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Liu J.,Soochow University of China | Liu J.,Jiangsu Engineering Research Center for Tumor Immunotherapy | Wang H.,Soochow University of China | Xie J.,Soochow University of China | And 2 more authors.
International Journal of Clinical and Experimental Pathology | Year: 2016

Neural fibrolipoma is a kind of benign tumor comprised of hypertrophied fibrofatty tissue with intermixed nerve tissue. Here we report one case of neural fibrolipoma with extensive calcification and ossification on the left neck, which has not been reported in the literature. Based on the literature of neural fibrolipoma, the clinical, pathological characteristics and treatment modalities of this rare tumor type are discussed.

Du P.,Soochow University of China | Du P.,Jiangsu Engineering Research Center for Tumor Immunotherapy | Du P.,Peoples Hospital of Gansu Province | Xiong R.,Soochow University of China | And 5 more authors.
Journal of Immunology Research | Year: 2016

T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1. © 2016 Peng Du et al.

Shi L.,SoochowUniversity | Shi L.,Soochow University of China | Shi L.,Jiangsu Engineering Research Center for Tumor Immunotherapy | Chen L.,SoochowUniversity | And 22 more authors.
Clinical Cancer Research | Year: 2016

Purpose: Radiofrequency ablation (RFA) has been shown to elicit tumor-specific T-cell immune responses, but is not sufficient to prevent cancer progression. Here, we investigated immunesuppressive mechanisms limiting the efficacy of RFA. Experimental Design: We performed a retrospective case-controlled study on patients with synchronous colorectal cancer liver metastases who had received primary tumor resection with or without preoperative RFA for liver metastases. Tumor-infiltrating T cells and tumoral PD-L1 expression in human colorectal cancer tissues were analyzed by immunohistochemistry. T-cell immune responses and PD-1/PD-L1 expression were also characterized in an RFA mouse model. In addition, the combined effect of RAF and PD-1 blockade was evaluated in the mouse RFA model. Results: We found that RFA treatment of liver metastases increased not only T-cell infiltration, but also PD-L1 expression in primary humancolorectal tumors. Using mouse tumor models, we demonstrated that RFA treatment of one tumor initially enhanced a strong T-cell-mediated immune response in tumor. Nevertheless, tumor quickly overcame the immune responses by inhibiting the function of CD8+ and CD4+ T cells, driving a shift to higher regulatory T-cell to Teff ratio, and upregulating PD-L1/ PD-1 expression. Furthermore, we established that the combined therapy of RFA and anti-PD-1 antibodies significantly enhanced T-cell immune responses, resulting in stronger antitumor immunity and prolonged survival. Conclusions: The PD-L1-PD-1 axis plays a critical role in dampening RFA-induced antitumor immune responses, and this study provides a strong rationale for combining RFA and the PD-L1/PD-1 blockade in the clinical setting. © 2015 American Association for Cancer Research.

Wu C.,Soochow University of China | Wu C.,Jiangsu Engineering Research Center for Tumor Immunotherapy | Zheng X.,Soochow University of China | Zheng X.,Jiangsu Engineering Research Center for Tumor Immunotherapy | And 18 more authors.
Oncotarget | Year: 2016

B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays important roles in gastric cancer, but the epigenetic regulatory mechanism by microRNA (miRNA) and the functional significance of Bmi-1 inhibition in gastric cancer remains elusive. In this study, we systematically investigated the functional roles of miRNA mediated Bmi-1 suppression in gastric cancer. Our results show that the expression of miR-15a is significantly reduced in gastric cancer and the protein expression levels of Bmi-1 are inversely correlated with miR-15a (P = 0.034) in gastric cancer patient samples. Functional studies revealed that ectopic expression of miR-15a decreased Bmi-1 in gastric cancer cell lines with reduced proliferation and tumor invasion. High levels of Bmi-1 in gastric cancer patients are significantly associated with better overall survival (P = 0.024) based on the Kaplan-Meier survival analysis.

Ji M.,Soochow University of China | Ji M.,Jiangsu Engineering Research Center for Tumor Immunotherapy | Liu Y.,Soochow University of China | Li Q.,Soochow University of China | And 9 more authors.
Cancer Biology and Therapy | Year: 2016

This study was aimed to detect the correlation among EGFR/KRAS status and PD-1/PD-L1 expression in non-small-cell lung cancer (NSCLC) patients. PD-1 and PD-L1 expressions were detected by immunohistochemistry in 100 surgically resected lung adenocarcinoma tissues and were statistically correlated with clinicopathological characteristics including EGFR and KRAS statuses. Besides, the overall survival (OS) times were analyzed. There was a statistical significances between PD-1 expression in tumor and KRAS status (P = 0.043), with a higher mutation rate in with lower PD-1 expression patients. There was a statistical significance between PD-L1 expression in tumor and EGFR status (P = 0.012), with a higher mutation rate in patients with lower PD-L1 expression. The OS of patients with EGFR mutation was significantly longer than those without EGFR mutation. The OS of patients with lower PD-L1 in tumor was significantly longer than those with higher PD-L1 expression. We found negative associations between PD-L1 expression in tumor and mutated EGFR status, as well as between PD-1 expression in tumor and mutated KRAS status. © 2016 Taylor & Francis Group, LLC

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