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Bangalore, India

The Jawaharlal Nehru Centre for Advanced Scientific Research is a multidisciplinary research institute. It was established by the Department of Science and Technology of the Government of India, to mark the birth centenary of Pandit Jawaharlal Nehru. It is located in Jakkur, Bangalore, India. Its mandate is to pursue and promote scientific research and training at the frontiers of science and engineering. At present Prof. M. R. S. Rao is the president of JNCASR and Prof. C. N. R. Rao is the honorary president and founder of the institute. Wikipedia.


Jana B.,Indian Institute of Science | Pal S.,Indian Institute of Technology Gandhinagar | Bagchi B.,Indian Institute of Science | Bagchi B.,Jawaharlal Nehru Center for Advanced Scientific Research
Journal of Chemical Sciences | Year: 2012

Dielectric dispersion and NMRD experiments have revealed that a significant fraction of water molecules in the hydration shell of various proteins do not exhibit any slowing down of dynamics. This is usually attributed to the presence of the hydrophobic residues (HBR) on the surface, although HBRs alone cannot account for the large amplitude of the fast component. Solvation dynamics experiments and also computer simulation studies, on the other hand, repeatedly observed the presence of a non-negligible slow component. Here we show, by considering three well-known proteins (lysozyme, myoglobin and adelynate kinase), that the fast component arises partly from the response of those water molecules that are hydrogen bonded with the backbone oxygen (BBO) atoms. These are structurally and energetically less stable than those with the side chain oxygen (SCO) atoms. In addition, the electrostatic interaction energy distribution (EIED) of individual water molecules (hydrogen bonded to SCO) with side chain oxygen atoms shows a surprising two peak character with the lower energy peak almost coincident with the energy distribution of water hydrogen bonded to backbone oxygen atoms (BBO). This two peak contribution appears to be quite general as we find it for lysozyme, myoglobin and adenylate kinase (ADK). The sharp peak of EIED at small energy (at less than 2 kBT) for the BBO atoms, together with the first peak of EIED of SCO and the HBRs on the protein surface, explain why a large fraction (∼80%) of water in the protein hydration layer remains almost as mobile as bulk water. Significant slowness arises only from the hydrogen bonds that populate the second peak of EIED at larger energy (at about 4 kBT). Thus, if we consider hydrogen bond interaction alone, only 15-20% of water molecules in the protein hydration layer can exhibit slow dynamics, resulting in an average relaxation time of about 5-10 ps. The latter estimate assumes a time constant of 20-100 ps for the slow component. Interestingly, relaxation of water molecules hydrogen bonded to back bone oxygen exhibit an initial component faster than the bulk, suggesting that hydrogen bonding of these water molecules remains frustrated. This explanation of the heterogeneous and non-exponential dynamics of water in the hydration layer is quantitatively consistent with all the available experimental results, and provides unification among diverse features. © Indian Academy of Sciences. Source


Bedre M.D.,Gulbarga University | Basavaraja S.,Jawaharlal Nehru Center for Advanced Scientific Research | Balaji D.S.,Gulbarga University | Venkataraman A.,Gulbarga University
International Journal of Polymeric Materials and Polymeric Biomaterials | Year: 2010

Conducting polypyrrole silver (Ppy-AgNC) nanocomposite was synthesized by an interfacial polymerization method. Ag+ ions from the AgNO 3 solution were taken in the formation of Ppy-AgNC. The incorporated silver was confirmed by X-ray diffraction (XRD). During the polymerization in a nitrate ion-containing solution, the impregnation leads to the formation of metallic silver. The size distribution of Ag into the polymer is confirmed by transmission electron microscopy (TEM), and proves the formation of a uniform species with spherical particles of Ag (mean diameter of 8-12nm) branching at the border of Ppy. The thermal behavior of the material was studied by thermogravimetric measurements. Copyright © Taylor & Francis Group, LLC. Source


Mohanty D.,National Institute of Immunology | Sankaranarayanan R.,Center for Cellular and Molecular Biology | Gokhale R.S.,Institute of Genomics and Integrative Biology IGIB | Gokhale R.S.,Jawaharlal Nehru Center for Advanced Scientific Research
Tuberculosis | Year: 2011

The cell envelope of Mycobacterium tuberculosis (Mtb) possesses a repertoire of unusual lipids that are believed to play an important role in pathogenesis. In this review, we specifically focus on computational, biochemical and structural studies in lipid biosynthesis that have established functional role of polyketide synthases (PKSs) and fatty acyl-AMP ligases (FAALs). Mechanistic and structural studies with FAALs suggest that this group of proteins may have evolved from omnipresent fatty acyl-CoA ligases (FACLs). FAALs activate fatty acids as acyl-adenylates and transfer them on to the PKSs which then produce unusual acyl chains that are the components of mycobacterial lipids. FAALs are a newly discovered family of enzymes; whereas involvement of PKSs in lipid metabolism was not known prior to their discovery in Mtb. Since Mtb genome contains multiple homologs of FAALs and PKSs and owing to the conserved reaction mechanism and overlapping substrate specificity; there is tempting opportunity to develop 'systemic drugs' against these enzymes as anti-tuberculosis agents. © 2011 Elsevier Ltd. All rights reserved. Source


Montessori A.,Third University of Rome | Falcucci G.,Parthenope University of Naples | La Rocca M.,Third University of Rome | Ansumali S.,Jawaharlal Nehru Center for Advanced Scientific Research | Succi S.,CNR Institute of Neuroscience
Journal of Statistical Physics | Year: 2015

It is shown that the combination of generalized Van der Waals equations of state with high-order discrete velocity lattices, permits to simulate the dynamics of liquid droplets at air-water density ratios, with very moderate levels of spurious currents near the droplet interface. Satisfactory agreement with experimental data on droplet collisions at density ratios of order thousand is reported. © 2015, Springer Science+Business Media New York. Source


Patent
Jawaharlal Nehru Center for Advanced Scientific Research | Date: 2012-08-30

Methods of forming a pattern on a substrate are provided. The methods include providing a substrate and radiating a laser beam through a transmitting phase mask on the substrate. The transmitting phase mask includes a pattern and radiating the laser beam through the transmitting phase mask forms the pattern on a first surface of the substrate.

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