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Girek T.,Jan Dlugosz University
Journal of Inclusion Phenomena and Macrocyclic Chemistry | Year: 2012

Selected examples of cyclodextrin-based rotaxanes are described in the aspect of their syntheses and possible applications, especially in the design of molecular devices and sensors. © 2012 Springer Science+Business Media B.V.

Stroinski A.,Polish Academy of Sciences | Swierczewski D.,Jan Dlugosz University
Annales Zoologici | Year: 2013

Abstract. The paper describes a new flatid genus, Peyrierasus gen. nov., and a new species P. philippiae sp. nov. from Anosyan mountains of southeastern Madagascar. Additionally, the illustrations of the female internal genital structures are provided. © Fundacja Natura optima dux.

Girek T.,Jan Dlugosz University | Goszczynski T.,Polish Academy of Sciences | Girek B.,Jan Dlugosz University | Ciesielski W.,Jan Dlugosz University | And 2 more authors.
Journal of Inclusion Phenomena and Macrocyclic Chemistry | Year: 2013

The design of proteins whose structure and function can be manipulated by binding with specific ligands such as cyclodextrins, has been of great interest in the field of protein engineering and also could be used as drug delivery systems in targeted cancer therapy (Loftsson and Duchêne, Int. J. Pharm. 329:1-11, 1; Loftsson et al.; Expert. Opin. Drug Deliv. 2:335-351, 2). CD/proteins conjugates are synthesized using original high temperature method in which mono-6-O-formyl-β-CD reacts with two proteins: basic pancreatic trypsin inhibitor and lysozyme. The proposed synthesis method has a high reproducibility which makes it useful for pharmaceutical purposes. That method allows to obtain the conjugate without losing protein's biological and enzymatic activity which will used in the reaction, and without violating the chemical structure of cyclodextrin molecules. © 2012 Springer Science+Business Media B.V.

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