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Gu H.,Nanjing Normal University | Gu H.,Jiangsu Province Key Laboratory of Biofunctional Materials | Zhou N.-L.,Nanjing Normal University | Zhou N.-L.,Jiangsu Province Key Laboratory of Biofunctional Materials | And 10 more authors.
Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities | Year: 2013

Anticoagulation properties of biomaterials are crucial for biomedical applications, especially for blood-contacting materials. Carboxylated graphene oxide complexes with L-glutamic acid was prepared. The complexes were characterized by FTIR, static contact angle (SCA), XRD and TG. The anticoagulation properties of complexes were evaluated by hemolysis test and recalcification time test. The results show that the L-glutamic acid has been coordinated on graphene oxide sheet layer. The plasma recalcification time were prolonged greatly as compared to whole blood. At lower concentrations, the hemolysis rates was less than 5%, which met the requirements of biomedical materials.

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