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Duan X.,Jiangsu Simcere Pharmaceutical Group | Liu R.,Jiangsu Simcere Pharmaceutical Group | Xu W.,Jiangsu Simcere Pharmaceutical Group | Ren T.,Jiangsu Simcere Pharmaceutical Group | Luo H.,Jiangsu Simcere Pharmaceutical Group
Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology | Year: 2013

With the advantage of clear target and little side effect, antibody drug has attracted widely attention of worldwide pharmaceutical companies. However, large scale mammalian cell culture and antibody quality analysis are the bottlenecks of antibody drug industrialization in China. Especially due to the significant effect of cell culture conditions on antibody heterogeneity. Therefore, it is extremely urgent to optimize cell culture conditions to favor the demands of antibody drug development. This review summarized the most recent advances in the effect of cell culture conditions on antibody quality, followed by addressing the key issues that might be strategically important for domestic antibody drug development.

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