Japan Science and Technology Agency

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Kawaguchi, Japan

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The present disclosure includes predicting a three-dimensional structure of one residue mutant of a membrane protein where respective amino acid residues have been substituted by all amino acids, calculating a solvation entropy change in formation of a tertiary structure from a primary structure or formation of the tertiary structure from secondary-structure units within a transmembrane segment, and extracting a candidate of an amino acid mutant to be thermostabilized based on a difference between a solvation entropy change in the membrane protein and a solvation entropy change in the amino acid mutant.


Patent
Canon Kabushiki Kaisha, Tokyo Institute of Technology, Japan Science and Technology Agency | Date: 2017-01-10

A novel amorphous oxide applicable, for example, to an active layer of a TFT is provided. The amorphous oxide comprises microcrystals.


Patent
Japan Science and Technology Agency | Date: 2017-05-17

As a technique for efficiently sealing many substances, such as beads, nucleic acid, protein, virus, cells, and lipid membrane complex, into an array, the present invention provides a method for sealing a substance, including: (i) a step of introducing a first solvent containing a substance on a substrate on which a plurality of receptacles capable of storing the substance are formed separated from each other by a side wall; and (ii) a step of introducing a second solvent having a greater specific gravity than that of the first solvent onto the first solvent, the step (ii) being carried out after the step (i).


Patent
Japan Science and Technology Agency | Date: 2017-05-24

It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to A peptides but to other amyloids; and a prophylactic or therapeutic drug for an amyloid-related disease, comprising the same. The present invention provides a benzothiazole compound represented by the following formula (1) wherein X represents a halogen atom; R^(1) represents an optionally substituted hydrocarbon group; R^(2) represents a hydrogen atom or an optionally substituted hydrocarbon group; R^(3) and R^(4) are the same or different and each represent a hydrogen atom, an optionally substituted hydrocarbon group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; R^(2) and R^(4) optionally together form an alkylene group; and R^(5) represents an anion.


Patent
Japan Science and Technology Agency | Date: 2017-06-21

Provided is a memory circuit including: a plurality of cells arranged in a plurality of rows and a plurality of columns so that the plurality of rows are grouped to form a plurality of banks each including one or more rows, each of the plurality of cells including: a bistable circuit configured to store data; and a non-volatile element configured to store data stored in the bistable circuit in a non-volatile manner and to restore data stored in a non-volatile manner to the bistable circuit; and a controller configured to: perform a store operation on each of the plurality of rows in turn; set a voltage supplied, as a power-supply voltage, to cells in a first bank of the plurality of banks to a first voltage, the first bank including a row on which the store operation is performed; and set a voltage supplied, as a power-supply voltage, to cells in a bank of the plurality of banks other than the first bank to a second voltage that is less than the first voltage but at which data in the bistable circuit is retained.


Patent
Japan Science and Technology Agency | Date: 2017-06-07

The present invention is a method for analyzing diffraction data obtained using a crystal structure analysis sample, the sample comprising a single crystal of a porous compound, and a compound for which a structure is to be determined, the single crystal of the porous compound having a three-dimensional framework, and pores and so on that are defined by the three-dimensional framework, and are three-dimensionally arranged in an ordered manner, the three-dimensional framework having been determined by crystal structure analysis, and molecules of the compound for which the structure is to be determined being arranged in the pores in an ordered manner, the method comprising: a step (I) that selects a space group that is identical to a space group of the single crystal of the porous compound, or a space group that has a symmetry lower than that, to be a space group of the crystal structure analysis sample; a step (II) that determines an initial structure of the crystal structure analysis sample using diffraction data with respect to a crystal structure of the single crystal of the porous compound as initial values; and a step (III) that refines the initial structure determined. The present invention is also: a computer program for analyzing diffraction data; and a computer-readable recording medium storing the computer program. The present invention thus provides a method that efficiently analyzes diffraction data when implementing single crystal structure analysis, a computer program that causes a computer to implement the method, and a computer-readable recording medium.


Provided is a gas-bubble spray member, the tip section of which is not damaged even when a high voltage is applied thereto. A gas-bubble spray member including: a core material formed from a conductive material; an outer shell section for tightly adhering to at least part of the core material and covering the core material, formed from an insulating material, and including an extending part extending beyond the tip of the core material; and a void having a gas-bubble spray port and formed between the extending part and the tip of the core material. Furthermore, the tip of the provided gas-bubble spray member avoids damage as a result of the formation of a thick section on the tip of the extended part that is thicker than the rest of the extended part.


Patent
Japan Science and Technology Agency | Date: 2017-01-24

An image registration device includes a mapping section for deciding a first mapping for transforming the first image to an environmental map and a second mapping for transforming the second image to an environmental map, a corresponding point pair extractor for extracting a pair of corresponding points by detecting one point in the first image and the corresponding one point in the second image, a rotational mapping deriver for deriving a rotational mapping for registering an image of the first image in the environmental map and an image of the second image in the environmental map with each other, based on positions and local feature amounts of the points in the first and second images, and a registration section for registering the data of the first image with the data of the second image based on the first mapping, the rotational mapping, and the second mapping.


Patent
Japan Science, Technology Agency, Tokyo Institute of Technology and Asahi Glass Co. | Date: 2017-03-16

A thin film of metal oxide includes zinc (Zn); tin (Sn); silicon (Si); and oxygen (O). In terms of oxide, based on 100 mol % of total of oxides of the thin film, SnO_(2 )is greater than 15 mol % but less than or equal to 95 mol %.


Patent
Japan Science, Technology Agency, Tokyo Institute of Technology and Asahi Glass Co. | Date: 2017-03-16

A light-emitting device includes a pair of first electrodes arranged separated from and opposing each other on a first surface of a substrate; a light-emitting layer arranged on at least one of the first electrodes; a second electrode arranged on the light-emitting layer; and a bridge layer connecting the first electrodes. The bridge layer is formed of a material having a resistance that falls within a range of 100 k to 100 M.

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