Wu J.,Maternal and Child Health Hospital of Jinan City |
Cai C.,Shanghai University |
Tong D.,Shanghai JiaoTong University |
Hou H.,Jian Guo
Genetic Testing and Molecular Biomarkers | Year: 2012
Despite the knowledge of many genetic alterations present in ovarian cancer, the complexity of this disease precludes placing its biology into a simple conceptual framework. Lysyl oxidase (LOX) is an extracellular matrix enzyme that catalyzes the cross-linking of collagens or elastin in the extracellular compartment. A novel polymorphism in the LOX gene, G473A (rs1800449), has been reported as being a risk factor for different diseases. The objective of this study was to investigate the association between the LOX G473A polymorphism and the susceptibility to ovarian cancer in the Chinese population. The LOX variant G473A was detected by a polymerase chain reaction-restriction fragment length polymorphism in 233 ovarian cancer cases and 246 age-matched controls. Data were analyzed using the chi-square test. Data showed that frequencies of the LOX 473AA genotype and the A allele were significantly higher in ovarian cancer patients than in controls (odds ratio [OR]=2.52, 95% confidence interval [CI] 1.28-4.96, p=0.006; and OR=1.62, 95% CI 1.18-2.20, p=0.002). In addition, the prevalence of the GA genotype, AA genotype, and A allele were significantly increased in recurrent ovarian cancer cases compared with primary ovarian cancer cases. Our data suggest that the G473A polymorphism of the LOX gene is associated with increased susceptibility to ovarian cancer. © 2012 Mary Ann Liebert, Inc.
Safety and efficacy of once-daily hydromorphone extended-release versus twice-daily oxycodone hydrochloride controlled-release in chinese patients with cancer pain: A phase 3, randomized, double-blind, multicenter study
Yu S.,Huazhong University of Science and Technology |
Shen W.,Shanghai JiaoTong University |
Yu L.,Jian Guo |
Hou Y.,Jian Guo |
And 2 more authors.
Journal of Pain | Year: 2014
Noninferiority of the efficacy of once-daily hydromorphone hydrochloride extended-release (hydromorphone ER) compared with twice-daily oxycodone hydrochloride controlled-release (oxycodone CR) was investigated in this randomized, double-blind study in Chinese patients with moderate to severe cancer pain requiring strong oral opioid analgesics. Randomization (1:1) to hydromorphone ER (8-32 mg) or oxycodone CR (10-40 mg) was followed by dose titration (up to 8 days) and dose maintenance (28 days, weekly visits). Primary endpoint was change from baseline to end of study in "worst pain in the past 24 hours" of Brief Pain Inventory (Short Form) score on last observation carried forward (per protocol set). A total of 137 of 260 randomized patients completed maintenance phase (hydromorphone ER: n = 70; oxycodone CR: n = 67); per protocol set: 81 patients. Mean age was 53.1 years (range: 18-70 years; males: 65.3%); most common Eastern Cooperative Oncology Group performance status = 2. Least square mean difference between 2 treatment groups for primary endpoint using analysis of covariance (baseline score, covariate) was -.1 (95% confidence interval: -1.3, 1.1), with upper bound of 95% confidence interval <1.5 (predefined noninferiority margin). Most common reason for deaths was disease progression (hydromorphone ER: 6.3%; oxycodone CR: 12.7%). Treatment-emergent adverse events were comparable between treatment groups. Hydromorphone ER was noninferior to oxycodone CR in alleviating cancer pain and was well tolerated. Perspective This article demonstrates clinical noninferiority of the efficacy of once-daily hydromorphone ER compared with twice-daily oxycodone CR in alleviating cancer pain in Chinese patients, with comparable safety profiles between the 2 treatment groups. Thus, a treatment option with the potential for a reduced dosing frequency exists for health care providers and patients. © 2014 by the American Pain Society.
News Article | November 16, 2016
SHANGHAI, Nov. 16, 2016 /PRNewswire/ -- 2016 China International Travel Mart (CITM) was held in Shanghai New International Expo Center from November 11 to 13, 2016. As the largest tourism fair in Asia, CITM this year attracted exhibitors from 106 countries and regions. These exhibitors are from tourism management organizations, tourism associations, travel agencies, tourist attractions, airlines, tourism vehicles and ships companies, hotel groups and tourism resorts. The total number of booths at CITM was over 2,500. China's tourism industry has been continuously growing and has become the drive for China's hospitality industry to innovate and reform. At CITM, hotel groups that are vitally close to tourism also made their grand appearances this year. Jin Jiang International Hotels Management Company Limited ("Jin Jiang International Hotels") and its 18 hotels also set up booths at 1B03 and 4A07, displaying its diversified hotel resources and specialties. It was also the most important and biggest appearance for Jin Jiang at an industrial exhibition this year. After having successfully acquired Louvre Hotels Group from France and strategically investing in Plateno Group, Jin Jiang has expanded its brand scale in a more diversified direction, offering more choices for its partners. At CITM this year, Jin Jiang international hotels booth, covering an area of 100 square meters, was both elegant and stylish, inviting guests to experience amenities and services at Shanghai Jin Jiang Hotel, Shanghai Jin Jiang Tower, Shanghai Jian Guo Hotel, Shanghai Rainbow Hotel, Shanghai Park Hotel, Shanghai Pacific Hotel, Shanghai Paradise Jin Jiang Hotel, Xi'an Jin Jiang International Hotel, Wuhan Jin Jiang International Hotel, Beijing Asia Hotel, Lanzhou Jin Jiang Sun Hotel, Kashi Yuexing Jin Jiang International Hotel, Kunming Jin Jiang Hotel, Nanchang Jin Feng Hotel, Shenzhen Hotel in Beijing, Jin Jiang Sanya Royal Garden Resort, Sanya Jin Jiang Baohong Hotel, and Yang Peng Jin Jiang Hotel in Yangzhou. These hotels are located in hub cities in their own regions, provincial capital cities or famous tourist cities. Some of them have extensive experience in accommodating important guests from home and abroad, some are city landmarks and some are ideal destinations for getaways. The diversified range shows Jin Jiang International Hotels' industrial resources and far-reaching layout. As China has become one of the most important markets in global tourism, CITM is playing a more and more important role in professional tourism fair and exhibition events across the world. CITM this year was co-hosted by China National Tourism Administration, Civil Aviation Administration of China and People's Government of Shanghai. The total exhibition area amounted to 57,500 square meters, accommodating tourism organizations, travel agencies, hotels, airlines and other companies related to tourism from across the world that are expecting to benefit from the rising market in China.
Tie C.,CAS Beijing National Laboratory for Molecular |
Zhang D.-W.,CAS Beijing National Laboratory for Molecular |
Chen H.-X.,Jian Guo |
Song S.-L.,Psychiatric Hospital |
Zhang X.-X.,CAS Beijing National Laboratory for Molecular
Journal of Mass Spectrometry | Year: 2012
With the combination of high separation ability of capillary electrophoresis (CE) and strong identification ability of mass spectrometry (MS), CE/MS is becoming a powerful tool for polar and ionic analytes analysis. Different interfaces have been developed to enhance the sensitivity and reliability since the first introduction of CE/MS in 1987. A sheathless porous interface based on a new ions transferring electric connection technique was reported to be with high sensitivity and reliability. In this work, a series of optical and electrochemical experiments were designed to study the electric connection process. The results indicated that closing CE electrical circuit and applying MS spray voltage were achieved by the small ions transferring through the interface porous wall. The new electric connection method significantly enhanced the sensitivity, resolution and stability of the CE/MS analysis. The interface was applied in CE/MS detection of morphine and 6-monoacetylmorphine in urine sample and showed an equal sensitivity to LC/MS. With the significant improvement of sensitivity and stability, the CE/MS with the new interface showed strong potential for the determination of low abundance analytes. Copyright © 2012 John Wiley & Sons, Ltd.
News Article | October 28, 2016
SINGAPORE, Oct. 28, 2016 /PRNewswire/ -- Jin Jiang International Hotels was presented at ITB Asia 2016 in Singapore from October 19th to 21st. As one of Asia's largest travel trade shows, ITB Asia attracted over 760 exhibitors from 73 countries this year. Jin Jiang International Hotel Management Company and its member hotels again attended the event and carried out in-depth exchanges with outstanding enterprise and industry elites from around the world and looked for opportunities for cooperation. Jin Jiang International Hotels presented at the trade show classic hotels with profound history, prestigious and refined luxury hotels and simple and modern business hotels, including Jin Jiang Hotel Shanghai, Jin Jiang Tower Shanghai, Park Hotel Shanghai, Rainbow Hotel Shanghai and Jian Guo Hotel Shanghai. Jin Jiang Hotel Shanghai is a famous five-star garden hotel with its unique modern buildings listed as one of Shanghai's municipal cultural conservation sites. Since its inauguration in 1951, the hotel has accommodated more than 500 heads of state and government from over 100 countries, including nearly all of the influential men and women over half a century that follows. Jin Jiang Tower Shanghai, a five-star luxury business hotel, accommodated over 360 officials and celebrities, winning the heart of guests at home and abroad. Park Hotel Shanghai is a classic hotel which opened in 1934 and for 30 years was acclaimed as the "tallest building in the Far East". Located in central Shanghai, it offers customers with luxurious, cozy guestrooms and delicious cuisine. Rainbow Hotel and Jian Guo Hotel Shanghai are four-star business hotels, located in the Hongqiao transportation hub and bustling Xujiahui CBD respectively. Their comprehensive facilities combined with a developed urban transportation network make for an ideal business travel destination. As a major international specialized trade show, ITB Asia has become an industry weathervane and an information exchange window in Asia. Mr. William Cai, Director of Sales & Marketing at Jin Jiang International Hotels, said: "As a world renowned travel trade platform, ITB Asia provides us with great opportunities to network with international buyers of business travel, conference and exhibition for cooperation. In the future, Jin Jiang International Hotels will learn from advanced international experience and further expand its domestic and overseas markets to build a full range hotel brand system integrating domestic and international hotels to meet the ever more diversified and personalized market demands." Global Business Travel Association (GBTA) predicts that China will overtake the US in its spending on business travel and become the world's largest business travel market in 2016. Shanghai is currently building an international financial center and an international shipping center as global business communication grows day by day. In addition, Shanghai is one of China's most popular inbound tourist destinations. All Jin Jiang hotels that made appearance at ITB Asia 2016 are located in Shanghai and therefore can leverage the advantages a key region offers to develop overseas markets, reflecting Jin Jiang Hotels' clear understanding of its own resources and market opportunities. For more information or reservations, please visit: www.jinjianghotels.com
Wedgner A.,Borouge Pte |
Wang C.X.,Jian Guo
ICPTT 2014 - Proceedings of the 2014 International Conference on Pipelines and Trenchless Technology | Year: 2014
During the lifetime of a pipeline the point is reached where the cost of water loss, leakage management, maintenance and repair works, together with the poor service to the customer justifies its replacement or rehabilitation. Trenchless rehabilitation techniques can have a lower cost and cause substantially less disruption to existing assets and the general population than conventional 'open cut' techniques. As trenchless technology has developed and increased in use, so has the use of polyethylene pipes in applications such as slip lining, close fit lining and pipe bursting. The majority of pipeline renovation and replacement techniques now use polyethylene as their principal pipe material and the techniques have been developed to the point where they have been used to rehabilitate pipelines of up to 1,400mm internal diameter. This presentation will give an introduction to the different methods by which water pipelines can be rehabilitated using polyethylene pipes and liners through the use of a variety of trenchless technology techniques. It shall also explain how Engineers and other technical staff working for water utilities can use the standard ISO 11295 to help identify and specify the most appropriate technique for their particular situation. The original polyethylene pipe materials were not intended for such applications and so the greater use of polyethylene in trenchless technology has been a key driver in the development of tougher materials. One development has been PE100 materials that have a high resistance to slow crack growth through the wall of the pipes. Such materials are referred to as HSCR PE100 and PE100-RC. The presentation will explain how slow crack growth can be initiated by the use of trenchless technology applications and how the new generation of PE100 materials resist the growth of cracks through the pipe wall. © 2014 American Society of Civil Engineers.
Ho M.-C.,Jian Guo |
Hsieh Y.-T.,Jian Guo |
Hsieh Y.-T.,Tzu Chi University
Journal of AAPOS | Year: 2013
An 8-year-old Taiwanese girl presented with hyperpigmentation and scattered hypopigmentation in her irides and choroids. Her skin showed hyperpigmentation with speckled hypopigmentation over cheeks and sun-exposed areas. Medical history was remarkable for frequent infectious episodes and lower extremity bruising. A peripheral blood smear revealed large inclusion bodies in the cytoplasm of neutrophils. The patient was diagnosed with Chediak-Higashi syndrome and continues to be monitored closely. Copyright © 2013 by the American Association for Pediatric Ophthalmology and Strabismus.
Wu J.,Jian Guo |
Liu C.,Jian Guo |
Qian S.,Jian Guo |
Hou H.,Jian Guo
DNA and Cell Biology | Year: 2013
Ovarian cancer remains a challenging disease for which improved treatments are urgently needed. Tim-3 acts as a negative regulatory molecule and plays a critical role in immune tolerance. In the current study, we investigated the expression of Tim-3 on peripheral CD4+ T and CD8+ T cells in ovarian cancer. A total of 52 ovarian cancer patients and 56 healthy controls were recruited and leukocytes from peripheral blood mononuclear cells were analyzed for Tim-3 surface expression by flow cytometry. Data showed that expression of Tim-3 was significantly increased in both CD4+ and CD8+ T cells in ovarian cancer cases than in controls (p<0.0001 and p<0.0001, respectively). Patients who had recurrent ovarian cancer had a higher proportion of Tim-3+CD4+ T cells than when they were newly diagnosed (p=0.013). When analyzing Tim-3 expression with cancer progression, results revealed elevated Tim-3 expression in both CD4+ and CD8+ T cells in cases with advanced International Federation of Gynecology and Obstetrics (FIGO) staging (III/IV) than those with stage I and II (p=0.009 and p=0.037, respectively). We also tested Tim-3 with tumor grade, and observed that patients with a higher tumor grade (G3) demonstrated further augmented Tim-3 expression in CD4+ and CD8+ T cells compared to those with lower tumor grades (p=0.010 and p=0.042, respectively). Our study suggested that Tim-3 may participate in the development and progression of ovarian cancer by its negative regulation on various T-cell subsets, and Tim-3 expression in CD4+ T cells could serve as a predictive marker for anticancer therapies. © 2013, Mary Ann Liebert, Inc. 2013.
News Article | July 25, 2014
Industrial magnet is of great importance these days and these magnets are highly powerful as a result of which they can be used in different useful applications. These magnets can be of varied types, shapes, patterns and sizes. These magnets are being tested and approved by the MMPA and MDFA in order to check that whether these magnets have been created by abiding the standard rules or instructions of the industry or not. Some common types of magnets that can be used for varied industrial purposes include ferrite, electromagnets, permanent magnets, sheet magnets, rubber magnets, samarium, neodymium and many more. If you are willing to buy magnet for industrial purposes, then in that case you must directly purchase the same from the manufacturing concern in order to get the same at highly affordable rates. Out of the different magnet types, motor magnet is mainly considered as the most efficient one and can be used for various applications. These magnets are being operated with the help of electricity and this is the reason that they react speedily and attract even heavier objects easily and conveniently without any hazard as a result of which accidental hazards can be highly avoided. These industrial purpose oriented magnets are being used in varied industries like glass, plastic electronics, automobile, ceramics, mining, construction, shipping, pharmaceutical and food industries. Industry safeguards and energy can be effectively generated by the same. These magnets can be utilized in different useful applications including separators, assemblies, plates, conveyors, cranes, chutes, tube grates, magnetized pulleys and many more. Recently, magnet trade is going ion increasing due to the increase of the usage of these magnets for a variety of industrial applications. There are innumerable electronic goods where these magnets are being used like censors, clocks, microphones, loudspeakers, CD drives, monitors, radios, televisions, toys, compasses, actuators, transformers, electric guitars, amplifiers and many more.