Jawaharlal Nehru Technological University

Hyderabad, India

Jawaharlal Nehru Technological University, Hyderabad is a university, focusing on engineering, located in Hyderabad, Telangana, India. Founded in 1965 as the Nagarjuna Sagar Engineering College, it was established as a university in 1972 by The Jawaharlal Nehru Technological University Act, 1972, also combining colleges in Kakinada and Anantapur. In 2008 the Jawaharlal Nehru Technological Universities Act, 2008 split the university back into four universities, Jawaharlal Nehru Architecture and Fine Arts University, Jawaharlal Nehru Technological University, Anantapur, Jawaharlal Nehru Technological University, Hyderabad and Jawaharlal Nehru Technological University, Kakinada.The university is situated at Kukatpally. It has ‘A’ grade accreditation by the NAAC. It has an intake of about 1000 students. Wikipedia.

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Prakash C.R.,Jawaharlal Nehru Technological University | Raja S.,Gandhi Institute of Technology and Management
Mini-Reviews in Medicinal Chemistry | Year: 2012

Kinases are probably the most important signaling enzymes, which represent about 20% of the druggable genome. Currently, more than 150 kinases are known. So, kinase inhibition therapy has become a very important area of drug research since most of our diseases are related to intra or intercellular signaling by kinases. Indole alkaloids are extensively studied for their biological activities in several pharmaceutical areas, including, for example, antitumor. Among this chemical family, indolinone displays very promising antitumor properties by inhibiting various kinase families. These small molecules have a low molecular weight and most of them bind to protein kinases competing with ATP for the ATP-binding site. This review focuses on the indolinone based drugs approved for the treatment of cancer, drugs under clinical trial and then chemical diversity of various synthetic analogues of indolinone and their metabolites as various kinase inhibitors. This review also focused on structural activity relationship (SAR), mechanisms of action and biological targets through which indolinone and its derivatives display their antitumor activity. © 2012 Bentham Science Publishers.

Soleymaninejadian E.,Jawaharlal Nehru Technological University | Pramanik K.,National Institute of Technology Rourkela | Samadian E.,Golestan University of Medical Sciences
American Journal of Reproductive Immunology | Year: 2012

Mesenchymal stem cells (MSCs) are defined as undifferentiated cells that are capable of self renewal and differentiation into several cell types such as chondrocyte, adipocyte, osteocyte, myocyte, hepatocyte, and neuron-like cells. MSC can be isolated from bone marrow, umbilical cord blood, adipose tissue, placenta, periosteum, trabecular bone, synovium, skeletal muscle, and deciduous teeth. Immunomodulatory of MSCs is one of the important issues nowadays, because this aspect can be clinically applied for graft-versus-host and autoimmune diseases. In this review, we tried to discuss in detail about cytokines and factors such as members of the transforming growth factor superfamily (transforming growth factor-β), hepatic growth factors (HGF), prostaglandin E2 (PGE2), IL-10, indolamine 2,3-dioxygenase (IDO), nitric oxide (NO), heme oxygenase-1 (HO-1), and human leukocyte antigen-G (HLA-G) that are involved in immunomodulatory of MSCs. © 2011 John Wiley & Sons A/S.

Basha S.A.,King Khalid University | Raja Gopal K.,Jawaharlal Nehru Technological University
Renewable and Sustainable Energy Reviews | Year: 2012

This article is a literature review of the effect of different catalysts and additives on biodiesel production, performance, combustion and emission characteristics. This study is based on the reports of about 60 scientists who published their findings between 1998 and 2010. It was reported that base catalyst produced more biodiesel compared to acid type catalysts. There was not much variation in engine performance with the use of catalyst. Combustion characteristics were improved with the use of additives. It was found that ignition delay was reduced and premixed combustion duration was increased with the addition of catalyst. HC emission and PM emission were reduced with the use of catalysts. © 2011 Elsevier Ltd. All rights reserved.

Chandel A.K.,University of Sao Paulo | Chandrasekhar G.,Jawaharlal Nehru Technological University | Silva M.B.,University of Sao Paulo | Silverio Da Silva S.,University of Sao Paulo
Critical Reviews in Biotechnology | Year: 2012

Geopolitical concerns (unstable supply of gasoline, environmental pollution, and regular price hikes), economic, and employment concerns have been prompting researchers, entrepreneurs, and policy makers to focus on harnessing the potential of lignocellulosic feedstock for fuel ethanol production and its commercialization. The carbohydrate skeleton of plant cell walls needs to be depolymerised into simpler sugars for their application in fermentation reactions as a chief carbon source of suitable ethnologic strains for ethanol production. The role of cellulolytic enzymes in the degradation of structural carbodydrates of the plant cell wall into ready-to-fermentable sugar stream is inevitable. Cellulase synergistically acts upon plant cell wall polysaccharides to release glucose into the liquid media. Cellulase predominantly dominates all the plant cell wall degrading enzymes due to their vast and diverse range of applications. Apart from the major applications of cellulases such as in detergent formulations, textile desizing, and development of monogastric feed for ruminants, their role in biorefinery is truly remarkable. This is a major area where new research tools based upon fermentation based formulations, biochemistry, and system biology to expedite the structurefunction relationships of cellulases including cellulosomes and new designer enzymatic cocktails are required. In the last two decades, a considerable amount of research work has been performed on cellulases and their application in biomass saccharification. However, there are still technical and economic impediments to the development of an inexpensive commercial cellulase production process. Advancements in biotechnology such as screening of microorganisms, manipulation of novel cellulase encoding traits, site-specific mutagenesis, and modifications to the fermentation process could enhance the production of cellulases. Commercially, cheaper sources of carbohydrates and modified fermentation conditions could lead to more cost-effective production of cellulases with the goal to reduce the cost of ethanol production from lignocellulosics. Implementation of integrated steps like cellulase production and cellulase mediated saccharification of biomass in conjunction with the fermentation of released sugars in ethanol in a single step so called consolidated bio-processing (CBP) is very important to reduce the cost of bioethanol. This paper aims to explore and review the important findings in cellulase biotechnology and the forward path for new cutting edge opportunities in the success of biorefineries. © 2012 Informa Healthcare USA, Inc.

Pongiannan R.K.,RVS College of Engineering and Technology | Paramasivam S.,ESAB Engineering Services Ltd. | Yadaiah N.,Jawaharlal Nehru Technological University
IEEE Transactions on Power Electronics | Year: 2011

This paper presents the design and development of dynamic partially reconfigurable pulsewidth modulation (DPRPWM) controller for three-phase voltage-source inverters (VSI) in a single Xilinx Spartan 3 XCS400PQ208 field programmable gate array (FPGA). The DPRPWM controller is designed such that it switches between the popular PWM techniques like sinusoidal PWM (SPWM) and space vector PWM (SVPWM). The FPGA platform supports the run-time reconfiguration of control functions and algorithms directly in hardware and meets hard real-time performance criteria in terms of timings for PWM generation as well as reconfiguration. The DPRPWM control is simulated and experimentally verified using a low-cost Xilinx Spartan FPGA. The results of SPWM and SVPWM controller are presented and the results prove that the DPRPWM controller for three-phase inverter is highly possible and can be extended to any level/phase PWM controllers. © 2010 IEEE.

Prasad C.J.,Krishna University | Aryasri A.R.,Jawaharlal Nehru Technological University
International Journal of Retail and Distribution Management | Year: 2011

Purpose: Retailing in India is an unchartered territory. Food and grocery is the most promising area for setting up retail business in India. An understanding of shopper retail format choice behaviour will enable retailers to segment their market and target specific consumer groups with strategies premeditated to meet their retail needs. The purpose of this paper is to make a detailed study on the effect of shoppers' demographic, geographic and psychographic dimensions in terms of format choice behaviour in the fast growing Indian food and grocery retailing. Design/methodology/approach: Descriptive research design is adopted applying mall intercept survey method using structured questionnaire for data collection. Both descriptive (mean and standard deviation) and inferential statistical tools like χ2, factor analysis and multivariate analysis are used to analyse the data collected from 1,040 food and grocery retail customers from upgraded neighbourhood kirana stores, convenience stores, supermarkets and hypermarkets in conjoint cities of Secunderabad and Hyderabad in Andhra Pradesh in India. Findings: The findings suggest that shoppers' age, gender, occupation, education, monthly household income, family size and distance travelled to store have significant association with retail format choice decisions. The choice decisions are also varied among shoppers' demographic attributes. The findings from shoppers' psychographic dimensions like values, lifestyle factors and shopping orientations resulted in segmentation of food and grocery retail consumers into hedonic, utilitarian, autonomous, conventional and socialization type. Practical implications: The study has practical implications for food and grocery retailers for better understanding the shopper behaviour in the context of changing consumer demographic and psychographic characteristics in an emerging Indian retail market. The findings may help the retailers to segment and target the food and grocery retail consumers and, as a consequence, to undertake more effective retail marketing strategies for competitive advantage. Originality/value: Given the absence of published academic literature and empirical findings relating to store format choice behaviour in food and grocery retailing in India, this study may serve as a departure point for future studies in this area of concern. The research is also relevant to retail marketers in terms of format development and reorientation of marketing strategies in the fastest growing Indian retail market. © Emerald Group Publishing Limited.

Swain U.,University of Hyderabad | Swain U.,University of Delhi | Subba Rao K.,Jawaharlal Nehru Technological University
Mechanisms of Ageing and Development | Year: 2011

Earlier we have used biochemical approach to assess the number of single (SSBs) and double (DSBs) strand breaks in brain cellular DNA. However, a quick method to obtain a reliable measure of DNA damage in cells was in need for population studies. Therefore, single cell gel electrophoresis technique (popularly known as " comet" assay) has been standardized using the Trevigen protocol. DNA damage was assessed in isolated neurons and astrocytes from the cortex of young (7 days), adult (6 months) and old (2 years). Marked increase is seen in DNA damage in terms SSBs and DSBs in both types of cells by 6 months of age, which increased further by 2 years of age. The number of 8-oxoguanine DNA glycosylase (OGG1) and uracil DNA glycosylase (UDG) sensitive sites also increased in DNA with age with the simultaneous decrease in OGG1, UDG and AP endonuclease (APE1) activities. Thus the comet assay adapted to our lab conditions has proven to be useful for a quick assessment of DNA damage in a large number of samples that constitute our future studies. © 2011 Elsevier Ireland Ltd.

Girijashankar V.,Jawaharlal Nehru Technological University
Physiology and Molecular Biology of Plants | Year: 2011

Eucalyptus is the second most widely planted multipurpose woody tree species in the world. It is a commercially important hardwood tree for paper and wood industries. In the past two decades, various research groups reported different genetic transformation protocols and attempts towards development of transgenic eucalyptus. Much of the work related to its genetic improvement through transgenic technology has been undertaken by private companies that keep the data confidential, patented and often share only a part of the scientific information as publications. The important areas which received scientific attention are wood quantity, quality, stress resistance and rootability. The present review deals with scientific advancements and insights made through the development of transgenic eucalyptus. © 2011 Prof. H.S. Srivastava Foundation for Science and Society.

Nagaraju G.P.,Emory University | Aliya S.,Jawaharlal Nehru Technological University | Alese O.B.,Emory University
Cytokine and Growth Factor Reviews | Year: 2015

Adiponectin is produced in the white adipose tissue and is known to have anti-metabolic and anti-inflammatory properties. Serum/plasma adiponectin levels depend on diet, physical activity, and inheritance. Epidemiologic observations suggest a potential link between obesity and gastrointestinal malignancies. Low levels of adiponectin, which are known to occur in obesity, may contribute to the high incidence of cancer in this population. This review discusses the biochemical and molecular evidence regarding the relationship between adiponectin and gastrointestinal carcinogenesis and provides several future perspectives on the role of adiponectin as a target for prevention and therapy. © 2014 Elsevier Ltd.

Rangarao K.V.,Jawaharlal Nehru Technological University | Venkatanarasimhan S.,Jawaharlal Nehru Technological University
IEEE Transactions on Antennas and Propagation | Year: 2013

This paper presents a new way of accurately determining peaks of the MUSIC ('Multiple emitter location and signal parameter estimation,' R. O. Schmidt, IEEE Trans. Antennas and Propagation, vol. AP-34, no. 3, pp. 276-280, Mar. 1986) spectrum, here considered from the point of view of estimating the directions of arrival (DOAs) of narrowband signals. It can be used, with any smart antenna geometry and for any purpose where MUSIC is applicable. The MUSIC algorithm for DOA estimation evaluates the MUSIC spectrum for various angles and chooses the maxima or peaks as the angles of arrival. The values obtained depend on the interval at which the spectrum is evaluated. The coarser the interval, the less accurate are the results in case of MUSIC. To improve accuracy and not depend on the interval, Root-MUSIC ('Direction finding for diversely polarized signals using polynomial rooting,' A. J. Weiss and B. Friedlander, IEEE Trans. Signal Processing, vol. 41, no. 5, pp. 1893-1905, May 1993), which involves finding the roots of a polynomial, is available. However, Root-MUSIC is applicable, in its original form, only to uniform linear arrays (ULA). The gold-MUSIC algorithm proposed in this paper is a two-stage process. The first stage evaluates the objective function at coarse intervals and determines peaks followed by an iterative approach based on gold-section univariate (GSU) minimization (Algorithms for Minimization Without Derivatives, R. Brent, Englewood Cliffs, NJ, USA: Prentice-Hall, 1983) to find accurate values of the peaks. If the number of peaks found so far is equal to the number of estimated peaks, the algorithm stops with this first stage. The second stage is an iterative step for fine resolution using finer intervals around the peaks found so far for finding peaks that were missing in previous iterations. This paper, also presents a method, based on a partitioning algorithm for estimating the number of emitters. The performance of gold-MUSIC is described, including its advantages and comparison of time complexities for MUSIC, Root-MUSIC and gold-MUSIC. The proposed algorithm gives good results even when the number of snapshots is small. This gives it an additional computational advantage. It does not compromise on the resolving power of MUSIC. © 1963-2012 IEEE.

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