Jiangsu Hengrui Medicine Co.

Xinpu, China

Jiangsu Hengrui Medicine Co.

Xinpu, China
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Patent
Shanghai Hengrui Pharmaceutical Co. and Jiangsu Hengrui Medicine Co. | Date: 2017-02-22

The present invention relates to amide derivatives and pharmaceutically acceptable salts thereof, preparation method therefor and medicinal application thereof. Specifically, the present invention relates to amide derivatives represented by general formula (I), preparation method therefor, pharmaceutical compositions containing the derivatives, and use thereof as therapeutic agent, especially as inhibitor for microsomal prostaglandin E synthase-1(mPGES-1), and use in preparation of medicines for treating and/or preventing diseases or illness such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.


Provided are an L-proline compound of a sodium-glucose cotransporter 2 inhibitor, and a monohydrate and a crystal of the L-proline compound. Specifically, provided are 1,6-dehydrated-1-C{4-chloro-3-[(3-fluoro-4-ethoxyphenyl)methyl]phenyl}-5-C-(hydrox ymethyl)--L-idopyranose L-proline (a compound of formula (I)), a monohydrate and an A-type crystal thereof and a preparation method therefor. The obtained A-type crystal of the compound of formula (I) has good chemical stability and crystal stability, and a crystallization solvent used has low toxicity and low residue, so the A-type crystal can be better used in clinical treatment.


Patent
Jiangsu Hengrui Medicine Co. and Shanghai Hengrui Pharmaceutical Co. | Date: 2016-11-01

Intermediate compounds used in the preparation of pyrrole six-membered heteroaryl ring derivatives are disclosed. In particular, compounds of formula (IB) are disclosed. The compounds of formula (IB) are used in the synthesis of Janus kinase (JAK) inhibitors. Substituents in formula (IB) have the same definitions as in the description.


Patent
Shanghai Hengrui Pharmaceutical Co. and Jiangsu Hengrui Medicine Co. | Date: 2015-03-31

Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof are provided. Specifically, amide derivatives represented by general formula (I) are provided. The amide derivatives represented by general formula (I) can be used as a therapeutic agent, particularly as an inhibitor for microsomal prostaglandin E synthase-1 (mPGES-1), and also to treat and/or prevent diseases or illnesses such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.


Patent
Jiangsu Hengrui Medicine Co. | Date: 2017-08-16

Provided is an I-type crystal of a JAK (Janus Kinase) inhibitor (3aR,5s,6aS)-N-(3-methoxyl-1,2,4-thiadiazole-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimi dine-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-formamide bisulfate represented by formula (I), and a preparation method therefor. The preparation method comprises crystallizing any crystal form of or amorphous compound solid of formula (I) in a single organic solvent to obtain the I-type crystal; this crystal has excellent crystal stability and chemical stability, and the crystal solvent used is low in toxicity and residues, making the compound better applicable to clinical treatment.


Patent
Shanghai Hengrui Pharmaceutical Co. and Jiangsu Hengrui Medicine Co. | Date: 2017-01-20

Methods for treating androgen receptor-mediated diseases, such as breast cancer, with imidazoline derivatives of formula (I) are provided:


Patent
Shanghai Hengrui Pharmaceutical Co. and Jiangsu Hengrui Medicine Co. | Date: 2016-10-19

The present invention provides a human PD-1 antibody, an antigen-binding fragment thereof, and medical use thereof, and further provides a chimeric antibody and humanized antibodies comprising a complementarity-determining region (CDR) of the antibody, a pharmaceutical composition comprising the human PD-1 antibody and the antigen-binding fragment thereof, and use of the antibody in preparing medicines for treating diseases or disorders.


Patent
Shanghai Hengrui Pharmaceutical Co. and Jiangsu Hengrui Medicine Co. | Date: 2016-03-23

The present invention relates to a cycloalkyl acid derivative, a preparation method thereof, and a pharmaceutical application thereof, and in particular, the present invention relates to a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level, wherein definitions of substituent groups in general formula (I) are the same as definitions in the specifications.


Patent
Shanghai Hengrui Pharmaceutical Co. and Jiangsu Hengrui Medicine Co. | Date: 2016-08-31

The present invention relates to pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof. Specifically, the present invention relates to pyridic ketone derivatives represented by a general formula (I) and pharmaceutical salts thereof, method of preparing same, and use thereof as MEK inhibitors and especially as therapeutic agents for cancer, where the definitions of the substituents in the general formula (I) are the same as the definitions in the specification.


Patent
Shanghai Hengrui Pharmaceutical Co. and Jiangsu Hengrui Medicine Co. | Date: 2016-09-07

The present invention provides pyrazolopyrimidone or pyrrolotriazone derivatives, method of preparing same, and pharmaceutical applications thereof. Specifically, the present invention provides pyrazolopyrimidone or pyrrolotriazone derivatives represented by a general formula (I) and pharmaceutical salts thereof, method of preparing same, and use thereof as a gonadotropin releasing hormone (GnRH) antagonist and especially as therapeutic agents for endometriosis, where the definitions of the substituents in the general formula (I) are the same as the definitions in the specification.

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