Takatsuki, Japan
Takatsuki, Japan

Time filter

Source Type

Patent
Japan Tobacco Inc. and Kyoto University | Date: 2016-03-16

[PROBLEM] The problem to be solved by the invention is to provide a novel pharmaceutical use of a JAK inhibitor. [SOLUTION MEANS] A therapeutic or preventive agent for a skin disease selected from the group consisting of senile xerosis, asteatosis, eczema and contact dermatitis, containing a JAK inhibitor as an active ingredient. [EFFECT] The followings are found: a JAK inhibitor increases the expression amounts of filaggrin, loricrin, involucrin and -defensin 3 as skin barrier function-related proteins; a JAK inhibitor significantly increases NMF production in a Tape Stripping-treated mouse; and a JAK inhibitor significantly accelerates a reduction in TEWL in a dry skin mouse model, namely improves the skin barrier function. The JAK inhibitor can be used as an active ingredient of a therapeutic or preventive agent for skin diseases such as senile xerosis, asteatosis, eczema, contact dermatitis, ichthyosis vulgaris, Netherton syndrome, type B peeling skin syndrome, etc.


A non-burning type flavor inhaler includes a control unit that controls power supplied from a power source to an atomizer. The control unit controls, in one puff action in a standard mode, controls the power source to supply standard power amount to the atomizer in a duration before a first duration elapses. The control unit, in one puff action in the reduced mode, controls the power source to supply first power amount greater than the standard power amount to the atomizer in a duration before a second duration elapses, and controls the power source to supply second power amount smaller than the first power amount to the atomizer in a duration after the second duration elapses and before a third duration elapses.


Patent
Japan Tobacco Inc. | Date: 2016-11-14

A flavor inhaler (100) comprises a cup (50) having a cup shape. The cup is inserted into the holder (30) in a direction in which an opening of the cup is directed toward the ignition end side and a bottom plate (52) of the cup is arranged at the non-ignition end side. The cup has a claw portion (54) that protrudes into an inside of the cup from an inner wall surface of a side wall (51) of the cup. The claw portion has at least an engagement portion (54A) that engages an end surface of the combustion type heat source (70) in a non-ignition end side.


Patent
Japan Tobacco Inc. | Date: 2016-10-28

A manufacturing method for a carbon heat source comprises: a step A1 of forming a first groove in a state where the plurality of carbon members are aligned in one line; a step A2 of changing, subsequent to the step A1 being performed, an orientation of the plurality of carbon members so that the first groove formed in the plurality of carbon members crosses relative to the first predetermined direction in a state where the plurality of carbon members are aligned in one line; and a step A3 of forming, subsequent to the step A2 being performed, a second groove in a state where the plurality of carbon members are aligned in one line.


Patent
Japan Tobacco Inc. | Date: 2016-11-01

A non-burning type flavor inhaler, comprises: a housing having an airflow path that continues from an inlet to an outlet; an atomizer configured to atomize an aerosol source without burning; a sensor including a capacitor, the sensor outputting a value indicating electric capacitance of the capacitor, the electric capacitance changed depending on a puff action of a user; and a controller configured to detect a start or an end of a puff duration on the basis of an output value that is output from the sensor. The controller detects the start or the end of the puff duration when an inclination formed by two or more of the output values has a predetermined sign and when an absolute value of the inclination having the predetermined sign is larger than a predetermined value.


Patent
Japan Tobacco Inc. | Date: 2016-11-01

A non-burning type flavor inhaler comprises: a first unit; a second unit including an aerosol source or a flavor source; and a control unit. The control unit integrates a first cumulative amount of electric power which is a cumulative value of the amount of electric power supplied to the heat source in the one-time puff action series, and the control unit notifies an end of the one-time puff action series when the first cumulative amount of electric power reaches the required amount of electric power.


Patent
Japan Tobacco Inc. | Date: 2016-11-01

A non-burning type flavor inhaler comprises: a housing having an air flow path that continues from an inlet to an outlet; an atomizer configured to atomize an aerosol source without burning; a sensor configured to output a value that changes in accordance with a puff action of a user; and a controller configured to detect a puff action of the user when a response value derived from a value that is output from the sensor satisfies an inhaling condition, the controller configured to identify that the user is an authorized user when the response value satisfies an identification condition that is different from the inhaling condition.


Patent
Japan Tobacco Inc. | Date: 2016-10-25

A tobacco material expansion method includes the steps of wetting and swelling a tobacco material by bringing the tobacco material into contact with a water vapor stream at 100 to 160 C., and drying the tobacco material by bringing the wetted swelled tobacco material into contact with a superheated water vapor stream at a temperature higher than that of the water vapor.


Patent
Japan Tobacco Inc. | Date: 2016-02-24

The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.


Patent
Japan Tobacco Inc. | Date: 2016-08-16

The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimers disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and/or cancer including colorectal cancer. The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.

Loading Japan Tobacco Inc. collaborators
Loading Japan Tobacco Inc. collaborators