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Kalanithi M.,Jayaraj Annapackiam College for Women | Rajarajan M.,Cardamom Planters Association College | Tharmaraj P.,Thiagarajar College of Engineering | Johnson Raja S.,P.A. College
Medicinal Chemistry Research | Year: 2015

Synthesis of new series of Cu(II), Co(II), and Ni(II) from the ligand 2-[N,N-bis-(3,5-dimethyl-pyrazolyl-1-methyl)]aminothiazole is described. The ligand and its complexes were characterized by various techniques such as elemental analysis, FT-IR, UV-Visible, 1H and 13C NMR spectra, mass spectrum, and conductometry. The electronic absorption spectra and magnetic susceptibility measurements suggest a square planar geometry for Cu(II) complex and distorted tetrahedral geometry for the other metal(II) complexes. The EPR spectrum of Cu(II) complex recorded at 77°K confirms the distorted square planar geometry. The antimicrobial activities of the ligand and metal complexes against the bacterial species such as Xanthomonas maltophilia, Chromobacterium violaceum, Acinetobacter, Staphylococci, Streptococci, and the fungus Candida albicans are carried out and the results indicated that all compounds exhibit more antibacterial activity than the standard drug. The synthesized compounds were investigated for analgesic activity and they act as potent analgesic drugs. © 2014 Springer Science+Business Media New York.


Kalanithi M.,Jayaraj Annapackiam College for Women | Kodimunthiri D.,Thiagarajar College of Engineering | Rajarajan M.,Cardamom Planters Association College | Tharmaraj P.,Thiagarajar College of Engineering
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2011

Coordination compounds of VO(IV), Co(II), Ni(II), Cu(II) and Zn(II) with the Schiff base obtained through the condensation of 2-aminothiazole with 3-formyl chromone were synthesized. The compounds were characterized by 1H, 13C NMR, UV-Vis, IR, Mass, EPR, molar conductance and magnetic susceptibility measurements. The Cu(II) complex possesses tetrahedrally distorted square planar geometry whereas Co(II), Ni(II), and Zn(II) show distorted tetrahedral geometry. The VO(IV) complex shows square pyramidal geometry. The cyclic voltammogram of Cu (II) complex showed a well defined redox couple Cu(II)/Cu(I) with quasireversible nature. The antimicrobial activity against the species Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albigans and Aspergillus niger was screened and compared to the activity of the ligand. Emission spectrum was recorded for the ligand and the metal(II) complexes. The second harmonic generation (SHG) efficiency was measured and found to have one fourth of the activity of urea. The SEM image of the copper(II) complex implies that the size of the particles is 2 μm. © 2011 Elsevier B.V. All rights reserved.


Kalanithi M.,Jayaraj Annapackiam College for Women | Rajarajan M.,Cardamom Planters Association College | Tharmaraj P.,Thiagarajar College of Engineering | Sheela C.D.,The American College
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

Tridentate chelate complexes of Co(II), Ni(II), Cu(II) and Zn(II) have been synthesized from the chalcone based ligands 2-[1-(3-(1H-imidazol-1-yl) propylimino)-3-(phenylallyl)]phenol(HL 1), 2-[1-(3-(1H-imidazol-1-yl) propylimino)-3-p-tolylallyl]phenol(HL 2), 2-[1-(3-(1H-imidazol-1-yl) propylimino)-3-4-nitrophenylallyl]phenol(HL 3). Microanalytical data, UV-vis spectrophotometric method, magnetic susceptibility measurements, IR, 1H NMR, Mass, and EPR techniques were used to characterize the structure of chelates. The electronic absorption spectra and magnetic susceptibility measurements suggest a distorted square planar geometry for the copper(II) ion. The other metal complexes show distorted tetrahedral geometry. The coordination of the ligands with metal(II) ions was further confirmed by solution fluorescence spectrum. The antimicrobial activity of the ligands and metal(II) complexes against the species Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albigans and Aspergillus niger has been carried out and compared. The electrochemical behavior of copper(II) complex is studied by cyclic voltammetry. © 2011 Elsevier B.V.


Kalanithi M.,Jayaraj Annapackiam College for Women | Rajarajan M.,Cardamom Planters Association College | Tharmaraj P.,Thiagarajar College of Engineering
Journal of Coordination Chemistry | Year: 2011

Tridentate chelate complexes M[LX·2H2O], where M = Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) have been synthesized from the Schiff base L = N-[1-(3-aminopropyl)imidazole]salicylaldimine and X = Cl. Microanalytical data, UV-Vis, magnetic susceptibility, IR, 1H-NMR, mass, and EPR techniques were used to confirm the structures. Electronic absorption spectra and magnetic susceptibility measurements suggest square-planar geometry for copper complex and octahedral for other metal complexes. EPR spectra of copper(II) complex recorded at 300 K confirm the distorted square-planar geometry of the copper(II) complex. Biological activities of the ligand and metal complexes have been studied on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by the well diffusion method. The activity data show the metal complexes to be more potent than the parent ligand against two bacterial species and one fungus. The electrochemical behavior of the copper complex was studied by cyclic voltammetry. © 2011 Taylor & Francis.


Kalanithi M.,Jayaraj Annapackiam College for Women | Rajarajan M.,Cardamom Planters Association College | Tharmaraj P.,Thiagarajar College of Engineering
Journal of Coordination Chemistry | Year: 2011

Tridentate chelate complexes of Co(II), Ni(II), and Cu(II) have been synthesized from 4-[N,Nbis-( 3,5-dimethyl-pyrazolyl-1-methyl)]aminoantipyrine. Microanalytical data, UV-Vis, magnetic susceptibility, Infrared, 1H- 13C-NMR, mass, thermal gravimetric analysis and electron paramagnetic resonance (EPR) techniques were used to confirm the structures. The electronic absorption spectra and magnetic susceptibility measurements suggest a distorted octahedral geometry for the metal. EPR spectra of the copper(II) complex at 77K confirm the distorted octahedral geometry of the copper(II) complex. The antimicrobial activities of the ligand and metal complexes against the bacteria such as Xanthomonas maltophilia, Chromobacterium violaceum, Acinetobacter, Staphylococci, Streptococci, and the fungus Candida albicans have been carried out. A comparative study of minimum inhibitory concentration values of the ligand and its metal complexes indicates that metal complexes exhibit higher antibacterial and antifungal activity than the free ligand. The electrochemical behavior of copper(II) complex was studied by cyclic voltammetry. The complexes show nuclease activity in the presence of oxidant. © 2011 Taylor & Francis.


Yesuthangam Y.,Jayaraj Annapackiam College for Women | Pandian S.,Madurai Kamaraj University | Venkatesan K.,Madurai Kamaraj University | Gandhidasan R.,Madurai Kamaraj University | Murugesan R.,Madurai Kamaraj University
Journal of Photochemistry and Photobiology B: Biology | Year: 2011

This paper describes the synthesis and photodynamic properties of six different chalcone derivatives. Using N,N-dimethyl-4-nitrosoaniline (RNO) bleaching assay, the singlet oxygen generating efficiencies of these chalcones are determined relative to rose bengal (RB). Superoxide dismutase (SOD) inhibitable cytochrome c reduction assay and electron magnetic resonance (EMR) spin trapping techniques are used to determine the superoxide anion radical (O2-) yield upon photoirradiation. Photoinduced DNA scission studies show that O2- is involved in the DNA strand break. In addition, antimicrobial activity of these chalcones is also investigated. Structure activity relationship accounts for the difference in the photogeneration of reactive oxygen species (ROS) by these sensitizers. Presence of electron releasing -OCH3 groups enhances the photogeneration of ROS. Cyclic voltammetry studies indicate a correlation between enzymatic O2- generation efficiency and redox potential of chalcones. Both O2- (Type I) and 1O2 (Type II) paths are involved in the photosensitization of chalcones. The LUMO energies obtained by molecular modeling correlate with the one-electron reduction potentials. © 2010 Elsevier Inc. All rights reserved.


Anbarasi C.M.,Jayaraj Annapackiam College for Women | Rajendran S.,Corrosion Research Center
Chemical Engineering Communications | Year: 2012

Inhibition of corrosion of carbon steel in dam water by octanesulfonic acid as its sodium salt (SOS) in the absence and presence of a bivalent cation zinc ion (Zn 2+) has been investigated using weight loss, potentiodynamic polarization, AC impedance spectra, Fourier transform-infrared spectroscopy (FT-IR), fluorescence spectra, scanning electron microscopy (SEM), and energy dispersive X-ray detection (EDAX) measurements. The formulation consisting of 250 ppm of SOS and 30 ppm of Zn 2+ offers 88% inhibition efficiency (IE) to carbon steel. The influence of sodium potassium tartrate on the IE of the SOS-Zn 2+ system has been evaluated. Polarization study reveals that SOS-Zn 2+ system controls the anodic reaction predominantly. AC impedance spectra reveal that a protective film is formed on the metal surface. The nature of the protective film formed on the metal surface has been analyzed by FT-IR spectra, SEM, and EDAX analysis. © 2012 Copyright Taylor and Francis Group, LLC.


Mary Anbarasi C.,Jayaraj Annapackiam College for Women | Jerli Auxilia A.,Jayaraj Annapackiam College for Women
International Journal of ChemTech Research | Year: 2016

Corrosion inhibition has become an important area of research because, corrosion cannot be prevented but it can be controlled. The topic corrosion is inter–disciplinary and it includes all the basic sciences, such as physics, chemistry, biology and all the disciplines of engineering, such as civil, mechanical, electrical and metallurgical engineering. The purpose of studying the process of corrosion is to find methods to control it. One approach is the use of corrosion inhibitors. This research is carried out to evaluate the corrosion inhibition behavior of hexanesulphonic acid (HS) along with nickel ion (Ni2+) on carbon steel in dam water using weight-loss method. Results of weight loss method indicated inhibition efficiency (IE) increased with increasing inhibitor concentration. Polarization study reveals that HSNi2+ system controls the anodic reaction predominantly. AC impedance spectra prove that a protective film is formed on the metal surface. The nature of the metal surface has been analyzed by Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Energy dispersive x-ray detector (EDAX) measurements. © 2016, Sphinx Knowledge House. All rights reserved.


Chandra P.H.,Jayaraj Annapackiam College for Women | Kalavathy S.M.S.T.,Jayaraj Annapackiam College for Women
Advances in Intelligent Systems and Computing | Year: 2013

Linking the two areas of membrane computing and picture grammars, Array P systems were introduced by Ceterchi et al (Nat Comput 2:229-249, 2003) which brought out the ability of the bio-inspired model of P system in handling the problem of picture generation. Another well-investigated model of picture generation is the array grammar system wherein prescribed teams of array productions and different derivation modes are introduced by Fernau and Freund (Bounded Parallelism in Array Grammars Used for Character Recognition. Springer, Berlin, pp. 40-49, 1996), while examining the problem of bounded parallelism for character recognition. Here a kind of array P system with the possibility of different teams having different modes of derivation is considered. We illustrate the model by generating different alphabetic characters. The generative power of such mechanism is also investigated. © 2013 Springer.


Anbarasi C.M.,Jayaraj Annapackiam College for Women | Rajendran S.,Corrosion Research Center
European Corrosion Congress 2011, EUROCORR 2011 | Year: 2011

The inhibition efficiencies(IE)of inhibitor systems constituting various combinations of Sodium 1- Octane sulfonate (SOS)-Zinc ions in controlling corrosion of carbon steel immersed in a dam water have been evaluated by weight loss method. . The formulation consisting of 250 ppm (SOS) of and 30 ppm of Zn 2+ offers 88 % inhibition efficiency to carbon steel. A synergistic effect exists between SOS and Zn 2+.The influence of sodium potassium tartrate and trisodium citrate on the IE of the SOS-Zn 2+ system has been evaluated. As the immersion period increases IE decreases. Polarization study reveals that SOS-Zn 2+ system controls the cathodic reaction predominantly. AC impedance spectra reveal that a protective film is formed on the metal surface. The nature of the metal surface has been analysed by FTIR spectra and SEM analysis. The protective film is found to be UV fluorescent.

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