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West Jerusalem, Israel

Ginsberg G.M.,Public Health Service | Block C.,Hebrew University of Jerusalem | Stein-Zamir C.,Jerusalem District Health Office | Stein-Zamir C.,Hebrew University of Jerusalem
International Journal of Public Health | Year: 2016

Objectives: Using cost-utility analysis, to evaluate whether or not to adopt a Neisseria meningitidis serogroup B vaccination programme for Israeli children. Methods: Epidemiological, demographic, health service utilisation and economic data were integrated into a spreadsheet model to calculate the cost per averted disability-adjusted life year (DALY) of the intervention. Results: Assuming 78 % vaccine efficacy with no herd immunity, vaccination will prevent 223 cases and 22 deaths over a 100-year period. Based on vaccine price of $60 per dose, total intervention costs ($315,400,000) are partially offset by a $22,700,000 reduction in treatment and sequelae costs as a result of decreased morbidity. The intervention was not cost-effective since the net cost ($292,700,000) per averted DALY gained (1249 mostly due to decreased mortality) was $234,394. Additional two dose catch-up programmes vaccinating children in cohorts aged 1–2 to 1–13 were also not cost-effective. Conclusions: The vaccination will become cost-effective if vaccine costs fall below $19.44 per dose. However, in identified high risk areas, the vaccine would be cost-effective and could be recommended for use both with and without catch-up campaigns. © 2016 Swiss School of Public Health (SSPH+) Source


Braustein H.E.,Tel Aviv University | Braustein I.E.,Jerusalem District Health Office
ECS Transactions | Year: 2013

There is a growing need for virus-detecting sensors with improved sensitivity and dynamic range, for applications including disease diagnosis, pharmaceutical research, agriculture and homeland security. We report a novel electrochemical biosensing method for improving the sensitivity for detection of the bacteriophage virus MS2, using nanoporous oxirane-derivatized beads. These beads are a commercial polymethyl-metacrylate (PMMA) polymer that has extremely high surface area to volume ratio, making it an ideal platform for surface based sensors. We have developed and evaluated a method for covalent bioconjugation of antibodies and biological support to polymeric beads. The resulting Solid State Kits (SSK) were used to selectively capture enzyme-labeled MS2 viruses from different solutions, enabling detection of a viral concentration of as low as 10 plaque-forming units per milliliter (pfu ml-1) by measuring the current (A) from the exposed SSK beads to the enzymatic reaction electrons movement not clear. The kit is connected to a "home made" designed micro-flow system, that exhibits sensitivity and dynamic range similar to the ELISA immuno-liquid array-based assay while outperforming protein micro-array methods. Immuno-Amperometric techniques, using nano-Bio-Polymers Solid Phase Disposable Kit, were used to measure and thus to validate the accuracy of novel technology for virus concentration determination. These work demonstrate the utility of immunoelectrochemical techniques for use in environmental-health quality assurance measurements of viruses. © 2014 The Electrochemical Society. Source


Knishkowy B.,Terem Family Medicine Center | Verbov G.,Jerusalem District Health Office | Amitai Y.,Bar - Ilan University | Stein-Zamir C.,Jerusalem District Health Office | Rosen L.,Tel Aviv University
International Journal of Adolescent Medicine and Health | Year: 2012

Background: Ultra-orthodox, Jewish adolescent boys are considered to have relatively high smoking rates, but are generally not targeted by Israel ' s smoking prevention programs. Objective: The objective of this trial was to test the effectiveness of a religion-based tobacco control intervention in reducing smoking prevalence among these youth. Methods: The study population participants were 340 boys from 63 religious boys ' schools in Jerusalem. The intervention consisted of a mailing that included a pamphlet describing the health effects of and rabbinical prohibitions on smoking. A cluster randomized trial was conducted between March and May, 2005. The primary endpoint was current smoking status. Secondary endpoints were future intent to smoke and attitudes towards smoking. Generalized estimating equations and mixed models of analysis of variance were used to perform the analyses. Results: The intervention did not significantly affect current smoking, intent to smoke or attitudes towards smoking. Prevalence of smoking and future intent to smoke were higher in schools without enforced smoking regulations [odds ratio (OR) 2.74, p = 0.026, OR 3.38, p = 0.018]. Increased smoking prevalence was associated with a high prevalence of smoking among friends (p = 0.031) and not finding smoking repulsive (p = 0.024). Conclusions: This study adds to the public health literature linking smoke-free schools and peer influences to adolescent smoking. Pamphlets containing rabbinic prohibitions on smoking initiation did not affect smoking behavior or intent to smoke. © 2012 by Walter de Gruyter. Source


Sharf M.,Jerusalem District Health Office | Sela R.,Jerusalem District Health Office | Zentner G.,Jerusalem District Health Office | Shoob H.,Jerusalem District Health Office | And 3 more authors.
Appetite | Year: 2012

Nutritional labelling of packaged foods, mandated by law, includes details of the food content and composition - information that can affect individual and public lifestyle decisions and health status. We studied the comprehension of food labels among 120 young adults (mean age 24.1. years) attending an international travel immunization clinic. Each participant was presented with 10 food packages of common local products and was interviewed regarding the label's content. Most subjects (77.5%) reported that they took note of the food labels; women, the more educated and those engaging regularly in physical exercise were more inclined to do so. Out of a possible 10 points the overall median comprehension score was 6.0 (mean 5.7 ± 1.8). The nutritional table section of the food label was understood the best, and the nutritional declaration section the least. The subjects thought they understood the food labels better than they actually did; 43.9% stated that they understood them very well, whereas only 27.2% achieved high scores. This inadequate comprehension of food labels represents a missed opportunity to provide essential information necessary for healthy food choices at the individual level. A combination of strategies is necessary, including improving food labels (simplification and standardization) combined with targeted educational programs. © 2011 Elsevier Ltd. Source


Daudi N.,Hebrew University of Jerusalem | Shouval D.,Hebrew University of Jerusalem | Stein-Zamir C.,Jerusalem District Health Office | Ackerman Z.,Hebrew University of Jerusalem
Breastfeeding Medicine | Year: 2012

Breastmilk specimens from three women with acute hepatitis A virus (HAV) infection were studied. Anti-HAV immunoglobulin M and immunoglobulin G antibodies were detected in serum and breastmilk specimens of the three women. The three women also had serum HAV RNA. However, HAV RNA was detected only in two of the three breastmilk specimens. It is interesting that none of the three infants contracted clinical HAV infection. Furthermore, mothers with HAV infection should not be encouraged to discontinue breastfeeding. © 2012, Mary Ann Liebert, Inc. Source

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