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Wang Z.,Nankai University | Wei P.,Nankai University | Xizhi X.,Jiangsu Lanfeng Biochemical Co. | Liu Y.,Nankai University | And 2 more authors.
Journal of Agricultural and Food Chemistry

On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthrene-based antofine derivatives (1-12 and 18-50) were designed targeting tobacco mosaic virus (TMV) RNA and synthesized and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds exhibited good to excellent in vivo anti-TMV activity, of which compounds 19 and 27 displayed higher activity than commercial Ribavirin, thus emerging as potential inhibitors of plant virus. The novel concise structure provides another new template for antiviral studies. © 2012 American Chemical Society. Source

Yu P.,Nanjing University of Technology | Yu P.,Jiangsu Key Laboratory of Industrial Water Conservation and Emission Reduction | Hu J.,Nanjing University of Technology | Hu J.,Jiangsu Key Laboratory of Industrial Water Conservation and Emission Reduction | And 6 more authors.
Journal of Chemical Research

Novel N-(5-aryl-1,3,4-thiadiazol-2-yl)-2-(3-oxo-1,2-benzothiazol-2(3H)-yl) acetamide derivatives were prepared by 1-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride and N-hydroxybenzotrizole condensation catalysis in a convenient and fast method. These compounds were identified by IR, 1H NMR and elemental analyses and the intermediate compound 5-(2-chlorophenyl)-1,3,4-thiadiazol-2-amine was confirmed by single-crystal X-ray diffraction. © 2014 Publishing Technology. Source

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