The Jawaharlal Nehru Centre for Advanced Scientific Research is a multidisciplinary research institute. It was established by the Department of Science and Technology of the Government of India, to mark the birth centenary of Pandit Jawaharlal Nehru. It is located in Jakkur, Bangalore, India. Its mandate is to pursue and promote scientific research and training at the frontiers of science and engineering. At present Prof. M. R. S. Rao is the president of JNCASR and Prof. C. N. R. Rao is the honorary president and founder of the institute. Wikipedia.
Jawaharlal Nehru Centre for Advanced Scientific Research | Date: 2017-02-08
The present disclosure relates to compounds which function as small molecule fluorescent probes which aid in recognition of specific sequences in DNA and detection of aggregates. Probes/dyes of the instant disclosure are specific to AT-rich sequences of DNA and aggregates. These small organic dyes/probes are capable of exhibiting switch-on fluorescence and play an important role in fluorescence spectroscopy, diagnostics, imaging and biomedical applications.
Jawaharlal Nehru Centre for Advanced Scientific Research | Date: 2015-04-03
The present disclosure relates to compounds which function as small molecule fluorescent probes which aid in recognition of specific sequences in DNA and detection of A aggregates. Probes/dyes of the instant disclosure are specific to AT-rich sequences of DNA and A aggregates. These small organic dyes/probes are capable of exhibiting switch-on fluorescence and play an important role in fluorescence spectroscopy, diagnostics, imaging and biomedical applications.
The Secretary Of State For Health and Jawaharlal Nehru Centre for Advanced Scientific Research | Date: 2015-03-13
The present disclosure relates to polyamine conjugates, its isomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure also relates to process of preparation of polyamine conjugates, its stereoisomers, prodrugs, pharmaceutically acceptable salts thereof, and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases mediated by microbes.
The Secretary Of State For Health and Jawaharlal Nehru Centre for Advanced Scientific Research | Date: 2017-01-18
The present disclosure relates to polyamine conjugates, its isomers, prodrugs and pharmaceutically acceptable salts thereof. The present disclosure also relates to process of preparation of polyamine conjugates, its stereoisomers, prodrugs, pharmaceutically acceptable salts thereof,and to pharmaceutical compositions containing them. The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases mediated by microbes.
Avinash M.B.,Jawaharlal Nehru Centre for Advanced Scientific Research
Nanoscale | Year: 2011
The chemistry of molecular assemblies involves weak yet complex non-covalent interactions, and the molecular organization of the π-conjugated material is crucial in determining the performance of an organic electronic device. Herein we demonstrate a bioinspired design strategy to tune the self-assembly of naphthalenediimides (NDIs) by minute structural variations, π-π stacking, hydrophobic interactions and metal interactions. We address some of the limitations associated with current design strategies, such as restriction to a specific molecular interaction or the difficulty in controlling the assembly due to several complicated intermolecular interactions. Hydrophobic-effect-induced J-type aggregation and sodium-interaction-induced H-type aggregation of tryptophan-appended NDIs have been illustrated. (1)H NMR spectra further reveal sodium cation-π interactions in tryptophan-appended NDIs, while NMR and IR spectroscopic studies confirm the structural variations associated with the molecular assembly. In summary, the molecular organization has been successfully transformed from nanospheres to particles, nanobelts, fibers and fractals. Such drastic changes in the morphology are clear and striking evidence of the importance of non-trivial weak non-covalent forces.
Thakur J.,Jawaharlal Nehru Centre for Advanced Scientific Research |
Sanyal K.,Jawaharlal Nehru Centre for Advanced Scientific Research
Genome Research | Year: 2013
CENPA/Cse4 assembles centromeric chromatin on diverse DNA. CENPA chromatin is epigenetically propagated on unique and different centromere DNA sequences in a pathogenic yeast Candida albicans. Formation of neocentromeres on DNA, nonhomologous to native centromeres, indicates a role of non-DNA sequence determinants in CENPA deposition. Neocentromeres have been shown to form at multiple loci in C. albicans when a native centromere was deleted. However, the process of site selection for CENPA deposition on native or neocentromeres in the absence of defined DNA sequences remains elusive. By systematic deletion of CENPA chromatin-containing regions of variable length of different chromosomes, followed by mapping of neocentromere loci in C. albicans and its related species Candida dubliniensis, which share similar centromere properties, we demonstrate that the chromosomal location is an evolutionarily conserved primary determinant of CENPA deposition. Neocentromeres on the altered chromosome are always formed close to the site which was once occupied by the native centromere. Interestingly, repositioning of CENPA chromatin from the neocentromere to the native centromere occurs by gene conversion in C. albicans. © 2013, Published by Cold Spring Harbor Laboratory Press.
Avinash M.B.,Jawaharlal Nehru Centre for Advanced Scientific Research |
Govindaraju T.,Jawaharlal Nehru Centre for Advanced Scientific Research
Advanced Materials | Year: 2012
Nature's elegant molecular designs and their assemblies with specific structure-property correlations have inspired researchers to design and develop bio-mimics for advanced functional applications. To realize such advanced molecular materials, naturally evolved amino acids are arguably the ideal auxiliaries due to their remarkable molecular/chiral recognition and distinctive sequence specific self-assembling properties. Over the years, this modular approach of derivatizing naphthalenediimides (NDIs) and perylenediimides (PDIs) with amino acids and peptides have resulted in several hitherto unknown molecular assemblies with phenomenal impact on their performance. Derivatization with versatile arylenediimides is especially interesting due to their wide spread applications in fields ranging from biomedicine to electronics. Herein some of these seminal reports of this rapidly emerging field and the design principles embraced are discussed. Bio-inspired molecular materials are an emerging area of scientific interest from both fundamental science and technological perspectives. This review focuses on the impressive progress made in recent times in engineering the molecular assemblies of naphthalenediimides and perylenediimides upon derivatization with amino acids and peptides. By this versatile modular approach, arylenediimides have been assembled into several unprecedented molecular systems for various potential applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Agency: European Commission | Branch: FP7 | Program: MC-ITN | Phase: FP7-PEOPLE-2013-ITN | Award Amount: 3.65M | Year: 2013
Nano2Funs main target is the education of a new generation of scientists with a solid multidisciplinary scientific background, a good attitude to team-work in an international environment and a well-developed propensity to exploit advances in fundamental research towards innovative applications. To achieve this ambitious goal, a network of advanced research laboratories operating both in the public and private sectors is proposed where a group of 17 young and brilliant researchers will be trained through research. Technological development through research and knowledge transfer are the flag-words of Nano2Fun, a multidisciplinary project that will bring the techniques of two-photon microscopy (2PM) and two-photon polymerization (2PP) to their full maturity, allowing their exploitation in commercially and industrially relevant applications. The precise chemical and photophysical control of the 2PM and 2PP processes at the nanoscale will be achieved through a coordinated effort of 16 teams with well-established expertise in the diverse and complementary research fields of (a) molecular and supramolecular synthesis, (b) advanced optical spectroscopy and photophysics, (c) theory and (d) the 2PM and 2PP technological applications. The effort of the academic research teams will be fully integrated with applied research and development going on in the advanced R&D laboratories of the 5 partners from the private sector in a virtuous loop that will cooperatively enhance the effectiveness of Nano2Fun team. The inherently multidisciplinary character of the research, that spans a full range of disciplines between chemistry and physics, and is precisely located where fundamental research meets commercial and industrial applications, offers an extremely profitable environment for the education of young researcher both in public and private sectors in a lively international environment at the forefront of research.
Jawaharlal Nehru Centre for Advanced Scientific Research | Date: 2016-02-17
Sorbent polymers which are selective to taking up hydrocarbons are provided for separating hydrocarbons from fluids and taking up hydrocarbons from off of and intermixed with solid materials. The hydrocarbons may at least partially be expressed out of and recovered from the polymer by squeezing. The polymers may be re-used for picking up additional hydrocarbons. Methods for producing and using the polymers are also provided.
Jawaharlal Nehru Centre for Advanced Scientific Research | Date: 2016-05-17
Aromatic diimide chromophores and methods for using the chromophores for the detection of volatile organic compounds are described. The chromophores are able to reversibly change colors in the presence or absence of volatile organic compounds.