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Delhi, India

Jawaharlal Nehru University, also known as JNU, is a public central university in New Delhi, India. In 2012, The National Assessment and Accreditation Council gave the university a grade of 3.9 out of 4, the highest grade awarded to any educational institution in the country. The university is ranked second among the public universities in India, as published by India Today. Wikipedia.

Goswami S.K.,Jawaharlal Nehru University
Sub-cellular biochemistry | Year: 2013

Since the Central dogma of Molecular Biology was proposed about 40 years ago; our understanding of the intricacies of gene regulation has undergone tectonic shifts almost every decade. It is now widely accepted that the complexity of an organism is not directed by the sheer number of genes it carries but how they are decoded by a myriad of regulatory modules. Over the years, it has emerged that the organizations chromatins and its remodeling; splicing and polyadenylation of pre-mRNAs, stability and localization of mRNAs and modulation of their expression by non-coding and miRNAs play pivotal roles in metazoan gene expression. Nevertheless, in spite of tremendous progress in our understanding of all these mechanisms of gene regulation, the way these events are coordinated leading towards a highly defined proteome of a given cell type remains enigmatic. In that context, the structures of many metazoan genes cannot fully explain their pattern of expression in different tissues, especially during embryonic development and progression of various diseases. Further, numerous studies done during the past quarter of a century suggested that the heritable states of transcriptional activation or repression of a gene can be influenced by the covalent modifications of constituent bases and associated histones; its chromosomal context and long-range interactions between various chromosomal elements (Holliday 1987; Turner 1998; Lyon 1993). However, molecular dissection of these phenomena is largely unknown and is an exciting topic of research under the sub-discipline epigenetics (Gasser et al. 1998). Source

Kumar B.,Jawaharlal Nehru University
Physical Review B - Condensed Matter and Materials Physics | Year: 2010

The mean-field triplon analysis is developed for spin- S quantum antiferromagnets with dimerized ground states. For the spin-1/2 case, it reduces to the well-known bond-operator mean-field theory. It is applied to a columnar dimer model on square lattice and to a model on honeycomb lattice with spontaneous dimerization in the ground state. Different phases in the ground state are investigated as a function of spin. It is found that under suitable conditions (such as strong frustration), a quantum ground state (dimerized singlet phase in the present study) can survive even in the limit S→∞. Two quick extensions of this representation are also presented. In one case, it is extended to include the quintet states. In another, a similar representation is worked out on a square plaquette. A convenient procedure for evaluating the total-spin eigenstates for a pair of quantum spins is presented in the appendix. © 2010 The American Physical Society. Source

Tripathy B.C.,Jawaharlal Nehru University
Plant signaling & behavior | Year: 2012

The introduction of molecular oxygen into the atmosphere was accompanied by the generation of reactive oxygen species (ROS) as side products of many biochemical reactions. ROS are permanently generated in plastids, peroxisomes, mitochiondria, the cytosol and the apoplast. Imbalance between ROS generation and safe detoxification generates oxidative stress and the accumulating ROS are harmful for the plants. On the other hand, specific ROS function as signaling molecules and activate signal transduction processes in response to various stresses. Here, we summarize the generation of ROS in the different cellular compartments and the signaling processes which are induced by ROS. Source

Tiwari D.K.,Jawaharlal Nehru University
International journal of nanomedicine | Year: 2011

Anti-HER2 antibody conjugated with quantum dots (anti-HER2ab-QDs) is a very recent fluorescent nanoprobe for HER2+ve breast cancer imaging. In this study we investigated in-vivo toxicity of anti-HER2ab conjugated CdSe/ZnS QDs in Wistar rats. For toxicity evaluation of injected QDs sample, body weight, organ coefficient, complete blood count (CBC), biochemistry panel assay (AST, ALT, ALP, and GGTP), comet assay, reactive oxygen species, histology, and apoptosis were determined. Wistar rat (8-10 weeks old) were randomly divided into 4 treatment groups (n = 6). CBC and biochemistry panel assay showed nonsignificant changes in the anti-HER2ab-QDs treated group but these changes were significant (P < 0.05) in QDs treated group. No tissue damage, inflammation, lesions, and QDs deposition were found in histology and TEM images of the anti-HER2ab-QDs treated group. Apoptosis in liver and kidney was not found in the anti-HER2ab-QDs treated group. Animals treated with nonconjugated QDs showed comet formation and apoptosis. Cadmium deposition was confirmed in the QDs treated group compared with the anti-HER2ab-QDs treated group. The QDs concentration (500 nM) used for this study is suitable for in-vivo imaging. The combine data of this study support the biocompatibility of anti-HER2ab-QDs for breast cancer imaging, suggesting that the antibody coating assists in controlling any possible adverse effect of quantum dots. Source

Ghosh J.,Jawaharlal Nehru University
Journal of Agrarian Change | Year: 2010

The dramatic rise and fall of world food prices in 2007-8 was largely a result of speculative activity in global commodity markets, enabled by financial deregulation measures in the United States and elsewhere. Despite the recent fall in agricultural prices in world trade, the food crisis has been exacerbated in many developing countries where food prices remain high and even continue to increase. The financial crisis also directly operates to increase food insecurity by imposing constraints on fiscal policies and food imports in balance-of-payments constrained developing countries, causing exchange rate devaluation through capital flight and adversely affecting employment, thereby reducing the ability of vulnerable groups to purchase food. © 2010 The Author - Journal compilation © 2010 Blackwell Publishing Ltd. Source

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