Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research

Nanjing, China

Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research

Nanjing, China

Time filter

Source Type

Xu G.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research | Jiang P.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research | Gou S.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research
Progress in Chemistry | Year: 2012

Multinuclear platinum anticancer complexes have been investigated intensively due to their novel structures and promising anticancer activities. Moreover, they are able to overcome cisplatin resistance because of their abilities to form different adducts with DNA compared with those formed by cisplatin. The research status of dinuclear and multinuclear anticancer platinum complexes is reviewed. Based on the different linking ligands, dinuclear and multinuclear are divided to six types, namely, alkyl diamines and their derivatives, heterocyclic compounds containing nitrogen atom(s), carboxylates, haloid anions, ligands containing sulfur atom(s) and other ligands. The possible anticancer mechanism and structure-activity relationship of these multinuclear platinum complexes are also discussed in this paper.


Zhu H.-B.,Nanjing Southeast University | Zhu H.-B.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research | Lu X.,Nanjing Southeast University | Lu X.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research | And 6 more authors.
Inorganica Chimica Acta | Year: 2011

Reaction of 4,4′-di(3-pyridyl-4-pyrimidinyl) disulfide (3-PPDS) with AgNO3 leads to a unique 2D extended structure {[Ag(3-PPDS)(NO 3)]}n (1) based on [Ag2(3-PPDS)2] macrocycle units, of which 1D inorganic [Ag(NO3)]n helical chains are generated. By contrast, definite Ag-S bonding interactions associated with the disulfide function have been established in {[Ag(2-PPDS)]ClO4}n (2), which is assembled of 4,4′-di(2-pyridyl-4-pyrimidinyl) disulfide (2-PPDS) with AgClO 4. Solid state luminescent properties of complexes 1 and 2 are also examined. © 2011 Elsevier B.V. All rights reserved.


Zhu H.-B.,Nanjing Southeast University | Zhu H.-B.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research | Lu X.,Nanjing Southeast University | Yang W.-N.,Nanjing Southeast University | Zhang S.-Y.,Nanjing Southeast University
Journal of Coordination Chemistry | Year: 2012

Five copper coordination complexes 1-5 with 2-bppm (2-bppm = bis(4-(pyridin-2-yl)pyrimidin-2-ylthio)methane) have been prepared and structurally elucidated. Complexes 1 and 2 are both discrete dinuclear [2 + 2] macrocyclic structures, simultaneously formed in one-pot reaction with Cu(NO 3) 2 with in situ reduction of Cu 2+. Similarly, dinuclear [2 + 2] macrocyclic motifs are found with 3 and 4, which are also obtained by one-pot reaction but with CuCl accompanied by in situ air oxidation of Cu +. Compound 5 exhibits a 1-D chain structure with 2-bppm and Cu2I2 connected one by one. Luminescence is measured for 2, 4, and 5, all based on d 10-closed shell Cu(I). © 2012 Taylor & Francis.


Zhu H.-B.,Nanjing Southeast University | Zhu H.-B.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research | Lu X.,Nanjing Southeast University | Li L.,Nanjing Southeast University | And 2 more authors.
Transition Metal Chemistry | Year: 2012

Assembly of di[4-(pyridin-3-yl)pyrimidinyl]- disulfide (3-ppds) with different metal salts resulted in a variety of coordination polymers that were structurally elucidated. For MnCI 2, a 1-D repeated rhomboidal chain structure [MnCI 2(3-ppds) 2] n (1) was obtained, whereas a 1-D helical chain structure [Zn(NO 3) 2(3-ppds)] n (2) was built from Zn(NO 3) 2. A 1-D zigzag chain structure [Cu 2- (OAc) 4(3-ppds)] n (3) was produced from Cu(OAc) 2. In all three complexes, the 3-ppds ligand plays the same role as a bis(monodentate) bridging linker but with variations in both C-S-S-C torsion angles and dihedral angles defined by its conjugated heteroaromatic rings (pyrimidine and pyridine). The luminescence properties of the complexes have been evaluated in the solid state. © Springer Science+Business Media B.V. 2012.


Zhu H.-B.,Nanjing Southeast University | Zhu H.-B.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research | Gou S.-H.,Nanjing Southeast University | Gou S.-H.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research
Coordination Chemistry Reviews | Year: 2011

This review outlines three types of in situ methods used for constructing metal-organic sulfur-containing heterocycle frameworks, viz., in situ S-S function reactions, in situ C-S bond cleavage and in situ thiol-S atom reactions. Each method is described in detail in three respects, namely (i) reaction parameters, (ii) the organic transformation and coordination modes involved, and (iii) fascinating structures and functional properties of those in situ-generated metal-coordination compounds. © 2010 Elsevier B.V.


Zhu H.-B.,Nanjing Southeast University | Zhu H.-B.,Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research | Shan R.-Y.,Nanjing Southeast University | Yang W.-N.,Nanjing Southeast University | And 2 more authors.
Zeitschrift fur Anorganische und Allgemeine Chemie | Year: 2013

The self-assembly of 4-MTPP [4-MTPP = 2-(methylthio)-4-(pyridin-4-yl) pyrimidine] with Cu(NO3)2 and AgNO3 was structurally investigated. For Cu(NO3)2, a discrete mononuclear CuII coordination compound, [Cu(4-MTPP) 2(NO3)2] (1), resulted that is exclusively based on Cu-N coordination. For AgNO3, a unique one-dimensional double-chain structure (2) was obtained with the Ag-N distances varying from 2.181(9) to 2.223(9) Å, and the average Ag-S distance being 2.98 Å. Compared to zero-dimensional 1, the extension to one-dimensional 2 is considered to result from the specific affinity between Ag+ and the ligand 4-MTPP that is attributed to the strong coordinating tendency of silver for aromatic nitrogen and thioether sulfur atoms. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Fang L.,Nanjing Southeast University | Fang L.,Jiangsu Province Hi Technology Key Laboratory for Bio medical Research | Gou S.,Nanjing Southeast University | Gou S.,Jiangsu Province Hi Technology Key Laboratory for Bio medical Research | Zhang Y.,China Pharmaceutical University
Chinese Journal of Organic Chemistry | Year: 2011

Galantamine, a natural alkaloid possessing AChE inhibitory and neuronal nicotinic receptor allosteric modulating effect, is widely used in clinic. Up to date, several different synthetic strategies have been developed for the total synthesis of galantamine, including the phenolic oxidative coupling reaction, the intramolecular Heck reaction, and so on. In this review, the recent progresses in the total synthesis of galantamine are reviewed. Furthermore, the evolution and the features of the existing strategies are also discussed.


Li Q.-L.,Jiangsu Province Hi Technology Key Laboratory for Bio medical Research | Ding S.-N.,Jiangsu Province Hi Technology Key Laboratory for Bio medical Research
Science China Chemistry | Year: 2016

Multicolor electrochemiluminescence (ECL) of semiconductor nanocrystals tuned by size effect has been successfully achieved using quantum dots (QDs) with core-shell structure for the first time. It would open a new way and provide a guidance for design and preparation of stable and strong multicolor ECL emitters for simultaneous multicomponent analysis application. © 2016 Science China Press and Springer-Verlag Berlin Heidelberg


Lu Q.,Jiangsu Province Hi Technology Key Laboratory for Bio medical Research | Zhang Y.,Jiangsu Province Hi Technology Key Laboratory for Bio medical Research | Liu S.,Jiangsu Province Hi Technology Key Laboratory for Bio medical Research
Journal of Materials Chemistry A | Year: 2015

A novel nanocomposite of zinc porphyrin functionalized graphene quantum dots (GQDs/ZnPor) was prepared and used as a photocatalyst for the degradation of an organic pollutant under visible-light irradiation. In order to synthesise the nanocomposites, large graphene sheets were first cleaved into small pieces of graphene oxide by a mixture of concentrated H2SO4 and HNO3. Then, the GQDs/ZnPor was synthesized by a simple hydrothermal route with ZnPor and the as-synthesized graphene oxide as precursors. The resultant GQDs/ZnPor nanocomposites were characterized by transmission electron microscopy (TEM) and optical measurements. The photocatalytic activity of GQDs/ZnPor was evaluated by the degradation of methylene blue (MB) under visible-light irradiation. Enhancement of the photocatalytic activity of GQDs/ZnPor compared with pure zinc porphyrin was achieved. The photocatalytic degradation mechanism of GQDs/ZnPor was also illustrated by photoluminescence measurements and free radical and hole scavenging experiments. The proposed GQDs/ZnPor has potential application for decomposing organic pollutants in water. This journal is © The Royal Society of Chemistry.

Loading Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research collaborators
Loading Jiangsu Province Hi Technology Key Laboratory for Bio Medical Research collaborators