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Yan L.,Nanjing Southeast University | Zhang M.,Shanghai Institute of Planned Parenthood Research | Wang Y.,Nantong University | Wang C.,Nantong University | Xiang Q.,Jiangsu Province Center for Diseases Control and Prevention
Journal of Human Genetics

We carry out a study to analyze the relation between polymorphisms of GSTT1, GSTM1 and the capacity of arsenic methylation in a human population exposed to arsenic in drinking water. 230 randomly chose subjects were divided into four subgroups based on the arsenic levels, and then the associations between the polymorphisms of GSTT1, GSTM1 and methylation of arsenic were investigated. The levels of inorganic arsenic (iAs), monomethylated arsenic (MMA), dimethylated arsenic (DMA) and total arsenic (TAs) in urine were higher in males than that in females. Moreover, the levels of iAs and TAs in urine in the subjects with genotype of GSTM1(+) were significantly higher than those with GSTM1(-); the level of DMA in the subjects with GSTT1(+) and GSTM1(+) were higher than those with GSTT1(-) and GSTM1(-), although it is not statistically significant. Secondary methylation index (SMI) was significantly higher in the subjects with genotype of GSTT1(+) than those with GSTT1(-). The levels of TAs in urine, together with the genotypes of GSTT1/GSTM1 were associated with the levels of MMA and DMA. Our results suggested that the polymorphisms of GSTT1 and GSTM1 were associated with the methylation of arsenic, especially the levels of DMA and SMI. © 2015 The Japan Society of Human Genetics. Source

Xiang Q.,Jiangsu Province Center for Diseases Control and Prevention | Liang Y.,Fudan University | Chen B.,Fudan University | Chen L.,Jiangsu Province Center for Diseases Control and Prevention

As part of a 2002-2003 investigation on the effects of high fluoride drinking water on IQ scores of children, serum fluoride (F) levels in the children were subjected to further study. Among the new findings, although IQ scores of boys and girls differed in the seven IQ level categories, there were no overall gender differences (boy/girl ratio 1.220 vs. 1.214 in the high and low F villages, respectively). However, the mean IQ was significantly higher and there were fewer children with an IQ less than 80 in the two quartiles with a serum fluoride level of less than 0.05 mg F/L. Analysis of the overall relationship between IQ scores and serum F levels indicates there may be no serum F level below which adverse effects on IQ might not be present. © 2011 The International Society for Fluoride Research Inc. Source

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