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Sarethy I.P.,Jaypee Institute of Information Technology
Protein and Peptide Letters | Year: 2017

Bioactive peptides from plants are an underexplored domain in the field of proteomics and peptidomics. Recent evidences of plant peptides being more than chemical signals and indeed, functioning in the responses of plants to diverse environmental cues such as stress and infection by pathogens, suggests their potentially wide applicability in agrochemical and pharmaceutical industries. With cutting-edge technologies available, studies on plant peptides still lag behind those from food or microorganisms. The current mini-review provides an overview of the major bioactivity documented of plant-based peptides. It further underlines the techniques associated with isolation and identification of peptides, the limitations associated with these techniques and the '-omics' revolution that is playing a major part in better understanding of these peptides. © 2017 Bentham Science Publishers.

Parwekar P.,Jaypee Institute of Information Technology
2011 2nd International Conference on Computer and Communication Technology, ICCCT-2011 | Year: 2011

Since the late 1980s the world is working towards connectivity and convergence. In the last three decades, the convergence of information resources has happened. However to achieve a true convergence the information assets have to be shared, used and executed fruitfully by the various gadgets which we use in our daily lives. Internet of Things is a concept which leverages on the power of networks to create ubiquitous sensor-actuator networks. With the advent of the cloud technologies, the concept of IOTs can be integrated with even the basic elements having limited computing power. This paper aims to evaluate the possibilities offered by integrating the two concepts of IOTs and Cloud Computing. © 2011 IEEE.

Kotiyal S.,Jaypee Institute of Information Technology | Bhattacharya S.,Jaypee Institute of Information Technology
Biochemical and Biophysical Research Communications | Year: 2014

A small heterogeneous population of breast cancer cells acts as seeds to induce new tumor growth. These seeds or breast cancer stem cells (BCSCs) exhibit great phenotypical plasticity which allows them to undergo "epithelial to mesenchymal transition" (EMT) at the site of primary tumor and a future reverse transition. Apart from metastasis they are also responsible for maintaining the tumor and conferring it with drug and radiation resistance and a tendency for post-treatment relapse. Many of the signaling pathways involved in induction of EMT are involved in CSC generation and regulation. Here we are briefly reviewing the mechanism of TGF-β, Wnt, Notch, TNF-α, NF-κB, RTK signalling pathways which are involved in EMT as well as BCSCs maintenance. Therapeutic targeting or inhibition of the key/accessory players of these pathways could control growth of BCSCs and hence malignant cancer. Additionally several miRNAs are dysregulated in cancer stem cells indicating their roles as oncogenes or tumor suppressors. This review also lists the miRNA interactions identified in BCSCs and discusses on some newly identified targets in the BCSC regulatory pathways like SHIP2, nicastrin, Pin 1, IGF-1R, pro-inflammatory cytokines and syndecan which can be targeted for therapeutic achievements. © 2014 Elsevier Ltd. All rights reserved.

Goswami N.,Jaypee Institute of Information Technology | Sahai A.,Jaypee Institute of Information Technology
Materials Research Bulletin | Year: 2013

In this article, structural transformation in nickel doped zinc oxide nanostructures is reported. The ZnO nanostructures are synthesized with 1-10% of nickel doping through a chemical precipitation method. The undoped and doped nanostructures were systematically investigated employing X-ray diffraction (XRD), transmission and scanning electron microscopy (TEM/SEM), Fourier transform infrared (FTIR) and micro-Raman spectroscopy (μRS). The wurtzite phase of the material and associated lattice parameters were ascertained through XRD analysis. TEM/SEM images reveal the structural transformation of ZnO nanostructures with variation in nickel doping. The study of vibrational modes of nanostructures at different stages of structural transformation, as performed through FTIR and Raman spectroscopy, assist in deciphering the pivotal role of doping concentration in gradual evolution of nickel doped ZnO structure from nanoparticles to nanorods. © 2012 Elsevier Ltd.

Sharma N.K.,Jaypee Institute of Information Technology
Pramana - Journal of Physics | Year: 2012

The capability of various metals used in optical fibre-based surface plasmon resonance (SPR) sensing is studied theoretically. Four metals, gold (Au), silver (Ag), copper (Cu) and aluminium (Al) are considered for the present study. The performance of the optical fibre-based SPR sensor with four different metals is obtained numerically and compared in detail. The performance of optical fibre-based SPR sensor has been analysed in terms of sensitivity, signal-to-noise (SNR) ratio and quality parameter. It is found that the performance of optical fibre-based SPR sensor with Au metal is better than that of the other three metals. The sensitivity of the optical fibre-based SPR sensor with 50 nm thick and 10 mm long Au metal film of exposed sensing region is 2.373 μm/RIU with good linearity, SNR is 0.724 and quality parameter is 48.281 RIU -1. The thickness of the metal film and the length of the exposed sensing region of the optical fibre-based SPR sensor for each metal are also optimized. © Indian Academy of Sciences.

Sahai A.,Jaypee Institute of Information Technology | Goswami N.,Jaypee Institute of Information Technology
Physica E: Low-Dimensional Systems and Nanostructures | Year: 2014

In this article we study the structural and vibrational properties of ZnO nanoparticles. The details of process and mechanism responsible for the synthesis of nanoparticles by a high yield yet facile chemical precipitation method are explained. The prepared nanomaterial was subjected to various characterizations. Elemental composition of ~30 nm average size nanoparticles was evident through transmission electron microscope (TEM) and energy dispersive X-ray spectroscopy (EDS). Identification of hexagonal wurtzite phase and determination of lattice parameters, crystallite size, strain, crystallinity index, ZnO bond length, Young's modulus, specific surface area, and dislocation density of prepared ZnO nanocrystallites were revealed through extensive X-ray diffraction (XRD) analysis. Vibrational properties of prepared nanoparticles are determined through micro-Raman (μR) and Fourier transform infrared (FTIR) spectroscopies. The FTIR and micro-Raman investigations of Infrared and Raman active vibrational modes of ZnO nanoparticles are not only mutually supportive but more significantly, the vibrational properties thus determined are highly correlated with the structural properties determined through TEM, EDS and XRD investigations. © 2013 Elsevier B.V.

Agrawal R.,Jaypee Institute of Information Technology
Communications in Computer and Information Science | Year: 2011

A lot of research effort has been put into community detection from all corners of academic interest such as physics, mathematics and computer science. In this paper I have proposed a Bi-Objective Genetic Algorithm for community detection which maximizes modularity and community score. Then the results obtained for both benchmark and real life data sets are compared with other algorithms using the modularity and MNI performance metrics. The results show that the BOCD algorithm is capable of successfully detecting community structure in both real life and synthetic datasets, as well as improving upon the performance of previous techniques. © 2011 Springer-Verlag.

Singla N.,Jaypee Institute of Information Technology | Chowdhury P.,Jaypee Institute of Information Technology
Chemical Physics Letters | Year: 2012

Excited state intramolecular proton transfer (ESIPT) has been studied in Indole-7-Carboxaldehyde (I7C). DFT, TDDFT, CIS theories with B3LYP/6-311++G (d, p), etc. basis sets have been used to obtain structural parameters and energies of I7C in ground, excited states for cis (N c), trans (N t) and zwitterionic (Z) conformers. Photo-physical pathway involving ESIPT from cis (N c) to zwitterion (Z) agrees well with the dual fluorescence at 451 and 862 nm obtained from computed results and experimental observations. Potential energy surface scan confirms the existence of ESIPT by asymmetric double minima in the excited state pathway along the Reaction Coordinate -N 15-H 12 donor. © 2012 Elsevier B.V. All rights reserved.

Goel A.,Jaypee Institute of Information Technology
2013 International Conference on Signal Processing and Communication, ICSC 2013 | Year: 2013

Carrier frequency offset (CFO) destroys the orthogonality of the subcarriers and causes intercarrier interference (ICI). ICI self-cancellation scheme proposed by Zhao et al. is the simplest scheme to mitigate the effect of ICI. It repeats the same data symbol on two adjacent subcarriers with phase inversion and therefore does not provide any frequency diversity. To achieve frequency diversity Tang et al. proposed a symmetric data conjugate transmission scheme to mitigate the effect of ICI but its BER performance degrades at higher values of CFO. In order to improve its BER performance, a phase rotated symmetric data conjugate transmission scheme to mitigate the effect of ICI has been proposed in this paper. Like symmetric data conjugate scheme, proposed scheme also repeats the same data symbol with phase rotation on two symmetrically located subcarriers to achieve frequency diversity. The analytical expression for optimal phase rotation factor to optimize the carrier-to-interference ratio (CIR) performance of the proposed scheme is also derived. It has been shown that proposed scheme provides better performance than that of the conventional symmetric data conjugate scheme especially at high CFO. © 2013 IEEE.

Sharma S.,Jaypee Institute of Information Technology
Biosensors & bioelectronics | Year: 2013

Amalgamation of nanotechnology and biology has opened new horizons for controlled synthesis of nanomaterials of nano and micro-lengthscales for diverse sensing, catalytic and electromechanical applications. Inspired from nature and driven by the need to have nanostructures of desired morphology, microbial architecture has been exploited as a template in the present work. Biocompatible 1-D gold microwires, generated by assembly of amino acid functionalized AuNPs over the proliferating fungal hyphae, served as potential microelectrodes for electron transfer between enzyme and electrode surface. Delocalization of electrons over longer length scales, large surface area provided by assembled AuNPs and high biocompatibility yielded excellent analytical performance characteristics with high sensitivity of 43.2 μA/mM/cm(2) with standard deviation of 0.88% and wide linear range from 5 μM to 20 mM of glucose. The gold microwires thus generated demonstrate appreciable repeatability over 20 cycles in a cyclic voltammogram, and reproducibility with root mean square deviation as low as 1.3%. High stability and biocompatibility attribute these microwires with myriad potential biosensing and catalytic applications in varied domains. © 2013 Elsevier B.V. All rights reserved.

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