Jawaharlal Nehru Center for Advanced Scientific Research

Bangalore, India

The Jawaharlal Nehru Centre for Advanced Scientific Research is a multidisciplinary research institute. It was established by the Department of Science and Technology of the Government of India, to mark the birth centenary of Pandit Jawaharlal Nehru. It is located in Jakkur, Bangalore, India. Its mandate is to pursue and promote scientific research and training at the frontiers of science and engineering. At present Prof. M. R. S. Rao is the president of JNCASR and Prof. C. N. R. Rao is the honorary president and founder of the institute. Wikipedia.

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Bedre M.D.,Gulbarga University | Basavaraja S.,Jawaharlal Nehru Center for Advanced Scientific Research | Balaji D.S.,Gulbarga University | Venkataraman A.,Gulbarga University
International Journal of Polymeric Materials and Polymeric Biomaterials | Year: 2010

Conducting polypyrrole silver (Ppy-AgNC) nanocomposite was synthesized by an interfacial polymerization method. Ag+ ions from the AgNO 3 solution were taken in the formation of Ppy-AgNC. The incorporated silver was confirmed by X-ray diffraction (XRD). During the polymerization in a nitrate ion-containing solution, the impregnation leads to the formation of metallic silver. The size distribution of Ag into the polymer is confirmed by transmission electron microscopy (TEM), and proves the formation of a uniform species with spherical particles of Ag (mean diameter of 8-12nm) branching at the border of Ppy. The thermal behavior of the material was studied by thermogravimetric measurements. Copyright © Taylor & Francis Group, LLC.

Jana B.,Indian Institute of Science | Pal S.,Indian Institute of Technology Gandhinagar | Bagchi B.,Indian Institute of Science | Bagchi B.,Jawaharlal Nehru Center for Advanced Scientific Research
Journal of Chemical Sciences | Year: 2012

Dielectric dispersion and NMRD experiments have revealed that a significant fraction of water molecules in the hydration shell of various proteins do not exhibit any slowing down of dynamics. This is usually attributed to the presence of the hydrophobic residues (HBR) on the surface, although HBRs alone cannot account for the large amplitude of the fast component. Solvation dynamics experiments and also computer simulation studies, on the other hand, repeatedly observed the presence of a non-negligible slow component. Here we show, by considering three well-known proteins (lysozyme, myoglobin and adelynate kinase), that the fast component arises partly from the response of those water molecules that are hydrogen bonded with the backbone oxygen (BBO) atoms. These are structurally and energetically less stable than those with the side chain oxygen (SCO) atoms. In addition, the electrostatic interaction energy distribution (EIED) of individual water molecules (hydrogen bonded to SCO) with side chain oxygen atoms shows a surprising two peak character with the lower energy peak almost coincident with the energy distribution of water hydrogen bonded to backbone oxygen atoms (BBO). This two peak contribution appears to be quite general as we find it for lysozyme, myoglobin and adenylate kinase (ADK). The sharp peak of EIED at small energy (at less than 2 kBT) for the BBO atoms, together with the first peak of EIED of SCO and the HBRs on the protein surface, explain why a large fraction (∼80%) of water in the protein hydration layer remains almost as mobile as bulk water. Significant slowness arises only from the hydrogen bonds that populate the second peak of EIED at larger energy (at about 4 kBT). Thus, if we consider hydrogen bond interaction alone, only 15-20% of water molecules in the protein hydration layer can exhibit slow dynamics, resulting in an average relaxation time of about 5-10 ps. The latter estimate assumes a time constant of 20-100 ps for the slow component. Interestingly, relaxation of water molecules hydrogen bonded to back bone oxygen exhibit an initial component faster than the bulk, suggesting that hydrogen bonding of these water molecules remains frustrated. This explanation of the heterogeneous and non-exponential dynamics of water in the hydration layer is quantitatively consistent with all the available experimental results, and provides unification among diverse features. © Indian Academy of Sciences.

Mohanty D.,National Institute of Immunology | Sankaranarayanan R.,Center for Cellular and Molecular Biology | Gokhale R.S.,Institute of Genomics and Integrative Biology IGIB | Gokhale R.S.,Jawaharlal Nehru Center for Advanced Scientific Research
Tuberculosis | Year: 2011

The cell envelope of Mycobacterium tuberculosis (Mtb) possesses a repertoire of unusual lipids that are believed to play an important role in pathogenesis. In this review, we specifically focus on computational, biochemical and structural studies in lipid biosynthesis that have established functional role of polyketide synthases (PKSs) and fatty acyl-AMP ligases (FAALs). Mechanistic and structural studies with FAALs suggest that this group of proteins may have evolved from omnipresent fatty acyl-CoA ligases (FACLs). FAALs activate fatty acids as acyl-adenylates and transfer them on to the PKSs which then produce unusual acyl chains that are the components of mycobacterial lipids. FAALs are a newly discovered family of enzymes; whereas involvement of PKSs in lipid metabolism was not known prior to their discovery in Mtb. Since Mtb genome contains multiple homologs of FAALs and PKSs and owing to the conserved reaction mechanism and overlapping substrate specificity; there is tempting opportunity to develop 'systemic drugs' against these enzymes as anti-tuberculosis agents. © 2011 Elsevier Ltd. All rights reserved.

Montessori A.,Third University of Rome | Falcucci G.,Parthenope University of Naples | La Rocca M.,Third University of Rome | Ansumali S.,Jawaharlal Nehru Center for Advanced Scientific Research | Succi S.,CNR Institute of Neuroscience
Journal of Statistical Physics | Year: 2015

It is shown that the combination of generalized Van der Waals equations of state with high-order discrete velocity lattices, permits to simulate the dynamics of liquid droplets at air-water density ratios, with very moderate levels of spurious currents near the droplet interface. Satisfactory agreement with experimental data on droplet collisions at density ratios of order thousand is reported. © 2015, Springer Science+Business Media New York.

Yadav P.,Jawaharlal Nehru Center for Advanced Scientific Research | Sharma V.K.,Jawaharlal Nehru Center for Advanced Scientific Research
Journal of Experimental Biology | Year: 2014

Insects including the fruit fly Drosophila melanogaster are under intense pressure to develop rapidly because they inhabit ephemeral habitats. We have previously shown that when selection for faster development was artificially imposed on D. melanogaster in the laboratory, reduction of pre-adult development time and shortening of the clock period occurs, suggesting a role for circadian clocks in the regulation of life history traits. Circadian clocks in D. melanogaster have also been implicated in the control of metabolic pathways, ageing processes, oxidative stress and defense responses to exogenous stressors. In order to rigorously examine correlations between pre-adult development time and other life history traits, we assayed pre-adult survivorship, starvation and desiccation resistance, body size and body weight, fecundity and adult lifespan in faster developing populations of D. melanogaster. The results revealed that selection for faster pre-adult development significantly reduced several adult fitness traits in the faster developing flies without affecting pre-adult survivorship. Although overall fecundity of faster developing flies was reduced, their egg output per unit body weight was significantly higher than that of controls, indicating that reduction in adult lifespan might be due to disproportionate investment in reproduction. Thus our results suggest that selection for faster pre-adult development in D. melanogaster yields flies with higher reproductive fitness. Because these flies also have shorter clock periods, our results can be taken to suggest that pre-adult development time and circadian clock period are correlated with various adult life history traits in D. melanogaster, implying that circadian clocks may have adaptive significance. © 2014. Published by The Company of Biologists Ltd.

Date S.V.,Jawaharlal Nehru Center for Advanced Scientific Research | Rizvi S.J.,Jawaharlal Nehru Center for Advanced Scientific Research
Indian Journal of Surgery | Year: 2015

A 16-year-old girl presented with abdominal discomfort, weakness, and jaundice. General examination revealed deep icterus with hard lymph nodes in left supraclavicular region. On gastrointestinal examination, we appreciated a hard intra-abdominal lump in the right hypochondrium. Biochemical evaluation showed features of obstructive jaundice. Imaging confirmed the presence of gall bladder lump with multiple intra-abdominal lymph nodes. Fine needle aspiration cytology of neck nodes demonstrated metastatic adenocarcinoma. Fine needle aspiration cytology of the gall bladder lump (done under sonographic guidance) confirmed poorly differentiated adenocarcinoma. To the best of our knowledge, malignancy of the gall bladder has not been reported in individuals less than 18 years in India, and only three cases have been reported worldwide in English literature. © 2013, Association of Surgeons of India.

Eggeman A.S.,University of Cambridge | Sundaresan A.,Jawaharlal Nehru Center for Advanced Scientific Research | Rao C.N.R.,Jawaharlal Nehru Center for Advanced Scientific Research | Midgley P.A.,University of Cambridge
Journal of Materials Chemistry | Year: 2011

The structure of two new phases in the bismuth manganite system are reported. The phases were determined by electron diffraction studies of two oxygen-deficient bulk samples. The first phase, a minority component of bulk BiMnO2.94 forms a n = 2 Ruddlesden-Popper phase with space group Cmc21. The second phase, from bulk BiMnO2.99, is an orthorhombic structure with space group Pmn21 and a unit cell approximately equal to times the parent perovskite cell. Importantly both phases are non-centrosymmetric and offer further potential for multiferroic studies. © 2011 The Royal Society of Chemistry.

Jawaharlal Nehru Center for Advanced Scientific Research | Date: 2011-07-11

The disclosure relates to a method of identification of antiviral molecules that help in efficient viral control and thereby aid in disease management. In particular, the disclosure relates to identification of anti-Tat molecules and hence is directed towards antiviral drug development. The disclosure also relates to Tat-inducible GFP-anti RFP shRNA vector, vector combinations, recombinant cell having instant vectors, methods and kits thereof.

Jawaharlal Nehru Center for Advanced Scientific Research | Date: 2012-11-13

The present invention relates to compounds that are cationic vancomycin analogues and their compositions. Method of making the compounds and their use as medicament for the treatment of bacterial infection are also disclosed.

Jawaharlal Nehru Center for Advanced Scientific Research | Date: 2012-08-30

Methods of forming a pattern on a substrate are provided. The methods include providing a substrate and radiating a laser beam through a transmitting phase mask on the substrate. The transmitting phase mask includes a pattern and radiating the laser beam through the transmitting phase mask forms the pattern on a first surface of the substrate.

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