Japan Medical Materials Corporation

Ōsaka, Japan

Japan Medical Materials Corporation

Ōsaka, Japan
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Trademark
Kyocera Corporation and Japan Medical Materials Corporation | Date: 2012-06-19

Artificial surgical implants, namely, total hip replacements and total knee prostheses; stems for artificial joints; cups for artificial joints; shells for artificial joints; artificial joints; artificial bones for implantation; medical machines, apparatus and instruments, namely, orthopedic fixation devices used in orthopedic transplant and/or implant surgery.


Trademark
Kyocera Corporation and Japan Medical Materials Corporation | Date: 2012-07-03

Artificial surgical implants, namely, total hip replacements, total knee prostheses, artificial joints, artificial bones; stems for artificial joints; cups for artificial joints; shells for artificial joints; cushion liners for artificial joints; medical machines, apparatus and instruments, namely, orthopedic fixation devices used in orthopedic transplant and/or implant surgery, and their parts and fittings.


Kyomoto M.,University of Tokyo | Kyomoto M.,Japan Medical Materials Corporation | Moro T.,University of Tokyo | Takatori Y.,University of Tokyo | And 3 more authors.
Biomaterials | Year: 2010

Poly(ether-ether-ketone) (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties and chemical stability. In the present study, we demonstrate the fabrication of an antibiofouling and highly hydrophilic high-density nanometer-scaled layer on the surface of PEEK by photo-induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) without using any photo-initiators, i.e., "self-initiated surface graft polymerization." Our results indicated that the diphenylketone moiety in the polymer backbone acted as a photo-initiator similar to benzophenone. The density and thickness of the poly(MPC) (PMPC)-grafted layer were controlled by the photo-irradiation time and monomer concentration during polymerization, respectively. Since MPC is a highly hydrophilic compound, the water wettability (contact angle <10°) and lubricity (coefficient of dynamic friction <0.01) of the PMPC-grafted PEEK surface were considerably lower than those of the untreated PEEK surface (90° and 0.20, respectively) due to the formation of a PMPC nanometer-scale layer. In addition, the amount (0.05 μg/cm2) of BSA adsorbed on the PMPC-grafted PEEK surface was considerably lower, that is more than 90% reduction, compared to that (0.55 μg/cm2) for untreated PEEK. This photo-induced polymerization process occurs only on the surface of the PEEK substrate; therefore, the desirable mechanical properties of PEEK would be maintained irrespective of the treatment used. © 2009 Elsevier Ltd. All rights reserved.


Patent
Japan Medical Materials Corporation and University of Tokyo | Date: 2011-08-24

Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).


Patent
Iwamoto, Nakayama and Japan Medical Materials Corporation | Date: 2010-09-29

The present invention provides a cell transplantation device which is capable of inserting cells for transplantation into a cell-deficient site without application of direct external force to the cells. The present invention discloses a cell transplantation device provided with a plate-type carrier with at least one pass-through hole formed on its side surface, a linear member to be threaded through the pass-through hole, and a pusher member which engages with the linear member that comes out from each exit of the pass-through holes.


Patent
Japan Medical Materials Corporation and University of Tokyo | Date: 2011-10-26

Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.


Patent
Japan Medical Materials Corporation and University of Tokyo | Date: 2010-09-29

An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.


Patent
Japan Medical Materials Corporation and University of Tokyo | Date: 2012-06-27

Disclosed are: a sliding member which is capable of maintaining wear resistance over a long period of time; an artificial joint member in which the polymer base is reduced in thickness; and an artificial joint which exhibits high lubricating properties in the body, biocompatibility and resistance to dislocation. Specifically disclosed is a polymer sliding material which has a coating layer (B) that is composed of a graft polymer containing a phosphorylcholine group and having a density of at least 1.4 g/cm^(3) on at least a part of the surface of a polymer base (A) that has a ketone group on the surface. The sliding material can be obtained by immersing the polymer base (A) into a liquid of a monomer (C) that has a phosphorylcholine group, and causing surface graft polymerization by irradiation of light. Also specifically disclosed are an artificial joint member using the polymer sliding material, and an artificial joint.


Patent
Japan Medical Materials Corporation and University of Tokyo | Date: 2010-07-07

The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate 1 capable of forming hydroxyl groups; and a biocompatible material layer 4 laminated on appropriate sections of the substrate 1, wherein hydroxyl groups are formed on at least a required section of a surface of the substrate 1 by surface treating to form a surface-treated layer 2, while the biocompatible material layer 4 is formed from a polymer containing phosphorylcholine groups, and wherein the substrate 1 and the biocompatible material layer 4 are joined via a binder layer 3 formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.


Patent
University of Tokyo and Japan Medical Materials Corporation | Date: 2010-08-18

Disclosed are: a sliding member which is capable of maintaining wear resistance over a long period of time; an artificial joint member in which the polymer base is reduced in thickness; and an artificial joint which exhibits high lubricating properties in the body, biocompatibility and resistance to dislocation. Specifically disclosed is a polymer sliding material which has a coating layer (B) that is composed of a graft polymer containing a phosphorylcholine group and having a density of at least 1.4 g/cm^(3 )on at least a part of the surface of a polymer base (A) that has a ketone group on the surface. The sliding material can be obtained by immersing the polymer base (A) into a liquid of a monomer (C) that has a phosphorylcholine group, and causing surface graft polymerization by irradiation of light. Also specifically disclosed are an artificial joint member using the polymer sliding material, and an artificial joint.

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