Wang X.-J.,716th Institute of CSIC |
Wang X.-J.,JARI Pharmaceutical Co. |
Yang M.-L.,JARI Pharmaceutical Co. |
Zhang L.-P.,JARI Pharmaceutical Co. |
And 7 more authors.
Chinese Chemical Letters
A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 μmol/L (mononuclear tumor cell line (U937)) and 5.58 μmol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA. © 2014 Ming-Li Yang. Source