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Liu Y.,Northeast Forestry University | Shao C.,Northeast Forestry University | Fan B.,Northeast Forestry University | Li S.,Jiangsu Food & Pharmaceutical Science College | And 2 more authors.
Drug research | Year: 2015

A simple HPLC method to determine the amount of 10-methoxycamptothecin (MCPT) and its major metabolite 10-hydroxycamptothecin (HCPT) in rat liver tissue was developed in the present study. Camptothecin (CPT) was used as internal standard (IS). A piecewise linear function was used over lower and higher concentrations, respectively. The calibration curves were linear (r (2) >0.99) over concentrations from 2.5 to 20 ng/mL and 20 to 320 ng/mL for both MCPT and HCPT. The method had an accuracy of 92.74% to 112.76%, and the intra- and inter-day precision (RSD%) were 11.85% or less for MCPT and HCPT. The stability data showed no significant degradation occurred under the experimental conditions. This method was successfully applied to the tissue distribution study of MCPT and its metabolite HCPT in liver tissue samples after intravenous administration. © Georg Thieme Verlag KG Stuttgart · New York.

Cai X.P.,Jiangsu Food & Pharmaceutical Science College | Zhang S.Q.,Sijiqing Sewage Treatment Plant Jiangsu Huaian | Li J.G.,Mudanjiang Normal University | Li J.G.,Harbin Institute of Technology
Water Resources and Environment - Proceedings of the International Conference on Water Resources and Environment, WRE 2015 | Year: 2016

In the experiment, it treated zinc containing wastewater with fly ash zeolite, researching zinc removal rate and influencing factors, such as fly ash zeolite dosage, reaction acidity, contact time and other factors, to determine the best experimental conditions. The results showed that zinc removal rate was up to 97% in general, when the initial zinc and fly ash zeolite ratio was 1: 300, pH was 6. 5, contact time reached 30 mins. © 2016 Taylor & Francis Group, London.

Yang J.,Jiangsu Food & Pharmaceutical Science College | Cui Y.,Zhoukou Normal University | Chen M.,Chaohu University
Open Automation and Control Systems Journal | Year: 2015

The hydraulic control system, an important composition of parallel machine tool, is a high order, nonlinear, parameter uncertain system, which seriously affects the dynamic performance of a machine tool, so it is very difficult to gain good performance with traditional control methods. The sliding mode control method based on RBF neural network is proposed in this paper. From the simulation results we can obtain that the proposed method is better than the traditional sliding model control method. Moreover, the result validates the proposed method of Hydraulic system for parallel machine tool and also provides the theoretical and experimental basis. © Yang et al.

Zheng H.-Z.,Jiangsu Food & Pharmaceutical Science College | Hwang I.-W.,Kyungpook National University | Kim B.-K.,Kyungpook National University | Kim Y.-C.,Korea Food Research Institute | Chung S.-K.,Kyungpook National University
Journal of the Korean Society for Applied Biological Chemistry | Year: 2014

Unripe apples contain significant amount of phenolics with various health benefits. A pilot scale enrichment process of unripe apple phenolics with Viscozyme L extraction and XAD-7 sorption process, based on the total phenolic content (TPC), phenolics content by high-performance liquid chromatography analyses, and antioxidant activities were studied. Antioxidant activities were tested by measuring oxygen radical absorbing capacity (ORAC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and ferric-reducing antioxidant power (FRAP). The phenolics-rich final product, apple antioxidant phenolics (AAP) has 771-fold higher TPC and 600-fold higher antioxidant activity of unripe apples. Through XAD-7 sorption AAP showed 52, 87, 70 and 44-fold increases in TPC, ORAC, DPPH and FRAP values, respectively. AAP showed more than 95% stability at the temperature range of 20 to 120°… and pH range of 1.47 to 8.5. Apple phenolics extraction process of Viscozyme L extraction coupled with XAD-7 sorption could be applied to the production of health benefit antioxidants. © 2014, The Korean Society for Applied Biological Chemistry.

Sun T.,Jiangsu Food & Pharmaceutical Science College | Li H.,Jiangsu Food & Pharmaceutical Science College
Open Mechanical Engineering Journal | Year: 2014

In order to improve the automation of end-hole drilling process in the production of suture needles with thread, a high-precision subpixel-based drilling method is proposed. According to the edge detection principle in mathematical morphology, combined with the characteristics of the magnified images of the ends of suture needles to be drilled, the morphological edge detection operators with variable structural elements are constructed to achieve noise suppression and fully extract the detailed information of edges of images of needle end holes to be drilled. Then, the subdivision method of spatial moments is adopted to realize the subpixel positioning of pixel-level edges. Finally, least squares fitting method is used to achieve the high-precision positioning of center of needle end hole to be drilled. The experimental results of the 0.5 mm needle samples show that, the drilling method proposed in this study has a concentricity error no more than ± 0.2 μm and an average drilling time of 0.65S, boasting good real-time performance and stability and meeting the automated production needs of drilling process of suture needles with thread. © 2014, Sun and Li; Licensee Bentham Open.

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