Jhalawar Medical College

Jhālāwār, India

Jhalawar Medical College

Jhālāwār, India
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Gadekar R.,VNS institute of pharmacy | Saurabh M.K.,Jhalawar Medical College | Thakur G.S.,Tropilite Foods Pvt.Ltd
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

The aim of this study was to investigate the feasibility of Curcumin patches formulation (CPF) as a transdermal therapeutic system for wound healing potential. A combination of Poly Vinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) most strongly enhanced the permeation of Curcumin patch which permeated through the skin could effectively pass into the systemic circulation and attend therapeutic concentration. All formulation showed good physicochemical properties like thickness, weight variation, drug content, folding endurance, moisture content.The drug release through the transdermal patches of Curcumin follows first order kinetics with diffusion controlled mechanism. The results showed wound healing and repair is accelerated by applying CPF-1 formulation of the wound area by an organized epidermis. Study on animal models showed enhanced rate of wound contraction and drastic reduction in healing time than control, which might be due to enhanced epithelialization. The animals treated with Vicco-turmeric Cream and CPF-1 Formulation showed significant (* p< 0.01) wound healing results when compared with control groups. The treated wound after nine days itself exhibit marked dryness of wound margins with tissue regeneration. Group treated with CPF-1 formulation showed better wound closure compared to control group. Histopathological studies of Curcumin patches showed well-organized collagen fibers, increased in fibroblast cells and new blood vessels formation as compared to control group.

Poonam,Jhalawar Medical College | Singla R.K.,Government of Punjab | Sharma T.,Government of Punjab
Journal of Clinical and Diagnostic Research | Year: 2010

Context: The anatomical and the morphological variations of the vertebral artery are significant for diagnostic and surgical procedures in the head and neck region, where an incompatible knowledge can lead to serious implications Aims: This study was conducted to know the variations in the origins of vertebral arteries and to discuss their clinical implications while performing diagnostic and interventional angiography, both to identify them correctly and to know where to look when vertebral arteries are not seen in the normal position. Material And Methods: Eighty vertebral arteries belonging to 40 cadavers were dissected in the head and neck region. Their source and mode of origin were studied. Out of the total cadavers, four were found to have abnormal origins of vertebral arteries, which were studied in detail along with their clinical implications. Results: An extremely rare and interesting case of the origin of the left vertebral artery from the external carotid artery was encountered in one of these specimens. The direct origin of the left vertebral artery from the aortic arch was also found in three cadavers, out of which one was found to be bifurcating after taking origin. No abnormality in the origin was encountered on the right sided vertebral arteries. Conclusion: The described morphological variations have clinical applications in the wide field of surgery, in the head and neck region. To know about these findings seems to be very important before undertaking any surgery or endovascular treatment in that region. Cerebral angiography must be included in the evaluation of patients with unexplained neurological findings.

AIM: To compare qualitatively Metoclopramide, Ondansetron and Granisetron alone and in combination with Dexamethasone in the Prevention of Postoperative Nausea and Vomiting in Day Care Laparoscopic Gynaecological Surgery under General Anaesthesia. METHOD: 180 adult female patients of ASA Grade I and II, BMI <30, aged 18 to 55 years undergoing laparoscopic gynaecological surgery under general anaesthesia included in the study. Patients with history of motion sickness and past history of PONV were excluded from the study. The study was carried out in six groups consisting of randomly selected 30 patients in each. Before induction of general anaesthesia, the antiemetic drugs under study given intravenously i.e. Metoclopramide (10 mg), Ondansteron (4mg) and Granisetron (3 mg) were given alone in group A, B and C respectively while in group D, E and F these drugs were combined with Dexamethasone (8 mg) respectively. The study drugs were given as intravenous injections. RESULT: The study found that Metoclopramide is very poor because of higher incidence of side effects and only 36.7% success rate in the prevention of PONV. The success rate in the prevention of PONV is poor in Ondansetron & Granisetron (nearly two-third, 63.3% & 66.7% respectively). The success rate found good (nearly three-fourth, 73.3%) in combination of Metoclopramide with Dexamethasone and very good in combination of Ondansetron & Granisetron with Dexamethasone (90% in both).

Daria U.,Jhalawar Medical College | Kumar V.,Jhalawar Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Aim: To compare a better choice between thiopentone and propofol for Modified electroconvulsive therapy. Method: 100 patients of ASA grade I and II of both sexes, aged 18 years and above scheduled to undergo electroconvulsive therapy under general anesthesia were studied in this crossover study. Thiopentone (2.5%) in dosage of 5 mg/kg and propofol (1%) in dosage of 2 mg/kg were given intravenously for anaesthesia. The two drugs were examined for induction and recovery time, effect on serum potassium and duration of seizure and incidence of side effects during induction and post ECT recovery period. Results: Mean induction and recovery time significantly less in propofol as 40.4 seconds and 22.1 minutes while in thiopentone as 49.4 seconds and 28.9 minutes. Mean seizure duration was 25.6 seconds in propofol and 28.1 seconds in thiopentone. The difference in mean seizure duration was statistically non significant. Incidence of side effects during induction and recovery was significantly very less in propofol. In conclusion propofol is a better choice for Modified-ECT.

Sharma M.K.,Jhalawar Medical College | Sharma H.,Jhalawar Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Introduction: The study of the epidermal ridges on the volar aspect of the hands and feet which form a variety of pattern configurations is called "DERMATOGLYPHICS". All configurations are laid down permanently from the 3rd month of the intra-uterine life and they remain unchanged throughout the life. A positive association of the dermatoglyphic features with different diseases like diabetes, mongolism, schizophrenia and leprosy have been well documented in recent years. Methods: In the present study, 50 diabetic cases and 50 controls were selected from the SMS Hospital, Jaipur, India for the establishment of the correlation between the two groups by checking for the presence and absence of any dermatoglyphic pattern. Hand prints were taken by Indian ink methods and examined for Total Finger Ridge Count (TFRC), Absolute Finger Ridge Count (AFRC), (a-b) ridge count, distal and lateral deviation (quantitative parameter) and digital and palmer pattern frequency, lateral deviation, angles and the C-line pattern frequency (qualitative parameter). Aim: The aim of the present was to evaluate the dermatoglyphic features and the specific variations which were to be used as diagnostic tools for an economic and early detection of diabetes. Results and Conclusion: The TFRC, AFRC, and the (a-b) ridge count were higher in all the patients but they were statistically insignificant. The 'atd' angles in the hands of both sides in the patients were increased in all the groups, except in males (left side), but they differed significantly on the right side (overall, p<.01) and on the left side (female, p<.001). The 'tad' and the 'tda' angles on both sides of the hands in all the groups were lower in the patients except in males (left 'tda'), but they differed only significantly in the females (left 'tad' p<.01, right 'tda' p<.001) and in the overall groups (right 'tda' p<.01) The whorl, loop and arch digital frequencies in females and in the overall groups (except loop) were increased insignificantly (p<.05). The vestige and the spiral whorl pattern were restricted to the thenar and the hypothenar areas of the male patients respectively as compared to the controls. Except an increase in the radial variety and the absence of the proximal variety, other C-line patterns were decreased in diabetics than in the controls. The results of the present research work indicate that dermatoglyphic abnormalities may be used as a diagnostic tool for predicting the possibility of the development of diabetes at a later date.

Sabharwal E.R.,Jhalawar Medical College
North American Journal of Medical Sciences | Year: 2012

Background: Urinary tract infections (UTI) are the most commonly encountered infections in obstetric patients. Although a variety of etiology is involved, Escherichia coli and other coliforms account for a large majority of these naturally acquired infections. The estimation of local etiology and susceptibility profile could support the most effective empirical treatment. Aim: The current study was undertaken to find the spectrum of micro-organisms responsible for causing UTI in obstetric patients and to find out the most appropriate antibiotic. Materials and Methods: Consecutive patients in different stages of pregnancy with or without symptoms of UTI attending the antenatal clinic during November 2011 to March 2012 were screened for significant bacteriuria. The bacterial uropathogens isolated were then subjected to antimicrobial susceptibility testing and screened for ESBL production and methicillin resistance. Results: During the 5-month study period, out of the 250 samples screened, a total of 60 (24%) samples of urine from pregnant females, in different stages of pregnancy were found to be positive on culture. The Enterobacteriaceae accounted for nearly two-thirds of the isolates and E. coli alone accounted for 63% of the urinary isolates followed by Klebsiella pneumonia 8%. Among the Gram-positive cocci, coagulase-negative Staphylococcus (15%) were more frequently isolated than Staphylococcus aureus (8.3%). A significantly high resistance was noted to the beta-lactam group of antimicrobials, fluoroquinolones and cotrimoxazole, both by the Gram-negative bacilli as well as Gram-positive cocci. Resistance was quite low against the aminoglycosides and nitrofurantoin and virtually absent against imipenem. Conclusion: The susceptibility patterns seen in our study seem to suggest that it is absolutely necessary to obtain sensitivity reports before initiation of antibiotic therapy in cases of suspected UTI.

Background and Objectives: The resistance to broad spectrum β-lactams which is mediated by the extended spectrum beta lactamase (ESBL) enzyme is an increasing problem now- adays. This resistance mechanism has been responsible for nosocomial outbreaks, serious therapeutic failure if it is not detected on time and the outbreak of multidrug resistant, gram negative pathogens that need expensive control measures. As no data was available on the prevalence of ESBL in this region, the current study was undertaken to determine the prevalence of the ESBL producing strains in our hospital based population of Jhalawar. Aim: To know the prevalence of ESBL producing organisms at our tertiary care hospital at Jhalawar. Material and Methods: A total of 219 consecutive, non-repetitive, gram negative isolates, which were resistant to one of the third generation cephalosporins (cefotaxime, ceftriaxone or ceftazidime) were selected as "Suspicious for ESBL production" as recommended by the Clinical and Laboratory Standards Institute (CLSI). These isolates were confrmed for ESBL production by the double disc synergy test (DDST) and the phenotypic confrmatory disc diffusion test (PCDDT) and they were further confrmed by the E-test ESBL strip randomly. Result: Out of the 219 isolates which were tested, 135 (61.6%) were found to be ESBL producers by PCDDT and 126 (57.5%) were found to be ESBL producers by DDST. Twenty-eight randomly selected isolates were further confrmed by the E-test ESBL strip, which showed a highly signifcant correlation with PCDDT (p value <0.001). The isolates of Escherichia coli (73.5%) were the most common ESBL producers, followed by Proteus vulgaris (60%), K. pneumoniae (58.1%) and others. The maximum ESBL production was seen in urine (66.4%), followed by pus (57.3%) and others (54.2%). Imipenem (98.5%), piperacillin/ tazobactum (72.6%) and amikacin (64.5%), in the decreasing order, were the most active and reliable agents for the treatment of the infections which were caused by the ESBL producing organisms. Conclusion: There is a high prevalence of ESBL production in our hospital and so, it is essential to report the ESBL production along with the routine sensitivity reports, which will help the clinician in prescribing proper antibiotics. Also, control measures which include the judicious use of antibiotics, antibiotic cycling, the implementation of appropriate infection control measures and the formulation of an antibiotic policy must be done, to prevent the spread of these strains.

Nagar R.C.,Jhalawar Medical College
Indian Journal of Surgery | Year: 2013

It is unusual to encounter a patient who stabbed his abdomen with a kitchen knife. A 25-year-old man was in police custody for 2 days. He stabbed his abdomen with a kitchen knife. He was brought to casualty with a retained knife in his abdomen. The knife had torn gastrocolic omentum and caused contusion on the transverse colon. His postoperative period was fair. © 2012 Association of Surgeons of India.

Kumar V.,Jhalawar Medical College | Daria U.,Jhalawar Medical College
Indian Journal of Psychiatry | Year: 2013

Background: Prisoners are having high percentage of psychiatric disorders. Majority of studies done so far on prisoners are from Western countries and very limited studies from India. Aim: Study socio-demographic profile of prisoners of a central jail and to find out current prevalence of psychiatric disorders in them. Materials and Methods: 118 prisoners were selected by random sampling and interviewed to obtain socio-demographic data and assessed on Indian Psychiatric Interview Schedule (IPIS) with additional required questions to diagnose psychiatric disorders in prisoners. Results: Mean age of prisoners was 33.7 years with 97.5% males, 57.6% from rural areas and 65.3% were married. Average education in studied years was 6.6 years and 50.8% were unskilled workers. 47.4% were murderers while 20.3% of drugs related crimes. 47.5% were convicted and history of criminal behavior in family was in 32.2% prisoners. Current prevalence of psychiatric disorders was 33%. Psychotic, depressive, and anxiety disorders were seen in 6.7%, 16.1%, and 8.5% prisoners respectively. 58.8% had history of drug abuse/dependence prior to imprisonment. Conclusion: One prison of Hadoti region of Rajasthan is full of people with mental-health problems who collectively generate significant levels of unmet psychiatric treatment need. Prisons are detrimental to mental-health. Beginning of reforms is the immediate need.

The present study conducted with the aim that ADA estimation is a simple cheaper and quicker biochemical test and could provide additional supportive evidence for the diagnosis of tuberculous meningitis, tuberculous pleural effusion, tuberculous ascites in clinically suspected cases and will therefore help in early institution of therapy to these patients. The data was collected and interpreted at department of Physiology and Department of Medicine Gandhi Medical College, Bhopal.

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