Jiang Xi Academic of science

Nanchang, China

Jiang Xi Academic of science

Nanchang, China
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Han X.-D.,Jiang Xi Academic of science | Ren C.-Q.,Shaanxi University of Science and Technology | Fu J.-P.,Jiang Xi Academic of science | Xiong W.,Jiang Xi Academic of science | And 4 more authors.
Synthesis (Germany) | Year: 2017

An efficient synthetic route to highly substituted pyrrolidone derivatives has been developed from an easily available alkynyl carboxamide and 4-methylbenzenesulfonic acid (PTSA). In the reaction, PTSA is not only used as acid catalyst but also as a reactant to provide a source for OTs group. A mechanism is proposed to involve the protonation of the alcohol substrate/cyclopropylcarbinol-homoallylic rearrangement/intramolecular N-nucleophilic cyclization reactions. Copyright © 2017, Georg Thieme Verlag. All rights reserved.


Han X.-D.,Jiang Xi Academic of science | Wang H.-B.,Jiang Xi Academic of science | Hu J.-W.,Jiang Xi Academic of science | Xiong W.,Jiang Xi Academic of science | And 5 more authors.
Tetrahedron Letters | Year: 2015

A series of 2-pyridone derivatives have been synthesized via a formal [3+3] annulation strategy starting from readily available α-EWG-α-formyl ketene-S,S-acetal 1 and α-carbamoyl ketene-S,S-acetals 2 in the presence of CH3COOH at 80 °C in excellent yields (91-98%). A mechanism involving sequential Baylis-Hillman reaction, intramolecular cycloaddition, Michael addition, and alkylthiol elimination processes for this novel reaction is described in the Letter. In addition, substituted 1-aryl pyridine-2(1H)-ones 4 have also been prepared in high yields via a Cu(OAc)2-mediated three-component reaction of 1, 2, and aryl boronic acid. © 2015 Elsevier Ltd.

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