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Objective: To investigate the relationship between genetic polymorphisms of ERCC1 and survival rate in advanced non-small cell lung cancer (NSCLC) patients treated with platinum based chemotherapy. Methods: A total of 204 patients with advanced NSCLC were routinely treated by platin-based chemotherapy. The polymorphic genotypes were analyzed by MALDI-TOF-MS method using DNA samples isolated from peripheral blood before treatment. Besides, 5% samples were extracted randomly for sequencing to test the accuracy of this method. To explored the association between SNP of ERCC1 (118) and prognosis to platinum-based chemotherapy in advanced NSCLC patients. Results: Among 204 patients, 61 achieved partial response, 116 achieved stable response, and 27 achieved progressive disease. The overall response rate was 29.9% (61/204). The effective rates of patients with the ERCC1 (118) C/C genotype, C/T + T/T genotype were 24.0% (29/121) and 38.6% (32/83), respectively, with significant difference (P < 0.05). The response rate of ERCC1 (118) C/T allele carriers was 1.992-fold than that of C/C allele carriers (95% confidence interval: 1.083-3.650, P = 0.025). MST, 1-year survival and 2-year survival rates of patients with the ERCC1 (118) C/C genotype, C/T + T/T genotype were 9.0 months, 34.7% (42/121) and 4.1% (5/121) vs 12.0 months, 60.2% (50/83) and 12.0% (10/83), respectively, with significant difference (P < 0.05). Conclusions: Polymorphisms of ERCC1 might be associated with overall survival period in patients with advanced NSCLC after treatment with platin-based chemotherapy, which might be the predictive markers for overall survival. Source


Zheng X.-Z.,The First Peoples Hospital of Yancheng | Wu J.,The First Peoples Hospital of Yancheng | Tan X.-Y.,Jiangsu Province Tumor Hospital
Medical Ultrasonography | Year: 2016

Aims: Virtual touch tissue quantification (VTTQ) has been widely used in adults, but its application in fetuses has not been reported. The purposes of this study were to describe the normal shear wave velocity (SWV) values of fetal brain, lung, and liver by VTTQ and to examine the clinical usefulness of this procedure in evaluation of gestational age-related SWV changes in the fetal brain, lung and liver. Material and methods: One hundred fetuses were enrolled in this study and were evaluated at 18 weeks (second trimester) and 35 weeks (third trimester) during pregnancy. The SWV was measured at the cerebral parenchyma, thalamus, cerebellum, choroid plexus, left lung, right lung, right and left lobe of the liver in each participant. Results: The SWV at the cerebral parenchyma were all significantly greater in the third trimesters than in the second trimesters (3.29±1.05 vs. 2.22±0.97 m/s, p<0.001), while the velocities at thalamus, cerebellum, choroid plexus, left lung, right lung, right lobe of the liver and left lobe of the liver did not differ between the second and the third trimesters (p>0.05). Moreover, the SWV at the cerebral parenchyma correlated significantly with gestational age (r=0.47, p<0.001). Conclusions: VTTQ can provide numerical measurements of fetal brain, lung and liver stiffness and can effectively and objectively indicate gestational age-related changes in cerebral parenchyma stiffness by measuring SWV values. Source


Sun L.,Jiangsu Province Tumor Hospital | Gu L.,Jiangsu Province Tumor Hospital
Chinese-German Journal of Clinical Oncology | Year: 2012

Objective: The aim of our study was to analyze the anesthesia of pneumonoresection in lung cancer patients with video-assisted thoracic surgery during one-lung ventilation. Methods: After fast-speed venous induced anesthesia, double-lumen bronchial catheter or endobronchial blocker tube were intubated in 551 patients, the position of double-lumen endobronchial tube or single lumen tube + endobronchial blocker tube was confirmed with fiber-optic bronchoscope after intubation. Interstitial positive pressure ventilation were used in all patients with video-assisted thoracic surgery (VATS) interstitial positive pressure ventilation, positive end expiratory pressure and continuous positive airway pressure in collapse lobers of lung were used in one lung ventilation, and ventilation parameters were adjusted necessarily. Results: 541 cases double-tubes bronchial catheter intubation and endobronchial blocker tube used by fiberscope were located very well. The level of S pO 2, P ETCO 2 could be maintained normal. Ten cases were forced to converse video-assisted thoracic surgery to thoracotomy because of 4 cases pulmonary adhesion, 4 cases severe pulmonary dysfunction hard to correct hyoxemia and 2 case abnormal anatomy respectively. Conclusion: Anesthesia key of video-assisted thoracic surgery is that double lung must separated completely. Effective management of one lung ventilation could make patients to pass perioperation smoothly. Long-time one lung ventilation such as pulmonary adhesion, severe pulmonary dysfunction should be considered to be relative contraindication. © 2012 Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg. Source


Zheng X.-Z.,The First Peoples Hospital of Yancheng | Wu J.,The First Peoples Hospital of Yancheng | Tan X.-Y.,Jiangsu Province Tumor Hospital
Medical Ultrasonography | Year: 2016

Aims: To explore the feasibility of quantitative evaluation of pulmonary function in patients with chronic obstructive pulmonary disease (COPD) using tissue velocity imaging (TVI) and strain rate imaging (SRI) via transthoracic lung ultrasonography. Material and methods: Eighty inpatients with clinically diagnosed COPD underwent pulmonary function test and transthoracic lung ultrasound on the same day. Lung ultrasound variables and pulmonary function parameters were analyzed. Results: All patients with COPD had faster breathing and significant reduced lung function compared with healthy participants (p<0.05). The lung ultrasound parameters, velocity (max-min, cm/s), displacement (max-min, mm), strain (max-min, %) and strain rate (max-min, 1/s) were significantly higher in patients with COPD (p<0.05). A good negative correlation was found between lung ultrasound variables and pulmonary function parameters in patients with COPD. Stepwise multiple regression analysis indicated that the velocity (max-min, cm/s) was the only independent determinant of FEV1/FVC (%). With the use of FEV1/FVC<70% as the criteria of irreversible pulmonary function impairment to distinguish an abnormal pulmonary function, the area under the ROC was 0.99 for the velocity (max-min, cm/s) of the lung tissue in the process of breathing. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the cut off value (1.19 cm/s) was 97.63%, 100%, 100%, 80%, and 98%, respectively (p<0.001). Conclusions: Tissue velocity imaging via transthoracic lung ultrasound is a useful modality in the assessment of pulmonary function in patients with COPD. Source


Sun L.,Jiangsu Province Tumor Hospital | Gu L.,Jiangsu Province Tumor Hospital | Shen Z.,Jiangsu Province Tumor Hospital | Zhu Y.,Jiangsu Province Tumor Hospital | Qian Y.,Nanjing Medical University
Chinese-German Journal of Clinical Oncology | Year: 2010

Objective: The aim of the study was to observe and compare the trend of T-lymphocyte subsets in the elder and adult esophageal carcinoma patients postoperatively. Methods: Forty-four esophageal carcinoma patients, classified as ASA physical status I-II, were divided into two groups. Twenty-two patients aged than 65 years were grouped as elder patient group, and the rest twenty-two patients, served as adult patient group, were younger than 60 years old. The jugular venous blood samples were collected before induction of anesthesia (T1) as baseline, after completion of surgery (T2), on the first, second and fifth postoperative days (T3, T4 and T5), respectively. The blood counts of CD3+, CD4+ and CD8+ T-lymphocyte were measured by flow cytometer. Results: Compared with the baseline level, the blood CD3+, CD4+ and CD4/CD8 levels were significantly decreased immediately after surgery, on the first and second postoperative days in the two groups (P < 0.01), which returned to baseline values on the fifth postoperative day (P> 0.05). On the fifth postoperative day, CD3+, CD4+ and CD4/CD8 levels in adult group were significantly higher than those in elder group (P < 0.05). Conclusion: The postoperative immune function in elder patients recovered more slowly than that in adult. © Springer-Verlag Berlin Heidelberg 2010. Source

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