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Soodamani V.,Janus Research Laboratories | Soodamani V.,Jawaharlal Nehru Technological University | Patel D.,Janus Research Laboratories | Nayakanti D.,Jawaharlal Nehru University | Josyula R.,Astrazeneca
Journal of Heterocyclic Chemistry | Year: 2015

In this article, we report a facile route for the synthesis of novel benzofuranyl benzimidazole derivatives. The methodology involves the Sonagashira reaction of 2-(3-iodo-4-methoxyphenyl)-1H-benzimidazole (3) with variety of terminal alkynes to have novel benzimidazole alkynyl derivatives followed by iodo-cyclisation to give novel iodo benzofuranyl benzimidazole derivatives. The resulting iodo benzofuranyl benzimidazoles were functionalized further via palladium mediated carbon-carbon bond formation for molecular diversity generating novel heterocyclic compounds. © 2014 HeteroCorporation. Source


Soodamani V.,Janus Research Laboratories | Sekar R.,SRM University | Nayakanti D.,Jawaharlal Nehru University | Josyula R.,Astrazeneca
Journal of Chemical Research | Year: 2014

A facile synthesis of novel 7-alkynylindazole derivatives involving the Pd/C-PPh3-CuI catalysed Sonogashira coupling of 7-iodoindazole with a wide range of terminal alkynes in aqueous medium is reported. An X-ray crystallographic study established the molecular structure of 7-(pent-1-ynyl)-1H-indazole. Source


Soodamani V.,Janus Research Laboratories | Patel D.,Sterling | Nayakanti D.,Jawaharlal Nehru University | Josyula R.,Astrazeneca
Journal of Heterocyclic Chemistry | Year: 2015

In this paper, we report the synthesis of novel 2-(5-indolyl)-1H-benzimidazole derivatives. The methodology involves the Sonogashira reaction of 4-(1H-benzimidazol-2-yl)-2-bromo-N,N-dimethylaniline (3) with variety of terminal alkynes to get corresponding novel 4-(1H-benzimidazol-2-yl)-2-alkynyl-N,N-dimethylaniline derivatives (4). These compounds on iodocyclization afforded novel iodoindolylbenzimidazole derivatives (5). The resulting compounds were functionalized further via palladium-mediated carbon-carbon bond formation for generating novel structurally diversified heterocyclic compounds. All these newly synthesized compounds were evaluated for antimicrobial activity. © 2014 HeteroCorporation. Source

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