Jiangsu Key Laboratory of New Power Batteries

Nanjing, China

Jiangsu Key Laboratory of New Power Batteries

Nanjing, China
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Liu Y.,Nanjing Normal University | Liu Y.,Jiangsu Key Laboratory of New Power Batteries | Wei M.,Nanjing Normal University | Wei M.,Jiangsu Key Laboratory of New Power Batteries | And 6 more authors.
Sensors and Actuators, B: Chemical | Year: 2018

A novel electrochemical sensor based on the molecularly imprinted polymer (MIP) film is presented for the determination of an anticancer drug Mitoxantrone (MTX). The MIP film was prepared by electrochemical polymerization of β-cyclodextrins (β-CD) and MTX on a glassy carbon electrode (GCE) for the first time, wherein β-CD served as the functional monomer, MTX as the template that was extracted afterwards, thereby creating the imprinted cavities complementary to the template in the polymer matrix. MTX could be specifically recognized and binding by the imprinted cavities. The developed MIP sensor exhibits a rapid electrochemical response, high sensitivity and selectivity for the determination of MTX in pharmaceutical formulations and spiked urine samples. Moreover, the proposed approach presents distinct advantages over reported electrochemical methods for determination of MTX because it is a one-step preparation and the template molecule could be easily removed by cyclic voltammetry scans, and no elution reagent is required. Under the optimal experimental conditions, the linear response range for MTX concentrations by the MIP sensor was 6 × 10−8 M–1 × 10−5 M with a detection limit of 3 × 10−8 M (S/N = 3), showing a good sensitivity and low LOD for MTX detection. This study demonstrates that the proposed MIP sensor is feasible for the detection of anticancer drugs. © 2017 Elsevier B.V.


Wei N.,Nanjing Normal University | Wei N.,Jiangsu Key Laboratory of New Power Batteries | Wei N.,Jiangsu Key Laboratory of Biofunctional Materials | Xin X.,Nanjing Normal University | And 6 more authors.
Biosensors and Bioelectronics | Year: 2011

The three-dimensionally ordered macroporous gold-nanoparticle-doped titanium dioxide (3DOM GTD) film was modified on the indium-tin oxide (ITO) electrode surface. Hemoglobin (Hb) has been successfully immobilized on the 3DOM GTD film and the fabrication process was characterized by Raman and UV-vis spectra. The results indicated that the Hb immobilized on the film retained its biological activity and the secondary structure of Hb was not destroyed. The direct electrochemistry and electrocatalysis of Hb immobilized on this film have been investigated. The Hb/3DOM GTD/ITO electrode exhibited two couples of redox peaks corresponding to the Hb intercalated in the mesopores and adsorbed on the external surface of the film with the formal potential of -0.20 and -0.48V in 0.1M PBS (pH7.0), respectively. The Hb/3DOM GTD/ITO electrode exhibits an excellent eletrocatalytic activity, a wide linear range for H2O2 from 5.0μM to 1.0mM with a limit of detection of 0.6μM, high sensitivity (144.5μAmM-1), good stability and reproducibility. Compared with the TiO2 nanoneedles modified electrode, the GTD modified electrode has higher sensitivity and response peak current. The 3DOM GTD provided a good matrix for bioactive molecules immobilization, suggesting it has the potential use in the fields of H2O2 biosensors. © 2011 Elsevier B.V.


Huang B.,Binzhou University | Huang B.,Jiangsu Key Laboratory of New Power Batteries | Zheng X.,Binzhou University | Lu M.,Binzhou University | And 4 more authors.
Journal of New Materials for Electrochemical Systems | Year: 2012

The spherical LiFePO 4/C nanoparticles are synthesized by modified carbothermal reduction method. XRD patterns show that the LiFePO 4 compound is orthorhombic crystal structure. SEM and TEM results indicate that the LiFePO 4 composite had a spherical morphology with carbon coated and the particle size is nanoscale. Charge/discharge tests and CV curves show that as-prepared sample exhibits discharge capacity of 153 mAh g -1 at 0.2 C rate with high electrode reaction reversibility. The discharge capacities of the material are 150, 132, 119, 111, 103 and 96 mAh g -1 at 1 C, 5 C, 10 C, 15 C, 20 C and 25 C rate and high voltage plateaus are achieved. The good rate performance of the composite is due to its nano particle size and spherical morphology, which reduced the diffusion path of lithium ions and electrons, increased the conductive specific surface and improved the processability of the LiFePO 4 cathode. © J. New Mat. Electrochem. Systems.

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