Jeongeup, South Korea
Jeongeup, South Korea

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Yhim H.-Y.,Chonbuk National University | Lee N.-R.,Chonbuk National University | Song E.-K.,Chonbuk National University | Kwak J.-Y.,Chonbuk National University | And 14 more authors.
International Journal of Cancer | Year: 2011

The prognostic relevance of tumor human papillomavirus (HPV) status in anal squamous cell carcinoma (SCC) had not been previously investigated, although its relevance to cervical, head and neck SCC is known. We retrospectively evaluated outcomes in 47 patients with anal SCC treated with combined chemoradiotherapy (CCRT) and determined tumor HPV status by HPV DNA chip method and p16 expression by immunohistochemistry (IHC) from paraffin-embedded tumor tissues. The median age was 65 years (range, 44-90 years). Sixteen (34%) patients were diagnosed with T stage 3 to 4, and 18 (38%) patients had regional nodal disease (N-positive). Thirty-five (75%) patients were HPV positive, and 31 (66%) patients were genotype 16 (HPV16-positive). Thirty-nine (83.0%) patients were positive for p16. After median follow-up of 51.7 months (range, 5.1-136.0 months), HPV16-positive group had significantly better 4-year progression-free survival (PFS, 63.1% vs. 15.6%, p < 0.001) and overall survival (84.6% vs. 39.8%, p = 0.008) than HPV genotype 16 negative (HPV16-negative) group. Patients with p16-positive tumor also had a better 4-year PFS (52.5% vs. 25.0%, p = 0.014) than those with p16-negative tumor. In multivariate analysis for PFS, N-positive and HPV16-negative were independent prognostic factors for shorter PFS. Comparing patterns of failure, time to loco-regional failure was statistically superior in HPV16-positive over HPV16-negative groups (p = 0.006), but time to systemic failure was not different (p = 0.098). Tumor HPV genotype 16 status is a prognostic and predictive factor in anal SCC treated with CCRT, and p16 expression determined by IHC might be advocated as a surrogate biomarker of HPV integration in anal SCC. Further studies are warranted. Copyright © 2010 UICC.


Rim H.-K.,Hoseo University | Moon P.-D.,Kyung Hee University | Choi I.-H.,Kyung Hee University | Lee E.-H.,Jeonbuk Science College | And 2 more authors.
Indian Journal of Medical Research | Year: 2013

Background & objectives: Obesity is now considered as a major risk factor for the development of fatty liver diseases, cardiovascular diseases, and atherosclerosis. SoSoSo is a newly developed dietary supplement made of seven medicinal herbs. This study was aimed at examining the anti-obesity effect of SoSoSo or its active ingredient chrysophanol on the production of inflammatory cytokines and adipokine in macrophyage cell line RAW264 and 3T3-L1 adipocytes. Methods: No release was measured as a form of nitrite by Griess method. The production of inflammatory cytokines and adipokine were measured with the ELISA method. The m-RNA expression of each cytokine and adipokine were measured using RT-PCR. The nuclear proteins for NF-αB were analyzed with western blotting. Results: SoSoSo or chrysophanol significantly inhibited the nitric oxide production in lipopolysaccharide-stimulated RAW264 cells as well as in RAW264 cells-conditioned medium (CM)-treated 3T3-L1 cells. The production of interleukin (IL)-6 and tumour necrosis factor (TNF)-α were inhibited by SoSoSo or chrysophanol. In addition, SoSoSo or chrysophanol inhibited the activation of nuclear factor-κB in RAW264 cells. SoSoSo or chrysophanol inhibited the productions of IL-6, TNF-α, and monocyte chemoattractant protein-1 as well as the reduction of adiponectin production in CM-treated 3T3-L1 cells. Interpretation & conclusions: These results suggest a potential of SoSoSo or chrysophanol as a source of anti-inflammatory agent for obesity. Further in vivo studies would be required to confirm these findings.


Joo J.,Jeonbuk Science College | Lee J.,Hanbat National University | Kim J.H.,Korea University | Jun H.,Seoul National University of Science and Technology | Jo D.,Dongseo University
Water (Switzerland) | Year: 2014

Traditional inter-event time definition (IETD) estimate methodologies generally take into account only rainfall characteristics and not drainage basin characteristics. Therefore, they may not succeed in providing an appropriate value of IETD for any sort of application to the design of urban drainage system devices. To overcome this limitation, this study presents a method of IETD determination that considers basin characteristics. The suggested definition of IETD is the time period from the end of a rainfall event to the end of a direct runoff. The suggested method can identify the independent events that are suitable for the statistical analysis of the recorded rainfall. Using the suggested IETD, the IETD of the Joong-Rang drainage system was determined and the area-IETD relation curve was drawn. The resulting regression curve can be used to determinate the IETD of ungauged urban drainage systems, with areas ranging between 40 and 4400 ha. Using the regression curve, the IETDs and time distribution of the design rainfall for four drainage systems in Korea were determined and rainfall-runoffsimulations were performed with the Storm Water Management Model (SWMM). The results were compared with those fromHuff's method which assumed a six-hour IETD. The peak flow rates obtained by the suggested method were 11%~15% greater than those obtained by Huff's method. The suggested IETD determination method can identify independent events that are suitable for the statistical analysis of the recorded rainfall aimed at the design of urban drainage system devices. © 2013 by the authors.


Jeong I.S.,Chosun University | Choi J.Y.,Chosun University | Nho E.Y.,Chosun University | Hwang I.M.,Chosun University | And 5 more authors.
Analytical Letters | Year: 2014

Food irradiation processing needs proper control to facilitate consumer assurance, choice, and protection, including accurate detection of irradiated food. This study was aimed at analyzing hydrocarbons induced by gamma and electron beam irradiation in Camembert and processed cheeses. The samples were irradiated at 0, 1, 3, 5, 7, and 10 kGy doses of γ-rays and an electron beam. The induced hydrocarbons were separated on a florisil column and identified by gas chromatography-mass spectrometry (GC-MS). The detected hydrocarbons were pentadecane and 1-tetradecene from palmitic acid, heptadecane and 1-hexadecene from stearic acid, and 8-heptadecene and 1,7-hexadecadiene from oleic acid. The concentrations of the radiation-induced hydrocarbons increased with irradiation dose. Among the induced hydrocarbons, 1-tetradecene and 1,7-hexadecadiene were found to be the major hydrocarbons in the cheese samples. For most irradiation doses, the concentration of hydrocarbons induced by the electron beam was slightly higher than by gamma rays. These hydrocarbons were detected only in irradiated samples at 1 kGy or above, and not in the nonirradiated ones. It was concluded that the detected hydrocarbons were good markers to distinguish irradiated and nonirradiated cheese. © 2014 Copyright Taylor and Francis Group, LLC.


Jeong I.S.,Chosun University | Kim J.S.,Chosun University | Hwang I.M.,Chosun University | Choi S.H.,Chosun University | And 5 more authors.
Korean Journal of Food Science and Technology | Year: 2013

Food irradiation has recently become one of the most successful techniques to preserve food with increased shelf life. This study aims to analyze hydrocarbons in almonds {Prunus amygosalus L) and peanuts (Arachis hypogaea) induced by electron beam irradiation. The samples were irradiated at 0, 1, 3, 5 and 10 kGy by e-bcam and using florisil column chromatography fat, and content was extracted. The induced hydrocarbons were identified using gas chromatography-mass spectrometry (GC/MS). The major hydrocarbons in both irradiated samples were 1,7-hexadecadiene {C16:2) and 8-heptadecene (C17:1) from oleic acid, 1,7,10-hexadecatriene (C16:3) and 6,9-heptadecadiene (C17:2) from linoleic acid and 1-tetradecene (C14:1) and pcntadecane (C15:0) from palmitic acid. Concentrations of the hydrocarbons produced by e-beam were found to be depended upon the composition of fatty acid in both almonds and peanuts. The C n-2compound was found to be higher than Cn-1, compound in oleic acid and palmitic acid, while in case of linoleic acid, Cn-1, compound was higher than Cn-2 compound. The radiation induced hydrocarbons were detected only in irradiated samples, with 1 kGy or above, and not in the non-irradiated ones. The production of 1,7-hcxadecadicne (C 16:2), 8-hcptadecenc (C17:1), 1,7,10-hexadecatriene (C,16,3) and 6,9-hepladecadiene (C,7:2), in high concentration gave enough information to suggest that these may be the possible marker compounds of electron beam irradiation in almonds and peanuts. © The Korean Society of Food Science and Technology.


Song M.-Y.,Chonbuk National University | Yim J.-Y.,Chonbuk National University | Yim J.-M.,Chonbuk National University | Kang I.-J.,Chonbuk National University | And 8 more authors.
Journal of Immunotherapy | Year: 2011

Nitric oxide (NO) synthesis is strongly induced during interleukin (IL)-2 treatment of mice and humans. Although this free radical can act as a cytotoxic effector molecule against cancer cells, immunosuppressive effects have also been suggested. We evaluated the effects of curcumin on IL-2-induced NO synthesis and IL-2-induced antitumor responses in a mouse ascites tumor model. Curcumin inhibited inducible nitric oxide synthase (iNOS) expression and NO production, and thereby enhanced the proliferation and cytotoxic activity of cocultured lymphocytes and macrophages during IL-2 stimulation which we earlier established as an in vitro model of IL-2-induced NO synthesis. Curcumin also decreased apoptosis of cocultured lymphocytes and macrophages during IL-2 stimulation. In contrast, the curcumin-induced changes in proliferation and apoptosis were not observed in cultures of lymphocytes alone, macrophages alone, and cocultured lymphocytes/iNOS-knock out macrophages, all of which produced little nitrite during IL-2 stimulation. In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model. Curcumin may be useful as an adjunct to increase the antitumor activity of IL-2 therapy. © 2011 by Lippincott Williams & Wilkins.


Yhim H.-Y.,Chonbuk National University | Kim H.S.,Jeonbuk Science College | Lee N.-R.,Chonbuk National University | Kwak J.-Y.,Chonbuk National University | And 3 more authors.
Tumori | Year: 2010

Multiple primarymalignancies are defined as two ormoremalignancies in an individual without any relationship between the tumors. Because of advances in the early detection, treatment, and supportive care for cancer, the number of cancer survivors has been gradually increasing, and this has led to an increase in the possible occurrence of subsequent malignancies. Recently, there have been reports that smoking is associated with a specific geneticmutation (the tumor suppressor gene TP53), and this genetic predisposition may be related to the development of multiple primary malignancies. Here we present a rare case of quadruple primarymalignancies of the liver, bladder, lung and stomach, some of which possibly linked to smoking-related TP53 mutation. Because of its extreme rarity and the clear relationship betweenmultiple primary malignancies and smoking-related TP53 mutation, we report this case along with a review of the relevant literature. Free full text available at www.tumorionline.it.

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