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Bangalore, India

The Jawaharlal Nehru Centre for Advanced Scientific Research is a multidisciplinary research institute. It was established by the Department of Science and Technology of the Government of India, to mark the birth centenary of Pandit Jawaharlal Nehru. It is located in Jakkur, Bangalore, India. Its mandate is to pursue and promote scientific research and training at the frontiers of science and engineering. At present Prof. M. R. S. Rao is the president of JNCASR and Prof. C. N. R. Rao is the honorary president and founder of the institute. Wikipedia.

The chemistry of molecular assemblies involves weak yet complex non-covalent interactions, and the molecular organization of the π-conjugated material is crucial in determining the performance of an organic electronic device. Herein we demonstrate a bioinspired design strategy to tune the self-assembly of naphthalenediimides (NDIs) by minute structural variations, π-π stacking, hydrophobic interactions and metal interactions. We address some of the limitations associated with current design strategies, such as restriction to a specific molecular interaction or the difficulty in controlling the assembly due to several complicated intermolecular interactions. Hydrophobic-effect-induced J-type aggregation and sodium-interaction-induced H-type aggregation of tryptophan-appended NDIs have been illustrated. (1)H NMR spectra further reveal sodium cation-π interactions in tryptophan-appended NDIs, while NMR and IR spectroscopic studies confirm the structural variations associated with the molecular assembly. In summary, the molecular organization has been successfully transformed from nanospheres to particles, nanobelts, fibers and fractals. Such drastic changes in the morphology are clear and striking evidence of the importance of non-trivial weak non-covalent forces. Source

Govindarajan R.,Tata Institute of Fundamental Research | Govindarajan R.,Jawaharlal Nehru Centre for Advanced Scientific Research | Sahu K.C.,Indian Institute of Technology Hyderabad
Annual Review of Fluid Mechanics | Year: 2014

This review highlights the profound and unexpected ways in which viscosity varying in space and time can affect flow. The most striking manifestations are through alterations of flow stability, as established in model shear flows and industrial applications. Future studies are needed to address the important effect of viscosity stratification in such diverse environments as Earth's core, the Sun, blood vessels, and the re-entry of spacecraft. Copyright © 2014 by Annual Reviews. All rights reserved. Source

Vasu K.,Indian Institute of Science | Nagaraja V.,Indian Institute of Science | Nagaraja V.,Jawaharlal Nehru Centre for Advanced Scientific Research
Microbiology and Molecular Biology Reviews | Year: 2013

Restriction-modification (R-M) systems are ubiquitous and are often considered primitiveimmunesystems in bacteria. Their diversity and prevalence across the prokaryotic kingdom are an indication of their success as a defense mechanism against invading genomes. However, their cellular defense function does not adequately explain the basis for their immaculate specificity in sequence recognition and nonuniform distribution, ranging from none to too many, in diverse species. The present review deals with new developments which provide insights into the roles of these enzymes in other aspects of cellular function. In this review, emphasis is placed on novel hypotheses and various findings that have not yet been dealt with in a critical review. Emerging studies indicate their role in various cellular processes other than host defense, virulence, and even controlling the rate of evolution of the organism. We also discuss how R-M systems could have successfully evolved and be involved in additional cellular portfolios, thereby increasing the relative fitness of their hosts in the population. Copyright © 2013, American Society for Microbiology. All Rights Reserved. Source

Thakur J.,Jawaharlal Nehru Centre for Advanced Scientific Research | Sanyal K.,Jawaharlal Nehru Centre for Advanced Scientific Research
Genome Research | Year: 2013

CENPA/Cse4 assembles centromeric chromatin on diverse DNA. CENPA chromatin is epigenetically propagated on unique and different centromere DNA sequences in a pathogenic yeast Candida albicans. Formation of neocentromeres on DNA, nonhomologous to native centromeres, indicates a role of non-DNA sequence determinants in CENPA deposition. Neocentromeres have been shown to form at multiple loci in C. albicans when a native centromere was deleted. However, the process of site selection for CENPA deposition on native or neocentromeres in the absence of defined DNA sequences remains elusive. By systematic deletion of CENPA chromatin-containing regions of variable length of different chromosomes, followed by mapping of neocentromere loci in C. albicans and its related species Candida dubliniensis, which share similar centromere properties, we demonstrate that the chromosomal location is an evolutionarily conserved primary determinant of CENPA deposition. Neocentromeres on the altered chromosome are always formed close to the site which was once occupied by the native centromere. Interestingly, repositioning of CENPA chromatin from the neocentromere to the native centromere occurs by gene conversion in C. albicans. © 2013, Published by Cold Spring Harbor Laboratory Press. Source

Das A.J.,Jawaharlal Nehru Centre for Advanced Scientific Research | Narayan K.S.,Jawaharlal Nehru Centre for Advanced Scientific Research
Advanced Materials | Year: 2013

A light harvesting device geometry is implemented for polymer solar cells that retain efficiency when the device area is scaled up. Patterning devices and incorporating suitable fluorescent dye doped polymers in the spaces between the patterns leads to 12% efficiency enhancement. Vacuum free deposition of electrodes is carried out using meltable alloys giving rise to device efficiency of 6%. The fluorescent layer along with the electrode serves as an active encapsulant leading to improved device stability. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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