Japanese Society for Pediatric Nephrology

Tokyo, Japan

Japanese Society for Pediatric Nephrology

Tokyo, Japan
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Ikezumi Y.,Japanese Society for Pediatric Nephrology | Ikezumi Y.,Niigata University | Honda M.,Japanese Society for Pediatric Nephrology | Matsuyama T.,Japanese Society for Pediatric Nephrology | And 9 more authors.
Clinical and Experimental Nephrology | Year: 2013

Objective: Serum β2 microglobulin (β2MG) is considered to be a marker of renal function, which is independently associated with age. However, only a few studies have reported the reference values for β2MG in children thus far, particularly in young children. In this study, we evaluated the distribution of serum β2MG values in healthy Japanese children and assessed its clinical usefulness. Method: The normal reference value of serum β2MG was assessed in serum samples from 1131 normal Japanese children (504 boys and 627 girls; age 0-17 years). To test the validity of the reference value, serum samples from children with various kidney diseases were also examined retrospectively. Results: The mean values for β2MG were significantly negatively correlated with age (r = -0.47, P < 0.001). No significant difference was observed between the values of boys and girls in any age group. The established β2MG reference range covered 99.7 % of patients with decreased kidney function below 75 % based on their serum creatinine (Cr) value and body length. Conclusion: The newly established β2MG reference value in children can be used to detect kidney impairment in children. Serum β2MG in combination with serum Cr used as markers for predicting glomerular function can provide an accurate detection of kidney dysfunction in children. © 2012 Japanese Society of Nephrology.


Nagai T.,Japanese Society for Pediatric Nephrology | Uemura O.,Japanese Society for Pediatric Nephrology | Uemura O.,Aichi Childrens Health and Medical Center | Ishikura K.,Japanese Society for Pediatric Nephrology | And 7 more authors.
Clinical and Experimental Nephrology | Year: 2013

Background: Renal inulin clearance is the gold standard for glomerular filtration rate (GFR), but is compromised by problems of collecting urine samples in children, especially those <6 years of age or with a bladder dysfunction. Therefore, we should utilize the serum creatinine (Cr)-based estimated GFR (eGFR), measuring serum Cr by enzymatic method. The updated Schwartz formulae were reported by enzymatic Cr instead of by the Jaffe method in American children aged 1-16 years old. We believe it would be better to determine serum Cr-based eGFR by the enzymatic method in Japanese children for evaluation of renal function. Methods: Serum Cr-based eGFR was determined by measuring inulin clearance and serum Cr level in 76 pediatric chronic kidney disease (CKD) patients (49 males and 27 females) aged 2-11 years with no underlying disease that would affect renal function. Results: We showed the inulin clearance by expression of the body length/serum Cr ratio in pediatric CKD patients, which resulted in the equation: inulin GFR = 0.342 × body length (cm)/serum Cr(mg/dL) ± 2.75. Additionally, we suggest the following serum Cr-based eGFR formula passing through the origin: eGFR (mL/min/1.73 m2)= 0.35 × body length (cm)/serum Cr (mg/dL), because it is simple and easy to remember, thus making it clinically useful. Conclusion: The new eGFR formula derived from body length and serum Cr level is applicable for clinical screening of renal function in Asian as well as Japanese children aged between 2 and 11 years old. © 2013 Japanese Society of Nephrology.


Yata N.,Japanese Society for Pediatric Nephrology | Yata N.,Tokyo Metropolitan Childrens Medical Center | Uemura O.,Japanese Society for Pediatric Nephrology | Honda M.,Japanese Society for Pediatric Nephrology | And 11 more authors.
Clinical and Experimental Nephrology | Year: 2013

Objective: The data available on reference ranges for cystatin C in children are limited, and there are discrepancies among the available data. The aim of this study was to describe the reference ranges for cystatin C in Japanese children by using 4 automated assays. Methods: Serum cystatin C levels were measured in 1128 Japanese children aged 3 month to 16 years without kidney disease. We calculated age-, gender-, race- and assay-specific cystatin C ranges. Results: For all 4 assays, the median serum cystatin C levels were raised in term infants compared with older children and decreased by the first 2 years. The median serum cystatin C levels remained constant throughout up to the age of 14 years and decreased in children aged 15-16 years. The median serum cystatin C levels in children aged 12-16 years were slightly higher in males than in females. Assay-specific differences were also observed in the levels of serum cystatin C measured. Conclusion: Age-, gender-, race- and assay-specific ranges for serum cystatin C should be used as another tool to assess kidney function in children. © 2013 Japanese Society of Nephrology.


Uemura O.,Japanese Society for Pediatric Nephrology | Honda M.,Japanese Society for Pediatric Nephrology | Matsuyama T.,Japanese Society for Pediatric Nephrology | Ishikura K.,Japanese Society for Pediatric Nephrology | And 8 more authors.
Clinical and Experimental Nephrology | Year: 2011

Background: Enzymatic methods have recently been used to measure creatinine (Cr) instead of the Jaffe method. Therefore, it is necessary to determine the reference serum Cr value for these enzymatic methods to evaluate renal function in Japanese children. Methods: To determine reference values of serum Cr in Japanese children, 1151 children (517 male, 634 female) aged between 1 month and 18 years had their serum Cr values measured by an enzymatic method. To be included in the study the children had to be without kidney disease, urogenital disease, infectious disease, inflammatory disease, dehydration, muscular disease, anomaly syndrome, cardiovascular disease, malignant disease, hypertension, liver or pancreas disease, or pregnancy. Results: The medians of reference values increased gradually with age, i.e., 0.30 mg/dl at 4 years old and 0.41 mg/dl at 10 years old. In adolescence, they increased significantly more rapidly in males than in females. We found a linear regression equation capable of estimating the reference value of serum Cr in children aged 2-11 years, and quintic regression equations capable of estimating the reference values of serum Cr in male and female children of all ages. Conclusion: The reference serum Cr levels determined by an enzymatic method related to age, gender, and body length, and our linear and polynomial equations showing the relationship between body length and serum Cr level will be applicable for screening of renal function in Asian as well as Japanese children. © 2011 Japanese Society of Nephrology.

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