010 | Year: 2010

To recover the lost information of the image, an Lattice-Boltzmann method based image inpainting algorithm was proposed in this paper. The examination results show that the our method can recover the apple image effectively, and has higher PNSR than the algorithm based on the curvature-driven diffusions(CDD). More over, the parallism of the LBMII can be used to build the high speed parallel image processing system. ©2010 IEEE.


Ma J.-Q.,University of Sichuan | Ding J.,University of Sichuan | Zhang L.,University of Sichuan | Liu C.-M.,Jiangsu University
Food and Chemical Toxicology | Year: 2014

Sesamin (Ses), one of the major lignan derived from sesame seeds, has been reported to have many benefits and medicinal properties. However, its protective effects against carbon tetrachloride (CCl4) induced injury in liver have not been clarified. The aim of the present study was to investigate the hepatoprotective effects of sesamin on oxidative stress and apoptosis in mice exposed to CCl4. Our data showed that sesamin significantly prevented CCl4-induced hepatotoxicity in a dose-dependent manner, indicated by both diagnostic indicators of liver damage (serum aminotransferase activities) and histopathological analysis. Moreover, CCl4-induced profound elevation of reactive oxygen species (ROS) production and oxidative stress, as evidenced by increasing of lipid peroxidation level and depleting of the total antioxidant capacity (TAC) in liver, were suppressed by treatment with sesamin. Furthermore, TUNEL assay showed that CCl4-induced apoptosis in mouse liver was significantly inhibited by sesamin. In exploring the underlying mechanisms of sesamin action, we found that activities of caspase-3 were markedly inhibited by the treatment of sesamin in the liver of CCl4 treated mice. Sesamin increased expression levels of phosphorylated Jun N-terminal kinases (JNK) in liver, which in turn inactivated pro-apoptotic signaling events restoring the balance between mitochondrial pro- and anti-apoptotic Bcl-2 proteins and decreasing the release of mitochondrial cytochrome c in liver of CCl4 treated mice. JNK was also involved in the mitochondrial extrinsic apoptotic pathways of sesamin effects against CCl4 induced liver injury by regulating the expression levels of phosphorylated c-Jun proteins, necrosis factor-alpha (TNF-α) and Bak. In conclusion, these results suggested that the inhibition of CCl4-induced apoptosis by sesamin is due at least in part to its anti-oxidant activity and its ability to modulate the JNK signaling pathway. © 2013 Elsevier Ltd.


Based on a complex variable boundary integral equation (CVBIE) suggested previously, this paper provides a numerical solution for the elastic inclusion problem using CVBIE. A dissimilar elastic inclusion is embedded in the infinite matrix. The original problem is decomposed into two problems. One is an interior boundary value problem (BVP) for the elastic inclusion, while the other is an exterior BVP for the matrix with notch. Both problems are connected by conventional boundary integral equations (BIEs) in complex variables. After performing discretization for the coupled BIEs, the inverse matrix technique is suggested to solve the relevant algebraic equations. Based on the properties of some integral operators, three ways for the inverse matrix technique are suggested. Several numerical examples are carried out to prove the efficiency of the suggested method. © 2011 Springer-Verlag.


Li J.,University of Texas at San Antonio | Qian C.,University of Texas at San Antonio | Ding S.,Jiangsu University
International Journal of Control | Year: 2010

This article considers the problem of global finite-time stabilisation by output feedback for a class of nonlinear systems comprised of a chain of power integrators perturbed by an uncertain vector field. To solve the problem, we first construct a homogeneous observer and controller in a recursive way for the nominal system without the perturbing nonlinearities. Then, using the homogeneous domination approach, we scale the homogeneous observer and controller with an appropriate choice of gain to render the uncertain nonlinear system globally finite-time stable. Due to the use of a reduced-order observer, the proposed output feedback controller is applicable to those systems with unknown gains associated with the power integrators. © 2010 Taylor & Francis.


Chen Y.Z.,Jiangsu University
Engineering Fracture Mechanics | Year: 2016

This paper provides a solution for a crack embedded in the thermal dissimilar elliptic inclusion. The whole medium is composed of a cracked inclusion and an infinite matrix. The inclusion and the matrix have different elastic properties and temperature distribution. The embedded crack is replaced by a very slender elliptic contour. The complex variable and the conformal mapping are used in the paper. From the evaluated stress concentration factor at the crown point, we can get the stress intensity factor at the crack tip from an existing equation. © 2016 Elsevier Ltd.


Yang H.,China University of Mining and Technology | Qin Y.,China University of Mining and Technology | Feng G.,Jiangsu University | Ci H.,China University of Mining and Technology
IEEE Sensors Journal | Year: 2013

A remote online carbon dioxide (CO2) concentration monitoring system is developed, based on the technologies of wireless sensor networks, in allusion to the gas leakage monitoring requirement for CO2 capture and storage. The remote online CO2 monitoring system consists of monitoring equipment, a data center server, and the clients. The monitoring equipment is composed of a central processing unit (CPU), air environment sensors array, global positioning system (GPS) receiver module, secure digital memory card (SD) storage module, liquid crystal display (LCD) module, and general packet radio service (GPRS) wireless transmission module. The sensors array of CO2, temperature, humidity, and light intensity are used to collect data and the GPS receiver module is adopted to collect location and time information. The CPU automatically stores the collected data in the SD card data storage module and displays them on the LCD display module in real-time. Afterwards, the GPRS module continuously wirelessly transmits the collected information to the data center server. The online monitoring WebGIS clients are developed using a PHP programming language, which runs on the Apache web server. MySQL is utilized as the database because of its speed and reliability, and the stunning cross-browser web maps are created, optimized, and deployed with the OpenLayers JavaScript web-mapping library. Finally, an experiment executed in Xuzhou city, Jiangsu province, China is introduced to demonstrate the implementation and application. © 2001-2012 IEEE.


Zhang Y.,Jiangsu University
Wei sheng yan jiu = Journal of hygiene research | Year: 2010

To explore time-course effect and region-specificity of endoplasmic reticulum stress in rat brain acutely exposed by methylmercury (MeHg). Forty-two SD rats were randomly divided into seven groups, and the rats intraperitoneally injected at the dose of 4 mg/kg bw. MeHg were decapitated at the times of 0.5, 1, 3, 6, 12 and 24 h, then rats in control group intraperitoneally injected by the corresponding volume of normal saline were decapitated. The cerebellum, cerebral cortex, brain stem, hippocampus and striatum were dissected out and weighted on ice at once. The expressions of Grp78 protein which is a marker of endoplasmic reticulum stress, were determined by Western blotting analysis. The contents of reduced glutathione (GSH) of cerebral cortex were also determined. After exposure to MeHg, the tendencies of expression of Grp78 were consistent in various brain regions. It began to increase at the time of 0.5 h and the peak levels reached at the times of 6 h or 12 h, then it began to decline. All expression levels returned nearly to the control levels at the time of 24h. The alternations of Grp78 protein in cerebral cortex and brain stem were statistically significant in comparison with those of control groups at the time of 0h among brain regions. Increases of Grp78 protein in cerebral cortex reached peak levels at the time of 6h after MeHg exposure, and the expressions of Grp78 protein corresponded to 150% of control levels. Increases of Grp78 protein in brain stem reached peak levels at the time of 12 h after MeHg exposure, and the expressions of Grp78 protein corresponded to 140% of control levels. Further, the contents of GSH in cerebral cortex showed the tendencies of first decreases and then gradually showed increases. These changes were inversely correlated to the change of Grp78 protein in cerebral cortex (r = -0.77). Rats acutely exposed with MeHg could show endoplasmic reticulum stress in a time dependent and region-specific pattern, and this alteration could be associated with oxidative stress in cerebral cortex.


Zhang C.,Jiangsu University | Zhang C.,CAS Shanghai Institute of Optics and fine Mechanics | Liu C.,CAS Shanghai Institute of Optics and fine Mechanics | Xu Z.,CAS Shanghai Institute of Optics and fine Mechanics
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2013

The propagation of a spatially inhomogeneous few-cycle laser field, linked to surface plasmon polaritons, through an ensemble of quantum wells is investigated under two conditions. It is found that the transmitted spectra sensitively depend on the spatial inhomogeneity due to the nonlinear propagation effects. Under the small-frequency mismatch condition, the transmitted spectral distribution is continuous for the spatially homogeneous case. However, when spatial inhomogeneity is introduced, the distribution is discrete instead, with clearly even- and odd-order harmonic peaks coexisting, which is related to the strong-field reshaping effect and the inversion symmetry breaking due to the introduction of the spatially inhomogeneous field. As for the large-frequency mismatch condition, only odd-order harmonics exist, no matter how strong the spatial inhomogeneity is. Under both conditions, the propagation effect can obviously enhance the intensity of higher spectral components. © 2013 American Physical Society.


Shan W.,Jiangsu University
Metallurgical and Mining Industry | Year: 2015

In order to review the effect on the art teaching supervision aided by computer, the comprehensive evaluation on the art teaching supervision and research results of the art teaching supervisor is required in the university. A full range system for art teaching supervision performance assessment that is a novel quantized method is researched in this paper. Furthermore, the comprehensive evaluation processing and evaluation model are accomplished. The application results for art teaching supervision performance review assessment which is developed as a computer management system demonstrated its high operability and achieved accurate can be convenient for the same requirements. © Metallurgical and Mining Industry.


Tian F.,University of Shanghai for Science and Technology | Huang Z.P.,Jiangsu University | Whitmore L.,Christian Doppler Laboratory
Physical Chemistry Chemical Physics | Year: 2012

Poly- and single-crystalline Ni nanowire arrays showing ultrahigh axial squareness are fabricated by direct-current electrodeposition in pores of anodic aluminum oxide templates. High voltage is shown to be the key in order for Ni nanowires to have a (220) preferred orientation. 2-Dimensional nucleation theory is used to understand the growth of the nanowires. Based on the structure and growth analyses, the magnetic properties of different kinds of nanowires are explained. This journal is © the Owner Societies 2012.


Chen M.-Y.,Jiangsu University | Zhou J.,Ningbo University
Optics Express | Year: 2014

A multi-core fiber coupler is proposed to extract one of the modes in a few-mode optical fiber from a light beam, leaving the other modes undisturbed, and allowing a new signal to be retransmitted on that mode. Selective coupling of higher-order modes from a few-mode optical fiber can be realized by increasing the coupling length difference of the modes in the fiber using the multi-core configuration. Low cross-talk and wide bandwidth operation are realized owing to the fact that only one mode can be effectively coupled. © 2014 Optical Society of America.


Jiang Y.,Jiangsu University
Fiber and Integrated Optics | Year: 2011

Through the modified transfer matrix method, the transmission properties of a one-dimensional coupled-resonator optical waveguide structure composed of metal layers and non-linear material layers is studied. Given proper incident frequency and structure parameters, an optical tri-stability has been achieved. The effect of loss has been considered. Copyright © Taylor & Francis Group, LLC.


Lin Y.-L.,Jiangsu University | Xie P.-G.,Sun Yat Sen University | Ma J.-G.,Hebei Medical University
Medical Science Monitor | Year: 2014

Background: CDH13 is a novel tumor suppressor gene often inactivated by aberrant promoter methylation in human cancers. Previous studies have shown that CDH13 methylation correlated with advanced disease and poor prognosis in non-muscle invasive bladder cancer (NMIBC). The aim of the current study was to investigate the correlations between CDH13 methylation and disease recurrence as well as progression of NMIBC.Material/Methods: The methylation status of CDH13 in 178 NMIBC samples and 38 normal bladder epithelial tissues was examined by methylation-specific PCR (MSP), and then correlated with clinicopathological features.Results: We found that CDH13 methylation occurs frequently in NMIBC, and significantly correlates with high grade, advanced stage, larger tumor size, and tumor recurrence and progression. Moreover, patients with methylated CDH13 exhibited significantly shorter recurrence-free survival (P<0.0001) and progression-free survival (P=0.0060) than patients with unmethylated CDH13. In addition, a multivariate Cox proportional hazard model analysis suggests that CDH13 methylation is an independent predictor for the recurrence (P=0.0043) and progression (P=0.0016) of NMIBC after initial transurethral resection.Conclusions: Our findings demonstrate that CDH13 methylation is a frequent event in NMIBC, and is associated with unfavorable tumor features. It should be used as an independent predictor for the recurrence and progression of NMIBC, and may be useful for the design of individualized therapeutic modalities. © Med Sci Monit, 2014.


Stephenson J.D.,University of Cambridge | Stephenson J.D.,University of Hawaii at Manoa | Li H.,University of Cambridge | Li H.,Jiangsu University | And 4 more authors.
Structure | Year: 2013

HIV-1 genomic RNA has a noncoding 5′ region containing sequential conserved structural motifs that control many parts of the life cycle. Very limited data exist on their three-dimensional (3D) conformation and, hence, how they work structurally. To assemble a working model, we experimentally reassessed secondary structure elements of a 240-nt region and used single-molecule distances, derived from fluorescence resonance energy transfer, between defined locations in these elements as restraints to drive folding of the secondary structure into a 3D model with an estimated resolution below 10 Å. The folded 3D model satisfying the data is consensual with short nuclear-magnetic-resonance-solved regions and reveals previously unpredicted motifs, offering insight into earlier functional assays. It is a 3D representation of this entire region, with implications for RNA dimerization and protein binding during regulatory steps. The structural information of this highly conserved region of the virus has the potential to reveal promising therapeutic targets. © 2013 Elsevier Ltd. All rights reserved.


Yang T.-H.,University of Aveiro | Yang T.-H.,Jiangsu University | Silva A.R.,University of Aveiro | Shi F.-N.,University of Aveiro
Dalton Transactions | Year: 2013

Reactions of lanthanide chlorides, copper hydroxycarbonate and 3,5-pyrazole dicarboxylic acid (H3pdc) under hydrothermal conditions result in six new 3d-4f heterometallic coordination polymers with two types of structures. Compounds [CuLn2(pdc)2(Hpdc)(H2O) 4]·2H2O (Ln = Tb (1), Dy (2), Er (3), and Y (4) exhibit a layered porous structure, made up of CuIILnIII di-nuclear units which are connected by protonated Hpdc2- ligand, while the others [Cu3Ln4(pdc)6(H 2O)8] (Ln = Eu (5), Gd (6)) display a three-dimensional (3-D) framework structure, in which six CuIILnIII di-nuclear units are cross-linked by two coordinated lanthanide atoms. The catalytic properties of 3 are investigated showing its activity and recyclability in the reaction of cyclopropanation of styrene. © 2013 The Royal Society of Chemistry.


Fei W.,Jiangsu University
International Journal of Control and Automation | Year: 2015

After discussing analysis of photovoltaic (PV) cell characteristics, and the study of existing PV system maximum power point tracking (MPPT) methods, a MPPT technology based on combination of incremental conductance (INC) and fuzzy control (FC) is proposed to improve the tracking behavior of the single method. The algorithm based on MATLAB 7.6 is developed. The simulation results show that combination algorithm can make the photovoltaic generation system quickly and accurately track the maximum power point (MPP), and its fast response and steady-state performance achieve expectation. Finally, the correctness and effectiveness of the algorithm is verified via power generation statistical data of PV system experimental platform. © 2015 SERSC.


Li X.,Suqian College | Wang S.,Jiangsu University
Xiyou Jinshu/Chinese Journal of Rare Metals | Year: 2012

TiC-reinforced Ni 3Al composites were fabricated through thermal explosion reaction. The thermal explosion reaction process of Ti-C-3Ni-Al system and the composites were analyzed by differential scanning calorimetric(DSC), X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results showed that the reaction of titanium and carbon was ignited by the reaction of nickel and aluminum. Pure TiC/Ni 3Al products were synthesized by the thermal explosion. The reaction temperature of Ti-C-3Ni-Al system was independent of TiC contents. The system composition and thermal explosion temperature were found to have obvious influences on the morphology of the composites. With the increase of TiC contents, TiC particulates became coarser and the micro pores of the products decreased. The relative density of the products increased at first and then decreased with the rise of the thermal explosion temperature and TiC contents. The microhardness of the composite was revealed to be higher with higher TiC content.


Wang Y.,York College - The City University of New York | Bi Q.,Jiangsu University
Nonlinear Dynamics | Year: 2012

The bifurcation phenomena of a compound K(m,m) equation are investigated in this paper. Three singular lines have been found in the associated topological vector field, which may evolve in the phase trajectories of the system. The influence of parameters as well as the singular lines on the properties of the equilibrium points has been explored in details. Transition boundaries have been obtained to divide the parameter space into regions associated with different types of phase trajectories. The existence conditions and related discussions for different traveling wave solutions have been presented in the end. © Springer Science+Business Media B.V. 2012.


Chen Y.Z.,Jiangsu University
Engineering Analysis with Boundary Elements | Year: 2012

This paper provides a numerical solution for an infinite plate containing two dissimilar elastic inclusions, which is based on complex variable boundary integral equation (CVBIE). The original problem is decomposed into two problems. One is an interior boundary value problem (BVP) for two elastic inclusions, while other is an exterior BVP for the matrix with notches. After performing discretization for the coupled boundary integral equations (BIEs), a system of algebraic equations is formulated. The inverse matrix technique is suggested to solve the relevant algebraic equations, which can avoid using the assembling of some matrices. Several numerical examples are carried out to prove the efficiency of suggested method and the hoop stress along the interface boundary is evaluated. © 2011 Elsevier Ltd. All rights reserved.


Zhao P.,Jiangsu University | Balakrishnan N.,McMaster University
Probability in the Engineering and Informational Sciences | Year: 2012

In this paper, we carry out stochastic comparisons of largest order statistics from multiple-outlier exponential models according to the likelihood ratio order (reversed hazard rate order) and the hazard rate order (usual stochastic order). It is proved, among others, that the weak majorization order between the two hazard rate vectors is equivalent to the likelihood ratio order (reversed hazard rate order) between largest order statistics, and that the p-larger order between the two hazard rate vectors is equivalent to the hazard rate order (usual stochastic order) between largest order statistics. We also extend these results to the proportional hazard rate models. The results established here strengthen and generalize some of the results known in the literature. © Copyright Cambridge University Press 2012.


Zheng S.,Zhejiang University of Finance and Economics | Zheng S.,Jiangsu University
Mathematical Problems in Engineering | Year: 2012

This paper investigates the projective synchronization (PS) of drive-response time-varying coupling complex dynamical networks with time delay via an adaptive-impulsive controlling method, in which the weights of links are time varying. Based on the stability analysis of impulsive control system, sufficient conditions for the PS are derived, and a hybrid controller, that is, an adaptive feedback controller with impulsive control effects, is designed. Numerical simulations are performed to verify the correctness and effectiveness of theoretical result.


Zhu H.,Huaiyin Institute of Technology | Yao H.,Jiangsu University
Nonlinear Dynamics | Year: 2012

In this paper, a new three-dimensional autonomous chaotic system is presented. There are three control parameters and three different nonlinear terms in the governed equations. Basic dynamic properties of the new system are investigated via theoretical analysis and numerical simulation. The nonlinear characteristic of the new three-dimensional autonomous system versus the control parameters is illustrated by bifurcation diagram, Lyapunov-exponent spectrum, phase portraits, etc. © 2011 Springer Science+Business Media B.V.


Yan Y.,Jiangsu University
Biotechnology and applied biochemistry | Year: 2010

Tumstatin45-132 is an 88-amino-acid fragment possessing the equivalent ability of full-length tumstatin to block new tumour blood-vessel formation and suppress tumour growth. TNFalpha (tumour necrosis factor alpha), an antitumour agent, is used in clinical therapy, but is limited by its strong systemic toxicity. Combining TNFalpha with tumstatin45-132 may represent a promising alternative approach in cancer therapy. In the present study, we expressed recombinant tumstatin45-132-TNFalpha in a baculovirus expression system. We evaluated the effects of tumstatin45-132-TNFalpha on neovascularization and cell viability by a chick-embryo-chorioallantoic-membrane assay and a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. In-vivo antitumour activities were examined in tumour-bearing mice. We observed that tumstatin45-132-TNFalpha inhibited angiogenesis and tumour-cell viability in vitro. In-vivo experiments showed that intratumoural injection of tumstatin45-132-TNFalpha significantly inhibited the growth of xenograft tumours in mice. MRI analysis revealed that tumstatin45-132-TNFalpha treatment also decreased mean blood-vessel density in vivo. Tumstatin45-132-TNFalpha exerted antitumour activities by decreasing proliferation, inducing apoptosis in tumour cells and anti-angiogenesis. In conclusion, our findings suggest that tumstatin45-132-TNFalpha has significant activity against F6 tumour cells and that it may be a potential approach for cancer therapy.


Yang L.,Jiangsu University | Xu L.,Yangzhou University
Information Sciences | Year: 2013

Rough set theory is a useful mathematical tool for dealing with the uncertainty and granularity in information systems. In this paper, rough approximations are introduced into quantales, a kind of partially ordered algebraic structure with an associative binary multiplication. The notions of (upper, lower) rough (prime, semi-prime, primary) ideals of quantales are proposed and verified to be the extended notions of usual (prime, semi-prime, primary) ideals of quantales respectively. Global order properties of all lower (upper) rough ideals of a quantale are also investigated. The rough radical of an upper rough ideal in a quantale is defined and the prime radical theorem of rings is generalized to upper rough ideals of quantales. Some results about homomorphic images of rough ideals and rough prime ideals of semigroups and rings are also generalized and improved in the field of quantales. © 2012 Elsevier Inc. All rights reserved.


Chen Y.Z.,Jiangsu University
Engineering Analysis with Boundary Elements | Year: 2012

This paper provides numerical solutions of the degenerate scale for shapes of quadrilaterals with arbitrary configuration in an exterior boundary value problem of antiplane elasticity or Laplace equation. The first step is to find the parameters in the Schwarz-Christoffel mapping. The first prevertex on the unit circle can be placed in a particular position, or at -1. From the single-valued condition of the mapping function, only one prevertex is independent. The real preverteces can be found from the condition that the computed ratio of two edges is equal to a ratio of two real edges assumed beforehand. An iteration is suggested to obtain the preverteces numerically. After those parameters are obtained, the degenerate sizes of four edges can be evaluated by a numerical integration. Several numerical examples and the computed results were provided. © 2012 Elsevier Ltd. All rights reserved.


Zhai J.,Jiangsu University | Qian C.,University of Texas at San Antonio
International Journal of Robust and Nonlinear Control | Year: 2012

This paper addresses the problem of using output feedback to globally control a class of nonlinear systems whose output functions are not precisely known. First, for the nominal linear system, we design a homogeneous state compensator without requiring precise information of the output function, and construct a nonlinear stabilizer with adjustable coefficients by using the generalized adding a power integrator technique. Then based on the homogeneous domination approach, a scaling gain is introduced into the proposed output feedback controller, which can be used by tuning the scaling gain to solve: (i) the problem of global output feedback stabilization for a class of upper-triangular systems; and (ii) the problem of global practical output tracking for a class of lower-triangular systems. Copyright © 2011 John Wiley & Sons, Ltd. Copyright © 2011 John Wiley & Sons, Ltd.


Liu Y.,Jiangnan University | Sun J.,Jiangsu University | Rao S.,Yangzhou University | Su Y.,Jiangnan University | Yang Y.,Jiangnan University
Food and Chemical Toxicology | Year: 2013

It is the first time to extract polysaccharides (CVPs) from Catathelasma ventricosum. The antihyperglycemic and antioxidant activity of CVPs in streptozotocin-induced diabetic mice were examined. Compared with untreated diabetic mice, the administration of CVPs for 30days caused a significant decrease in the concentrations of blood glucose, total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C) and maleic dialdehyde (MDA), and a significant increase in the concentrations of high density lipoprotein-cholesterol (HDL-C) and the activities of antioxidant enzymes. Specially, when normal mice were treated with CVPs, all detection indexes and pathologic morphologies of liver, kidney and pancreas are similar to untreated normal mice, which indicated CVPs are safe for normal mice. In addition, the average molecular weight of CVPs was estimated to be from 3.7×103 to 1.7×107Da and they were mainly composed of glucose (93.5%) with the conformation of α-d-Glucopyranose. © 2013 Elsevier Ltd.


Ye S.,Jiangsu University
Wei sheng wu xue bao = Acta microbiologica Sinica | Year: 2010

OBJECTIVE: We identified the interaction between toxin Slr0664 and antitoxin Slr1114, encoded by ssr114/ slr0664 system in the chromosome of cyanobacteria Synechocystis sp. PCC6803. METHODS: We constructed a recombinant plasmid in which only H6-Ssr1114 was induced to express, and another plasmid in which both H6-Ssr1114 and Slr0664 was co-expressed in E. coli B121(DE3). After induction, we used affinity capture technique to purify H,-Ssr1114 and copurified H6-Ssr1114 and Slr0664 under different conditions. We confirmed the co-purified H,-Ssrl 114 and S1l0664 by using mass spectrographic analysis. RESULTS: When induced to express, Slr0664 showed cell toxicity leading to cell growth suppression or death. However, cells could grow normally if both H6-Ssr1114 and Slr0664 were induced to co-express. We could purify both H6-Ssr1114 and Slr0664 by His-Bind under native conditions, but only H4-Ssr1114 could be purified under denature conditions. The results of mass spectrometric analysis showed that the copurified proteins were H,-Ssrlll4 and Slr0664. CONCLUSION: The antitoxin Slr1114 and toxin Slr0664 in ssr1114/slr0664 TA system was interacted with each other.


Xiang J.,Jiangsu University of Science and Technology | Li J.,Jiangsu University of Science and Technology | Zhang X.,Jiangsu University of Science and Technology | Ye Q.,Jiangsu University of Science and Technology | And 2 more authors.
Journal of Materials Chemistry A | Year: 2014

Carbon nanofibers with ferromagnetic metal nanoparticles (CNF-M, M = Fe, Co, and Ni) have been synthesized by carbonizing electrospun polyacrylonitrile nanofibers including metal acetylacetonate in an argon atmosphere, and their phase composition, microstructure, magnetic properties and electromagnetic (EM)-wave absorbability have been studied. The microstructure analysis shows that the in situ formed metal nanoparticles are well distributed along carbon-based nanofibers and encapsulated by ordered graphite layers. The investigation of magnetic properties and EM-wave absorbability reveals that the as-synthesized CNF-M has typical characteristics of ferromagnetic materials and exhibits excellent EM-wave absorption properties (reflection loss exceeding -20 dB) from the C-band to the Ku-band (4-18 GHz) over an absorber thickness of 1.1-5.0 mm due to the efficient complementarities of complex permeability and permittivity resulting from the magnetic metal nanoparticles and lightweight carbon, as well as the particular particle/graphite core/shell microstructures in CNF-M. Moreover, a minimum reflection loss value of -67.5, -63.1, and -61.0 dB is achieved at 16.6, 12.9, and 13.1 GHz with a matching thickness of 1.3, 1.6, and 1.7 mm for CNF-Fe, CNF-Co, and CNF-Ni, respectively. These magnetic carbon nanofibers are attractive candidates for the new type of high performance EM-wave absorbing materials. This journal is © the Partner Organisations 2014.


In the title mixed-ligand metal-organic polymeric compound, {[Zn(C10H8O4)(C12H14N6)]·H2O} n , the asymmetric unit con-tains a divalent ZnII cation lying on a twofold axis, one half of a fully deprotonated benzene-1,4-di-acetate (PBEA) ligand, one half of a 1,4-bis-[(1H-1,2,4-triazol-1-yl)methyl]benzene (BTX) ligand and a water molecule, also lying on a twofold axis. Each ZnII centre is surrounded by two O-donor atoms from monodentate carboxyl-ate groups belonging to two different PBEA2- ligands and by two triazole N-donor atoms from two different BTX ligands. Single-crystal X-ray diffraction analysis revealed that the compound has a fivefold inter-penetrating diamondoid three-dimensional metal-organic framework. © 2014 International Union of Crystallography.


Shi W.,Jilin Normal University | Guo F.,Jilin Normal University | Chen J.,Jiangsu University | Che G.,Jilin Normal University | Lin X.,Jilin Normal University
Journal of Alloys and Compounds | Year: 2014

In this work, n-type graphite-like C3N4 (denoted as g-C3N4) was fabricated and modified with p-type Indium vanadate (InVO4) to form a novel InVO4/g-C 3N4 p-n heterojunction photocatalyst for the efficient photocatalytic degradation of rhodamine B (Rh B). The photocatalysts were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), UV-vis diffuse reflectance spectroscopy (DRS), photoluminescence (PL) and Fourier transform infrared spectroscopy (FT-IR). The photocatalytic activities were evaluated in the degradation of Rh B aqueous solution. The results showed that the as-prepared InVO4/g-C3N4 hybrid materials displayed much higher photocatalytic activity than the pure g-C 3N4 and InVO4 particles. Among them, the 30 wt% InVO4/g-C3N4 sample exhibited the highest photocatalytic activity. The visible-light photocatalytic activity enhancement of InVO4/g-C3N4 heterojunction photocatalyst could be attributed to its strong absorption in the visible region and low recombination rate of the electron-hole pairs. It was further found that the photodegradation of Rh B molecules is mainly attributed to the oxidation action of the generated O2- radicals and partly to the oxidation process of OH radicals. © 2014 Elsevier B.V. All rights reserved.


Yan J.-K.,Hong Kong Polytechnic University | Yan J.-K.,Jiangsu University | Wang W.-Q.,Hong Kong Polytechnic University | Wu J.-Y.,Hong Kong Polytechnic University
Journal of Functional Foods | Year: 2014

Cordyceps (Ophiocordyceps sinensis) sinensis, the Chinese caterpillar fungus, is a unique and precious medicinal fungus in traditional Chinese medicine which has been used as a prestigious tonic and therapeutic herb in China for centuries. Polysaccharides are bioactive constituents of C. sinensis, exhibiting several activities such as immunomodulation, antitumour, antioxidant and hypoglycaemic. As natural C. sinensis fruiting body-caterpillar complexes are very rare and expensive, the polysaccharides documented over the last 15-20. years from this fungal species were mostly extracted from cultivated fungal mycelia (intracellular polysaccharides) or from mycelial fermentation broth (exopolysaccharides). Extraction and purification of the polysaccharides is a tedious process involving numerous steps of liquid and solid phase separations. Nevertheless, a large number of polysaccharide structures have been purified and elucidated. However, relationships between the structures and activities of these polysaccharides are not well established. This review provides a comprehensive summary of the most recent developments in various aspects (i.e., production, extraction, structure, and bioactivity) of the intracellular and exopolysaccharides from mycelial fermentation of C. sinensis fungi. The contents and data will serve as useful references for further investigation, production and application of these polysaccharides in functional foods and therapeutic agents. © 2014.


Peng R.,Jiangsu University | Peng R.,University of Minnesota | Yi F.,Harbin Engineering University
Physica D: Nonlinear Phenomena | Year: 2013

Identifying the epidemic risk for infectious disease is crucial in order to effectively perform control measures. In a series of our work, from an analytical aspect we study the effects of epidemic risk and population movement on the spatiotemporal transmission of infectious disease via an SIS epidemic reaction-diffusion model proposed by Allen et al. (2008) in [36]. In Allen et al. (2008) [36], Peng (2009) [37], it was assumed that the habitat of the populations consists of only the low and high risk areas. The present paper concerns a more complicated heterogeneous environment where the moderate risk area occurs, and deals with two cases: (i) only the moderate and high risk areas exist; (ii) the low, moderate and high risk areas coexist. In each case, we rigorously determine the asymptotic profile of the positive steady state (i.e., the endemic equilibrium) as the migration rate of either the susceptible or infected population tends to zero. Our results show how epidemic risk and population movement affect the spatial distribution of infectious disease and thereby suggest important implications for predicting the patterns of disease occurrence and designing optimal control strategies. Numerical simulations are carried out to support the theoretical results. © 2013 Elsevier B.V. All rights reserved.


One of the recent breakthroughs in cancer research is the identification of activating mutations in various receptor tyrosine kinase(RTK) pathways in many cancers including colorectal cancer(CRC). We hypothesize that, alternative to mutations, overexpression of various oncogenic RTKs may also underpin CRC pathogenesis, and different RTK may couple with distinct downstream signaling pathways in different subtypes of human CRC. By immunohistochemistry, we show here that RTK members ErbB2, ErbB3 and c-Met were in deed differentially overexpressed in colorectal cancer patient samples leading to constitutive activation of RTK signaling pathways. Using ErbB2 specific inhibitor Lapatinib and c-Met specific inhibitor PHA-665752, we further demonstrated that this constitutive activation of RTK signaling is necessary for the survival of colorectal cancer cells. Furthermore, we show that RTK overexpression pattern dictates the use of downstream AKT and/or MAPK pathways. Our data are important additions to current oncogenic mutation models, and further explain the clinical variation in therapeutic responses of colorectal cancer. Our findings advocate for more personalized therapy tailored to individual patients based on their type of RTK expression in addition to their mutation status.


Lin Y.-L.,Jiangsu University | Xie P.-G.,Sun Yat Sen University | Wang L.,Hebei University of Engineering | Ma J.-G.,Hebei Medical University
Medical Science Monitor | Year: 2014

Background: Aberrant methylation of protocadherin 17 (PCDH17) has been reported in several human cancers. However, the methylation status of PCDH17 in prostate cancer and its clinical significance remains unclear. The aim of this study was to investigate the methylation status of PCDH17 and its clinical significance in patients with prostate cancer after radical prostatectomy. Material/Methods: The methylation status of PCDH17 in 152 prostate cancer tissues and 51 non-tumoral prostate tissues was examined by methylation-specific PCR (MSP). Then the association between PCDH17 methylation and clinicopathologic parameters was analyzed. Kaplan-Meier survival analysis, log-rank test and multivariate Cox proportional hazard model analysis were used to analyze the correlation between PCDH17 methylation and prognosis of patients with prostate cancer. Results: Our data demonstrated that PCDH17 methylation occurred frequently in prostate cancer. PCDH17 methylation was significantly associated with higher pathological Gleason score (P=0.0315), advanced pathological stage (P=0.0260), higher level of preoperative PSA (P=0.0354), positive angiolymphatic invasion (P=0.0461), positive lymph node metastasis (P=0.0362), and biochemical recurrence (BCR) (P=0.0018). In addition, PCDH17 methylation was an independent predictor of poor biochemical recurrence-free (BCR-free) survival and overall survival for patients with prostate cancer. Conclusions: PCDH17 methylation is a frequent tumor-specific event in prostate cancer, and is significantly correlated with shorter BCR-free survival and overall survival of patients with prostate cancer after radical prostatectomy. PCDH17 methylation in tumor samples after radical prostatectomy may be used as an independent prognostic biomarker. © Med Sci Monit, 2014.


Yin J.P.,Jiangsu University
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Year: 2012

To investigate whether cardiac fibroblasts (CFs) treated by LPS can actively secrete high-mobility group box protein 1 (HMGB1) and to analyze the correlation between HMGB1 releasing and the accumulation of collagen type I , III . CFs were isolated from the heart of 7-14-day-old BALB/c mice and cultured in DMEM with 10% fetal bovine serum (FBS). We collected the CFs and cell supernatants after treated by LPS for 0, 6, 12, 24, 36, 48 h, respectively. The mRNA and protein expression levels of HMGB1, collagen 1a1 (col1a1) and collagen 3a1 (col3a1) in CFs after LPS stimulation were detected by RT-PCR and Western blotting, respectively. The intracellular localization of HMGB1 in treated CFs was investigated by immunofluorescence. After 0-6 h of LPS stimulation, the mRNA levels of HMGB1, col1a1, col3a1 had no significant changes; but increased obviously at 12, 24, 36, 48 h. HMGB1 was found in the cell supernatant by Western blotting after 24 h LPS stimulation, and its expression decreased following the first rise in CFs. Meanwhile, immunofluorescence showed HMGB1 translocation from nucleus to cytoplasm. The levels of col1a1 and col3a1 were up-regulated in CFs after stimulation. LPS can induce HMGB1 translocation from nucleus to cytoplasm and across cellular membrane to the outside of CFs at a time-dependent manner. Col1a1 and Col3a1, which are closely associated with myocardial fibrosis, were obviously up-regulated by LPS stimulation, which indicates that actively released HMGB1 might contribute to myocardial fibrosis following the endotoxin induced-sepsis.


Hu Q.,Jiangsu University
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica | Year: 2012

To study the effect of dragon's blood powder with different grain size on the transdermal permeability and adhesion of ZJHX paste. Dragon's blood powder with grain sizes of 4, 19, 55 microm were got by ultrafine grinding technology, and then prepared into rubber pastes A, B, C and D, together with dragon's blood powder with grain size of 93 microm of original description. Franz diffusion cell method was adopted to compare the difference in transdermal permeability of dragon's blood powder with different grain sizes, with dracorhodin as the index, and compared their effect on the adhesion of pastes with initial adhesion, permanent adhesion and peel strength as the indexes. Q(s)-t equations of pastes A, B, C, D were as follows: Q(s)=1.369 6t + 3.985 5, Q(s) = 1.262 8t +3.738 1, Q(s) = 1.192 3t + 3.320 6, Q(s) = 1.152 2t + 2.366 1, respectively, which showed that the adhesion of A was the best good. With the decrease in the grain size of dragon's blood powder, accumulative penetration of dracorhodin increases, which facilitates transdermal permeability and adhesion.


Zhao W.,Nanjing Southeast University | Zhao W.,Jiangsu University | Cheng M.,Nanjing Southeast University | Hua W.,Nanjing Southeast University | And 2 more authors.
IEEE Transactions on Industrial Electronics | Year: 2011

A flux-switching permanent-magnet (PM) (FSPM) machine is a new class of stator-PM brushless machines, which offers the advantages of high reliability, high power density, and high efficiency. In this paper, by employing redundant winding in the existing FSPM machine topology, a new redundant FSPM (R-FSPM) machine is proposed for a fault-tolerant operation of critical applications. The redundant winding configuration is analyzed, and the corresponding suitable control strategy for the postfault operation is proposed. The electromagnetic performance of the R-FSPM motor drive under normal and fault conditions is analyzed by using a cosimulation method coupling magnetic and electrical circuit solvers. Finally, a 12-stator-tooth/10-rotor-pole R-FSPM machine is prototyped for verification. Both simulation and experimental results are presented, verifying the fault-tolerant characteristic of the proposed motor drive. © 2010 IEEE.


Li Z.,Jiangsu University
IEEE Transactions on Industrial Electronics | Year: 2011

The hardware-circuit-realized adaptive method (HCAM) and neuron-based adaptive algorithm (NAA) are two typical adaptive detection methods for harmonic and reactive currents. HCAM and NAA have the same detection principle (adaptive noise-canceling technology and a strong adaptive ability). In this letter, the algorithm of HCAM is obtained according to its detection circuit, whereas the simplest NAA is derived from a NAA. A comparison of the algorithm of HCAM with the simplest NAA shows that they are the same. This is the consistency between HCAM and NAA. The accuracy of this consistency is validated by simulation and experimental results. © 2011 IEEE.


Cui F.L.,Jiangsu University
Zhonghua nan ke xue = National journal of andrology | Year: 2011

To study the effects of MTA1 small interfering RNA (siRNA) on the anchorage-independent growth and anoikis of prostate cancer cell line PC-3. After transfection of human prostate cancer PC-3 cells by MTA1 siRNA, we detected the expression of the MTA1 gene by real-time PCR and Western blot, the anchorage-independent growth of the cells by clone formation in soft agar, and their anoikis by DNA fragmentation assay and flow cytometry. Compared with the control group, MTA1 siRNA transfection significantly decreased the mRNA and protein levels of MTA1, inhibited the anchorage-independent growth of the PC-3 cells, and induced their anoikis, all in a dose- and time-dependent manner (r = 0.935, P = 0.001; r = 0.901, P = 0.0005; r = 0.916, P = 0.0003). MTA1 siRNA can inhibit the anchorage-independent growth of prostate cancer cells by inducing their anoikis.


An L.M.,Jiangsu University
Zhonghua nan ke xue = National journal of andrology | Year: 2011

To detect the sperm plasma membrane integrity (PMI) of varicocele (VC) patients using SYBR-14/PI fluorescent staining and flow cytometry, and investigate its clinical significance. We collected semen samples from 120 men, including 30 grade-1 varicocele patients (VC1), 30 grade-2 (VC2), 30 grade-3 (VC3), and 30 normal fertile volunteer controls. Conventional semen analyses were performed by computer-assisted semen analysis (CASA). All the semen samples were washed with PBS and then subjected to SYBR-14/PI staining for the detection of sperm PMI by flow cytometry. The proportion of normal sperm with PMI was indicated as the percentage of sperm emitting green fluorescence (SYBR-14+/PI- %), sperm PMI was determined and sperm fertilization capacity predicted. Significant differences were detected in SYBR-14+/PI- and SYBR-14-/PI+ between the normal men and varicocele male patients (P < 0.01). The percentages of the sperm with PMI (SYBR-14+/PI- %) were remarkably lower in the VC1, VC2 and VC3 groups ([54.85 +/- 3.78]%, [45.37 +/- 4.12]% and [35.14 +/- 4.91]%) than in the normal controls ([70.79 +/- 6.71]%). SYBR-14+/PI-% was correlated positively with sperm motility (r=0.965, P < 0.01) and the percentage of grade a + b sperm (r = 0.874, P < 0.01), negatively with the percentage of grade d sperm (r = -0.965, P <0.01), but not significantly with pH, semen volume and liquefaction time (P > 0.05). SYBR-14/PI fluorescent staining and flow cytometry can quickly and exactly detect sperm PMI. Varicocele decreases sperm PMI, which might be an important cause of male infertility.


Qiao X.,Jiangsu University | Seo H.J.,Pukyong National University
Journal of Alloys and Compounds | Year: 2014

This paper reports on the luminescence studies of Eu3+-doped strontium fluoroapatite. The goal of this paper is to establish and characterize the possible sites for Eu3+ substitution in Sr5(PO 4)3F lattice. Eu3+-doped Sr5(PO 4)3F phosphor was prepared by the solid state reaction method. The X-ray powder diffraction result of as-synthesized powder phosphor reveals the single phase Sr5(PO4)3F and it also indicates that the incorporation of Eu3+ ions does not affect the crystal structure. Photoluminescence (PL) studies of Eu3+-doped Sr5(PO4)3F phosphor are performed to study spectral properties of the sample. Site-selective excitation and emission spectra together with the decay curves are investigated by site-selective laser-excitation spectroscopy. The three crystallographic sites for Eu 3+ ions are identified in the 7F0 → 5D0 excitation spectra by using a pulsed, tunable, and narrowband dye laser. The luminescence due to the 5D0 → 7FJ (J = 1, 2) transitions under excitation at each crystallographic site exhibits its own spectral features. Three crystallographic sites in Sr5(PO4)3F give rise to different crystal-field splits of the 7F1 and 7F2 multiplets. Heterovalent substitution by rare-earth ions (Eu3+) for Ca2+ positions in the hexagonal crystal lattice requires charge compensation. The charge-compensation mechanism, site symmetry, and the crystal-field strength on Eu3+ in Sr 5(PO4)3F are discussed for better understanding of preferential substitution of Eu3+ in the Sr5(PO 4)3F lattice. © 2014 Elsevier B.V. All rights reserved.


Wu L.-K.,Jiangsu University | Meng X.-F.,National Supercomputer Center
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We make simulations with 2 flavor Wilson fermions to investigate the nature of the end points of Roberge-Weiss (RW) first order phase transition lines. The simulations are carried out at 9 values of the hopping parameter κ ranging from 0.155 to 0.198 on different lattice spatial volume. The Binder cumulants, susceptibilities, and reweighted distributions of the imaginary part of the Polyakov loop are employed to determine the nature of the end points of RW transition lines. The simulations show that the RW end points are of first order at the values of κ in our simulations. © 2013 American Physical Society.


Miao X.,Jiangsu University | Guo X.,Sun Yat Sen University | Xiao Z.,Sun Yat Sen University | Ling L.,Sun Yat Sen University
Biosensors and Bioelectronics | Year: 2014

Direct recognition of double-stranded DNA (dsDNA) was crucial to disease diagnosis and gene therapy, because DNA in its natural state is double stranded. Here, a novel sensor for the sequence-specific recognition of dsDNA was developed based on the structure change of ferrocene (Fc) redox probe modified molecular beacon (MB). For constructing such a sensor, gold nanoparticles (AuNPs) were initially electrochemical-deposited onto glass carbon electrode (GCE) surface to immobilize thiolated MB in their folded states with Au-S bond. Hybridization of MB with target dsDNA induced the formation of parallel triplex DNA and opened the stem-loop structure of it, which resulted in the redox probe (Fc) away from the electrode and triggered the decrease of current signals. Under optimal conditions, dsDNA detection could be realized in the range from 350. pM to 25. nM, with a detection limit of 275. pM. Moreover, the proposed method has good sequence-specificity for target dsDNA compared with single base pair mismatch and two base pairs mismatches. © 2014 Elsevier B.V.


Zhang L.,Jiangsu University | Tu K.N.,University of California at Los Angeles
Materials Science and Engineering R: Reports | Year: 2014

Composite lead-free solders, containing micro and nano particles, have been widely studied. Due to grain boundary drag or Zener drag, these particles can refrain the solder microstructure from coarsening in services, especially for Cu6Sn5, Ag3Sn intermetallic compounds and the β-Sn phases. Due to dispersion hardening or dislocation drag, the mechanical properties of the composite solder alloys were enhanced significantly. Moreover, these particles can influence the rate of interfacial reactions, and some particles can transform into a layer of intermetallic compound. Wettability, creep resistance, and hardness properties were affected by these particles. A systematic review of the development of these lead-free composite solders is given here, which hopefully may find applications in microbumps to be used in the future 3D IC technology.


Yu Y.,East China Normal University | Yu Y.,Jiangsu University | Yang Y.,East China Normal University | Gu H.,East China Normal University | And 2 more authors.
Biosensors and Bioelectronics | Year: 2013

This study presents a facile electrochemical method for simultaneous and selective on-line detection of glucose and L-lactate in the striatum of anesthetic rats through the integration of selective electrochemical detection with in vivo microdialysis system. A positively-charged polyelectrolyte, (diallyldimethylammonium chloride) (PDDA), was attached onto carbon mesoporous material (CMM) through non-covalent interaction, which provided an ideal environment for the assembling and dispersion of nanoparticle electrocatalysts. Platinum nanoparticles with wide loadings from 5 to 50. wt% were successfully self-assembled on PDDA-functionalized CMM via electrostatic interaction. TEM results showed that with the increase in the Pt loadings, both the size and interconnectivity between particles increased, with particle sizes ranging from 3.2±0.4 to 6.8±1.4. nm. Moreover, the electrocatalytic activities of the as-prepared six Pt/PDDA-CMM hybrid nanocomposites were also observed to show an inverted-V-shaped profile as a function of loading amount of Pt NPs. Integrated with glucose oxidase (GOx), L-lactate oxidase (LOD) and the in vivo microdialysis system, the constructed dual oxidase/Pt/PDDA-CMM/Nafion biosensors were successfully applied for the simultaneous and on-line detection of glucose and L-lactate. After post-calibration, the basal level of glucose and L-lactate in the striatum of anesthetic rats was calculated to be 0.27±0.03 and 0.71±0.05. mM (mean ±s.d., n=3), respectively. What is more important, the dual oxidase biosensors almost suffered from little cross-talk, which is characteristic of an excellent sensor with high performance. This property, along with the good linearity and a high stability substantially enables this method promising application in physiology and pathology. © 2012 .


Liu X.-K.,City University of Hong Kong | Chen Z.,CAS Technical Institute of Physics and Chemistry | Zheng C.-J.,CAS Technical Institute of Physics and Chemistry | Chen M.,City University of Hong Kong | And 3 more authors.
Advanced Materials | Year: 2015

Nearly 100% triplet harvesting in conventional fluorophor-based organic light-emitting devices is realized through energy transfer from exciplex. The best C545T-doped device using the exciplex host exhibits a maximum current efficiency of 44.0 cd A-1, a maximum power efficiency of 46.1 lm W-1, and a maximum external quantum efficiency of 14.5%. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liu X.,Jiangsu University | Xiao Z.-J.,Nanjing Normal University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

In this work, we study six tree-dominated B→a 1(1260)a 1(1260) and b 1(1235)b 1(1235) decays in the perturbative QCD (pQCD) approach, where a 1 (b 1) is a P13 (P11) axial-vector meson. Based on the perturbative calculations and phenomenological analysis, we find that (a) the CP-averaged branching ratio of B0→a1+a1- decay in the pQCD approach is 54.7×10 -6, which agrees well with the current data and the predictions given in the QCD factorization approach within errors; (b) the numerical results for the decay rates of the other five channels are found to be in the order of 10 -6to 10 -5, which could be accessed at B factories and Large Hadron Collider experiments; (c) other physical observables such as polarization fractions and direct CP-violating asymmetries are also investigated with the pQCD approach in the present work and the predictions can be confronted with relevant experiments in the near future; (d) the different phenomenologies shown between B→a 1a 1 and B→b 1b 1 decays are expected to be tested by the ongoing Large Hadron Collider and forthcoming SuperB experiments, which could shed light on the typical QCD dynamics involved in these decay modes, as well as in P13 meson a 1 and P11 meson b 1. © 2012 American Physical Society.


Zhang C.,Jiangsu University | Zhang C.,CAS Shanghai Institute of Optics and fine Mechanics | Yao J.,CAS Shanghai Institute of Optics and fine Mechanics | Ni J.,CAS Shanghai Institute of Optics and fine Mechanics
Optics Express | Year: 2012

We theoretically investigate the X-ray supercontinuum generated by interaction of multi-cycle, chirped polarization gating pulses with the helium gas. It is shown that with this scheme, an isolated sub-50-attosecond pulse can be obtained straightforwardly without any phase compensation. Interestingly, if one selects an extremely broad spectral range near the highorder harmonic cutoff, an isolated and intense sub-24-attosecond pulse can be generated after phase compensation, which could be used to detect and control the electronic dynamics inside the atoms. Furthermore, it is found that the generation of such a broad and smooth X-ray supercontinuum is not so stringent on the selection of the simulated parameters, allowing for the experimental demonstration of this technique in the future. © 2012 Optical Society of America.


Liu X.,Jiangsu University | Li H.-N.,Academia Sinica, Taiwan | Li H.-N.,National Tsing Hua University | Li H.-N.,National Cheng Kung University | Xiao Z.-J.,Nanjing Normal University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2012

We point out that the recent Belle measurements of the B d/s→J/ψη( ′) decays imply large pseudoscalar glueball contents in the η( ′) meson. These decays are studied in the perturbative QCD approach, considering the η-η ′-G mixing, where G represents the pseudoscalar glueball. We show that the perturbative QCD predictions for the B d/s→J/ψη( ′) branching ratios agree well with the data for the mixing angle G30° between the flavor-singlet state and the pure pseudoscalar glueball. Extending the formalism to the η-η ′-G-η c tetramixing, the abnormally large observed B d→Kη ′ branching ratios are also explained. The proposed mixing formalism is applicable to other heavy meson decays into η( ′) mesons, and could be tested by future LHC beauty experiments and Super-B factory data. © 2012 American Physical Society.


Qian J.,Jiangsu University
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2010

This study was purposed to analyze the methylation status of death-associated protein kinase (dapk) gene promoter in Chinese patients with acute myeloid leukemia (AML) and its relationship with clinical features. The methylation-specific PCR (MSP) technique was used to detect dapk promoter methylation in bone marrow samples from 112 cases of AML. The results indicated that gene dapk promoter hypermethylation was detected in 82 cases (73.2%), but not in 13 control group. There was no correlation of dapk gene hypermethylation with sex, age, WBC counts, platelet counts, hematologic parameters, chromosomal abnormalities and different subtypes of AML patients. It is concluded that dapk gene hypermethylation may be a common molecular event in AML.


Liu C.,Gannan Normal University | Liu C.,Tongji University | Miao D.,Tongji University | Qian J.,Jiangsu University
International Journal of Approximate Reasoning | Year: 2014

Recently, much attention has been given to multi-granulation rough sets (MGRS) and different kinds of multi-granulation rough set models have been developed from various viewpoints. In this paper, we propose four types of multi-granulation covering rough set (MGCRS) models under covering approximation space, where a target concept is approximated by employing the maximal or minimal descriptors of objects in a given universe of discourse U. And then, we investigate a number of basic properties of the four types of MGCRS models, and discuss the relationships and differences among the classical MGRS model and our MGCRS models. Moreover, the conditions for two distinct MGCRS models which produce identical lower and upper approximations of a target concept in a covering approximation space are also studied. Finally, the relationships among the four types of MGCRS models are explored. We find that for any subset X⊆U, the lower approximations of X and the upper approximations of X under the four types of MGCRS models can construct a lattice, if we consider the binary relation of inclusion. © 2014 Elsevier Inc. All rights reserved.


Su Y.,Yancheng Teachers University | Su Y.,Jiangsu University | Wang Z.,Yancheng Teachers University
Fuzzy Sets and Systems | Year: 2014

In this paper, we firstly give out the formulas for calculating the upper (lower) approximation implications and coimplications of a binary operation on a complete lattice. Then, we discuss some properties of the upper (lower) approximation implications and coimplications. Finally, we investigate the relations between the upper (lower) approximation implications and the lower (upper) approximation coimplications. © 2014 Elsevier B.V. All rights reserved.


Wang R.,Jiangsu University
Zhonghua nan ke xue = National journal of andrology | Year: 2013

To compare the clinical effects of conventional, sleeve and Shang Ring circumcisions in the treatment of redundant prepuce and phimosis. We reviewed the clinical data of 918 patients with redundant prepuce or phimosis, 279 treated by conventional circumcision, 354 by sleeve circumcision and 285 by Shang Ring circumcision. We documented the preoperative characteristics, intra-operative blood loss, operation time, 4-hour and 7-day postoperative visual analogue scores, surgeons' satisfaction, incision healing time, degrees of preputial edema, postoperative complications, patients' satisfaction with penile appearance and peri-operative cost, and compared them among the three groups. Shang Ring circumcision significantly reduced the operation time and intra-operative blood loss as compared with conventional and sleeve circumcisions (P < 0.05). The postoperative incision healing time was (18.6 +/- 5.2) d in the conventional circumcision group, (11.4 +/- 3.7) d in the sleeve circumcision group and (20.3 +/- 5.7) d in the Shang Ring circumcision group, significantly shorter in the sleeve group than in the other two (P < 0.05). As for the surgeons' satisfaction, postoperative complications, degree of preputial edema and patients' satisfaction with penile appearance, sleeve circumcision showed similar effects to Shang Ring circumcision but significantly better than conventional circumcision (P < 0.05). The 7-day postoperative visual analogue score and peri-operative cost were significantly lower in the conventional and sleeve circumcision groups than in the Shang Ring group (P < 0.05). Each of the three circumcision methods has its own advantages and disadvantages. The treatment decision should be individualized and based on a comprehensive consideration of the patients' age and economic status as well as surgeons' advice and surgical skills.


Qiao F.,Jiangsu University | Sang Y.,Dalian University of Technology
Journal of Materials Science: Materials in Electronics | Year: 2014

In this paper, vertically aligned CdSe/CdS nanorods multilayer was achieved via a novel and simple thermal annealing approach on silicon substrate. The high uniformity in morphology and structure of nanorods arrays was obtained by adjusting the annealing ramp and solution concentration. The mechanism of this self-assembly was explained by the thermally decomposed organics surrounding the nanorods through annealing process, which induces decreased interspace between nanorods and more freedom for nanorods self-assembly into ordered packing; the decrease in organic capping molecules was further confirmed by the thermogravimetric analysis and the fourier transform infrared spectroscopy results; and nanorods arrays showed effectively enhanced photo-induced charge transfer properties compared to that of random packing ones as tested in the surface photovoltage measurement. The results here may offer a way towards device-scale nanorods superlattices for application in photovoltaic devices. © 2014 Springer Science+Business Media New York.


Lin D.-Y.,Zhejiang University | Zhao Y.-T.,Jiangsu University
Advanced Engineering Materials | Year: 2011

Gradient hydroxyapatite (HA) coatings are prepared on Ti6Al4V substrates and consist of different proportions of HA and yttria-stabilized zirconia (YSZ). Their surface morphology, cross-sectional structure and phase composition are investigated. The surface morphology is coarse and uneven with well-distributed concaves. The coatings become crystalline after post-treatment in water vapor. The structure of the atomic (Ti, Ca, P, Zr etc) intermixed zone in the interfacial field indicates that there is a diffusion layer (∼3-5.0 μm) between the coating and the substrate. The coating is found to be bioactive and nontoxic. The coating has a much-higher binding strength than monolithic-HA coatings. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Liu X.,Jiangsu University | Xiao Z.-J.,Nanjing Normal University | Zou Z.-T.,Yantai University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2013

We investigate B→K0*(1430)K* decays in the perturbative QCD (pQCD) factorization approach, where B denotes Bu, Bd, and Bs mesons, respectively, and the scalar K0*(1430) is considered as a meson based on the model of the conventional two-quark structure. With the light-cone distribution amplitude of K0*(1430) defined in two scenarios, namely Scenario 1 and Scenario 2, we make the first estimation for the branching ratios and CP-violating asymmetries for those concerned decay modes in the pQCD factorization approach. For all considered B→K0*(1430)K* decays in this paper, only one preliminary upper limit on the branching ratio of B0→K0 *(1430)0K̄*0 measured at 90% C.L. by the Belle Collaboration is available now. It is therefore of great interest to examine the predicted physical quantities at two B factories, the Large Hadron Collider experiments, and the forthcoming Super-B facility, and then to test the reliability of the pQCD approach employed to study the considered decay modes involving a p-wave scalar meson as one of the final state mesons. Furthermore, these pQCD predictions combined with the future precision measurements are also helpful to explore the complicated QCD dynamics involved in the light scalars. © 2013 American Physical Society.


In order to realize the curve-type assistance characteristic of the electric power steering system, the parabola-type assistance characteristic is brought out, and realizing it by designing the electric power steering system which is controlled by computer. And then math model of computer control system is constructed, and adopting Z-transform to analysis the stabilization of the system. The result shows that computer control system can realize the curve-type assistance characteristic. © (2013) Trans Tech Publications, Switzerland.


Liu X.,Jiangsu University
Wei sheng yan jiu = Journal of hygiene research | Year: 2013

To study the effect of L-arabinose on the blood glucose level of adult, and to find out the optimal amount of daily L-arabinose intake for maintaining their health. 50 adult were randomly selected and assigned to 5 group with different dose of L-arabinose or placebo, respectively. The preprandial blood glucose level and 1 h and 2h postprandial blood glucose were detected per 3 days. To investigate the variation of weight, 20 fat person was performed with daily L-arabinose or placebo intake for given daily for six months. Results After 30 days feeding, the decrease of postprandial blood glucose level was observed in group with 3% L-arabinose sample, and the groups with 5% - 10% have a significantly decreasing in the postprandial blood glucose level compared with control group result in (5.60 +/- 0.08) and (5.24 +/- 0.12), respectively (P < 0.05). The average body weight have a significantly reduce and after six months averagely reduced 5.5 kg, and the control group have no obviously variation. The daily consumption of L-arabinose would inhibit the postprandial blood glucose level and slimming down body which have a benefit for heath.


The medium is composed of an elliptic inclusion and many confocal elliptic layers. The crack is embedded in the elliptic inclusion. The remote loading is applied at the remote place of the matrix. Complex variable method and conformal mapping are used to study the mentioned problem. This paper provides a numerical solution for the mentioned crack problem. The continuity condition for the traction and displacement along the interface is reduced to a relation of two sets of Laurent series coefficients for the complex potentials defined in the interior or exterior to the interface. This formulation is called the matrix transfer method in this paper. From the following three conditions, the traction-free condition along creak face, the continuity condition for the traction and displacement along the interfaces and the remote loading condition, the problem is finally solved. Servable numerical examples are provided. For the exterior finite matrix case, the relevant solution is also provided. © 2015, Springer-Verlag Wien.


Han H.,Korea Research Institute of Standards and Science | Huang Z.,Jiangsu University | Lee W.,Korea Research Institute of Standards and Science | Lee W.,Korean University of Science and Technology
Nano Today | Year: 2014

Silicon nanostructures exhibit promising application potentials in many fields in comparison with their bulk counterpart or other semiconductor nanostructures. Therefore, the exploiting of controllable fabrication methods of silicon nanostructures, and the exploring of further applications of silicon nanostructures gain extensive attentions. In this review, recent advances in metal-assisted chemical etching of silicon, a low-cost and versatile method enabling fine control over morphology feature of silicon nanostructures, are summarized. The overview concerning the applications of silicon nanostructures in the field of energy conversion and storage, and sensors are also presented. © 2014 The Authors.


Shi Q.,Jiangsu University
Paiguan Jixie Gongcheng Xuebao/Journal of Drainage and Irrigation Machinery Engineering | Year: 2015

In order to explore the downwash flow field characteristic of small-size unmanned helicopter hedgehopping, numerical simulations were conducted. The full-size physical model of the small-size helicopter was established by SolidWorks software. The external flow field and meshing were established by Ansys Workbench software and ICEM software. Three-dimensional flow field of small-size unmanned helicopter hedgehopping was simulated by Fluent software. The results show that in the downwash flow field, the main movement form is vertical, accompanied by circumferential rotation and radial shrinkage. The maximum velocity appeared at the bottom of the location of 0.8R (R is the radius of the rotor) far from the axis of rotor rotation. With the vertical height declining, the maximum velocity and velocity gradient decrease. The acquired flow field can serve as a design reference for a small-size unmanned helicopter. ©, 2015, Editorial Department of Journal of Drainage and Irrigation Machinery Engineering. All right reserved.


Yin C.,Jiangsu University
Advance Journal of Food Science and Technology | Year: 2015

This study discusses the multimedia assistant tools in Food Safety Course teaching and discover the reason of study efficiency decreasing. It is that the multimedia has been seriously generalized behind this kind of prosperity scene. The author systematically analyzes the reason why the teacher's teaching result and student's learning efficient is low based on the information cognized theory. And think the cognitive load is the key to research the multimedia application in teaching. © Maxwell Scientific Organization, 2015.


Chen Y.Z.,Jiangsu University
Engineering Analysis with Boundary Elements | Year: 2016

This paper provides a numerical solution for the degenerate scale problem in plane elasticity using the null field complex variable boundary integral equation (CVBIE). After performing the coordinate transformation, the CVBIE can be formulated in the normal scale. After making discretization, a linear algebraic equation is obtained. The influence matrix in the normal scale is invertible. By introducing two basic solutions, the degenerate scale problem is finally solved. Several numerical examples are given. © 2015 Elsevier Ltd.All rights reserved.


Ding S.-H.,Jiangsu University | Li S.-H.,Nanjing Southeast University
Kongzhi yu Juece/Control and Decision | Year: 2011

Finite-time control theory has attracted much attention in recent years, since finite-time stable systems usually possess better robustness and disturbance rejection properties. First of all, the origin for finite-time control method is discussed, and the frequently-used criteria for finite-time control systems is listed. Then the present research development for finite-time control systems is summarized. Finally, the future outlook on finite-time control is discussed.


Chen Y.Z.,Jiangsu University
International Journal of Solids and Structures | Year: 2015

By using the technique of coordinate transform, the degenerate scale problem of two rigid lines in series can be solved in the normal scale. It is assumed that the distance between two rigid lines is much longer than the size of the rigid lines. In this case, the formulated equation can be significantly simplified, and an approximate solution is obtainable. Numerical examination proves that the approximate solution can also be used to a wider range with a close distance between two lines. © 2014 Elsevier Ltd.


Huang Z.,Jiangsu University | Yuan H.,CAS Academy of Opto Electronics
Radio Science | Year: 2014

In this article a radial basis function (RBF) neural network improved by Gaussian mixture model is developed to be used for forecasting ionospheric 30 min total electron content (TEC) data given the merits of its nonlinear modeling capacity. In order to understand more about the response of developed network model with respect to stations situated at different latitude, estimated TEC overhead of GPS ground stations BJFS (39.61°N, 115.89°E), WUHN (30.53°N, 114.36°E), and KUNM (25.03°N, 102.80°E) for 6 months in 2011 are used for training data set, validating data and test data set of RBF network model. The performance of the trained model is evaluated at a set of criteria. Our results show that the predicted TEC is in good agreement with observations with mean relative error of about 9% and root-mean-square error of less than 5 total electron content unit, 1 TECU = 1016 el m -2. Our comparison further indicates that RBF network offers a powerful and reliable tool for the design of ionospheric TEC forecast. ©2014. American Geophysical Union. All Rights Reserved.


Wu D.,Nanjing University | Wu D.,Jiangsu University | Liu X.,Nanjing University
Applied Physics Letters | Year: 2010

The far- and near-field properties of Au/Ag alloy nanoshell have been investigated by using Mie theory. With increasing Au content in shell, the dipole peak of alloy nanoshell shows a redshift from that of Ag nanoshell to that of Au nanoshell. It is found that the effect of the variation in shell thickness on the near-field for Au/Ag alloy nanoshells plays dominant role and the variation in the Au content leads to a significant modulation. We have further found that the near-infrared excitation at smaller wavelength can induce stronger near-field in Au/Ag alloy nanoshell with suitable geometry. © 2010 American Institute of Physics.


Background: This study examined use of healthcare services by elderly people with a long-term condition living in rural China and participating in that country's New Cooperative Medical Scheme (NCMS). Methods: Data were taken from the 2009 China Health and Nutrition Survey. Results: The study results showed that education level and annual income were low among rural elders (aged ≥65 years); the illiteracy rate was 58.0% (200/345) and 67.6% (92/136) had an annual income of less than 5000 Chinese yuan renminbi. The elders had low rates of treatment and use of preventive healthcare services while the prevalence of chronic disease was highest among them when compared to other age groups. Among the few elders who received preventive healthcare, most received it at village clinics. Conclusions: Preventive healthcare services and chronic disease management are urgently needed by rural elders in China. NCMS should initiate payments to township health centers to enable them to undertake community outreach and education campaigns among rural residents, and train village doctors in standard chronic condition management and prevention, with prioritization of the provision of prevention and management of chronic conditions by village clinics. © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.


Yin J.,Jiangsu University
Civil Engineering and Urban Planning 2012 - Proceedings of the 2012 International Conference on Civil Engineering and Urban Planning | Year: 2012

Mechanical behaviors of structured soils can usually be quantitatively assessed based on the mechanical behaviors of the corresponding reconstituted clays. The method of preparing reconstituted soils will affect the quality of reconstituted samples remarkably, and therefore, affect their mechanical parameters. To guarantee the quality of reconstituted soil samples, a large diameter oedometer apparatus was modified for preparing reconstituted clay samples. To investigate the compression and strength behaviors of the reconstituted clay samples prepared by the modified apparatus, standard oedometer tests and triaxial undrained shear tests were also conducted. Odometer tests results suggest that the compression behavior of reconstituted clays is mainly influenced by initial water content for given clay. Triaxial undrained shear tests results show that the strength envelope is also influenced remarkably by initial water content for the reconstituted clays. Undrained shear strength can be well normalized by the normalized water content. © 2012 ASCE.


Wu D.J.,Nanjing University | Wu D.J.,Jiangsu University | Liu X.J.,Nanjing University | Liu X.J.,Xian Jiaotong University
Applied Physics Letters | Year: 2010

The near-field enhancement of silica-silver-gold (SSG) nanoshells has been investigated by using Mie theory. If the thickness of Au shell is smaller than 5 nm, the maximum of near-field for SSG increases first and then decreases with increasing Ag layer thickness. Thus, the near-field for SSG can be modified by Ag layer and can possess more excellent near-field enhancement. If the thickness of Au shell is larger than 10 nm, the maximum of near-field of SSG nanoshell decreases with increasing Ag layer thickness. We further discuss the influence of Au shell thickness on the near-field of SSG nanoshell. © 2010 American Institute of Physics.


EPS-1 was an exopolysaccharide produced by the medicinal fungus Cordyceps sinensis (Cs-HK1). In the present study, EPS-1 was sulfated with chlorosulfonic acid (CSA)-pyridine (Pyr) at different volume ratios, yielding four sulfated derivatives, SEPS-1A, B, C and D, with different degrees of substitution (DS: 0.25-1.38) and molecular weights (17.1-4.1 kDa). The sulfation of EPS-1 occurred most frequently at the C-6 hydroxyl groups due to their higher reactivity. In aqueous solution, the native EPS-1 formed random coils or aggregated networks, but the sulfated derivatives formed single helices. The antioxidant activities of the sulfated EPS-1 derivatives for scavenging hydroxyl radicals (•OH) and 2,2-azinobis-3-ehtylbenzothiazolin-6-sulfonic acid radicals (ABTS•+) were significantly increased with increasing DS and decreasing molecular weight (MW). Sulfation has thus been shown to be an effective and favorable strategy for improving the physico-chemical properties and bioactivities of fungal polysaccharides.


Sun T.,South China University of Technology | Sun T.,Jiangsu University | Pei H.,South China University of Technology | Pan Y.,South China University of Technology | Zhang C.,Qingdao University of Science and Technology
International Journal of Robust and Nonlinear Control | Year: 2013

The paper addresses the problem of environmental boundary tracking for the nonholonomic mobile robot with uncertain dynamics and external disturbances. To do environmental boundary tracking, a reference velocity is designed for the nonholonomic mobile robot. In this paper, a radial basis function neural network (NN) is used to approximate a nonlinear function containing the uncertain model terms and the elements of the Hessian matrix of the environmental concentration function. Then, the NN approximator is combined with a robust control to construct a robust adaptive NN control for the mobile robot to track the desired environment boundary. It is proved that the tracking error can be guaranteed to converge to zero in the ultimate. Simulation results are presented to illustrate the stability of the robust adaptive control. Copyright © 2011 John Wiley & Sons, Ltd.


Zhu M.,Yangzhou University | Zhu M.,Jiangsu University | Wang Y.,Yangzhou University | Wang C.,Yangzhou University | And 2 more authors.
Catalysis Science and Technology | Year: 2013

Hollow carbon nanonets (HCN), which are attractive materials for catalyst support, were fabricated using the pre-synthesized hematite nanoparticles as the hard template. And then the HCN supported Pd nanoparticles (Pd/HCN) were prepared by precipitation-reduction method. The catalytic performance of Pd/HCN was investigated using Suzuki and Heck coupling reactions as model reactions. The results demonstrated that the as-prepared Pd/HCN nanocomposites exhibit high catalytic activity for the two types of coupling reactions under ligand free conditions. Especially, the Suzuki reactions between various aryl halides and phenylboronic acid gave excellent yields in water. Moreover, the as-prepared Pd/HCN catalysts can be easily recovered from the reaction medium by centrifugation for recycling, and the catalytic efficiency shows no obvious loss even after 6 repeated cycles. © 2013 The Royal Society of Chemistry.


Qi J.,Jiangsu University | Li X.,Peking University | Qian X.,Massachusetts Institute of Technology | Feng J.,Peking University
Applied Physics Letters | Year: 2013

In this letter we propose a universal strategy combining external electric field with the ripple of membrane to tune the bandgap of semiconducting atomic monolayer. By first-principles calculations we show that the bandgap of rippled MoS2 monolayer can be tuned in a large range by vertical external electric field, which is expected to have little effect on MoS2 monolayer. This phenomenon can be explained from charge redistribution under external electric field by a simple model. This may open an avenue of optimizing monolayer MoS2 for electronic and optoelectronic applications by surface patterning. © 2013 AIP Publishing LLC.


Qian W.-D.,Jiangsu University
2010 2nd International Conference on Computational Intelligence and Natural Computing, CINC 2010 | Year: 2010

Road pavement perfoemance evaluation and prediction is two most important parts of pavement management system. In order to scientifically and accurately predict the future road pavement situation,evaluation indexes and main influence factors of pavement performance were analyzed. Then functional performance,structure performance, safety performance, and comfortability performance was selected as the evolution index and three factors were taken as parameters, including temperature, annual precipitation,annual average daily traffic. The two prediction models of BP neural network and hybrid algorithms based on neural network and genetic algorithm were built respectively. Forecasting result shows that neural network model based on genetic algorithms has higher prediction accuracy and more network generalization than those of BP neural network. ©2010 IEEE.


Chen X.,Jiangsu University | Wang L.,Jilin University
Computers and Mathematics with Applications | Year: 2010

In this paper, the variational iteration method is applied to neutral functional-differential equations with proportional delays. Illustrative examples are given to show the efficiency of the method. We also compare the performance of the method with that of a particular Runge-Kutta method and a one-leg θ-method. © 2010 Elsevier Ltd. All rights reserved.


Sun Q.Z.,Jiangsu University
Zhonghua nan ke xue = National journal of andrology | Year: 2010

OBJECTIVE: To investigate the pathohistological characteristics of the prostate tissues in patients who receive a second TURP and to evaluate their clinical significance. METHODS: We collected surgical specimens from 50 cases of TURP (the control group) and another 50 cases of re-TURP (the re-TURP group), detected the expressions of CD34, vascular endothelial growth factor (VEGF) and androgen receptor (AR) in the prostate tissues by immunohistochemistry (S-P), and determined microvessel density (MVD) and the expressions of VEGF and AR. We performed statistical analyses on the results obtained from the specimens of the control group as well as from those of the first and second operations of the re-TURP group. RESULTS: VEGF and AR expressed in all the specimens. The expressions of VEGF and AR and MVD were significantly higher in the re-TURP group than in the controls (P < 0.05), but showed no significant differences between the first and second operations in the re-TURP group (P > 0.05). Positive correlations were found between the expressions of AR and VEGF, VEGF and MVD, and AR and MVD (r = 0.650, 0.705 and 0.525, P < 0.05). CONCLUSION: Increased AR, VEGF and MVD in the prostatic tissues may be one of the important causes of recurrence of BPH after TURP, and could be considered as the risk factors for postoperative recurrence and targeted indicators for preventive measures.


Chen Y.Z.,Jiangsu University
International Journal of Applied Mechanics | Year: 2014

This paper provides a closed form solution for dissimilar elliptical inclusion in plane elasticity. A dissimilar elliptical inclusion is embedded in the infinite matrix with different elastic properties. The infinite matrix is applied by the constant remote loading. Complex variable method is used and two sets of the complex potentials are assumed in the analysis. One set is used for the matrix portion, and other for the inclusion portion. Catching the idea from the eigenstrain problem, we can assume the stresses in the inclusion to be constant. From the continuity conditions for stresses and displacements along the interface, we can get the two sets of the complex potentials in a closed form. In the analysis, an adequate form of the complex potential defined in the elliptical inclusion portion is analyzed in detail. © 2014 Imperial College Press.


Zhang B.,Jiangsu University
2015 IEEE International Conference on Information and Automation, ICIA 2015 - In conjunction with 2015 IEEE International Conference on Automation and Logistics | Year: 2015

In order to detect the morphological decomposition in L2 processing of polymorphemic words, the present study has used one behavioral task - the masked priming to monitor the online L2 derivational processing. Experiment results showed great priming effects when the derived words were presented before their stems (e.g., speaker-speak), indicating the morphological decomposition in L2 processing. It was also discovered that, the decomposition takes place for all the derived words, regardless of participants' familiarity with them. Based on these results, it was proposed that, the morphological decomposition is an automatic processing mechanism for polymorphemic words. As a universal mechanism, it can be used by both L1 and L2 speakers. Based on these findings, it is suggested that, the natural language processing and artificial language decoding research should stress the discovery and application of universal language patterns. © 2015 IEEE.


Zhang C.,Beijing University of Chemical Technology | Zhang C.,Jiangsu University | Su H.,Beijing University of Chemical Technology | Baeyens J.,Beijing University of Chemical Technology | And 2 more authors.
Renewable and Sustainable Energy Reviews | Year: 2014

The uncontrolled discharge of large amounts of food waste (FW) causes severe environmental pollution in many countries. Within different possible treatment routes, anaerobic digestion (AD) of FW into biogas, is a proven and effective solution for FW treatment and valorization. The present paper reviews the characteristics of FW, the principles of AD, the process parameters, and two approaches (pretreatment and co-digestion) for enhancing AD of food waste. Among the successive digestion reactions, hydrolysis is considered to be the rate-limiting step. To enhance the performance of AD, several physical, thermo-chemical, biological or combined pretreatments are reviewed. Moreover, a promising way for improving the performance of AD is the co-digestion of FW with other organic substrates, as confirmed by numerous studies, where a higher buffer capacity and an optimum nutrient balance enhance the biogas/methane yields of the co-digestion system. © 2014 Elsevier Ltd. All rights reserved.


Huang L.,Jiangsu University | Huang L.,Jiangxi Agricultural University | Zhao J.,Jiangxi Agricultural University | Chen Q.,Jiangxi Agricultural University | Zhang Y.,Jiangxi Agricultural University
Food Chemistry | Year: 2014

Total volatile basic nitrogen (TVB-N) content is an important reference index for evaluating pork freshness. This paper attempted to measure TVB-N content in pork meat using integrating near infrared spectroscopy (NIRS), computer vision (CV), and electronic nose (E-nose) techniques. In the experiment, 90 pork samples with different freshness were collected for data acquisition by three different techniques, respectively. Then, the individual characteristic variables were extracted from each sensor. Next, principal component analysis (PCA) was used to achieve data fusion based on these characteristic variables from 3 different sensors data. Back-propagation artificial neural network (BP-ANN) was used to construct the model for TVB-N content prediction, and the top principal components (PCs) were extracted as the input of model. The result of the model was achieved as follows: the root mean square error of prediction (RMSEP) = 2.73 mg/100 g and the determination coefficient (Rp2)=0.9527 in the prediction set. Compared with single technique, integrating three techniques, in this paper, has its own superiority. This work demonstrates that it has the potential in nondestructive detection of TVB-N content in pork meat using integrating NIRS, CV and E-nose, and data fusion from multi-technique could significantly improve TVB-N prediction performance. © 2013 Published by Elsevier Ltd.


Chen Y.Z.,Jiangsu University
Journal of Thermal Stresses | Year: 2015

By using the conformal mapping technique and the continuity conditions along the interface, a general solution and numerical analysis for thermal elliptic inclusion in plane elasticity are presented. In the study, two types of temperature distributions in the inclusion, the constant distribution and the linear distribution, are assumed. In the first case, the strains and stresses in the inclusion remain constant. However, in the second case, the strains and stresses in the inclusion do not stay constant. For a particular case, a numerical example is carried out. © 2015 Taylor and Francis Group, LLC.


Cheng M.,Nanjing Southeast University | Hua W.,Nanjing Southeast University | Zhang J.,Nanjing Southeast University | Zhao W.,Jiangsu University
IEEE Transactions on Industrial Electronics | Year: 2011

Permanent magnet (PM) brushless machines having magnets and windings in stator (the so-called stator-PM machines) have attracted more and more attention in the past decade due to its definite advantages of robust structure, high power density, high efficiency, etc. In this paper, an overview of the stator-PM machine is presented, with particular emphasis on concepts, operation principles, machine topologies, electromagnetic performance, and control strategies. Both brushless ac and dc operation modes are described. The key features of the machines, including the merits and drawbacks of the machines, are summarized. Moreover, the latest development of the machines is also discussed. © 2006 IEEE.


Shi F.,Jiangsu University | Gong L.-Z.,Hefei University of Technology
Angewandte Chemie - International Edition | Year: 2012

Teamwork: Through relay catalysis by a Ru II complex and a chiral phosphoric acid ((S)-BPA in the scheme) recently developed by Zhou's group, hydrogen gas can act as the terminal reductant in the catalytic asymmetric hydrogenation of heterocycles. This is a completely new concept in the area of asymmetric hydrogenation. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Yuan G.,Jiangsu University
2011 IEEE 3rd International Conference on Communication Software and Networks, ICCSN 2011 | Year: 2011

This paper has been studied the theory of software testing and analyzed the existing software test management tool, which are based on the theory big movement in our laboratory, the intensive development projects to change in demand characteristics and a web-based software testing management system. The system is available from the test requirements, test planning, test execution to defect the tracking management of the entire testing process and test related tasks management. System is flexible on the set functions and roles of authority, the system can scale from staff, personnel changes and the constraints; system test cases and test case template are reference for other functions, the test case design process can take full advantage of existing resources; it is emphasis on the needs of the system test management and requirements change control, so that users can quickly adjust the test plan according to the demand change. The software testing system in our laboratory has been formed and the testing process has become standardized. The test the quality and efficiency have been improved and developed by our laboratory quality assurance of software products that provides the support. © 2011 IEEE.


Zhu M.,Yangzhou University | Zhu M.,Jiangsu University | Wang C.,Yangzhou University | Meng D.,Yangzhou University | Diao G.,Yangzhou University
Journal of Materials Chemistry A | Year: 2013

In this article, a study was presented on the catalytic activity of silver nanoparticles immobilized on magnetic Fe3O4@C (MFC) core-shell nanocomposites (Ag/MFC) that were used as carriers. MFC composites consist of a magnetic core of an Fe3O4 microsphere onto which a thin layer of carbon was coated by in situ carbonization of glucose under hydrothermal conditions. The catalytic activity of the as-prepared Ag/MFC is investigated by photometrically monitoring the reduction of 4-nitrophenol and methylene blue by an excess of NaBH4. The kinetic data of both reduction reactions could be explained by the assumption of a pseudo-first-order reaction with regard to 4-nitrophenol or methylene blue. Significantly, the Ag/MFC catalysts can be easily separated from the reaction media by applying an external magnet, and can be reused for several cycles. This journal is © The Royal Society of Chemistry 2013.


Background: Colorectal cancer (CRC) is a severe disease with considerable morbidity and mortality. Stable presence of miRNAs in serum enables them to be biomarkers for early diagnosis and surveillance of the progress of CRC. Methods: The blood samples of S3 CRC patients of I-IV stage pre therapy and 50 controlled healthy people were collected and total serum RNA was extracted. The level of miR-423-5p and miR-484 in serum were detected by qPCR. Results: In stage I - II CRC, serum miR-423-5p was significantly elevated compared with the control, whereas miR-484 was attenuated. In stage III - IV, no significance difference in miR-423-5p level was found between CRC patients and the control, and miR-484 level increased dramatically. Conclusions: The study provides the possibility that the detection of miR-484-5p and miR-484 may be a useful method for early diagnosis and surveillance of the progress of CRC.


You Q.,Huaiyin Institute of Technology | You Q.,Jiangsu Key Laboratory for Biomass based Energy and Enzyme Technology | Yin X.,Huaiyin Institute of Technology | Yin X.,Jiangsu University | And 2 more authors.
Bioresource Technology | Year: 2013

Lipase from Burkholderia cepacia was immobilized on modified attapulgite by cross-linking reaction for biodiesel production with jatropha oil as feedstock. Effects of various factors on biodiesel production were studied by single-factor experiment. Results indicated that the best conditions for biodiesel preparation were: 10g jatropha oil, 2.4g methanol (molar ratio of oil to methanol is 1:6.6) being added at 3h intervals, 7 wt% water, 10 wt% immobilized lipase, temperature 35°C, and time 24h. Under these conditions, the maximum biodiesel yield reached 94%. The immobilized lipase retained 95% of its relative activity during the ten repeated batch reactions. The half-life time of the immobilized lipase is 731h. Kinetics was studied and the Vmax of the immobilized lipases were 6.823mmolL-1. This immobilized lipase catalyzed process has potential industrial use for biodiesel production to replace chemical-catalyzed method. © 2013 Elsevier Ltd.


Xuechong G.,Jiangsu University
Journal of Computer and System Sciences | Year: 2014

The compact information algebra and the continuous information algebra are two special information algebras, which are algebraic structures modeling computation in many different contexts. We show that the set of all continuous mappings between two continuous information algebras also forms a continuous information algebra. Further, we obtain that the two categories COMP and CON, consisting of compact information algebras and continuous information algebras as objects respectively, continuous mappings as morphisms, are both Cartesian closed. © 2014 Elsevier Inc. All rights reserved.


Li K.,Zhejiang University | Li K.,Jiangsu University | Su H.,Zhejiang University
Energy and Buildings | Year: 2010

There are several ways to forecast building energy consumption, varying from simple regression to models based on physical principles. In this paper, a new method, namely, the hybrid genetic algorithm-hierarchical adaptive network-based fuzzy inference system (GA-HANFIS) model is developed. In this model, hierarchical structure decreases the rule base dimension. Both clustering and rule base parameters are optimized by GAs and neural networks (NNs). The model is applied to predict a hotel's daily air conditioning consumption for a period over 3 months. The results obtained by the proposed model are presented and compared with regular method of NNs, which indicates that GA-HANFIS model possesses better performance than NNs in terms of their forecasting accuracy. © 2010 Elsevier B.V. All rights reserved.


Liu J.,CAS Shanghai Institute of Optics and fine Mechanics | Liu J.,University of Chinese Academy of Sciences | Shen D.,Fudan University | Huang H.,Jiangsu University | And 4 more authors.
Optics Express | Year: 2014

Highly efficient and high-power operation of Raman fiber lasers in fixed-wavelength and wavelength-tunable cavity configurations based on a graded-index multimode fiber is reported. Fixed-wavelength and wavelength tunable operating regimes are achieved using volume Bragg gratings (VBGs) with center wavelengths of 1658 nm and 1750 nm, respectively. The fixed-wavelength laser yielded a maximum output power of 10.5 W at 1658.3 nm with a FWHM linewidth of ∼0.1 nm for the launched pump power of 23.4 W, corresponding to a slope efficiency of 82.7% with respect to the launched pump power. The measured beam quality in the form of M2 factor is ∼1.35, corresponding to the fundamental mode of the fiber. For the wavelength-tunable Raman fiber laser, a wavelength tuning range of 37 nm from 1638.5 to 1675.1 nm is obtained with a maximum output power of 3.6 W at 1658.5 nm for the launched pump power of 13.0 W. © 2014 Optical Society of America.


Ma L.,Nanjing Southeast University | Ma L.,Jiangsu University | Da F.,Nanjing Southeast University | Zhang K.-J.,Nanjing Southeast University
IEEE Transactions on Circuits and Systems I: Regular Papers | Year: 2011

In this paper, the exponential H∞ filtering problem is studied for discrete time-delay stochastic systems with Markovian jump parameters and missing measurements. The measurement missing phenomenon, which is related to the modes of subsystems, is described in the form of random matrix function and the missing probability of each sensor at every mode is governed by an individual random variable taking values in the interval [0,1]. This description of missing measurements is more general than the existing ones, where the missing probability is described by a Bernoulli distribution white sequence or a certain diagonal matrix. By using Lyapunov method and the properties of conditional mathematical expectation, we propose a novel approach to achieve the delay-dependent exponential stability criterion such that the filtering error system is mean-square exponentially stable and satisfies a prescribed H∞ performance level. Moreover, there is no equation restriction on decay rate. Then, based on the obtained sufficient criterion, the filter matrices can be directly characterized by solving a set of linear matrix inequalities (LMIs). Finally, a numerical example is provided to show the validity of the main result. © 2011 IEEE.


Xue W.,Zhejiang University | Xue W.,Jiangsu University | Mao W.,Zhejiang University
Journal of Dynamic Systems, Measurement and Control, Transactions of the ASME | Year: 2013

The problems of admissible finite-time stability (AFTS) and admissible finite-time stabilization for a class of uncertain discrete singular systems are addressed in this study. The definition of AFTS is first given. Second, a sufficient condition for the AFTS of the nominal unforced system is established, which is further extended to the uncertain case. Then, a sufficient condition is proposed for the design of a state feedback controller such that the closed-loop system is admissibly finite-time stable for all admissible uncertainties. Both the AFTS and the controller design conditions are presented in terms of linear matrix inequalities (LMIs) with a fixed parameter. Finally, two numerical examples are provided to illustrate the effectiveness of the developed theory. Copyright © 2013 by ASME.


Zhu M.,Yangzhou University | Zhu M.,Jiangsu University | Meng D.,Yangzhou University | Wang C.,Yangzhou University | Diao G.,Yangzhou University
ACS Applied Materials and Interfaces | Year: 2013

In this work, CuFe2O4 nanospheres with hierarchically porous structure have been synthesized via a facile solvothermal procedure. The superstructures consist of the textured aggregations of nanocrystals with high specific surface area, pore volume, and uniform pore size distribution.To figure out the formation mechanism, we discussed in detail the effects of a series of experimental parameters, including the concentrations of the precipitation agent, stabilizer agent, and reaction temperature and time on the size and morphology of the resulting products. Furthermore, the electrochemical properties of CuFe2O4 nanospheres were evaluated by cyclic voltammetry and galvanostatic charge-dischrge studies. The results demonstrate that the as-prepared CuFe2O4 nanospheres are excellent electrode material in supercapacitor with high specific capacitance and good retention. The hierarchically CuFe2O4 nanospheres show the highest capacitance of 334F/g, and 88% of which can still be maintained after 600 charge-discharge cycles. © 2013 American Chemical Society.


Wu X.L.,Jiangsu University | Huang W.M.,Nanyang Technological University | Tan H.X.,Nanyang Technological University
Journal of Polymer Research | Year: 2013

Shape recovery in a commercial ether-vinyl acetate copolymer (EVA) was systematically characterized by studying its creep and the thermoresponsive shape-memory effect (SME). The influences of the programming temperature and maximum uniaxial tension strain on the shape-fixity ratio and the shape-recovery ratio were investigated quantitatively. In addition to excellent SME, high elasticity and high creep were observed at around room temperature (with the EVA in the glassy state). The underlying mechanisms for the different shape-recovery phenomena (i.e., creep and the SME) are discussed. Two potential applications utilizing the shape-recovery property and high elasticity of this EVA are presented. © 2013 Springer Science+Business Media Dordrecht.


ABSTRACT This paper provides a closed form solution for degenerate scale problem of the Joukowcki thin airfoil configuration in antiplane elasticity. The solution depends on a conformal mapping function for the Joukowcki thin airfoil configuration. Copyright © 2013 The Society of Theoretical and Applied Mechanics, R.O.C.


Cao X.,Jiangsu University
International journal of nanomedicine | Year: 2011

The purpose of this study was to develop calcium phosphate nanocomposite particles encapsulating plasmid DNA (CP-pDNA) nanoparticles as a nonviral vector for gene delivery. CP-pDNA nanoparticles employing plasmid transforming growth factor beta 1 (TGF-β1) were prepared and characterized. The transfection efficiency and cell viability of the CP-pDNA nanoparticles were evaluated in mesenchymal stem cells, which were identified by immunofluorescence staining. Cytotoxicity of plasmid TGF-β1 and calcium phosphate to mesenchymal stem cells were evaluated by MTT assay. The integrity of TGF-β1 encapsulated in the CP-pDNA nanoparticles was maintained. The well dispersed CP-pDNA nanoparticles exhibited an ultralow particle size (20-50 nm) and significantly lower cytotoxicity than Lipofectamine™ 2000. Immunofluorescence staining revealed that the cultured cells in this study were probably mesenchymal stem cells. The cellular uptake and transfection efficiency of the CP-pDNA nanoparticles into the mesenchymal stem cells were higher than that of needle-like calcium phosphate nanoparticles and a standard calcium phosphate transfection kit. Furthermore, live cell imaging and confocal laser microscopy vividly showed the transportation process of the CP-pDNA nanoparticles in mesenchymal stem cells. The results of a cytotoxicity assay found that both plasmid TGF-β1 and calcium phosphate were not toxic to mesenchymal stem cells. CP-pDNA nanoparticles can be developed into an effective alternative as a nonviral gene delivery system that is highly efficient and has low cytotoxicity.


Gang X.,Jiangsu University | Huicheng Y.,Nanjing Normal University
Archive for Rational Mechanics and Analysis | Year: 2015

In this paper, we are concerned with the global existence and stability of a smooth supersonic flow with vacuum state at infinity in a three-dimensional infinitely long divergent nozzle. The flow is described by a three-dimensional steady potential equation, which is multi-dimensional quasilinear hyperbolic (but degenerate at infinity) with respect to the supersonic direction, and whose linearized part admits the form (Formula presented.) for (Formula presented.). From the physical point of view, due to the expansive geometric property of the divergent nozzle and the mass conservation of gases, the moving gases in the nozzle will gradually become rarefactive and tend to vacuum states at infinity, which implies that such a smooth supersonic flow should be globally stable for small perturbations since there are no strong resulting compressions in the motion of the flow. We will confirm such a global stability phenomenon by rigorous mathematical proofs and further show that there do not exist vacuum domains in any finite parts of the nozzle. © 2015 Springer-Verlag Berlin Heidelberg


Zhang J.,Jiangsu University
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

In the cation of the title compound, {[Y(NO 3) 2(C 6H 18N 3OP) 4][AgMoS4]} n, the Y atom is coordinated by eight O atoms from two chelating nitrate groups and four hexamethylphosphoramide (hmp) ligands, which gives rise to a distorted squareantiprismatic environment. Together with the two nitrate ligands, the overall charge for the complex cation is +1, which leads to the anionic chain having a monovalent repeat unit. The polymeric anionic chain, with Mo - Ag - Mo and Ag - Mo - Ag angles of 161.916 (13) and 153.915 (13)°, respectively, presents a distorted linear configuration. The cations and the anions are linked via weak C - H⋯S hydrogenbonding interactions while the cations exhibit intermolecular C - H⋯O interactions. The structure is isotypic with the corresponding W, Yb, Eu, Nd, La and Dy complexes.


Zou C.,Chinese University of Hong Kong | Zou C.,Jiangsu University | Yu S.,Chinese University of Hong Kong | Xu Z.,Chinese University of Hong Kong | And 6 more authors.
Journal of Pathology | Year: 2014

Adaptation of cancer cells to a hypoxic microenvironment is important for their facilitated malignant growth and advanced development. One major mechanism mediating the hypoxic response involves up-regulation of hypoxia-inducible factor 1 (HIF-1) expression, which controls reprogramming of energy metabolism and angiogenesis. Oestrogen-related receptor-α (ERRα) is a pivotal regulator of cellular energy metabolism and many biosynthetic pathways, and has also been proposed to be an important factor promoting the Warburg effect in advanced cancer. We and others have previously shown that ERRα expression is increased in prostate cancer and is also a prognostic marker. Here we show that ERRα is oncogenic in prostate cancer and also a key hypoxic growth regulator. ERRα-over-expressing prostate cancer cells were more resistant to hypoxia and showed enhanced HIF-1α protein expression and HIF-1 signalling. These effects could also be observed in ERRα-over-expressing cells grown under normoxia, suggesting that ERRα could function to pre-adapt cancer cells to meet hypoxia stress. Immunoprecipitation and FRET assays indicated that ERRα could physically interact with HIF-1α via its AF-2 domain. A ubiquitination assay showed that this ERRα-HIF- 1α interaction could inhibit ubiquitination of HIF-1α and thus reduce its degradation. Such ERRα-HIF-1α interaction could be attenuated by XCT790, an ERRα-specific inverse agonist, resulting in reduced HIF-1α levels. In summary, we show that ERRα can promote the hypoxic growth adaptation of prostate cancer cells via a protective interaction with HIF-1α, suggesting ERRα as a potential therapeutic target for cancer treatment. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.


Xie F.,Jiangsu University | Hou Y.,China University of Mining and Technology
Industrial Lubrication and Tribology | Year: 2011

Purpose - The purpose of this paper is to reveal the characteristics of hydrodynamic load capacity and torque transferred by oil film with variable viscosity, and the effect of groove number, width and depth on the hydrodynamic load capacity and torque transfer. Design/methodology/approach - The radial temperature of friction pair and viscosity of YLA-N32 hydraulic oil were measured through experiments, and a viscosity-diameter expression was deduced using polynomial fitting method. Analytical expressions for hydrodynamic load capacity and torque of the oil film were deduced based on hydrodynamic lubrication theory. Findings - The investigation shows the hydrodynamic load capacity and transferred torque with variable viscosity are much less than that with constant viscosity. Load capacity increases with the increase of groove depth which is the most significant influence factor, while it has the least influence on torque. Groove width has great influence on load capacity and torque. The load capacity increases with the increase of groove width; contrarily, torque decreases with the increase of groove width. Groove number has little influence on load capacity, while it has great influence on torque. The torque decreases with the increase of groove number. Originality/value - In this paper, analytical solutions for hydrodynamic load capacity and torque of the oil film with variable viscosity are deduced. The paper reveals the relationship between hydrodynamic load capacity, torque transfer and groove number, width and depth. © Emerald Group Publishing Limited.


Song B.,Yeungnam University | Song B.,Jiangsu University | Park J.H.,Yeungnam University | Wu Z.-G.,Yeungnam University | And 2 more authors.
Journal of the Franklin Institute | Year: 2013

This paper is concerned with the problem of stability analysis for neutral stochastic delay systems. Firstly, expectations of stochastic cross terms containing the Itô integral are investigated by the martingale theory. Based on this, an improved delay-dependent stability criterion is derived for neutral stochastic delay systems. In the derivation process, the mathematical development avoids bounding stochastic cross terms, and neither the model transformation method nor free-weighting-matrix method is used. Thus the method leads to a simple criterion and shows less conservatism. Finally, two examples are provided to demonstrate the effectiveness and reduced conservatism of the proposed conditions. © 2013 The Franklin Institute. Published by Elsevier Ltd. All rights reserved.


Wang H.-J.,Jiangsu University | Chen X.-Y.,Zhejiang Academy of Agricultural Sciences
Journal of Hazardous Materials | Year: 2011

Combination of two kinds of advanced oxidation processes (AOPs) is an effective approach to control wastewater pollution. In this research, a pulsed discharge plasma system with multi-point-to-plate electrode and an immobilized TiO2 photocatalysis system is coupled to oxidize target pollutant in aqueous solution. Kinetic analysis (pseudo-first order kinetic constant, k) and energy efficiency (energy yield value at 50% phenol conversion, G50) of phenol oxidation in different reaction systems (plasma alone and plasma-photocatalysis) are reviewed to account for the synergistic mechanism of plasma and photocatalysis. The experimental results show that higher k and G50 of phenol oxidation can be obtained in the plasma-photocatalysis system under the conditions of different gas bubbling varieties, initial solution pH and radical scavenger addition. Moreover, the investigation tested hydroxyl radical (OH) is the most important species for phenol removal in the synergistic system of plasma-photocatalysis as well as in the plasma alone system. © 2010 Elsevier B.V.


Gu J.-Z.,Jiangsu University
International Journal of Structural Stability and Dynamics | Year: 2014

This paper presents analytically obtained free vibration frequencies of castellated beams, that take into account the effects of both web shear and rotary inertia. The results show that the rotary inertia effect on the free vibration frequencies is very important for beams with no or weak effect from web shear. However, for beams where the web shear effect is dominant the rotary inertia effect can be almost ignored. © 2014 World Scientific Publishing Company.


Chen Y.Z.,Jiangsu University
International Journal of Applied Mechanics | Year: 2010

A single crack problem is studied. In the problem, the tractions applied on both crack faces are same in magnitude and same in direction. In this case, it is shown that a logarithmic singularity exists in the vicinity of crack tip in addition to the inverse half singularity. A complete expression for the singular stresses at the vicinity of crack tip is obtained. © 2010 Imperial College Press.


The title compound, {[Cu2I2(C12H 8N6)(C18H15P)2] ·2CH3CN}n, contains centrosymmetric dinuclear Cu2I2(PPh3)2 units bridged by 3,6-bis-(4-pyrid-yl)-1,2,4,5-tetra-zine ligands lying also across crystallographic inversion centers, giving a chain structure in the ab plane. The distorted tetra-hedral CuI atoms in the dinuclear unit are coordinated by two bridging iodide anions, one pyridine N atom from the substituted tetra-zine ligand and one terminal triphenyl-phosphine P-atom donor. The Cu⋯Cu distance is 2.8293 (12) Å, implying a weak Cu⋯Cu inter-action.


Zhang H.,Jiangsu University | Georgescu P.,Technical University Gheorghe Asachi
Mathematical Methods in the Applied Sciences | Year: 2014

This paper deals with the dynamics of a class of hybrid dynamical systems, which are subject to time-dependent impulsive perturbations within a finite-time interval and describe control strategies for integrated pest management. By using suitably defined Lyapunov functionals, sufficient conditions for the finite-time contractive stability of the null solution are found by means of monotonicity arguments. Finally, a numerical simulation illustrates the theoretical analysis. © 2014 John Wiley & Sons, Ltd.


Ding J.,Jiangsu University
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2012

To investigate the inhaled allergens spectrum of 890 allergic rhinitis patients in Shanghai, and to provide basic epidemiologic information for the prevention and treatment of allergic rhinitis. Thirteen allergens skin prick test results of 890 allergic rhinitis patients recruited were retrospectively analyzed. The main common inhaled allergens in allergic rhinitis patients in Shanghai were house dust mite (91.24%), dermatophagoides farinae (86.58%), tropical mite (51.98%), dog hair (15.96%). Moreover, the positive frequency was decreased with age increasing, and gender group had no obvious difference. House dust mite and dermatophagoides farinae were the main allergens of allergic rhinitis patients in Shanghai. Skin prick test is helpful for the discovery of the allergens so as to provide important basis of immunotherapy.


Xu M.,Jiangsu University | Xu M.,University of Houston | Mo Y.-Y.,University of Mississippi Medical Center
Cellular and Molecular Life Sciences | Year: 2012

As master gene regulators, microRNAs are involved in diverse cellular pathways. It is well known that microRNAs are often dysregulated in many types of cancer and other human diseases. In cancer, microRNAs may function as oncogenes or tumor suppressors. Interestingly, recent evidence suggests that microRNA-mediated gene regulation interconnects with the Akt pathway, forming an Akt-microRNA regulatory network. MicroRNAs and Akt in this network work together to exert their cellular functions. Thus, a better understanding of this Akt-microRNA regulatory network is critical to successful targeting of the PI3K/Akt pathway for cancer therapy. We review recent advances in the understanding of how microRNAs affect Akt activity as well as how microRNAs are regulated through the Akt pathway. We also briefly discuss the clinical implication of gene regulation mediated through Akt-associated microRNAs. © 2012 Springer Basel AG.


Hu Z.,Jiangsu University
Cehui Xuebao/Acta Geodaetica et Cartographica Sinica | Year: 2013

The unsupervised change detection technique on multi-temporal SAR images not only needs to detect the changed region but also subdivide the changed region in a complex geographical environment so that the backscatter enhanced class and the backscatter weakened class can be further identified. The generalized Gaussian distribution model can approximate a large variety of statistical distributions at the cost of only one additional parameter to be estimated (i.e., the shape parameter) compared with the traditional Gaussian distribution model. In particular, the generalized Gaussian distribution model is proved to be more suitable to describe the distributions of unchanged and changed classes on SAR log-ration difference image than the Gaussian one. An change detection algorithm in SAR images based on the generalized Gaussian distribution model and KI dual thresholds criterion is proposed. The probability density distributions of the unchanged class, the backscatter enhanced class and the backscatter weakened class on SAR difference image are modeled. The dual thresholds criterion function is defined based on KI criterion. An optimal automatic dual thresholds selection approach is proposed only using the gray histogram of the difference image. The unchanged, the backscatter enhanced and the backscatter weakened classes are detected. The two temporal SAR images from Radarsat satellite are used to experiment and the results show that the proposed approach is feasible and effective. Improving the accuracy and speed of SAR image unsupervised change detection technique by using the spatial context information will be studied as a future development of this work.


Wu Y.,Jiangsu University | Han M.,Shanghai Normal University
International Journal of Bifurcation and Chaos | Year: 2013

In this paper, the number and distributions of limit cycles of a planar quartic vector field are considered. Through perturbation technique and qualitative analysis of differential equation, it is shown that the quartic vector field has 21 limit cycles as parameters satisfy proper conditions. The distributions of limit cycles in the above perturbed planar quartic vector field are also presented. © 2013 World Scientific Publishing Company.


Liu G.,Jiangsu University
Scientometrics | Year: 2013

Terahertz technology is one of the most promising research areas in the 21st century. In this work, we intend to compare the research status quo on terahertz technology between 1990 and 2010 using knowledge domain visualization techniques. Our data consists of 633 patents retrieved from Aureka management platform and 10,344 journal articles indexed in the ISI web of knowledge. Our analysis is a combination of two information visualization tools for analysis, Aureka and CiteSpace. Aureka is allowed for the analysis of patents filed/granted each year, priority country, inventors, assignees, citation counting, and cluster analysis, while networks of co-authors, countries, institutions, document co-citation networks and document co-citation clusters, are performed by CiteSpace. This research provides a comprehensive domain visualization map of innovation and knowledge in the area of terahertz technology. Our result shows that Aureka and CiteSpace are two promising visualization approaches to analyze patents and papers in any given field. © 2012 Akadémiai Kiadó, Budapest, Hungary.


Xue Y.-L.,Jiangsu University | Zhang Y.-G.,Shandong Academy of Sciences | Liu X.-H.,Zhejiang University of Technology
Asian Journal of Chemistry | Year: 2012

A cyclopropane derivative, 1-cyano-N-(2,4-dichlorophenyl) cyclopropanecarboxamide (C11H8N2OCl2) was synthesized and its structure was studied by X-ray diffraction, FTIR, 1H NMR, MS and elemental analysis. The crystals are monoclinic, space group C2 with a = 14.387(9), b = 6.926(4), c = 12.237(7) A°, a = 90.00, b = 100.386(10), g = 90.00°, V = 1199.4(12) A°3, Z = 4, F(000) = 520, Dc = 1.413 g/cm3, μ = 0.520 cm-1, the final R = 0.0603 and wR = 0.1653. A total of 2976 reflections were collected, of which 1134 were independent (Rint = 0.0381). The preliminary biological test showed that the synthesized compound is bioactive against the KARI of Escherichia coli.


Zhu Z.,Jiangsu University | Sun Y.,Nanjing Institute of Technology
Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering | Year: 2012

To realize the rotor displacement self-sensing for a 3-degree-of-freedom hybrid magnetic bearing (3-DOF- HMB). This paper presents a novel predictive modeling method of rotor displacement for 3-DOF-HMB using particle swarm optimized-least squares support vector machines (PSO- LS-SVM). First, the structure and working principle of 3-DOF-HMB is explained and the nonlinear mathematical model in the large air-gap is derived. Then, through the collection of representative current displacement data based on the nonlinear model, the predictive model of 3-DOF-HMB is obtained by training LS-SVM. Besides, the PSO algorithm is used to optimize parameters of LS-SVM to improve the performance of the predictive model. Finally, take mean squared error (MSE) and absolute error (AE) as model evaluation index to conduct comparative simulation research. The result is discussed and the effectiveness of predictive modeling and self-sensing method is verified. © 2012 Chin. Soc. for Elec. Eng.


Long X.,Jiangsu University | Oh K.,Chungnam National University | Cheng G.,Peking University
Journal of Cleaner Production | Year: 2013

This paper investigates the effects of environmental policy on environmental conditions resulting from China's accession to the WTO. We estimate environmental technological efficiency under both weak and strong disposability assumptions and use the difference to calculate the pollution abatement cost (PAC). We then undertake Tobit regression analysis on several explanatory variables, including dummies for different time periods and regions. Generally, our findings show that China's accession to the WTO did not guarantee better environmental conditions even though China adopted stronger regulations to meet the higher standards. In particular, the eastern region does not seem to be strictly regulated. These interesting results may be partly attributable to China's need to attract foreign investment and may represent a case in which institutional regulations are not always effective in practice. © 2012 Elsevier Ltd. All rights reserved.


Objective: To observe the expression of Toll-like receptor 8 (TLR8) in human cervical cancer cell-line HeLa cells, and the effects of TLR8 agonist CL075 on the survival and proliferation of HeLa cells. Methods: PCR and RT-PCR were used to detect the expression of TLR8 in 13 cancer cell lines, and the expression of COX-2, Bcl-2, VEGF mRNA in the HeLa cells stimulated by TLR8 agonist CL075 were also measured by RT-PCR. Immunofluorescence technique was used to determine the exact location of TLR8 in the cells. The percentage of viable cells was determined by trypan blue exclusion after the HeLa cells were stimulated with TLR8 agonist CL075 (0.1 μg/ml, 0.5 μg/ml, 1.0 μg/ml, 2.5 μg/ml), and cell cycle and apoptosis were analyzed by flow cytometry, and the proliferation was measured by MTT. Results: Compared with the other cancer cell lines, the expression of TLR8 in HeLa cells was the highest (703.7 ± 20.6). After stimulation by CL075, the cells had a remarkable increase of the percentage of cells in G2/M + S phases. In the control group, the percentage of cells in G2/M + S phases was (39.02 ± 2.33) %, whereas after stimulated with 1.0 μg/ml CL075, the percentage of cells in G2/M + S phases reached the highest ratio (57.67 ± 1.73) %, and the percentage of cells in G2/M + S phases had a less decrease after 2.5 μg/ml CL075 stimulation and the percentage was (56.14 ± 3.73) %. After the CL075 treatment, there was no significant changes of apoptosis compared with that of the control cells (P > 0.05) , but after DDP treatment the apoptosis had a significant change (P < 0.01). After stimulation by 1.0 μg/ml CL075 for 24 h, no significant difference (P > 0.05) was found by MTT test, but a significant difference was found at 48 h and 72 h (P < 0.01). An increased expression of COX-2, Bcl-2 and VEGF mRNA was observed in HeLa cells after stimulation by TLR8 agonist CL075 for 24 h and 48 h (P < 0.05). Conclusions: Expression of TLR8 is significantly increased in HeLa cells. The proportion of cells at different phases has a significant change after CL075 stimulation, which may up-regulate the proliferation of HeLa cells. These data suggested that TLR8 agonist may influence the tumor development and TLR8 may become a potential target in the treatment for cervical cancer.


Zhou Z.,Jiangsu University
Macromolecular Theory and Simulations | Year: 2014

The average mean-square radii of gyration for the products of the linear polymerization, the star-shaped polymerization, and the hyperbranched polymerization of AB2-type monomer in the absence or presence of a multifunctional core initiator are investigated using the Dobson-Gordon's method. The dependence relationships between the average radii of gyration and the average degree of polymerization calculated using the Dobson-Gordon's method for the linear polymerization products are in good agreement with those obtained from the matrix algebra method of the rotational isomeric state model. The radii of gyration of the star-shaped and hyperbranched polymers are much smaller than those of the linear polymers if their average degrees of polymerization are equal. The conversion of groups, the core/monomer feed ratio, and the core functionality affect the average radius of gyration of the products. However, compared with the other factors, the degree of polymerization is the most influential factor on the average radii of gyration for the hyperbranched polymer system. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Fang X.J.,Jiangsu University
Zhonghua zhong liu za zhi [Chinese journal of oncology] | Year: 2010

To evaluate the impact of a new CD44 variant on invasion of human breast cancer cell line MCF-7, and its possible mechanisms. The full length cDNA encoding CD44v17 was obtained from the total RNA isolated from the MCF-7/ADR cells by reverse transcript-polymerase chain reaction (RT-PCR) and subcloned into pMD19-T vector. The CD44v17 gene sequence and reading frame were confirmed by two restriction enzymes and nucleotide sequencing, and then inserted into the eukaryotic expression vector pcDNA3.1. The pcDNA3.1-CD44v17 was transfected into MCF-7 cells by Lipofectamine. The changes of MMP-2 and MMP-9 expression at gene and protein levels were detected by RT-PCR and gelatin zymography, respectively. The number of the cells through the artificial matrix membrane in every group was counted to compare the change of the invasive ability regulated by CD44 variant. The ERK and p-ERK were investigated by Western blotting to approach the molecular mechanisms of MMP-2 and MMP-9 expression regulated by CD44 variant. The new gene sequence was successfully cloned into recombinant vector pcDNA3.1 and identified by the two restriction enzymes. It was confirmed that the reconstructed plasmid contained the sequence of CD44 gene variant which was composed of 1 to 4 exons, 16 to 17 exons, and 1 to 205 bases of 18 exons. The new gene sequence was sent to NCBI for publication and obtained the registered number FJ216964. The up-regulated levels of the CD44 gene mRNA and protein were respectively detected by RT-PCR and flow cytometry in MCF-7 cells transfected with pcDNA3.1-CD44v17. The invasiveness of the cells and the activity of MMP-2 and MMP-9 were clearly activated by hyaluronic acid (HA) treatment and blocked by CD44 neutralizing antibody. Pretreated MCF-7/CD44v17 cells with the neutralizing antibody against CD44 and the inhibitor of MAPKs signaling pathway strongly block the expression of p-ERK. A new CD44 gene variant has been found in adriamycin-resistant human breast cancer MCF-7/ADR cells. The expression vector pcDNA3.1-CD44v17 has been cloned and constructed successfully. HA can be integrated with CD44 variant and then regulates the expression of MMP-2 and MMP-9, which increases the invasion ability of MCF-7 cells through the Ras/MAPK signaling pathway.


Chen Y.Z.,Jiangsu University
International Journal of Fracture | Year: 2015

This paper provides a solution for a crack stiffened by elliptic layer in antiplane elasticity. The crack is embedded in an elliptic region and stiffened by a confocally elliptic layer. The whole medium is composed of three portions, the cracked elliptic plate, the confocally elliptic layer and the infinite matrix. The remote loading is applied. The cracked elliptic plate and the infinite matrix have the same shear modulus of elasticity. The stiffening elliptic layer has a higher shear modulus of elasticity. By using the complex variable and the continuity conditions along interfaces, the problem can be solved. One numerical example with different sizes and properties of materials is given to show the effect of the stiffening layer. © 2015, Springer Science+Business Media Dordrecht.


Chen Y.Z.,Jiangsu University
Engineering Analysis with Boundary Elements | Year: 2013

This paper provides a solution for Eshelby's elastic inclusions in a finite plate based on the complex variable boundary integral equation (CVBIE) method. In the formulation, an inclusion with Eshelby's eigenstrains is embedded in an elliptic plate, and the exterior boundary is applied by some static loading. Two BIEs are suggested in the present study. One of BIEs is used for the finite inclusion region, and the other is used for region bounded by interface and the exterior boundary. After the discretization of BIEs, a numerical solution is suggested. In the solution, an inverse matrix technique is suggested which can eliminate one unknown vector in advance. Three numerical examples under different generalized loadings are provided. Interaction between the prescribed eigenstrains and the static loading along the exterior boundary is studied in detail. © 2013 Elsevier Ltd. All rights reserved.


Qiao X.,Jiangsu University | Seo H.J.,Pukyong National University
Materials Letters | Year: 2014

A new visible-light-driven photocatalysts of Cs2V4O11 nanowires with extremely high length-diameter ratio were synthesized by the conventional hydrothermal reaction. The sample was characterized by XRD measurement and structure refinement, scanning electron microscope (SEM) and UV-vis absorption spectra. Cs2V4O11 nanowire has efficient absorption in the UV-visible light wavelength region with a band gap energy of 2.47 eV and an indirect allowed electronic transition. Photocatalytic activities of Cs2V4O11 nanowires by photo-degradation reaction of methylene blue (MB) were investigated under visible-light irradiation in air. Cesium vanadate nanowires show a high photocatalytic activity and could be a potential photocatalyst driven by visible-light. © 2014 Elsevier B.V.All rights reserved.


Xue Y.-L.,Jiangsu University | Liu X.-H.,Zhejiang University of Technology | Zhang Y.-G.,Shandong Academy of Sciences
Asian Journal of Chemistry | Year: 2012

A cyclopropane derivative, 1-cyano-N-phenylcyclopropanecarboxamide (C 11H 10N 2O) was synthesized and its structure was studied by X-ray diffraction, FTIR, 1H NMR spectrum and MS. The crystals are monoclinic, space group Pbca with a = 10.0466(19), b = 9.6067(17), c = 20.790(3) Å, α = 90.00, b = 90.00, g = 90.00°, V = 2006.5(6) Å 3, Z = 8, F(000) = 784.00, Dc = 1.233 g/cm 3, μ = 0.815 cm -1, the final R = 0.0567 and wR = 0.1456. A total of 8716 reflections were collected, of which 1967 were independent (R int = 0.045). Theoretical calculation of the title compound was carried out with B3LYP/6-31G (d.p.). The full geometry optimization was carried out using 6-31G(d.p.) basis set and the frontier orbital energy. The structure-activity relationship was also studied. The preliminary biological test showed that the synthesized compound is bioactive against the ketol-acid reductoisomerase of Escherichia coli.


Xue Y.-L.,Jiangsu University | Zhang Y.-G.,Shandong Academy of Sciences | Liu X.-H.,Zhejiang University of Technology
Asian Journal of Chemistry | Year: 2012

A cyclopropane derivative, 1-cyano-N-(4-bromophenyl)cyclopropanecarboxamide (C11H9N2OBr) was synthesized and its structure was studied by X-ray diffraction, FTIR, 1H NMR spectrum and MS. The crystal is triclinic, space group P-1 with α = 8.902(4), β = 10.944(5), c = 12.733(6) Å, α = 103.753(8), β = 106.812(9), γ = 104.004(9)°, V = 1087.1(9) Å3, Z = 4, F(000) = 528, Dc = 1.620 g/cm 3, the final R = 0.0604 and wR = 0.1197. A total of 5404 reflections were collected of which 3790 were independent (Rint = 0.0578). There are two intramolecular hydrogen bonds in the crystal lattice. The preliminary biological test showed that the synthesized compound had weak activity against the KARI of Escherichia coli.


Sun J.,Jiangsu University
Plant signaling & behavior | Year: 2012

Extracellular ATP (eATP) is now recognized as an important signaling agent in plant growth and defense response to environmental stimuli. eATP has dual functions in plant cell signaling, which is largely dependent on its concentration in the extracellular matrix (ECM). A lethal level of eATP (extremely low or high) causes cell death, whereas a moderate level of eATP benefits plant growth and development. Ecto-apyrases (Nucleoside Triphosphate-Diphosphohydrolase) help control the eATP concentrations in the ECM, and thus contributing to the mediation of plant growth and defense response upon environmental stress. In this review, we summarize eATP signaling in plants and highlight the correlation between eATP homeostasis control and programmed cell death.


Zhang H.,Dalian University of Technology | Zhang Z.,Dalian University of Technology | Zhang Z.,Jiangsu University | Ye H.,Dalian University of Technology
Microfluidics and Nanofluidics | Year: 2012

Computational modeling and simulation can provide an effective predictive capability for flow properties of the confined fluids in micro/nanoscales. In this paper, considering the boundary slip at the fluid-solid interface, the motion property of fluids confined in parallel-plate nanochannels are investigated to couple the atomistic regime to continuum. The corrected second-order slip boundary condition is used to solve the Navier-Stokes equations for confined fluids. Molecular dynamics simulations for Poiseuille flows are performed to study the influences of the strength of the solid-fluid coupling, the fluid temperature, and the density of the solid wall on the velocity slip at the fluid boundary. For weak solid-fluid coupling strength, high temperature of the confined fluid and high density of the solid wall, the large velocity slip at the fluid boundary can be obviously observed. The effectiveness of the corrected second-order slip boundary condition is demonstrated by comparing the velocity profiles of Poiseuille flows from MD simulations with that from continuum. © 2011 Springer-Verlag.


Wang H.,Jiangsu University | Shen J.,University of Shanghai for Science and Technology
Applied Physics B: Lasers and Optics | Year: 2014

The size of nanoparticles is measured by laser diode self-mixing interferometry, which employs a sensitive, compact, and simple optical setup. However, the signal processing of the interferometry is slow or expensive. In this article, a fast and economic signal processing technique is introduced, in which the self-mixing AC signal is transformed into DC signals with an analog circuit consisting of 16 channels. These DC signals are obtained as a spectrum from which the size of nanoparticles can be retrieved. The technique is examined by measuring the standard nanoparticles. Further experiments are performed to compare the skimmed milk and whole milk, and also the fresh skimmed milk and rotten skimmed milk. © 2013 Springer-Verlag Berlin Heidelberg.


Liu W.,Jiangsu University
Renewable Energy | Year: 2016

A typical 1.5 MW wind turbine suitable for Xuzhou City is designed and simulated in this paper. The wind turbine blade-hub-tower coupling system and most of the parameters are designed and calculated in the design process. In the kinetic analysis process, the force analysis under 4 different situations are taken to verify the structure design, which are under quiescent condition, under random angle and random wind turbine, under maximal wind speed and over maximal wind speed. At last, the modal analysis selected the turbine hub and tower to solve the inherent frequencies and vibration modes. The first 5 order inherent frequencies and vibration modes of the hub and tower are solved to verify the design rationality. © 2016 Elsevier Ltd.


Zhang C.,Jiangsu University | Zhang C.,CAS Shanghai Institutes for Biological Sciences | de Silva S.,Ohio State University | Wang J.-H.,CAS Shanghai Institutes for Biological Sciences | Wu L.,Ohio State University
PLoS ONE | Year: 2012

Cross-species transmission and adaptation of simian immunodeficiency viruses (SIVs) to humans have given rise to human immunodeficiency viruses (HIVs). HIV type 1 (HIV-1) and type 2 (HIV-2) were derived from SIVs that infected chimpanzee (SIVcpz) and sooty mangabey (SIVsm), respectively. The HIV-1 restriction factor SAMHD1 inhibits HIV-1 infection in human myeloid cells and can be counteracted by the Vpx protein of HIV-2 and the SIVsm lineage. However, HIV-1 and its ancestor SIVcpz do not encode a Vpx protein and HIV-1 has not evolved a mechanism to overcome SAMHD1-mediated restriction. Here we show that the co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in SIVcpz and HIV-1. We found evidence for positive selection of SAMHD1 in orangutan, gibbon, rhesus macaque, and marmoset, but not in human, chimpanzee and gorilla that are natural hosts of Vpx-negative HIV-1, SIVcpz and SIVgor, respectively, indicating that vpx drives the evolution of primate SAMHD1. Ancestral host state reconstruction and temporal dynamic analyses suggest that the most recent common ancestor of SIVrcm, SIVmnd, SIVcpz, SIVgor and HIV-1 was a SIV that had a vpx gene; however, the vpx gene of SIVcpz was lost approximately 3643 to 2969 years ago during the infection of chimpanzees. Thus, HIV-1 could not inherit the lost vpx gene from its ancestor SIVcpz. The lack of Vpx in HIV-1 results in restricted infection in myeloid cells that are important for antiviral immunity, which could contribute to the AIDS pandemic by escaping the immune responses. © 2012 Zhang et al.


Chen Y.Z.,Jiangsu University
Engineering Analysis with Boundary Elements | Year: 2014

This paper suggests the t-version complex variable boundary integral equation (CVBIE) for the interior region in plane elasticity. All the kernels in the t-version CVBIE are expressed explicitly. The property for the operator acting upon the displacement is studied. It is proved that there are three types of rigid mode movement of displacement for the t-version CVBIE, if the boundary is assumed under a traction free condition. Discretization of the t-version CVBIE is suggested. For the hypersingular integral, the integration is carried out exactly in the concept of Hadamards finite part integral. Two particular examples which have known solution beforehand are used to examine the accuracy in computation. The Neumann and the Dirichlet boundary value problems are examined numerically. It is proved that the computation error is acceptable in the examples. © 2014 Elsevier Ltd.


This paper provides the transfer matrix method for the solution of multiple elliptic layers with different elastic properties. In the study, the medium is composed of an elliptic inclusion and many confocal elliptic layers. In the present study, the exterior layer is a finite confocal elliptic layer. Some derivations in the present study are similar to those in Chen (Acta Mech 2014). However, some derivations in the present study are quite different from those in Chen (Acta Mech 2014). Equations for evaluating the coefficients in the Laurent series for complex potentials are suggested, which are derived from the transfer matrix and the boundary condition. A numerical example for the case of an elliptic inclusion and two confocal elliptic layers is provided in this paper. © 2014, Springer-Verlag Wien.


Zhang J.,Jiangsu University
Acta Crystallographica Section E: Structure Reports Online | Year: 2010

Hexamethyl-phospho-ramide (hmp), tetra-thio-molybdate, silver sulfide and dysprosium nitrate were self-assembled to form an anionic [AgMoS4] n n- chain in the title complex, {[Dy(NO3) 2(C6H18N3OP)4][AgMoS 4]}n. The central Dy atom in the cation is coordinated by eight O atoms from two nitrate and four hmp ligands, resulting in a distorted square-anti-prismatic environment. Together with the two nitrate ligands, the cation is monovalent, which leads to the anionic chain having an [AgMoS 4] repeat unit. The polymeric anionic chain, with Mo - Ag - Mo and Ag - Mo - Ag angles of 161.911 (13) and 154.014 (13)°, respectively, presents a distorted linear configuration. The title complex is isostructural with the W analogue.


Jeng T.-M.,Chienkuo Technical University | Tzeng S.-C.,Chienkuo Technical University | Xu R.,Jiangsu University
International Journal of Heat and Mass Transfer | Year: 2014

This study experimentally investigated the heat transfer characteristics of a rotating cylinder under lateral air impinging jet. The height and diameter of the cylinder were fixed, and the variable parameters were as follows: (1) the jet Reynolds number (Rej = 655-60237); (2) the rotational Reynolds number (Rer = 1975-7899); (3) the ratio of the cylinder diameter (D) to the nozzle width (w) (D/w = 2-16); (4) the relative jet-impinging distance (L/w = 1-16, L is the shortest nozzle-to-cylinder distance). This experiment measured detailed temperature on the heated wall surface of the cylinder using an infrared thermo tracer, and observed the smoke flow characteristics of the stationary and rotating cylinder under impinging jet flow using visualization technique. The experimental results showed that the rotation changed the separation position of impinging jet flow on the cylinder, and allowed the surface temperature of the cylinder to tend towards uniformity along the circumferential direction of the cylinder. In addition, the heat transfer experiment included the pure rotating condition, the pure jet-flow condition and the coexistent condition of rotation and jet flow. The results showed that the average Nusselt number (Nu) increased with the increase of Rej and Rer, and decreased with the increase of D/w. The influence of D/w on Nu decreased with the increase of L/w, and Nu first increased and then decreased with the increase of L/w. In other words, there is a critical L/w value that can produce the highest Nu, and the critical L/w value increased with D/w. Finally, this study proposed reasonable and accurate empirical correlations of Nu in view of three test conditions. All the results can provide reference for practical design of the cooling system in relevant power machinery. © 2013 Elsevier Ltd. All rights reserved.


Yang C.,University of Hong Kong | Zhou M.,University of Hong Kong | Xu Q.,Jiangsu University
Physical Chemistry Chemical Physics | Year: 2013

MnO2/carbon composites with ultrathin MnO2 nanofibers (diameter of 5-10 nm) uniformly deposited on three dimensional ordered macroporous (3DOM) carbon frameworks were fabricated via a self-limiting redox process. The MnO2 nanofibers provide a large surface area for charge storage, whereas the 3DOM carbon serves as a desirable supporting material providing rapid ion and electron transport through the composite electrodes. Cyclic voltammetry, galvanostatic charge-discharge and electrochemical impedance spectroscopy (EIS) were used to characterize the capacitive performance of these composites. Optimization of the composition results in a composite with 57 wt% MnO2 content, which gives both a high specific capacitance (234 F g-1 at a discharge current of 0.1 A g-1) and good rate capability (52% retention of the capacitance at 5 A g-1). An asymmetric supercapacitor was fabricated by assembling the optimized MnO 2/carbon composite as the positive electrode and 3DOM carbon as the negative electrode. The asymmetric supercapacitor exhibits superior electrochemical performances, which can be reversibly charged and discharged at a maximum cell voltage of 2.0 V in 1.0 M Na2SO4 aqueous electrolyte, delivering both high energy density (30.2 W h kg-1) and power density (14.5 kW kg-1). Additionally, the asymmetric supercapacitor exhibits an excellent cycle life, with 95% capacitance retained after 1000 cycles. © 2013 The Owner Societies.


Miao X.,Jiangsu University | Zou S.,Guangzhou University | Zhang H.,Sun Yat Sen University | Ling L.,Sun Yat Sen University
Sensors and Actuators, B: Chemical | Year: 2014

High level of carcinoembryonic antigen (CEA) can signal the presence of cancer directly. Thus simple and sensitive detection of CEA is of great importance. Here, sensitive CEA detection in human serum was realized by using Ag@Au core-shell nanoparticles (CSNPs) and dynamic light scattering (DLS) based on monitoring the average diameter change of Ag@Au CSNPs after the specific bind between CEA antibody (anti-CEA) and CEA. Under optimal conditions, CEA could be detected linearly in the range of 60 pg/mL to 50 ng/mL, with a detection limit of 35.6 pg/mL. Moreover, satisfactory results were obtained when the assay was used in human serum CEA detection. © 2013 Elsevier B.V.


Tang D.-Q.,Jiangsu University | Yin X.-X.,Jiangsu Key Laboratory for the study of New Drug and Clinical PharmacyXuzhou Medical CollegeYunlongChina | Ong C.N.,Nus Environmental Research Instnational University Of Singapore5 gineering Srive 1Singapore117411Singapore
Mass Spectrometry Reviews | Year: 2014

Hydrophilic interaction chromatography (HILIC) is an emerging separation mode of liquid chromatography (LC). Using highly hydrophilic stationary phases capable of retaining polar/ionic metabolites, and accompany with high organic content mobile phase that offer readily compatibility with mass spectrometry (MS) has made HILIC an attractive complementary tool to the widely used reverse-phase (RP) chromatographic separations in metabolomic studies. The combination of HILIC and RPLC coupled with an MS detector expands the number of detected analytes and provides more comprehensive metabolite coverage than use of only RP chromatography. This review describes the recent applications of HILIC-MS/MS in metabolomic studies, ranging from amino acids, lipids, nucleotides, organic acids, pharmaceuticals, and metabolites of specific nature. The biological systems investigated include microbials, cultured cell line, plants, herbal medicine, urine, and serum as well as tissues from animals and humans. Owing to its unique capability to measure more-polar biomolecules, the HILIC separation technique would no doubt enhance the comprehensiveness of metabolite detection, and add significant value for metabolomic investigations. © 2014 Wiley Periodicals, Inc.


Zheng W.,Jiangsu University
Current Medicinal Chemistry | Year: 2013

Sulfur (S), as the second element in the main group 6A just below oxygen (O), has been often used as an isosteric replacement for O in enzymatic mechanistic studies. In addition, S has also been used as an isosteric replacement for CH2. These S-based mechanistic probes have been used in the studies with protein enzyme systems such as the sirtuin family of the protein Nε-acyl-lysine deacylases, phosphotransferases, and fatty acid desaturase, as well as various RNA enzymes (ribozymes). These probes are basically the O→S mutants of the corresponding O(or CH 2)-containing substrates for the enzymatic reactions under study. This article will review the significant contributions that the S-based probes have been able to make toward an enhanced mechanistic understanding of different types of the enzyme-catalyzed reactions. © 2013 Bentham Science Publishers.


Qu J.,Changzhou University | Lai C.,Jiangsu University
Journal of Nanomaterials | Year: 2013

Titanium dioxide (TiO2) is star materials due to its remarkable optical and electronic properties, resulting in various applications, especially in the fields of dye-sensitized solar cells (DSSCs). Photoanode is the most important part of the DSSCs, which help to adsorb dye molecules and transport the injected electrons. The size, structure, and morphology of TiO2 photoanode have been found to show significant influence on the photovoltaic performance of DSSCs. In this paper, we briefly summarize the synthesis and properties of one-dimensional (1D) TiO2 nanomaterials (bare 1D TiO2 nanomaterial and 1D hierarchical TiO2) and their photovoltaic performance in DSSCs. © 2013 Jie Qu and Chao Lai.


Han X.,Jiangsu University | Wang Y.,Tianjin University | Zhu L.,Tianjin University
Energy Conversion and Management | Year: 2013

Direct liquid-immersion cooling of concentrator solar cells was proposed as a solution for receiver thermal management of concentrating photovoltaic (CPV) systems. This research investigates the performance and long-term stability of silicon CPV solar cells operated in De-ionized (DI) water, isopropyl alcohol (IPA), dimethyl silicon oil, and ethyl acetate, respectively. Current-voltage characteristics of silicon CPV solar cells are measured. The presence of a thin liquid layer (1.5 mm) results in an increase in the silicon CPV solar cells efficiency by 8.5-15.2% from the reference value. With an increase of the liquid layer thickness above the cell surface up to 9 mm, due to more incident light is absorbed by the thicker liquid layer, the degree of the improvements to the cell efficiency decreases, which also depends to a noticeable degree on the liquid species. Further, more power output from the cells operated in liquids is achieved under higher concentration ratio. The long-term cell performance is discussed through three separate liquid immersion tests. The results from 1.5 mm test demonstrate that degradation of cells performance immersed in IPA and in ethyl acetate mainly occurs by a decrease of Jsc and efficiency during 170 days of test. But the long-term organic liquids immersion test (180 days) without silicone sealant involved gives confidence of the reliable performance of the silicon CPV solar cells operated in liquids except for DI water. Therefore, the observed performance decay of the cells in 1.5 mm test is due to the interaction between the silicone sealant and IPA or ethyl acetate. However, long-term immersion results from 9 mm test (100 days) show that the stable electrical performance of the cell is difficult to be achieved when immersed in DI water, which is consistent with the previous report. © 2012 Elsevier Ltd. All rights reserved.


Liu X.,Jiangsu University | Li H.-N.,Academia Sinica, Taiwan | Xiao Z.-J.,Nanjing Normal University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2016

We extend the perturbative QCD formalism including the Glauber gluons, which has been shown to accommodate the measured B→ππ and B0→ρ0ρ0 branching ratios simultaneously, to the analysis of the B→Kπ and KK¯ decays. It is observed that the convolution of the universal Glauber phase factors with the transverse-momentum-dependent kaon wave function reveals weaker (stronger) Glauber effects than in the pion (ρ meson) case as expected. Our predictions for the branching ratios and the direct CP asymmetries of the B→Kπ and KK¯ modes at next-to-leading-order accuracy agree well with data. In particular, the predicted difference of the B±→K±π0 and B0→K±π direct CP asymmetries, ΔAKπ≡ACPdir(K±π0)[0.021±0.016]-ACPdir(K±π)[-0.081±0.017]=0.102±0.023, is consistent with the measured ΔAKπ=0.119±0.022 within uncertainties, and the known B→Kπ puzzle is resolved. The above B→ππ, Kπ and KK¯ studies confirm that the Glauber gluons associated with pseudo-Nambu-Goldstone bosons enhance the color-suppressed tree amplitude significantly, but have a small impact on other topological amplitudes. © 2016 American Physical Society.


Chen L.,Jiangsu University
Proceedings - 2015 International Conference on Intelligent Transportation, Big Data and Smart City, ICITBS 2015 | Year: 2015

Based on the theory of process improvement of software engineering, software project management system based on Struts structure is proposed. The system requirement analysis is given and the whole process of project management is analyzed. The designed software project management system includes human resource management, scheduling and task management, risk management, cost management, quality management and knowledge base management. By means of testing software project management system and network equipment, it can be seen that the performance of this system is stable and reliable. Besides, it is simple touse and can be put intopractical use. © 2016 IEEE.


Natural rubber (NR) reinforced by in situ polymerization of zinc dimethacrylate (ZDMA) exhibits excellent mechanical properties. However, the corresponding reinforcement mechanism is still unclear. Using synchrotron wide-angle X-ray diffraction (WAXD) measurements, we observed that strain-induced crystallization of NR/ZDMA composites had a direct affect on the ultimate mechanical properties. An increase in ZDMA fraction resulted in a lower strain at the onset of crystallization. Further analysis revealed that three factors contributed to the reduction in onset strain, including higher whole cross-linking density due to the emergence of ionic cross-linking clusters, strain amplification of nanodispersion of poly-ZDMA (PZDMA), and the confinement effect of the filler network. The results of dynamic Monte Carlo simulation showed that the confinement effect of the filler network on chain segments favored segmental orientation in regions near the polymer–filler interface, thus inducing a decline in onset strain. © 2015, Springer Science+Business Media Dordrecht.


Nie Y.,Jiangsu University
Journal of Macromolecular Science, Part B: Physics | Year: 2015

The addition of nanoparticles remarkably improves the mechanical properties and strain-induced crystallizability of natural rubber. To reveal the underlying mechanism for the enhancement of these physical properties, we analyzed the microstructural changes of rubber due to the inclusion of clay and carbon black by using the tube model. The rubber filled with clay exhibited a stronger confinement effect of entanglements on the chain conformation compared with the pure rubber and that filled with carbon black. As a result, we propose a new thermodynamic approach to the entropic elasticity of entangled rubber by a combination of the blob scaling argument and the tube model. The thermodynamic analysis demonstrated that the restriction effects of both entanglements and the filler network led to a reduction of the conformational entropy in clay-filled rubber, resulting in the decrease of the onset strain of crystallization. These results revealed the mechanism of the strain-induced crystallization and filler reinforcement from the viewpoint of thermodynamics. © 2015 Taylor and Francis Group, LLC.


Wang Y.,Jiangsu University
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji | Year: 2010

bHLH transcription factors play essential roles in the regulation of eukaryotic growth and development. Animal bHLH transcription factors comprise of 45 families. They are involved in regulating biological processes such as neurogenesis, myogenesis, gut development and response to environmental toxins. In the past two decades, extensive studies had been conducted on identification of bHLH family members and their biological functions in animals. Based on introduction of origin of the 45 animal bHLH family names, this article reviewed the progresses of studies on bHLH family members and functions of three model animals namely mouse, fruit fly and nematode. There are 114, 59 and 42 bHLH proteins in mouse, fruit fly and nematode, respectively. Among them, the functions of 108 mouse, 47 fruit fly and 20 nematode bHLH proteins have been well characterized. Among the 22 nematode bHLH proteins of unknown functions, 15 have not yet been assigned into certain families. This article also explained misused names of several bHLH family members, thus providing clear and overall background information for relevant researchers to conduct in-depth studies on structures and functions of bHLH transcription factors.


Shao G.B.,Jiangsu University
Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji | Year: 2010

Discovery of histone lysine specific demethylase 1 (LSD1) indicates that even histone methylation is reversible. Structural analysis shows that LSD1 is a flavin-dependent amine oxidase, which is able to catalyze the specific removal of methyl groups from mono- and dimethylated Lys4 and Lys9 of histone H3. Functional studies demonstrate that LSD1 regulates activation and inhibition of gene transcription in the nucleus, which is known as the innermost gene switch of cells. LSD1 plays important roles in embryonic development and tumorigenesis. Here, we review recent insights into the structure and chemical mechanism of LSD1, and its regulatory roles in development and cancer.


Wang Z.,Jiangsu University
Environmental Engineering and Management Journal | Year: 2013

A wet flue gas desulfurization (WFGD) system adopting electrostatically-assited twin-fluid atomization injector was presented. Spatial distributions of the droplet sizes, velocity for different voltages were measured using limewater and SO2 removal efficiency for different voltages and Ca/S ratios were tested using limewater drops. The physical and chemical improvement mechanisms were analyzed using spray characteristics and double film theory. The analysis showed that electrostatically-assited atomization could improve the spray characteristics, which could decrease the average droplets size, avoid the agglomeration of drops, and improve drops velocity spatial distribution. The SO2 removal efficiency could be increased because of physical properties which were decreasing average droplets size, making the drops more uniformity distribution in reactor, and enhancing drops inner circling and chemical properties which were increasing the Ca2+ concentration on the droplets surface and enhancing mass transfer driving force droplets absorbing SO2 due to droplets electrification and non-excess charge polarization where electrical field existing.


Yin J.,Jiangsu University
Gongcheng Lixue/Engineering Mechanics | Year: 2013

Natural soft clays are generally subject to the effects of a soil structure. How to reflect the effects in the corresponding constitutive model is an important issue. Based on the modified cam clay model, a parameter designated as structure yield stress was introduced to describe the shape of an initial yield surface due to the soil structure, and an anisotropic parameter was presented to characterize the rotation of a yield surface due to initial anisotropy. According to the mechanism of abrupt loss of a soil structure for natural clays, the elastic stress strain relationship was applied in the pre-yield state, and corresponding hardening law and associated flow rule consistent with a modified cam-clay model were adopted since the resistance of a soil structure in the post-yield state is completely exhausted. According to the condition of consistency, the incremental stress-strain relationship was established and a modified Cam Clay model for structured soft clays was developed. Significant improvements were demonstrated in the performance of the new model by comparing with experimental data in the stress path tests for Bothkennar soft clay.


Peng S.F.,Jiangsu University
Zhonghua zhong liu za zhi [Chinese journal of oncology] | Year: 2010

To detect the expression levels of transcription factors and associated cytokines of Th17 and Treg cells in peripheral blood mononuclear cells (PBMC) of patients with gastric cancer, and explore the possible pathological mechanism of these cells involved in the development of gastric cancer. The mRNA levels of RORgammat, FoxP3 in PBMC were determined by quantitative real-time PCR (QRT-PCR) from 57 patients with gastric cancer, 31 patients with benign gastric illness and 40 healthy people. The concentration of IL-17, IL-23, TGF-beta, IL-10 in plasma were detected by enzyme linked immunosorbent assay (ELISA). Compared with healthy volunteers, patients with gastric cancer showed higher levels of RORgammat and FoxP3 in PBMC (P < 0.05). The ratio of FoxP3/RORgammat in gastric cancer group was higher than that in the volunteer group and benign gastric illness group (P < 0.05). The ratio of FoxP3/RORgammat was higher in advanced disease than early disease (P < 0.05). The expressions of IL-17, IL-23, TGF-beta and IL-10 were higher in patients with gastric cancer than that in healthy volunteers (P < 0.05). In addition, The expression of TGF-beta and IL-10 were significantly increased in the advanced disease group than that in the early group (P < 0.05), but IL-17 and IL-23 was not significantly changed between the two groups (P > 0.05). There are higher levels of Th17 and Treg cells in gastric cancer patients, and it also shows a persistent predominant tendency of Treg cells and a reduced tendency of Th17 cells in advanced disease. Detecting the expression of Th17/Treg transcription factor and related cytokines would contribute to the diagnosis and prediction of the disease development and prognosis.


Zhu L.,Jiangsu University
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology | Year: 2013

To detect the levels of mir-18a-5p, mir-23a-3p, mir-24-3p, mir-25-3p and TGF-β1 in tumor microenvironment of esophageal squamous cell cancer (ESCC) patients and explore their clinical significances and correlations. The mRNA expressions of mir-18a-5p, mir-23a-3p, mir-24-3p, mir-25-3p and TGF-β1 were measured by real-time quantitative RT-PCR in ESCC cell lines ECA-109 and TE-1, normal esophageal squamous epithelial cells, tumor tissues and tumor-adjacent normal tissues from 52 ESCC patients. The expression of TGF-β1 protein in the three types of cells, tumor tissues and tumor-adjacent normal tissues from 52 ESCC patients was detected by Western blotting. The expressions of mir-18a-5p, mir-24-3p, mir-25-3p and mir-23a-3p in ECA-109 were significantly higher than those in normal esophageal squamous epithelial cells (P<0.05); that is also true of the first three miRNAs in TE-1 (P<0.05). Compared with the normal esophageal squamous epithelial cells, the expression of TGF-β1 was reduced in ECA-109 and TE-1 (P<0.05). Compared with the normal tissues, ESCC tumor tissues were characterized by significant overexpressions of mir-18a-5p, mir-23a-3p, mir-24-3p and mir-25-3p with the rates being 86.5% (45/52), 63.5% (33/52), 78.8% (41/52), 86.5% (45/52), respectively (all P<0.05), and by significantly decreased expression of TGF-β1 (P<0.05). The up-regulation of mir-18a-5p, mir-23a-3p, mir-24-3p, mir-25-3p and the down-regulation of TGF-β1 were not correlated with sex, age, tumor size and tumor site in ESCC patients, but the overexpressions of mir-18a-5p, mir-23a-3p, mir-25-3p were significantly related to tumor differentiation (P<0.05), and a significant variation of mir-25-3p was found in different T stages (P<0.05). TGF-β1 level was lower in tumor tissues compared to normal tissues from the 52 ESCC patients, and higher in stage TIII/IV; than stage TI/II;(P<0.05), and a significant variation was found in histological differentiation (P<0.05). There was no correlation between mir-18a-5p, mir-23a-3p and TGF-β1, but mir-24-3p and mir-25-3p had an inverse correlation with TGF-β1 in tumor microenvironment of ESCC. Mir-18a-5p, mir-23a-3p, mir-24-3p, mir-25-3p and TGF-β1 might play important roles in the carcinogenic process of ESCC.


Zhang J.,Jiangsu University | Sun X.-Y.,PingAn Health Cloud Co. of China | Zhang L.-Y.,Chinese Peoples Liberation Army
Journal of Clinical Neuroscience | Year: 2015

This study aimed to identify the difference of microRNA-7 (miR-7) expression levels between schizophrenia patients and healthy controls and to investigate the regulatory effects of miR-7 on the SHANK3 gene in schizophrenia. miR-7 levels in plasma were detected by quantitative polymerase chain reactions (qPCR) in 50 schizophrenia patients and 50 healthy controls. The hippocampal neuron cell line, HT22, was transfected with lentiviral vector overexpressing or knocking-down miR-7, and the expression levels of SHANK3 mRNA and Shank3 protein were measured by qPCR and immunofluorescence. A luciferase assay was carried out to analyze the regulatory effects of miR-7 on SHANK3. Circulating miR-7 level was significantly increased in schizophrenia patients (p = 0.022). Overexpression of miR-7 suppressed the expression of SHANK3 while the levels of SHANK3 mRNA and Shank protein were significantly increased by miR-7 knockdown. We conclude that miR-7 binds to 3-prime untranslated regions of SHANK3 mRNA and causes the alteration of neuronal morphology and function, potentially playing a crucial role in the pathophysiological process of schizophrenia. © 2015 Elsevier Ltd. All rights reserved.


Application of superhydrophobic surfaces is partly limited by the escaping of the entrapped air beneath the liquid sitting on the superhydrophobic surfaces, i.e., the so-called Cassie-Wenzel wetting transition. Here, to characterize this wetting transition, a linear force response relation with certain abnormal systematic deflection showing the wetting transition information is constructed for the process of squeezing the test liquid drop by two parallel structured (superhydrophobic) surfaces. The linear force response relation is validated by replotting the experimental data from the former work. And then the wetting transition information is investigated on a numerically generated force response curve with certain errors by taking into account the liquid pressure variation during the wetting transition. Results show that the wetting transition can cause an obvious bulge on the linear force response curve. We believe that this method has a potential application in characterizing the robustness of superhydrophobic surfaces. © 2016 Author(s).


Wang G.-G.,Jiangsu University | Guo L.,CAS Changchun Institute of Optics and Fine Mechanics and Physics | Duan H.,Northeast Normal University | Wang H.,CAS Changchun Institute of Optics and Fine Mechanics and Physics
Journal of Computational and Theoretical Nanoscience | Year: 2014

A novel robust meta-heuristic optimization algorithm, which can be considered as an improvement of the recently developed firefly algorithm, is proposed to solve global numerical optimization problems. The improvement includes the addition of information exchange between the top fireflies, or the optimal solutions during the process of the light intensity updating. The detailed implementation procedure for this improved meta-heuristic method is also described. Standard benchmarking functions are applied to verify the effects of these improvements and it is illustrated that, in most situations, the performance of this improved firefly algorithm (IFA) is superior to or at least highly competitive with the standard firefly algorithm, a differential evolution method, a particle swarm optimizer, and a biogeography-based optimizer. Especially, this new method can accelerate the global convergence speed to the true global optimum while preserving the main feature of the basic FA. © 2014 American Scientific Publishers.


Shi W.,CAS Changchun Institute of Applied Chemistry | Shi W.,Jiangsu University | Song S.,CAS Changchun Institute of Applied Chemistry | Zhang H.,CAS Changchun Institute of Applied Chemistry
Chemical Society Reviews | Year: 2013

Because of their unique chemical and physical properties, inorganic semiconducting nanostructures have gradually played a pivotal role in a variety of research fields, including electronics, chemical reactivity, energy conversion, and optics. A major feature of these nanostructures is the quantum confinement effect, which strongly depends on their size, shape, crystal structure and polydispersity. Among all developed synthetic methods, the hydrothermal method based on a water system has attracted more and more attention because of its outstanding advantages, such as high yield, simple manipulation, easy control, uniform products, lower air pollution, low energy consumption and so on. Precise control over the hydrothermal synthetic conditions is a key to the success of the preparation of high-quality inorganic semiconducting nanostructures. In this review, only the representative hydrothermal synthetic strategies of inorganic semiconducting nanostructures are selected and discussed. We will introduce the four types of strategies based on exterior reaction system adjustment, namely organic additive- and template-free hydrothermal synthesis, organic additive-assisted hydrothermal synthesis, template-assisted hydrothermal synthesis and substrate-assisted hydrothermal synthesis. In addition, the two strategies based on exterior reaction environment adjustment, including microwave-assisted and magnetic field-assisted hydrothermal synthesis, will be also described. Finally, we conclude and give the future prospects of this research area. © 2013 The Royal Society of Chemistry.


Li Y.,Jiangsu University
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2013

This study was aimed to investigate the expression pattern of gene PDLIM4 (PDZ and LIM domain 4) and analyze its clinical correlation with the patients suffered from acute myeloid leukemia (AML). The expression pattern of PDLIM4 in AML was detected by using EvaGreen real-time quantitative PCR (RQ-PCR). The results showed that the PDLIM4 transcript significantly decreased in 94 AML patients, compared with 21 controls (P < 0.01). The decrease of PDLIM4 transcript was found in 42 (45%) AML patients. PDLIM4 low-expression occurred among the subtypes of M1/M2/M3 more frequently than that in M4/M5/M6 (56% vs 20%, P < 0.01). AML patients with PDLIM4 low-expression had an overall survival (OS) higher than that in AML patients without PDLIM4 low-expression (P < 0.05). Analysis with receiver operating characteristic curve (ROC) displayed that PDLIM4 expression possesses the diagnostic value to differentiate AML from controls, with ROC curve area of 0.865 (95% CI: 0.801-0.930). It is concluded that reduced PDLIM4 expression is a common and favorable event for the good prognosis in AML, and can be used as a potential diagnostic biomarker of cancer.


Zheng Y.-W.,Yokohama City University | Nie Y.-Z.,Yokohama City University | Nie Y.-Z.,Jiangsu University | Taniguchi H.,Yokohama City University
World Journal of Gastroenterology | Year: 2013

Hepatocellular carcinoma (HCC) is one of the most common cancers, and is also the leading cause of death worldwide. Studies have shown that cellular reprogram-ming contributes to chemotherapy and/or radiotherapy resistance and the recurrence of cancers. In this article, we summarize and discuss the latest findings in the area of cellular reprogramming in HCC. The aberrant expression of transcription factors OCT4, KLF4, SOX2, c-MYC, NANOG, and LIN28 have been also observed, and the expression of these transcription factors is associated with unfavorable clinical outcomes in HCC. Studies indicate that cellular reprogramming may play a critical role in the occurrence and recurrence of HCC. Recent reports have shown that DNA methylation, miR-NAs, tumor microenvironment, and signaling pathways can induce the expression of stemness transcription factors, which leads to cellular reprogramming in HCC. Furthermore, studies indicate that therapies based on cellular reprogramming could revolutionize HCC treatment. Finally, a novel therapeutic concept is discussed: reprogramming control therapy. A potential reprogram-ming control therapy method could be developed based on the reprogramming demonstrated in HCC studies and applied at two opposing levels: differentiation and reprogramming. Our increasing understanding and control of cellular programming should facilitate the exploitation of this novel therapeutic concept and its application in clinical HCC treatment, which may represent a promising strategy in the future that is not restricted to liver cancer. © 2013 Baishideng Publishing Group Co., Limited. All rights reserved.


Wu L.-K.,Jiangsu University | Meng X.-F.,National Supercomputer Center
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2014

The phase structure of QCD with imaginary chemical potential provides information on the phase diagram of QCD with real chemical potential. With imaginary chemical potential iμI=iπT, previous studies show that the Roberge-Weiss (RW) transition endpoints are triple points at both large and small quark masses, and second order transition points at intermediate quark masses. The triple and second order endpoints are separated by two tricritical ones. We present simulations with Nf=2 Wilson fermions to investigate the nature of RW transition endpoints. The simulations are carried out at 8 values of the hopping parameter κ ranging from 0.020 to 0.140 on different lattice volumes. The Binder cumulant, susceptibility, and reweighted distribution of the imaginary part of the Polyakov loop are employed to determine the nature of RW transition endpoints. The simulations show that the two tricritical points are within the ranges 0.070-0.080 and 0.120-0.140, respectively. © 2014 American Physical Society.


Li S.,Jilin University | Yu M.,Jiangsu University | Li H.,Qingdao University | Zhang H.,Jilin University | Jiang Y.,Jilin University
Mediators of Inflammation | Year: 2012

Guillain-Barré syndrome (GBS) is an acute autoimmune-mediated inflammatory demyelinating disease that causes rapidly progressing paralysis and occasionally respiratory failure. We hypothesized that interleukin (IL)-17 and IL-22 are elevated in GBS and participate in the autoimmune inflammatory response of GBS. We used sandwich enzyme-linked immunosorbent assay (ELISA) to measure the IL-17 and IL-22 levels in the CSF, and plasma from 22 GBS patients at the acute phase and 18 healthy controls (HC). The results show that CSF and plasma levels of IL-17 and IL-22 are elevated in GBS patients compared with HC. IL-17 and IL-22 levels in CSF, respectively, are correlated with GBS disability scale scores (GDSs). Meanwhile, IL-17 and IL-22 levels in CSF, IL-22 in CSF, and plasma of GBS patients have positive correlation, respectively. The increased levels of IL-17 and IL-22 in CSF may be explained by the disruption of blood-brain barrier (BBB) and peripheral nervous system (PNS) local inflammation in GBS. Meanwhile, the elevated levels of these two cytokines in plasma suggest the activation of Th17 and Th22 cells in the systemic immune response of GBS. Our data provide preliminary evidence that GBS is associated with high levels of IL-17 and IL-22 in CSF and plasma. These cytokines display pathogenic potential and may serve as useful biomarkers for GBS. © 2012 Shujuan Li et al.


Cao R.,Nanjing Southeast University | Cao R.,University of Michigan | Cheng M.,Nanjing Southeast University | Mi C.,University of Michigan | And 3 more authors.
IEEE Transactions on Energy Conversion | Year: 2012

In this paper, a complementary and modular linear flux-switching permanent magnet (MLFSPM) motor is investigated, in which both the magnets and armature windings are placed in the short mover, while the long stator consists of iron core only. The proposed MLFSPM motor incorporates the high power density of a linear permanent magnet synchronous motor and the simple structure of a linear induction motor. It is especially suitable for long stator applications such as urban rail transit. The objective of this paper is to build the mathematical model for the purpose of control of this motor. The simulation results by means of finite-element analysis (FEA) verified the theoretical analysis and the effectiveness of this model. Both the analytical model and the FEA results are validated by experiments based on a prototype motor. © 2012 IEEE.


Lu M.M.,China University of Mining and Technology | Xie K.H.,Zhejiang University | Wang S.Y.,University of Newcastle | Li C.X.,Jiangsu University
International Journal of Geomechanics | Year: 2013

On the basis of the axisymmetric consolidation model, the governing equation and the corresponding solution were developed for the consolidation of a composite foundation with an impervious column by incorporating an arbitrary stress increment. The consolidation behavior was then investigated as part of the parameter analysis for a composite foundation with an impervious column. The results show that the consolidation rate for a composite foundation with an impervious column was slower than that for a composite foundation with a granular column but was more rapid than that for a natural soil foundation. The consolidation rate accelerated with increasing values of the column-soil constrained modulus ratio or the top-to-bottom stress increment ratio and with decreasing values of the loading period or the radius ratio of the influence zone to the column. The column-soil total stress ratio increased with consolidation and approached the value of the columnsoil constrained modulus ratio. © 2012 AmericanSociety of Civil Engineers.


Bao W.,Jiangsu University
World Transactions on Engineering and Technology Education | Year: 2014

In China, engineering universities traditionally have placed more emphasis on the cultivation of students' science and engineering knowledge, whilst ignoring the significance of intercultural communication ability. This article is based on a test of sophomores at an engineering university conducted to establish the correlation between their language ability and social culture competence. Based on the analysis of the results, suggestions on how to enhance students' intercultural communication awareness have been put forward.


Zhang J.,Jiangsu University
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

In the title compound, {[Lu(NO3)2(C6H 18N3OP)4][AgWS4]}n , hexamethylphosphoramide (hmp), tetra-thio-tungstate, silver iodide and lutetium nitrate were self-assembled, forming an anionic {[AgWS4] -}n chain extending parallel to [001]. The Lu III atom in the cation is coordinated by eight O atoms from two nitrate groups and four hmp ligands in a distorted square-antiprismatic geometry. Together with the two nitrate groups, the cation is monovalent, which leads to the anionic chain having a [WS4Ag] repeat unit. The polymeric anionic chain has a distorted linear configuration with W - Ag - W and Ag - W - Ag angles of 161.66 (2) and 153.503 (12)°, respectively. The title complex is isotypic with the Y, Yb, Eu, Nd, La, Dy and Sm analogues.


Zhang A.,Northwestern University | Xu M.,Jiangsu University | Mo Y.-Y.,University of Mississippi Medical Center
Journal of Molecular Cell Biology | Year: 2014

Advances in functional genomics have led to discovery of a large group of previous uncharacterized long non-coding RNAs (lncRNAs). Emerging evidence indicates that lncRNAs may serve as master gene regulators through various mechanisms. Dysregulation of lncRNAs is often associated with a variety of human diseases including cancer. Of significant interest, recent studies suggest that lncRNAs participate in the p53 tumor suppressor regulatory network. In this review, we discuss how lncRNAs serve as p53 regulators or p53 effectors. Further characterization of these p53-associated lncRNAs in cancer will provide a better understanding of lncRNAmediated gene regulation in the p53 pathway. As a result, lncRNAs may prove to be valuable biomarkers for cancer diagnosis or potential targets for cancer therapy. © 2014 The Author (2014). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.


Qi J.,Jiangsu University | Qi J.,Nanjing University of Aeronautics and Astronautics | Qian X.,Massachusetts Institute of Technology | Qi L.,Massachusetts Institute of Technology | And 5 more authors.
Nano Letters | Year: 2012

Two-dimensional atomic sheets such as graphene and boron nitride monolayers represent a new class of nanostructured materials for a variety of applications. However, the intrinsic electronic structure of graphene and h-BN atomic sheets limits their direct application in electronic devices. By first-principles density functional theory calculations we demonstrate that band gap of zigzag BN nanoribbons can be significantly tuned under uniaxial tensile strain. The unexpected sensitivity of band gap results from reduced orbital hybridization upon elastic strain. Furthermore, sizable dipole moment and piezoelectric effect are found in these ribbons owing to structural asymmetry and hydrogen passivation. This will offer new opportunities to optimize two-dimensional nanoribbons for applications such as electronic, piezoelectric, photovoltaic, and opto-electronic devices. © 2012 American Chemical Society.


Qiao F.,Jiangsu University
Materials Science Forum | Year: 2016

Recently, photovoltaic devices based on colloidal semiconductor nanocrystals (NCs) have attracted a great interest due to their flexible synthesis with tunable band gaps and shape-dependent optical and electronic properties. However, the surface of NCs typically presents long chain with electrically insulating organic ligands, which hinder the device applications for NCs. So the major challenge of NCs for photovoltaic devices application is to decrease the inter NC space and the height of the tunnel barriers among NCs, therefore increase the transport properties of NCs. In this article, recent development of colloidal semiconductor NCs and possible routes for improving transport properties of colloidal NCs were reviewed. Among those methods, the thermal annealing approach provides a simple and cost-effective way to fabricate superlattice and to decrease the inter-space among NCs, which may be used for the preparation of other nanocrystalline superstructure and functional devices. © 2016 Trans Tech Publications, Switzerland.


Dai W.,Tsinghua University | Chen X.-F.,Jiangsu University | Zhang B.-W.,Central China Normal University | Wang E.,Central China Normal University
Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics | Year: 2015

The transverse momentum spectrum of η meson in relativistic heavy-ion collisions is studied at the Next-to-Leading Order (NLO) within the perturbative QCD, where the jet quenching effect in the QGP is incorporated with the effectively medium-modified η fragmentation functions using the higher-twist approach. We show that the theoretical simulations could give nice descriptions of PHENIX data on η meson in both p+p and central Au + Au collisions at the RHIC, and also provide numerical predictions of η spectra in central Pb + Pb collisions with sNN=2.76 TeV at the LHC. The ratios of η/π0 in p+p and in central Au + Au collisions at 200 GeV are found to overlap in a wide pT region, which matches well the measured ratio η/π0 by PHENIX. We demonstrate that, at the asymptotic region when pT→∞ the ratios of η/π0 in both Au + Au and p+p are almost determined only by quark jets fragmentation and thus approach to the one in e+e- scattering; in addition, the almost identical gluon (quark) contribution fractions to η and to π result in a rather moderate variation of η/π0 distribution at intermediate and high pT region in A+A relative to that in p+p; while a slightly higher η/π0 at small pT in Au + Au can be observed due to larger suppression of gluon contribution fraction to π0 as compared to the one to η. The theoretical prediction for η/π0 at the LHC has also been presented. © 2015 The Authors.


Wu L.,Tsinghua University | Zhu J.,Jiangsu University | Xie H.,Tsinghua University
Applied Optics | Year: 2015

By using the principle of stereovision, 3D digital image correlation (3D-DIC) can determine the 3D morphology and deformation of a target and has been widely used in experimental mechanics as a noncontact 3D measurement technique. To eliminate the limitations of the conventional 3D-DIC system, this study proposes a calibration-free single-lens 3D-DIC system based on a bilateral telecentric lens and a bi-prism. The performance of the proposed system is verified by tests of rigid-body translation along the out-of-plane direction. As a comparison, the same rigid-body translations are measured using a single-entocentric-lens 3D-DIC system. The results show that the measurement accuracy of the proposed system is higher than that of the entocentric-lens-based one. As an application, the proposed system is used to measure the thermal linear expansion of a ceramic plate at elevated temperatures. The reasonable measurement results verify its applicability in deformation measurements, even in high-temperature environments. © 2015 Optical Society of America.


Du H.,Nanjing Southeast University | Du H.,Hefei University of Technology | Li S.,Nanjing Southeast University | Ding S.,Jiangsu University
Asian Journal of Control | Year: 2013

In this paper, the consensus problem is investigated via bounded controls for the multi-agent systems with or without communication. Based on the nested saturation method, the saturated control laws are designed to solve the consensus problem. Under the designed saturated control laws, the transient performance of the closed-loop system can be improved by tuning the saturation level. First of all, asymptotical consensus algorithms with bounded control inputs are proposed for the multi-agent systems with or without communication delays. Under these consensus algorithms, the states' consensus can be achieved asymptotically. Then, based on a kind of novel nonlinear saturation functions, bounded finite-time consensus algorithms are further developed. It is shown that the states' consensus can be achieved in finite time. Finally, two examples are given to verify the efficiency of the proposed methods. © 2012 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society.


Yan X.,Zhejiang University | Yan X.,University of Utah | Li S.,University of Utah | Li S.,Hangzhou Normal University | And 10 more authors.
Journal of the American Chemical Society | Year: 2013

Metallacyclic cores provide a scaffold upon which pendant functionalities can be organized to direct the formation of dimensionally controllable nanostructures. Because of the modularity of coordination-driven self-assembly, the properties of a given supramolecular core can be readily tuned, which has a significant effect on the resulting nanostructured material. Herein we report the efficient preparation of two amphiphilic rhomboids that can subsequently order into 0D micelles, 1D nanofibers, or 2D nanoribbons. This structural diversity is enforced by three parameters: the nature of the hydrophilic moieties decorating the parent rhomboids, the concentration of precursors during self-assembly, and the reaction duration. These nanoscopic constructs further interact to generate metallohydrogels at high concentrations, driven by intermolecular hydrophobic and π-π interactions, demonstrating the utility of coordination-driven self-assembly as a first-order structural element for the hierarchical design of functional soft materials. © 2013 American Chemical Society.


Liu X.,Jiangsu University | Wang W.,University of Bonn | Xie Y.,Central China Normal University | Xie Y.,University of Edinburgh
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2014

We formulate the most general time-dependent distributions of Bs→J/ψ(→l+l-)φ(→K+K-) in which the direct charge parity (CP) violation is explicitly incorporated. We investigate the B→J/ψV decays in the perturbative QCD approach where V is a light vector meson. Apart from the leading-order factorizable contributions, we also take into account QCD vertex corrections and the hard-spectator diagrams. With the inclusion of these sizable corrections, most of our theoretical results for CP-averaged branching ratios, polarization fractions, CP-violating asymmetries, and relative phases are consistent with the available data. Based on the global agreement, we further explore the penguin contributions and point out that the φs extracted from Bs→J/ψφ can be shifted away by O(10-3). © 2014 American Physical Society.


Lu H.,Jiangsu University
European journal of histochemistry : EJH | Year: 2012

This study aimed at exploring the expression of Surfactant protein-C (SP-C) and Ki67 in autopsy lung tissues of premature infants dying from respiratory distress syndrome (RDS) who were exposed to mechanical ventilation and elevated oxygen concentrations. The possible influence of pulmonary surfactant (PS) on the expression of SP-C and Ki67 was also investigated. Thirty preterm infants were selected who were histologically and clinically diagnosed as RDS. Preterm infants with RDS were divided into 4 groups, according to the time of death: infants ventilated for 1-3 days, 4-8 days, 9-16 days and >6 days. Five premature infants died within 1 day after delivery for non- pulmonary reasons served as controls. The expression of SP-C and Ki67 in lungs was detected by immunohistochemistry. Compared with the control group, the expression of SP-C and Ki67 in RDS infants decreased significantly after 1-3 days of ventilation, but increased after 4 days and reached peak value after 9-16 days. No significant difference in the expression of SP-C and Ki67 was found between infants treated with PS and those without. Thus our results suggest SP-C and Ki67 may have participated in the pulmonary pathological process in ventilated/oxygen treated preterm infants with RDS, and exogenous surfactant had no effect on the expression of SP-C and Ki67 in the lungs of ventilated/oxygen treated preterm infants with RDS.


Zhang Z.,Jiangsu University | Zhang N.,Xian University of Architecture and Technology | Feng Z.,Xian Jiaotong University
Expert Systems with Applications | Year: 2014

The multi-satellite control resource scheduling problem (MSCRSP) is a kind of large-scale combinatorial optimization problem. As the solution space of the problem is sparse, the optimization process is very complicated. Ant colony optimization as one of heuristic method is wildly used by other researchers to solve many practical problems. An algorithm of multi-satellite control resource scheduling problem based on ant colony optimization (MSCRSP-ACO) is presented in this paper. The main idea of MSCRSP-ACO is that pheromone trail update by two stages to avoid algorithm trapping into local optima. The main procedures of this algorithm contain three processes. Firstly, the data get by satellite control center should be preprocessed according to visible arcs. Secondly, aiming to minimize the working burden as optimization objective, the optimization model of MSCRSP, called complex independent set model (CISM), is developed based on visible arcs and working periods. Ant colony algorithm can be used directly to solve CISM. Lastly, a novel ant colony algorithm, called MSCRSP-ACO, is applied to CISM. From the definition of pheromone and heuristic information to the updating strategy of pheromone is described detailed. The effect of parameters on the algorithm performance is also studied by experimental method. The experiment results demonstrate that the global exploration ability and solution quality of the MSCRSP-ACO is superior to existed algorithms such as genetic algorithm, iterative repair algorithm and max-min ant system. © 2013 Elsevier Ltd. All rights reserved.


Yang J.,China Pharmaceutical University | Lu Y.,China Pharmaceutical University | Yang J.,Center for Drug Evaluation | Zhang H.,Jiangsu University
Clinical Pharmacokinetics | Year: 2013

Background and Objectives: Many attempts have been made to predict the warfarin maintenance dose in patients beginning warfarin therapy using a descriptive model based on multiple linear regression. Here we report the first attempt to develop a comprehensive mechanistic model integrating in vitro-in vivo extrapolation (IVIVE) with a pharmacokinetic-pharmacodynamic model to predict the warfarin maintenance dose in Han Chinese patients. The model incorporates demographic factors [sex, age, body weight (BW)] and the genetic polymorphisms of cytochrome P450 (CYP) 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1). Methods: Information on the various factors, mean warfarin daily dose and International Normalized Ratio (INR) was available for a cohort of 197 Han Chinese patients. Based on in vitro enzyme kinetic parameters for S-warfarin metabolism, demographic data for Han Chinese and some scaling factors, the S-warfarin clearance (CL) was predicted for patients in the cohort with different CYP2C9 genotypes using IVIVE. The plasma concentration of S-warfarin after a single oral dose was simulated using a one-compartment pharmacokinetic model with first-order absorption and a lag time and was combined with a mechanistic coagulation model to simulate the INR response. The warfarin maintenance dose was then predicted based on the demographic data and genotypes of CYP2C9 and VKORC1 for each patient and using the observed steady-state INR (INRss) as a target value. Finally, sensitivity analysis was carried out to determine which factor(s) affect the warfarin maintenance dose most strongly. Results: The predictive performance of this mechanistic model is not inferior to that of our previous descriptive model. There were significant differences in the mean warfarin daily dose in patients with different CYP2C9 and VKORC1 genotypes. Using IVIVE, the predicted mean CL of S-warfarin for patients with CYP2C9*1/*3 (0.092 l/h, n = 11) was 57 % less than for those with wild-type*1/*1 (0.215 l/h, n = 186). In addition,*1/*1 patients needed about 1 week to reach steady state, whereas*1/*3 patients needed about 2 weeks. In terms of the predicted INRss values, only ten patients had INRss values outside the expected therapeutic range (1.5-2.8). To evaluate our mechanistic model, we predicted the warfarin maintenance dose for 183 patients and explained 42 % of its variation, which is comparable to our previous prediction using a descriptive model based on multiple linear regression. The mean predicted/observed warfarin doses (mg/day) for different combinations of CYP2C9 and VKORC1 genotypes were 1.54/3.75 (n = 1) for*1/*1 and GG, 3.33/3.66 (n = 36) for*1/*1 and AG, 2.31/2.41 (n = 136) for*1/*1 and AA, and 1.56/1.69 (n = 10) for*1/*3 and AA, respectively. Sensitivity analysis indicated BW and genetic polymorphisms of CYP2C9 and VKORC1 were important factors affecting the warfarin maintenance dose in the study population. Conclusion: The mechanistic model reported is the first to integrate IVIVE with a pharmacokinetic-pharmacodynamic model to describe the association of the warfarin maintenance dose with sex, age, BW and the genotypes of CYP2C9 and VKORC1. The model was effective in predicting S-warfarin clearance and in simulating its plasma concentration-time curve in a cohort of Han Chinese patients. In addition, the model accurately predicted the INR response and warfarin maintenance dose in a cohort of Han Chinese patients. © 2013 Springer International Publishing Switzerland.


Cao J.,Jiangsu University | Shi F.,Shandong Lvdu Bio technique Industry
Evolutionary Bioinformatics | Year: 2012

Rapid alkalinization factors (RALFs) are plant small peptides that could induce a rapid pH increase in the medium of plant cell suspension culture and play a critical role in plant development. The evolutionary process of the RALF gene family remains unclear. To obtain details of the phylogeny of these genes, this study characterized RALF genes in Arabidopsis, rice, poplar and maize. Phylogenetic trees, evolutionary patterns and molecular evolutionary rates were used to elucidate the evolutionary process of this gene family. In addition, the different signatures of selection, expression patterns, and subcellular localization of RALFs were also analyzed. We found that the RALF gene family had a rapid birth process after the separation of the eudicot and monocot species about 145 million years ago, that tandem duplication played a dominant role in the expansion of Arabidopsis and rice RALF gene family, and that RALFs were under purifying selection according to estimations of the substitution rates of these genes. We also identified a diverse expression pattern of RALF genes and predominant extracellular localization feature of RALF proteins. Our findings shed light on several key differences in RALF gene family evolution among the plant species, which may provide a scaffold for future functional analysis of this family. © the author(s), publisher and licensee Libertas Academica Ltd.


Pectin lyases are a group of enzymes that are thought to contribute to many biological processes, such as the degradation of pectin. However, until this study, no comprehensive study incorporating phylogeny, chromosomal location, gene duplication, gene organization, functional divergence, adaptive evolution, expression profiling and functional networks has been reported for Arabidopsis. Sixty-seven pectin lyase genes have been identified, and most of them possess signal sequences targeting the secretory pathway. Phylogenetic analyses identified five gene groups with considerable conservation among groups. Pectin lyase genes were non-randomly distributed across chromosomes and clustering was evident. Functional divergence and adaptive evolution analyses suggested that purifying selection was the main force driving pectin lyase evolution, although some critical sites responsible for functional divergence might be the consequence of positive selection. A stigma- and receptacle-specific expression promoter was identified, and it had increased expression in response to wounding. Two hundred and eighty-eight interactions were identified by functional network analyses, and most of these were involved in cellular metabolism, cellular transport and localization, and stimulus responses. This investigation contributes to an improved understanding of the complexity of the Arabidopsis pectin lyase gene family. © 2012 Jun Cao.


To investigate the effect of OX40/OX40L interaction on the nuclear factor of activated T cells c1 (NFATc1) in ApoE-/- mice. Lymphocytes were prepared from mouse spleens after Collar-treated Surgery, then incubated with a range of agonistic anti-OX40 mAbs and inhibitory anti-OX40L mAb to stimulate or inhibit OX40-OX40L interaction in vitro. The expression of NFATc1 mRNA and protein in lymphocytes of ApoE-/- mice was measured by Real Time PCR and flow cytometry, respectively. (1) After stimulating OX40-OX40L signal pathway, the expression of NFATc1 mRNA and protein in leukocytes of ApoE-/- mice was significantly increased, with maximal effect occurring at 20 μg/ml anti-OX40 mAb-stimulated, and peaked at 24 h at any concentration (P < 0.01). (2) Anti-OX40L mAb significantly suppressed the expression of NFATc1 in leukocytes of ApoE-/- mice, with maximal effect occurring at 20 μg/ml anti-OX40L mAb, and peaked at 24 h (P < 0.001). OX40-OX40L interaction can regulate the mRNA and protein expressions of NFATc1 in lymphocytes of ApoE-/- mice.


Chen Q.,Jiangsu University | Xiao D.-S.,Guangzhou University
Nitric Oxide - Biology and Chemistry | Year: 2014

Adult hippocampus is highly vulnerable to iron-induced oxidative stress. Aerobic exercise has been proposed to reduce oxidative stress but the findings in the hippocampus are conflicting. This study aimed to observe the changes of redox-active iron and concomitant regulation of cellular iron homeostasis in the hippocampus by aerobic exercise, and possible regulatory effect of nitric oxide (NO). A randomized controlled study was designed in the rats with swimming exercise treatment (for 3 months) and/or an unselective inhibitor of NO synthase (NOS) (L-NAME) treatment. The results from the bleomycin-detectable iron assay showed additional redox-active iron in the hippocampus by exercise treatment. The results from nonheme iron content assay, combined with the redox-active iron content, showed increased storage iron content by exercise treatment. NOx (nitrate plus nitrite) assay showed increased NOx content by exercise treatment. The results from the Western blot assay showed decreased ferroportin expression, no changes of TfR1 and DMT1 expressions, increased IRP1 and IRP2 expression, increased expressions of eNOS and nNOS rather than iNOS. In these effects of exercise treatment, the increased redox-active iron content, storage iron content, IRP1 and IRP2 expressions were competely reversed by L-NAME treatment, and decreased ferroportin expression was in part reversed by L-NAME. L-NAME treatment completely inhibited increased NOx and both eNOS and nNOS expression in the hippocampus. Our findings suggest that aerobic exercise could increase the redox-active iron in the hippocampus, indicating an increase in the capacity to generate hydroxyl radicals through the Fenton reactions, and aerobic exercise-induced iron accumulation in the hippocampus might mainly result from the role of the endogenous NO.© 2013 Elsevier Inc. All rights reserved.


Gu C.,Jiangsu University
International Journal of Information Technology and Web Engineering | Year: 2015

Cryptographic multilinear maps have extensive applications. However, current constructions of multilinear maps suffer from the zeroizing attacks. For a candidate construction of multilinear maps described by Garg, Gentry, and Halevi (GGH13), Hu & Jia recently presented an efficient attack, which broke the GGH13-based applications of multipartite key exchange (MPKE) and witness encryption (WE) based on the hardness of 3-exact cover problem. By introducing random matrix, the author presents an improvement of the GGH13 map, which supports the applications for public tools of encoding in the GGH13 map, such as MPKE and WE. The security of the construction depends upon new hardness assumption. Moreover, the author's improvement destroys the structure of the ring element in the principal ideal lattice problem, and avoids potential attacks using algorithm of solving short principal ideal lattice generator. © Copyright 2015, IGI Global. Copying or distributing in print or electronic forms without written permission of IGI Global is prohibited.


Wang H.,Jiangsu University | Li J.,Dalian University of Technology
Gaodianya Jishu/High Voltage Engineering | Year: 2013

In order to testify the important effect of hydroxyl radicals (·OH) on organic compounds degradation during a pulsed discharge process in aqueous system, by choosing phenol as a target pollutant, the degradation rates of phenol and the energy efficiencies of reaction system were reviewed under different additive collectors when air and O2 were used as bubbling gas, respectively. Under the same experimental conditions, the concentrations of H2O2 produced by pulsed discharge in deionized water were also measured. The experimental results showed that, in the carrier gases of air and O2, the degradation rates of phenol and the energy efficiencies of phenol decreased with the increase of the concentration of addition (both Na2CO3 and n-butanol) during a pulsed discharge process. And the important effect of ·OH on organic compounds degradation in the pulsed discharge plasma system was testified. Furthermore, the measurement results of H2O2 proved the collecting effect of collectors on ·OH.


Hui L.L.,Jiangsu University
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology | Year: 2012

This study was aimed to evaluate the effect of triptolide (TPL) on the reversal of multidrug resistance in K562/A02 cell line. The sensitivity of K562 and K562/A02 to adriamycin (ADM) and reversal of drug resistance were determined with MTT method. The concentration of intracellular ADM and P-glycoprotein expression were detected by flow cytometry. Luciferase reporter gene assay was used to detect the transcriptional activity of MDR1 promoter. The results showed that TPL significantly decreased the resistance degree of K562/A02 cells, inhibited P-glycoprotein expression (mean fluorescent intensity decreased from 123 ± 13 to 39 ± 13) and increased the intracellular concentration of ADM (mean fluorescent intensity increased from 18 ± 5 to 34 ± 6) in K562/A02 cells. Luciferase reporter gene assay demonstrated that TPL inhibited the transcriptional activity of MDR1 promoter by 75%. It is concluded that TPL may effectively reverse the multidrug resistance in K562/A02 cells via modulating P-glycoprotein expression and increasing intracellular ADM accumulation.


Chen Y.Z.,Jiangsu University
Engineering Analysis with Boundary Elements | Year: 2016

This paper provides a numerical solution for the degenerate scale in the antiplane elasticity with the traction free condition along the half-plane boundary. The image method is used in the formulation of the fundamental solution. After using the Betti׳s reciprocal theorem between the fundamental field and the physical field, the null field boundary integral equation (BIE) is obtained. After performing the coordinate transform, the BIE can be alternatively formulated in the normal scale, and a linear algebraic equation is obtained after discretization. The influence matrix in the normal scale is invertible. The degenerate scale can be evaluated by the invertible property of the influence matrix. © 2016 Elsevier Ltd


Li W.W.,Jiangsu University
Zhonghua nan ke xue = National journal of andrology | Year: 2012

To detect sperm plasma membrane integrity (PMI) of cigarette smoking infertile males using SYBR-14/ PI fluorescent staining and flow cytometry and investigate its clinical significance. We collected semen samples from 132 cigarette smoking infertile men and 70 normal fertile controls, the former divided into a heavy-smoker group (> 20 cigarettes a day, n = 68) and a light-smoker group (< or = 20 cigarettes a day, n = 64). We performed computer-assisted semen analysis of the semen samples, and determined sperm PMI by flow cytometry after rinsing with PBS and staining by SYBR-14/PI, the sperm with normal PMI indicated as the percentage of those emitting green fluorescence (SYBR-14+/PI- %), dead sperm as the percentage of those emitting red (SYBR-14-/PI+), and moribund sperm as the percentage of those emitting both green and red (SYBR-14+/PI+). Both the heavy- and light-smoker groups showed significant differences in SYBR-14-/PI+ % and SYBR-14+/PI- % from the normal controls (P < 0.01 or P < 0.05). SYBR-14+/PI- % was remarkably lower, while SYBR-14-/PI+ % markedly higher in the heavy-smoker than in the light-smoker group (P < 0.05). There was a significant correlation between SYBR-14+/PI- % and sperm motility (r = 0.938, P = 0.000). SYBR-14/PI fluorescent staining and flow cytometry analysis could quickly and exactly detect sperm PMI. Cigarette smoking reduces sperm PMI and consequently sperm motility, which might be an important factor of male infertility.


Guo F.,Jilin Normal University | Shi W.,Jilin Normal University | Lin X.,Jilin Normal University | Yan X.,Jiangsu University | And 2 more authors.
Separation and Purification Technology | Year: 2015

In this work, novel visible-light-driven BiVO4/InVO4 composite photocatalysts were fabricated by a facile hydrothermal method. The XRD results indicated that the prepared photocatalyst is a two-phase composite of BiVO4 and InVO4. SEM results illustrated that with the increase of BiVO4 content the morphology of BiVO4/InVO4 composites changed from hierarchical microsphere to leaf-like nanostructure. The photocatalytic activities of the as-synthesized samples were evaluated towards the degradation of rhodamine B (Rh B) aqueous solution. The results showed that the as-fabricated BiVO4/InVO4 photocatalysts displayed much higher photocatalytic activities in comparison with pure InVO4. The BiVO4/InVO4 composite with a BiVO4 content of 80 wt% exhibited the highest photocatalytic performance. The enhanced photocatalytic activity of the BiVO4/InVO4 composite photocatalyst was attributed predominantly to the efficient separation of photoinduced electrons and holes because of the heterojunction formed between BiVO4 and InVO4. The possible photocatalytic mechanism of BiVO4/InVO4 composite was also discussed in detail. Superoxide radicals were the major active species. © 2014 Elsevier B.V. All rights reserved.


Luo M.J.,Jiangsu University
Journal of High Energy Physics | Year: 2015

Abstract: The observed cosmic acceleration was attributed to an exotic dark energy in the framework of classical general relativity. The dark energy behaves very similar with vacuum energy in quantum mechanics. However, once the quantum effects are seriously taken into account, it predicts a completely wrong result and leads to a severe fine-tuning. To solve the problem, the exact meaning of time in quantum mechanics is reexamined. We abandon the standard interpretation of time in quantum mechanics that time is just a global parameter, replace it by a quantum dynamical variable playing the role of physical clock. We find that synchronization of two spatially separated clocks can not be precisely realized at quantum level. There is an intrinsic quantum uncertainty of distant clock time, which implies an apparent vacuum energy fluctuation and gives an observed dark energy density (Formula presented.) at tree level approximation, where LP and LH are the Planck and Hubble scale cutoffs. The fraction of the dark energy is given by (Formula presented.), which does not evolve with the internal clock time. The “dark energy” as a quantum cosmic variance is always seen comparable with the matter energy density by an observer using the internal clock time. The corrected distance-redshift relation of cosmic observations due to the distant clock effect are also discussed, which again gives a redshift independent fraction (Formula presented.). The theory is consistent with current cosmic observations. © 2015, The Author(s).


A hierarchy of super AKNS equations associated with a sl(2|1) matrix-valued spectral problem is derived. It is shown that each equation in the hierarchy is bi-super Hamiltonian. Moreover, a new finite dimensional super Hamiltonian system (FDSHS), together with its Lax representation, r-matrix and conversed integrals of motion, is obtained from the spectral problem by binary nonlinearization. © 2015 World Scientific Publishing Company.


Bi Q.,Jiangsu University
Science China Technological Sciences | Year: 2010

The dynamics of a typical Belousov-Zhabotinsky (BZ) reaction with multiple time scales is investigated in this paper. Different forms of periodic bursting phenomena, and specially, three types of chaotic bursters with different structures can be obtained, which are in common with the behaviors observed in experiments. The bifurcations connecting the quiescent state and the repetitive spikes are presented to account for the occurrence of the N K oscillations as well as the different forms of chaotic bursters. The mechanism of the period-adding bifurcation sequences is explored to reveal why the length of the periods in the sequences does not change continuously with the continuous variation of the parameters. © 2010 Science in China Press and Springer-Verlag Berlin Heidelberg.


Zhu X.,Nanjing Southeast University | Zhu X.,Jiangsu University | Cheng M.,Nanjing Southeast University
Science China Technological Sciences | Year: 2010

In this paper, a new hybrid excited doubly salient stator-permanent-magnet motor is proposed, where both permanent magnets and DC field windings are located in the stator. In theory, the mathematical model and design method of the motor are developed. The corresponding output power equation and the relationship between the flux control capability and the extended speed range are deduced in details. By using an efficient "one-step" three-dimensional (3D) finite element method, the electromagnetic performances are analyzed, in which the leakage flux outside the stator circumference and end-effect are taken into account. Based on the operation principle of the motor, the control strategy and scheme are developed and implemented experimentally. Both experimental results and finite element analysis show that the proposed motor not only maintains the advantages of doubly salient permanent magnet motors, but also offers high energy efficiency over a wide speed range, which makes the motor an interesting candidate for electric vehicles. © 2010 Science in China Press and Springer Berlin Heidelberg.


Zhou X.,Jiangsu University | Zhou X.,Nanjing Normal University | Wang G.,Nanjing Normal University
Journal of Environmental Sciences | Year: 2010

The ecological floating bed system is a natural alternative to technical methods of wastewater treatment and involves complex processes induced by plants or microorganisms in the wastewater. This study aimed to identify nutrient concentration variations during Oenanthe javanica (Blume) DC growth and decay in the ecological floating bed system. Results showed that the third-order polynomial equation was suitable to describe pollutant concentration changes, showing that the effect of O. javanica ecological floating bed system on polluted water could be divided into the purification phase and decay phase. During the purification phase, nutrient concentrations rapidly decreased because O. javanica influenced water microbial communities and water physical parameters (i.e., dissolved oxygen, pH, and temperature), and had a direct uptake of nutrients. However, during the decay phase, nitrogen and phosphorus concentrations in the plant tissues decreased, and these lost nutrients ultimately transferred to water and led to water quality deterioration. Results also showed that the uptake and storage of O. javanica in nutrients were temporary and the plant served only as media of the nutrients removed from the water. Under these circumstances, harvesting was an appropriate intervention to improve the treatment efficiency of O. javanica ecological floating bed system. © 2010 The Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences.


Chen Y.Z.,Jiangsu University
Acta Mechanica | Year: 2016

This paper provides a stress analysis for multiple confocal elliptic dissimilar layers with thermal loadings. The layers are under different temperature distributions. In the problem, no static loading is applied. The different assumed values of the thermal expansion coefficients and temperatures for two layers become the generalized loading. The medium is composed of many confocal elliptic dissimilar layers. The conformal mapping method is used in the paper throughout. The complex potentials are expressed in the form of Laurent series in the ring region. The transfer matrix method is used to study the continuity condition for the stress and displacement along the interfaces. Two cases, or the infinite matrix and the finite matrix, are studied in this paper. For two cases, several numerical results are provided. © 2016 Springer-Verlag Wien


Ding S.,Jiangsu University | Li S.,Nanjing Southeast University | Zheng W.X.,University of Western Sydney
Automatica | Year: 2012

A global nonsmooth stabilization scheme is presented for a class of nonlinear cascaded systems with uncontrollable linearization. A stepwise constructive control methodology is proposed for the driving subsystem by using the adding a power integrator technique. Under suitable conditions and based on homogeneous properties, it is proved that the stabilization of the driving subsystem implies the stabilization of the overall cascaded system. Due to the versatility of the adding a power integrator technique and homogeneous properties, the proposed controller not only can be used to stabilize the cascaded system asymptotically, but also is able to lead to an interesting result of finite-time stabilization under appropriate conditions. © 2012 Elsevier Ltd. All rights reserved.


Zhao W.X.,Jiangsu University | Cheng M.,Nanjing Southeast University | Chau K.T.,University of Hong Kong | Chan C.C.,University of Hong Kong
IET Electric Power Applications | Year: 2012

This study investigates the operations of a recently developed fault-tolerant flux-switching permanent-magnet (FT-FSPM) brushless motor, in which the concentrated coils of each stator phase are wound on alternate teeth and permanent-magnets (PMs) are located in the stator, offering a number of significant advantages over conventional PM brushless machines, such as simpler rotor structure, easier cooling in PMs and independence of phases. The control strategy of the FT-FSPM motor is proposed for torque ripple minimisation, in which the key is to introduce harmonic currents to compensate for non-ideal sinusoidal back-electromotive force (EMF). Both simulation and experimental results confirm that the proposed control algorithms can reduce torque ripple and offer good dynamic performance under normal and fault conditions. Hence, it can be concluded that the developed motor drive system is suitable for applications where reliability, efficiency and power density are of importance in such applications as electric and hybrid electric vehicles. © 2012 The Institution of Engineering and Technology.


Hybrid organic/inorganic solar cells based on pyridine-treated CdSe quantum dots and poly(3-hexylthiophene)(P3HT) nanofibers were fabricated. By tuning the ligands of CdSe dots and morphology modification of blend film through thermal annealing, the insulating and less stable pyridine ligands of CdSe QDs can be removed by gentle heating and modified morphology results in more efficient charge separation and transport properties, and this leads to an improved power conversion efficiency of 1.22%. These results demonstrate a promising approach to improve charge transport in the hybrid nanocrystal-polymer composite photovoltaic cells. © 2013 Elsevier Ltd. All rights reserved.


Li P.,Nanjing Forestry University | Wang J.,Jiangsu University
Nongye Jixie Xuebao/Transactions of the Chinese Society for Agricultural Machinery | Year: 2014

In recent years, with the rapid development of greenhouse agriculture and information technology, more and more modern information technologies were applied in greenhouse environment management. And those technologies promote the development of intelligent management technology for greenhouse environment. Aiming at the demands of intelligent management for greenhouse environment information oriented to internet of things(IOT), this paper analyzed the research progress of intelligent management for greenhouse environment information from three aspects, information acquisition, information processing and decision-making service of greenhouse environment, and the future studies about intelligent management of greenhouse environment were proposed.


Ma K.,Tsinghua University | Xie H.,Tsinghua University | Zhu J.,Jiangsu University
Measurement Science and Technology | Year: 2014

In this work, we propose two novel methods for the measurement of the slope of reflective surfaces, namely phase-shift based coherent gradient sensing: both a three-step and four-step phase shifting method are deduced theoretically and the full-field phase value can be calculated accurately by three or four inteferograms. Using these two methods, the automatic process of the fringes can be realized and the experimental results show that the relative errors of the curvature measurement with both methods are less than 5%. These successful results verify the feasibility of these methods, and both have a good potential to be utilized for measuring the slope, curvature, and shape of a thin film/substrate system. © 2014 IOP Publishing Ltd.


Wu L.,Tsinghua University | Zhu J.,Jiangsu University | Xie H.,Tsinghua University
Measurement Science and Technology | Year: 2014

Three-dimensional (3D) digital image correlation (DIC) is an effective measurement method to obtain both 3D morphology and displacements of a target. The aim of this study was to investigate the 3D DIC technique using a single camera and a bi-prism so as to benefit from the high accuracy of measurements and the compatibility of the measurement system. A modified virtual point (MVP) model based on the analysis of light refraction in the prism using a backward ray-tracing method was proposed. As applications, the measurements of morphology and rigid-body translations of a cylindrical specimen and the deflection of a cantilever were conducted. The results show that the proposed method is capable of accurate determination of the 3D morphology and displacements. They also verify that the MVP model is feasible and that the designed bi-prism for the single-camera 3D DIC technique is reliable in morphology retrieval and displacement measurements. © 2014 IOP Publishing Ltd.


Sun G.,Nanjing Southeast University | Sun G.,University of Michigan | Zhou R.,Jiangsu University of Science and Technology | Lu J.,Jiangsu University | Mazumder J.,University of Michigan
Acta Materialia | Year: 2015

Laser-aided direct metal deposition (DMD) was used to form a AISI 4340 steel coating on an AISI 4140 steel substrate. Stress in the coating was relieved before mechanical testing. The defect density and microstructural property of the DMD coating were analyzed. The thermal analysis, continuous cooling transformation (CCT), residual stress, micro-hardness, nano-hardness and elastic modulus of the DMD coating before and after stress relief were studied. Tensile testing, lap shear testing and bend testing were done on the stress-relieved DMD coatings. Finally, evaluation of the effect of porosity on fracture behavior was characterized. A porosity and residual stress-based fracture mechanism was proposed. A better deposition strategy is needed to improve the microstructure (decrease porosity), and the mechanical properties of DMD could be tailored through appropriate heat treatments. © 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.