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Kalanithi M.,Jayaraj Annapackiam College for Women | Rajarajan M.,Cardamom Planters Association College | Tharmaraj P.,Thiagarajar College of Engineering | Johnson Raja S.,P.A. College
Medicinal Chemistry Research | Year: 2015

Synthesis of new series of Cu(II), Co(II), and Ni(II) from the ligand 2-[N,N-bis-(3,5-dimethyl-pyrazolyl-1-methyl)]aminothiazole is described. The ligand and its complexes were characterized by various techniques such as elemental analysis, FT-IR, UV-Visible, 1H and 13C NMR spectra, mass spectrum, and conductometry. The electronic absorption spectra and magnetic susceptibility measurements suggest a square planar geometry for Cu(II) complex and distorted tetrahedral geometry for the other metal(II) complexes. The EPR spectrum of Cu(II) complex recorded at 77°K confirms the distorted square planar geometry. The antimicrobial activities of the ligand and metal complexes against the bacterial species such as Xanthomonas maltophilia, Chromobacterium violaceum, Acinetobacter, Staphylococci, Streptococci, and the fungus Candida albicans are carried out and the results indicated that all compounds exhibit more antibacterial activity than the standard drug. The synthesized compounds were investigated for analgesic activity and they act as potent analgesic drugs. © 2014 Springer Science+Business Media New York. Source


Anbarasi C.M.,Jayaraj Annapackiam College for Women | Rajendran S.,Corrosion Research Center
Chemical Engineering Communications | Year: 2012

Inhibition of corrosion of carbon steel in dam water by octanesulfonic acid as its sodium salt (SOS) in the absence and presence of a bivalent cation zinc ion (Zn 2+) has been investigated using weight loss, potentiodynamic polarization, AC impedance spectra, Fourier transform-infrared spectroscopy (FT-IR), fluorescence spectra, scanning electron microscopy (SEM), and energy dispersive X-ray detection (EDAX) measurements. The formulation consisting of 250 ppm of SOS and 30 ppm of Zn 2+ offers 88% inhibition efficiency (IE) to carbon steel. The influence of sodium potassium tartrate on the IE of the SOS-Zn 2+ system has been evaluated. Polarization study reveals that SOS-Zn 2+ system controls the anodic reaction predominantly. AC impedance spectra reveal that a protective film is formed on the metal surface. The nature of the protective film formed on the metal surface has been analyzed by FT-IR spectra, SEM, and EDAX analysis. © 2012 Copyright Taylor and Francis Group, LLC. Source


Kalanithi M.,Jayaraj Annapackiam College for Women | Rajarajan M.,Cardamom Planters Association College | Tharmaraj P.,Thiagarajar College of Engineering
Journal of Coordination Chemistry | Year: 2011

Tridentate chelate complexes of Co(II), Ni(II), and Cu(II) have been synthesized from 4-[N,Nbis-( 3,5-dimethyl-pyrazolyl-1-methyl)]aminoantipyrine. Microanalytical data, UV-Vis, magnetic susceptibility, Infrared, 1H- 13C-NMR, mass, thermal gravimetric analysis and electron paramagnetic resonance (EPR) techniques were used to confirm the structures. The electronic absorption spectra and magnetic susceptibility measurements suggest a distorted octahedral geometry for the metal. EPR spectra of the copper(II) complex at 77K confirm the distorted octahedral geometry of the copper(II) complex. The antimicrobial activities of the ligand and metal complexes against the bacteria such as Xanthomonas maltophilia, Chromobacterium violaceum, Acinetobacter, Staphylococci, Streptococci, and the fungus Candida albicans have been carried out. A comparative study of minimum inhibitory concentration values of the ligand and its metal complexes indicates that metal complexes exhibit higher antibacterial and antifungal activity than the free ligand. The electrochemical behavior of copper(II) complex was studied by cyclic voltammetry. The complexes show nuclease activity in the presence of oxidant. © 2011 Taylor & Francis. Source


Yesuthangam Y.,Jayaraj Annapackiam College for Women | Pandian S.,Madurai Kamaraj University | Venkatesan K.,Madurai Kamaraj University | Gandhidasan R.,Madurai Kamaraj University | Murugesan R.,Madurai Kamaraj University
Journal of Photochemistry and Photobiology B: Biology | Year: 2011

This paper describes the synthesis and photodynamic properties of six different chalcone derivatives. Using N,N-dimethyl-4-nitrosoaniline (RNO) bleaching assay, the singlet oxygen generating efficiencies of these chalcones are determined relative to rose bengal (RB). Superoxide dismutase (SOD) inhibitable cytochrome c reduction assay and electron magnetic resonance (EMR) spin trapping techniques are used to determine the superoxide anion radical (O2-) yield upon photoirradiation. Photoinduced DNA scission studies show that O2- is involved in the DNA strand break. In addition, antimicrobial activity of these chalcones is also investigated. Structure activity relationship accounts for the difference in the photogeneration of reactive oxygen species (ROS) by these sensitizers. Presence of electron releasing -OCH3 groups enhances the photogeneration of ROS. Cyclic voltammetry studies indicate a correlation between enzymatic O2- generation efficiency and redox potential of chalcones. Both O2- (Type I) and 1O2 (Type II) paths are involved in the photosensitization of chalcones. The LUMO energies obtained by molecular modeling correlate with the one-electron reduction potentials. © 2010 Elsevier Inc. All rights reserved. Source


Kalanithi M.,Jayaraj Annapackiam College for Women | Kodimunthiri D.,Thiagarajar College of Engineering | Rajarajan M.,Cardamom Planters Association College | Tharmaraj P.,Thiagarajar College of Engineering
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2011

Coordination compounds of VO(IV), Co(II), Ni(II), Cu(II) and Zn(II) with the Schiff base obtained through the condensation of 2-aminothiazole with 3-formyl chromone were synthesized. The compounds were characterized by 1H, 13C NMR, UV-Vis, IR, Mass, EPR, molar conductance and magnetic susceptibility measurements. The Cu(II) complex possesses tetrahedrally distorted square planar geometry whereas Co(II), Ni(II), and Zn(II) show distorted tetrahedral geometry. The VO(IV) complex shows square pyramidal geometry. The cyclic voltammogram of Cu (II) complex showed a well defined redox couple Cu(II)/Cu(I) with quasireversible nature. The antimicrobial activity against the species Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albigans and Aspergillus niger was screened and compared to the activity of the ligand. Emission spectrum was recorded for the ligand and the metal(II) complexes. The second harmonic generation (SHG) efficiency was measured and found to have one fourth of the activity of urea. The SEM image of the copper(II) complex implies that the size of the particles is 2 μm. © 2011 Elsevier B.V. All rights reserved. Source

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