Xia Z.-Y.,Jiangsu Provincial Corps Hospital |
Xu R.-T.,Jiangsu Provincial Corps Hospital |
Shen L.,Jiangsu Provincial Corps Hospital
Chinese Journal of Interventional Imaging and Therapy | Year: 2014
Objective: To explore the relationship between 18F-FDG PET/CT imaging manifestations, semi-quantitative standardized uptake value (SUV) and pathological findings of postoperative recurrence of cardia carcinoma at the anastomotic stoma. Methods: PET/CT imaging and pathological data of 78 patients with postoperative anastomotic stoma recurrence of cardia carcinoma were collected, and the PET/CT performances, semi-quantitative SUVs and pathological results were analyzed, respectively. Results: (1)Among all 78 patients, there were 56 cases of moderate-low differentiated adenocarcinomas (59/78, 75.64%), 4 undifferentiated adenocarcinomas (4/78, 5.13%), 7 high differentiated adenocarcinomas (7/78, 8.97%), 5 mucinous adenocarcinomas (5/78, 6.41%), 2 signet-ring cell carcinomas (2/78, 2.56%) and 1 adeno-squamous carcinoma (1/78, 1.28%). (2)PET/CT imaging found no uptake in 5 cases (5/78, 6.41%), patchy shadows uptake in 15 (15/78, 19.23%), nodular uptake in 33 (33/78, 42.31%), while annular uptake in 25 cases (25/78, 32.05%). (3)The overall SUVmaxof recurrence of cardia carcinoma was 4.04±2.06. SUVmaxof moderate-low differentiated adenocarcinoma and undifferentiated adenocarcinoma was relatively higher than that of other pathological types of cardia carcinoma (P<0.05), both of them mainly manifested as nodular and annular form on PET/CT. (4)The diagnostic accuracy rate of PET/CT for cardia carcinoma at the anastomotic stoma was 91.03% (71/78). Conclusion: Postoperative recurrence of cardia carcinoma at the anastomotic stoma has various PET/CT performances, mainly display as nodular and annular uptake. High differentiated adenocarcinoma, mucinous adenocarcinoma and signet-ring cell carcinoma or tumors without uptake on PET/ CT imaging or presenting as patchy shadows uptake are easy to be misdiagnosed. Copyright © 2014 by the Press of Chinese Journal of Medical Imaging and Technology.
Chen J.,Jiangsu Provincial Corps Hospital |
Zhang W.-B.,Jiangsu Provincial Corps Hospital |
Yan C.-H.,Jiangsu Provincial Corps Hospital |
Liu H.,Jiangsu Provincial Corps Hospital |
Li C.-L.,General Hospital
Chinese Journal of Medical Imaging Technology | Year: 2014
Objective: To explore the value of high frequency ultrasound in evaluation on the impact of recruits training on achilles tendon. Methods: Totally 1773 soldiers of multiple contingents who joined the army in December 2012 were examined with high frequency ultrasound before and 1 month, 3 months after recruits training. The differences of achilles tendon thickness on short axis, circumference of short axis and area of short axis in different time were compared, and abnormal results were recorded and analyzed. Results: There was no significant correlation between achilles tendon thickness on short axis, circumference of short axis, nor area of short axis with height, weight and body mass index (all P>0.05). There were statistical differences in achilles tendon thickness on short axis and area of short axis (all P<0.05), but not in achilles tendon circumference of short axis (P>0.05). Ankle injury was observed in 13 soldiers. Pain in the achilles tendon terminal area occurred in 12, while no special ultrasonic performance was found in 6, but soft tissue slight swelling was detected in achilles tendon terminal area in 5, and achilles tendon calcification was observed in 1 soldier. No achilles tendon rupture was found. Conclusion: High-frequency ultrasound can accurately check achilles tendon, measure the thickness on short axis, circumference of short axis and area of short axis, and timely find related infantry.
Jiang L.,Jiangsu Provincial Corps Hospital |
Gao K.,PLA Fourth Military Medical University |
Zheng J.,Jiangsu Provincial Corps Hospital |
Chen J.,Jiangsu Provincial Corps Hospital |
Wu H.,Jiangsu Provincial Corps Hospital
Chinese Journal of Clinical Oncology | Year: 2010
Objective: Preoperative clinical staging is the key for selecting the ideal therapy for esophageal cancer. Mini-probe endoscopic ultrasonography (MCUS), an accurate diagnostic technique for T and N staging of esophageal cancer, is used commonly in other countries but seldom in China. This study aimed to investigate the role of Multi-slice Computer Tomography (MSCT) with MCUS in the preoperative assessment of patients with esophageal cancer in order to determine their value in surgical decision making. Methods: A total of 158 patients with esophageal cancer were prospectively enrolled into the study. Participants were randomly assigned into group A (n=79) or group B (n=79) and then received a preoperative X-Ray barium meal and gastroscope. They also had MSCT examination or MCUS according to their group. The outcome of preoperative staging and predictive surgery programs with postoperative pathologic staging and final surgery programs were compared between group A and group B. Result: There were 152 patients available for analysis. There was no statistical difference in the baseline characteristics between group A (n=75) and group B (n=77). The accuracy of preoperative T staging, N staging and surgical procedure prediction in group A were 60.00%, 77.33% and 73.33%. The corresponding rates in group B were 84.41%, 83.12% and 89.61%. In T staging and surgical procedure prediction, significant statistical differences were observed between the two groups with P=0.001 and P=0.010, respectively. However the analysis showed no significant differences in N staging between the two groups (P=0.370). The relationship between multiple clinicopathologic factors and surgical procedures was analyzed. Conclusion: Group B has higher accuracy in preoperative staging for esophageal cancer and provides better evidence to make surgery decisions than group A. We suggest that mini-probe endoscopic ultrasonography become a routine medical examination in more hospitals.
Wang Y.,Nantong University |
Long L.,Nantong University |
Yang J.,Nantong University |
Wu Y.,Jiangsu Provincial Corps Hospital |
And 7 more authors.
Neurochemical Research | Year: 2013
Ski-interacting protein (SKIP) is a highly conserved protein from yeast to Human. As an essential spliceosomal component and transcriptional co-regulator it plays an important role in preinitiation, splicing and polyadenylation. SKIP can also combine with Ski to overcome the G1 arrest and the growth-suppressive activities of pRb. Furthermore SKIP has the capacity to augment TGF-β dependent transcription. While the distribution and function of SKIP in peripheral nervous system lesion and regeneration remain unclear. Here, we investigated the spatiotemporal expression of SKIP in an acute sciatic nerve crush model in adult rats. Western Blot analysis revealed that SKIP was expressed in normal sciatic nerves. It gradually increased, reached a peak at 1 week after crush, and then returned to the normal level at 4 weeks. Besides, we observed that up-regulation of SKIP was approximately in parallel with Proliferating cell nuclear antigen (PCNA), and numerous Schwann cells (SCs) expressing SKIP were PCNA and Ki-67 positive. Collectively, we hypothesized peripheral nerve crush induced up-regulation of SKIP in the sciatic nerve, which was associated with SCs proliferation. © 2013 Springer Science+Business Media New York.
Shi G.,Jiangsu Provincial Corps Hospital |
Xia Z.,Jiangsu Provincial Corps Hospital |
Zhu X.,Nanjing General Hospital of Nanjing Military Command
Life Science Journal | Year: 2013
Objective To investigate the clinical value of serum tumor markers combined positron emission tomography and computed tomography (PET/CT) diagnosis on non-small cell lung cancer (NSCLC). Methods 65 cases of patients with suspected lung cancer of X-ray examination were considered as NSCLC group, in which 39 cases were males, 26 cases were females, the age was from 38 to 75 years old and the mean one was (56.4±6.5) years old. 30 patients with benign lung disease patients were selected as benign lung disease group, in which 18 cases were males, 12 cases were females, the age was from 34 to 67 years old and the mean one was (55.2±6.0) years old; 30 healthy subjects were as the healthy control group, in which 17 cases were males, 13 cases were females, the age was from 36 to 74 years old and the mean one was (55.3±5.7) years old. The NSCLC patients hospitalized line 18F-FDG PET/CT and serum tumor markers in check, and cells or pathological results. Healthy control group and benign lung disease group, only test serum tumor markers. The detection of serum tumor markers: Serum carcinoembryonic antigen (CEA), cytokeratin fragment antigen (Cyfra21-1), neuron-specific enolase enzyme (NSE), the squamous cell antigens (SCCAg), tissue polypeptide specific antigen (TPS), gastrin-releasing peptide precursor (Pro-GRP). Result Benign lung disease serum TPS, NSE level was significantly higher than the healthy control group (P<0.01), TPS positive rate was significantly higher than the healthy control group (P<0.05). NSCLC group, serum TPS CYFRA21-1, NSE, Pro-GRP, CEA, SCCAg levels and the positive rate was significantly higher than the healthy control group and lung benign disease group (P <0.01). The sensitivity, specificity, positive predictive value and negative predictive value of PET/CT combined with tumor markers were higher than simple tumor markers. Conclusion Serum tumor markers joint 18F-FDG PET/CT imaging has a higher diagnostic value, could better guide clinical treatment of NSCLC.
Li-Yun Y.,Jiangsu Provincial Corps Hospital |
Gen-Lin S.,Jiangsu Provincial Corps Hospital
Chinese Journal of Evidence-Based Medicine | Year: 2015
Objective: To systematically review the diagnostic value of the combined test of serum CA153, CA125 and CEA in detection of breast cancer. Methods: Clinical diagnostic tests about CA153, CA125 and CEA in patients with breast cancer were retrieved in PubMed, EMbase, CBM, The Cochrane Library (Issue 3, 2014), CNKI, VIP, and WanFang Data from January 1st, 2004 to April 16st, 2014. References of included literature were also retrieved. Literature screening according to the inclusion and exclusion criteria, data extraction and methodological quality assessment were completed by two reviewers independently. Meta-analysis was then conducted using Meta-Disc 1.4 software. Results: A total of 21 studies involving 4 263 subjects were enrolled. In all studies, the results of meta-analysis indicated that: the DOR, AUC and Q index of the single test (CA153) were 18.71 (95%CI 11.62 to 30.11), 0.858 9, and 0.789 7; while those of the combined test (CA153, CA125 and CEA) were 37.95 (95%CI 21.97 to 65.57), 0.959 1, 0.903 1. Compared with the single test, the diagnostic efficacy of the combined test was higher (Z=3.675, P=0.001 5). Conclusion: Compared with the detection of CA153 alone, the combined detection of CA125, CA153 and CEA has higher efficacy and accuracy in the diagnosis of breast cancer. © 2015 Editorial Board of Chin J Evid-based Med.