Jiangsu Key Laboratory of Drug Screening Nanjing China

Laboratory of, China

Jiangsu Key Laboratory of Drug Screening Nanjing China

Laboratory of, China

Time filter

Source Type

Li X.,Jiangsu Key Laboratory of Drug Screening Nanjing China | Xu Z.,Jiangsu Key Laboratory of Drug Screening Nanjing China | Wang S.,Jiangsu Key Laboratory of Drug Screening Nanjing China | Guo H.,Jiangsu Key Laboratory of Drug Screening Nanjing China | And 4 more authors.
Hepatology Research | Year: 2015

Aim: To investigate the effects of emodin on the treatment of non-alcoholic fatty liver in rats induced by liquid fructose-feeding in rats and the possible underlying mechanisms. Methods: Sprague-Dawley rats were divided into the control, fructose-feeding group, and three fructose-feeding groups treated with 40, 80 and 160mg/kg emodin, respectively. After 4weeks of feeding, liquid consumption, food intake, bodyweight, liver index, serum triglyceride (TG), glucose and aminotransferases (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]), liver TG contents and histology features were examined. The hepatic expression of lipogenic and fatty acid oxidation key enzymes, and an upstream transcriptional factor, sterol regulatory element-binding protein 1c (SREBP1c) were determined. Glucose regulated protein 78 (GRP78), a liver endoplasmic reticulum stress (ERS) marker and the unfolded protein response (UPR) related proteins were also measured. Results: Emodin reduced bodyweight, liver index, serum TG levels of fructose-feeding rats with no significant difference in serum glucose, AST and ALT levels. Emodin improved hepatic steatosis by inhibiting SREBP1c activation and its target genes, and enhancing carnitine palmitoyltransferase 1 expression in fructose-feeding rats. Emodin resolved hepatic ERS and the UPR induced by liquid fructose in rats. Conclusion: Emodin is capable of improving the lipid accumulation through the ERS-SREBP1c pathway in fructose-induced non-alcoholic fatty liver disease. © 2015 The Japan Society of Hepatology.

Loading Jiangsu Key Laboratory of Drug Screening Nanjing China collaborators
Loading Jiangsu Key Laboratory of Drug Screening Nanjing China collaborators