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Liu G.Q.,Nanjing Southeast University | Zhou H.F.,Nanjing Southeast University | Zhou H.F.,Tsinghua University | Zhou H.F.,Jiangsu Longliqi Bioscience Co. | And 5 more authors.
Advanced Materials Research | Year: 2014

We developed a SMEDDS to enhance the oral delivery of resveratrol by using high performance liquid chromatography, a pseudo ternary phase diagram and a central composite design (CCD). We found that the optimal formulation of 12.69% greoil gtcc, 62.29% Cremophor EL, and 25.02% Labrasol. We characterized the particle size and zeta potential of the final SMEDDS. © (2014) Trans Tech Publications, Switzerland.


PubMed | Tsinghua University, Jiangsu Longliqi Bioscience Co. and Nanjing Southeast University
Type: | Journal: BioMed research international | Year: 2014

To improve the bioavailability of orally administered lipophilic coenzyme Q10 (CoQ10), we formulated a novel lipid-free nano-CoQ10 system stabilized by various surfactants. Nano-CoQ10s, composed of 2.5% (w/w) CoQ10, 1.67% (w/w) surfactant, and 41.67% (w/w) glycerol, were prepared by hot high-pressure homogenization. The resulting formulations were characterized by particle size, zeta potential, differential scanning calorimetry, and cryogenic transmission electron microscopy. We found that the mean particle size of all nano-CoQ10s ranged from 66.3 1.5 nm to 92.7 1.5 nm and the zeta potential ranged from -12.8 1.4 mV to -41.6 1.4 mV. The CoQ10 in nano-CoQ10s likely existed in a supercooled state, and nano-CoQ10s stored in a brown sealed bottle were stable for 180 days at 25 C. The bioavailability of CoQ10 was evaluated following oral administration of CoQ10 formulations in Sprague-Dawley rats. Compared to the values observed following administration of CoQ10-Suspension, nano-CoQ10 modified with various surfactants significantly increased the maximum plasma concentration and the area under the plasma concentration-time curve. Thus, the lipid-free system of a nano-CoQ10 stabilized with a surfactant may be an effective vehicle for improving oral bioavailability of CoQ10.


Zhou H.,Tsinghua University | Zhou H.,Jiangsu Longliqi Bioscience Co. | Yue Y.,Tsinghua University | Liu G.,Tsinghua University | And 4 more authors.
Nanoscale Research Letters | Year: 2010

The purpose of this study was to investigate the influence of the inner lipid ratio on the physicochemical properties and skin targeting of surfactant-free lecithin-based coenzyme Q10-loaded lipid nanocapsules (CoQ10-LNCs). The smaller particle size of CoQ10-LNCs was achieved by high pressure and a lower ratio of CoQ10/GTCC (Caprylic/capric triglyceride); however, the zeta potential of CoQ10-LNCs was above /- 60 mV/ with no distinct difference among them at different ratios of CoQ10/GTCC. Both the crystallisation point and the index decreased with the decreasing ratio of CoQ10/GTCC and smaller particle size; interestingly, the supercooled state of CoQ10-LNCs was observed at particle size below about 200 nm, as verified by differential scanning calorimetry (DSC) in one heating-cooling cycle. The lecithin monolayer sphere structure of CoQ10-LNCs was investigated by cryogenic transmission electron microscopy (Cryo-TEM). The skin penetration results revealed that the distribution of Nile red-loaded CoQ10-LNCs depended on the ratio of inner CoQ10/GTCC; moreover, epidermal targeting and superficial dermal targeting were achieved by the CoQ10-LNCs application. The highest fluorescence response was observed at a ratio of inner CoQ10/GTCC of 1:1. These observations suggest that lecithin-based LNCs could be used as a promising topical delivery vehicle for lipophilic compounds. © 2010 The Author(s).


Zhou H.,Tsinghua University | Zhou H.,Jiangsu Longliqi Bioscience Co. | Yue Y.,Tsinghua University | Liu G.,Tsinghua University | And 5 more authors.
Nanoscale Research Letters | Year: 2010

Purpose of this study was to establish a lecithin nanoemulsion (LNE) without any synthetic surfactant as a topical delivery vehicle and to evaluate its topical delivery potential by the following factors: particle size, morphology, viscosity, stability, skin hydration and skin penetration. Experimental results demonstrated that an increasing concentration of soybean lecithin and glycerol resulted in a smaller size LNE droplet and increasing viscosity, respectively. The droplet size of optimized LNE, with the glycerol concentration above 75% (w/w), changed from 92 (F10) to 58 nm (F14). Additionally, LNE, incorporated into o/w cream, improved the skin hydration capacity of the cream significantly with about 2. 5-fold increase when the concentration of LNE reached 10%. LNE was also demonstrated to improve the penetrability of Nile red (NR) dye into the dermis layer, when an o/w cream, incorporated with NR-loaded LNE, applied on the abdominal skin of rat in vivo. Specifically, the arbitrary unit (ABU) of fluorescence in the dermis layer that had received the cream with a NR-loaded LNE was about 9. 9-fold higher than the cream with a NR-loaded general emulsion (GE). These observations suggest that LNE could be used as a promising topical delivery vehicle for lipophilic compounds. © 2009 to the authors.


Zhang Y.-Y.,Jiangsu Longliqi Bioscience Co. | Ge Q.,Wuxi Shunye Technology Co. | Yang L.-L.,Wuxi Shunye Technology Co. | Shi X.-J.,Wuxi Shunye Technology Co. | And 3 more authors.
Applied Surface Science | Year: 2015

A supcrhydrophobic surfacc. highly water repellant and self-cleaning, is typically made by introducing micro- And nanoscale roughness onto the surface of a low surface energy material. Herein, we offer a new process of superhydrophobic film formation, accomplishing the same thing through the production of micro- And nanoscale surface porosities. Such a material is prepared by introducing zinc acetate (ZnAc2) and sodium chloride (NaCl) into a commercially available PTFE (polytetrafluoroethylene) emulsion. On drying, baking and washing with acetic acid, the PTFE film produced from the emulsion had both micro- And nanoscale surface porosities, and demonstrated superhydrophobic properties, with a static contact angle >150 and a slide angle <1(K From SEM observation. NaCl contributes microscale porosity, while ZnAc2 decomposes to ZnO. contributing nanoscale porosity. Using either ZnAc2 or NaCl alone produces a surface with a static contact angle >150° but with a slide angle >10 . Based on XPS and SEM data, we explore herein the affect of chemistry and porosity on the mechanism of superhydrophobic surface formation, and the durability of that surface under abrasion. © 2015 Elsevier B.V. All rights reserved.


Trademark
Jiangsu Longliqi Bioscience Co. | Date: 2010-12-21

Hair lotions; Soaps and detergents; Cakes of toilet soap; Cleansing milk for toilet purposes; Cleaning and washing preparations; Fabric softeners for laundry use; Stain removers; Perfumes; Non-medicated mouth washes; Leather polishes; Cosmetics; Cosmetic creams for skin care; Deodorant for personal use; Skin whitening creams; Sunscreen creams; Toilet water; Dentifrices; Beauty masks; Laundry detergents.


Trademark
Jiangsu Longliqi Bioscience Co. | Date: 2010-12-21

Vitamin preparations; Sterilising preparations; Dietetic foods adapted for medical use; Nutritive substances for micro-organisms for medical use; Air freshening preparations; Depuratives for the body; Pesticides; Sanitary pads; Sanitary napkins; Dental abrasives; Amino acids for nutritional purposes; Dietary and nutritional supplements; Liquid nutritional supplement; Mineral nutritional supplements; Nutritional supplements; Protein supplements.


Trademark
Jiangsu Longliqi Bioscience Co. | Date: 2011-07-12

Non-medicated additives for use as ingredients in nutritional supplements, namely, extracts derived from snake, sheep, salmon, gingko, coneflower and fungus.


Trademark
Jiangsu Longliqi; Bioscience Co. | Date: 2013-08-28

Hair lotions; soap; cleansing milk for toilet purposes; cakes of toilet soap; laundry preparations; fabric softeners for laundry use; cleaning preparations; stain removers; perfumes; mouth washes, not for medical purposes; dentifrices; leather preservatives polishes; cosmetics; cosmetic preparations for skin care; deodorants for human beings or for animals; skin whitening creams; sunscreen preparations; toilet water; beauty masks; washing preparations; cosmetics for animals; air fragrancing preparations. Vitamin preparations; sterilising preparations; dietetic foods adapted for medical purposes; dietetic substances adapted for medical use; air purifying preparations; depuratives; preparations for destroying noxious animals; sanitary pads; sanitary napkins; dental abrasives; protein supplements for animals; nutritional supplements; medical capsules.


Trademark
Jiangsu Longliqi Bioscience Co. | Date: 2015-11-24

Flour; barley meal; rice; rice flour, powder; soya flour; gluten prepared as foodstuff, namely dried pieces of wheat gluten; tea-based beverages; honey; cereal preparations, namely processed oats and processed corn; chips being cereal products, namely, grain-based chips.

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