Sabharwal E.R.,Jhalawar Medical College
North American Journal of Medical Sciences | Year: 2012
Background: Urinary tract infections (UTI) are the most commonly encountered infections in obstetric patients. Although a variety of etiology is involved, Escherichia coli and other coliforms account for a large majority of these naturally acquired infections. The estimation of local etiology and susceptibility profile could support the most effective empirical treatment. Aim: The current study was undertaken to find the spectrum of micro-organisms responsible for causing UTI in obstetric patients and to find out the most appropriate antibiotic. Materials and Methods: Consecutive patients in different stages of pregnancy with or without symptoms of UTI attending the antenatal clinic during November 2011 to March 2012 were screened for significant bacteriuria. The bacterial uropathogens isolated were then subjected to antimicrobial susceptibility testing and screened for ESBL production and methicillin resistance. Results: During the 5-month study period, out of the 250 samples screened, a total of 60 (24%) samples of urine from pregnant females, in different stages of pregnancy were found to be positive on culture. The Enterobacteriaceae accounted for nearly two-thirds of the isolates and E. coli alone accounted for 63% of the urinary isolates followed by Klebsiella pneumonia 8%. Among the Gram-positive cocci, coagulase-negative Staphylococcus (15%) were more frequently isolated than Staphylococcus aureus (8.3%). A significantly high resistance was noted to the beta-lactam group of antimicrobials, fluoroquinolones and cotrimoxazole, both by the Gram-negative bacilli as well as Gram-positive cocci. Resistance was quite low against the aminoglycosides and nitrofurantoin and virtually absent against imipenem. Conclusion: The susceptibility patterns seen in our study seem to suggest that it is absolutely necessary to obtain sensitivity reports before initiation of antibiotic therapy in cases of suspected UTI.
Nagar R.C.,Jhalawar Medical College
Indian Journal of Surgery | Year: 2013
It is unusual to encounter a patient who stabbed his abdomen with a kitchen knife. A 25-year-old man was in police custody for 2 days. He stabbed his abdomen with a kitchen knife. He was brought to casualty with a retained knife in his abdomen. The knife had torn gastrocolic omentum and caused contusion on the transverse colon. His postoperative period was fair. © 2012 Association of Surgeons of India.
Gadekar R.,VNS Institute of Pharmacy |
Saurabh M.K.,Jhalawar Medical College |
Thakur G.S.,Tropilite Foods Pvt.Ltd
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012
The aim of this study was to investigate the feasibility of Curcumin patches formulation (CPF) as a transdermal therapeutic system for wound healing potential. A combination of Poly Vinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) most strongly enhanced the permeation of Curcumin patch which permeated through the skin could effectively pass into the systemic circulation and attend therapeutic concentration. All formulation showed good physicochemical properties like thickness, weight variation, drug content, folding endurance, moisture content.The drug release through the transdermal patches of Curcumin follows first order kinetics with diffusion controlled mechanism. The results showed wound healing and repair is accelerated by applying CPF-1 formulation of the wound area by an organized epidermis. Study on animal models showed enhanced rate of wound contraction and drastic reduction in healing time than control, which might be due to enhanced epithelialization. The animals treated with Vicco-turmeric Cream and CPF-1 Formulation showed significant (* p< 0.01) wound healing results when compared with control groups. The treated wound after nine days itself exhibit marked dryness of wound margins with tissue regeneration. Group treated with CPF-1 formulation showed better wound closure compared to control group. Histopathological studies of Curcumin patches showed well-organized collagen fibers, increased in fibroblast cells and new blood vessels formation as compared to control group.
Poonam,Jhalawar Medical College |
Singla R.K.,Government of Punjab |
Sharma T.,Government of Punjab
Journal of Clinical and Diagnostic Research | Year: 2010
Context: The anatomical and the morphological variations of the vertebral artery are significant for diagnostic and surgical procedures in the head and neck region, where an incompatible knowledge can lead to serious implications Aims: This study was conducted to know the variations in the origins of vertebral arteries and to discuss their clinical implications while performing diagnostic and interventional angiography, both to identify them correctly and to know where to look when vertebral arteries are not seen in the normal position. Material And Methods: Eighty vertebral arteries belonging to 40 cadavers were dissected in the head and neck region. Their source and mode of origin were studied. Out of the total cadavers, four were found to have abnormal origins of vertebral arteries, which were studied in detail along with their clinical implications. Results: An extremely rare and interesting case of the origin of the left vertebral artery from the external carotid artery was encountered in one of these specimens. The direct origin of the left vertebral artery from the aortic arch was also found in three cadavers, out of which one was found to be bifurcating after taking origin. No abnormality in the origin was encountered on the right sided vertebral arteries. Conclusion: The described morphological variations have clinical applications in the wide field of surgery, in the head and neck region. To know about these findings seems to be very important before undertaking any surgery or endovascular treatment in that region. Cerebral angiography must be included in the evaluation of patients with unexplained neurological findings.
Agarwal S.,Jhalawar Medical College
Journal of Medicine | Year: 2012
The present study conducted with the aim that ADA estimation is a simple cheaper and quicker biochemical test and could provide additional supportive evidence for the diagnosis of tuberculous meningitis, tuberculous pleural effusion, tuberculous ascites in clinically suspected cases and will therefore help in early institution of therapy to these patients. The data was collected and interpreted at department of Physiology and Department of Medicine Gandhi Medical College, Bhopal.