Jalan University

Kampar, Malaysia

Jalan University

Kampar, Malaysia
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Sreehari Sastry S.,Acharya Nagarjuna University | Babu S.,Acharya Nagarjuna University | Vishwam T.,Gandhi Institute of Technology and Management | Sie Tiong H.,Jalan University
Journal of Chemical Thermodynamics | Year: 2014

Speed of sound (U), density (ρ) and viscosity (η) values for the equimolar mixtures of (methyl benzoate + 1-propanol) and (ethyl benzoate + 1-propanol) with 1-butanol/1-pentanol including those of pure liquids were measured over the entire mole fraction range at T = 303.15 K. Using these experimentally determined values, various thermo-acoustic parameters such as excess isentropic compressibility (KsE), excess molar volume (VE) and excess free length (LfE), excess Gibbs free energy (ΔG â̂ - E) and excess enthalpy (HE) have been calculated. The excess functions have been fitted to the Redlich-Kister type polynomial equation. The deviations for excess thermo-acoustic parameters have been explained on the basis of the intermolecular interactions present in these binary mixtures. The experimentally determined values of speed of sound have been used to check the applicability of different speed of sound models of Nomoto, Impedance relation, Van Dael and Vangeel, Junjie's, free length theory and Rao's relation. Viscosity results have been used to test the applicability of standard viscosity models of Grunberg-Nissan, Hind-Mc Laughlin, Katti-Chaudhary, Heric and Brewer, Frenkel and Tamura and Kurata at various temperatures for the binary liquid systems under study. © 2013 Elsevier Ltd. All rights reserved.

Mooi L.Y.,University Tunku Abdul Rahman | Yew W.T.,University Tunku Abdul Rahman | Hsum Y.W.,Jalan University | Soo K.K.,Jalan University | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2012

Protein kinase C (PKC) has been implicated in carcinogenesis and displays variable expression profiles during cancer progression. Studies of dietary phytochemicals on cancer signalling pathway regulation have been conducted to search for potent signalling regulatory agents. The present study was designed to evaluate any suppressive effect of maslinic acid on PKC expression in human B-lymphoblastoid cells (Raji cells), and to identify the PKC isoforms expressed. Effects of maslinic acid on PKC activity were determined using a PepTag® assay for non-radioactive detection of PKC. The highest expression in Raji cells was obtained at 20 nM PMA induced for 6 hours. Suppressive effects of maslinic acid were compared with those of four PKC inhibitors (H- 7, rottlerin, sphingosine, staurosporine) and two triterpenes (oleanolic acid and ursolic acid). The IC50 values achieved for maslinic acid, staurosporine, H-7, sphingosine, rottlerin, ursolic acid and oleanolic acid were 11.52, 0.011, 0.767, 2.45, 5.46, 27.93 and 39.29 μM, respectively. Four PKC isoforms, PKC βI, βII, δ, and ζ were identified in Raji cells via western blotting. Maslinic acid suppressed the expression of PKC βI, δ, and ζ in a concentration-dependent manner. These preliminary results suggest promising suppressive effects of maslinic acid on PKC activity in Raji cells. Maslinic acid could be a potent cancer chemopreventive agent that may be involved in regulating many downstream signalling pathways that are activated through PKC receptors.

Sreehari Sastry S.,Acharya Nagarjuna University | Babu S.,Acharya Nagarjuna University | Vishwam T.,Gandhi Institute of Technology and Management | Parvateesam K.,Acharya Nagarjuna University | Sie Tiong H.,Jalan University
Physica B: Condensed Matter | Year: 2013

Various thermo-acoustic parameters, such as excess isentropic compressibility (Ks E), excess molar volume (V E), excess free length (Lf E), excess Gibb's free energy (ΔG*E), and excess Enthalpy (HE), have been calculated from the experimentally determined data of density, viscosity and speed of sound for the binary mixtures of ethyl benzoate+1-propanol, or +1-butanol, or +1-pentanol over the entire range of composition at different temperatures (303, 308, 313, 318 and 323 K). The excess functions have been fitted to the Redlich-Kister type polynomial equation. The deviations for excess thermo-acoustic parameters have been explained on the basis of the intermolecular interactions present in these binary mixtures. © 2013 Elsevier B.V.

Win Y.-F.,Jalan University | Win Y.-F.,Universiti Sains Malaysia | Teoh S.-G.,Universiti Sains Malaysia | Ha S.-T.,Jalan University | And 2 more authors.
Asian Journal of Chemistry | Year: 2013

Three organotin(IV) carboxylate complexes derivatives of 2-methyl-3-nitrobenzoic acid (HL) have been successfully synthesized and characterized quantitatively and qualitatively. The complexes obtained are screened for their preliminary in vitro cytotoxic assay on human liver hepatocellular carcinoma cells (HepG2) and antibacterial screening activity. Results of the infrared and NMR spectroscopy on the acid and complexes showed that the coordination took place via oxygen atoms from the carboxylate anions. With the exceptional case, based on the spectroscopy studies indicated that one methanol molecule also take part in the coordination to tin(IV) atom moiety in complex 3 resulting the tin(IV) atom exhibited five coordination in solid state. From the preliminary in vitro cytotoxic assay on HepG2 and antibacterial screening activity, triphenyltin(IV) (complex 3) showed slightly better activity compared to diorganotin(IV) complexes (1 and 2).

Chong A.Y.-L.,Hong Kong Polytechnic University | Chan F.T.S.,Hong Kong Polytechnic University | Ooi K.-B.,Jalan University | Darmawan N.,University College
Journal of Computer Information Systems | Year: 2011

The aim of this paper is to investigate if employee alignment will influence the business-IT alignment in organizations. We measured employee alignment through perceived organizational trust, perceived communications on business-IT strategies to employees, perceived employee commitment to business-IT strategies and perceived knowledge on business-IT strategies. Structural equation modelling (SEM) is used to test the model and hypotheses in this research. The findings from this study indicated that perceived organizational trust, perceived communications on business-IT strategies to employees and perceived knowledge on business-IT strategies have a positive and significant relationship with business-IT alignment of organizations. This study addresses the lack of empirical research by investigating whether employee alignment would improve an organization's businessIT alignment.

Aziz H.,National University of Malaysia | Aziz H.,Jalan University | Hatah E.,National University of Malaysia | Makmor Bakry M.,National University of Malaysia | Islahudin F.,National University of Malaysia
Patient Preference and Adherence | Year: 2016

Background: A previous systematic review reported that increase in patients’ medication cost-sharing reduced patients’ adherence to medication. However, a study among patients with medication subsidies who received medication at no cost found that medication nonadherence was also high. To our knowledge, no study has evaluated the influence of different medication payment schemes on patients’ medication adherence. Objective: This study aims to review research reporting the influence of payment schemes and their association with patients’ medication adherence behavior. Methods: This study was conducted using systematic review of published articles. Relevant published articles were located through three electronic databases Medline, ProQuest Medical Library, and ScienceDirect since inception to February 2015. Included articles were then reviewed and summarized narratively. Results: Of the total of 2,683 articles located, 21 were included in the final analysis. There were four types of medication payment schemes reported in the included studies: 1) out-of-pocket expenditure or copayments; 2) drug coverage or insurance benefit; 3) prescription cap; and 4) medication subsidies. Our review found that patients with “lower self-paying constraint” were more likely to adhere to their medication (adherence rate ranged between 28.5% and 94.3%). Surprisingly, the adherence rate among patients who received medication as fully subsidized was similar (rate between 34% and 84.6%) as that of other payment schemes. The studies that evaluated patients with fully subsidized payment scheme found that the medication adherence was poor among patients with nonsevere illness. Conclusion: Although medication adherence was improved with the reduction of cost-sharing such as lower copayment, higher drug coverage, and prescription cap, patients with full-medication subsidies payment scheme (received medication at no cost) were also found to have poor adherence to their medication. Future studies comparing factors that may influence patients’ adherence to medication among patients who received medication subsidies should be done to develop strategies to overcome medication nonadherence. © 2016 Aziz et al.

Fan S.-H.,Jalan University | Ali N.A.,National University of Malaysia | Basri D.F.,National University of Malaysia
Evidence-based Complementary and Alternative Medicine | Year: 2014

The present study aims to investigate the analgesic activity of the methanol extract of the galls of Quercus infectoria in rats using hot plate and tail-flick methods. The extract was administered intraperitoneally at a dose of 20 mg/kg while morphine sulfate and sodium salicylate (10 mg/kg) served as standards. The methanol extract exhibited significant analgesic activity in the tail-flick model (P<0.05) by increasing the reaction time of the rats to 8.0 sec at 30 min after treatment in comparison to control (4.4 sec). Morphine sulfate produced a reaction time of 11.9 sec in the same test. At the peak of activity (30 min), the extract produced maximum possible analgesia (MPA) of 34.2%, whilst morphine sulfate achieved a peak MPA of 70.9%. No analgesic effects have been observed using sodium salicylate in the tail-flick model. In the same model, the extract and sodium salicylate demonstrated comparable reaction times. Tail-flick is a better method to evaluate analgesic activity as no significant results were observed for all treatments using hot plate with the exception of morphine sulfate, which showed significant results only at 45 and 60 min after treatment. In conclusion, the methanol extract of the galls of Quercus infectoria displayed analgesic activity. © 2014 Sook-Ha Fan et al.

Sastry S.S.,Acharya Nagarjuna University | Ha S.T.,Jalan University | Gowri Sankara Rao B.,Acharya Nagarjuna University | Mallika K.,Acharya Nagarjuna University | Kumari T.V.,Acharya Nagarjuna University
Liquid Crystals | Year: 2012

An image analysis technique in conjunction with polarising optical microscopy (POM) is proposed for assessment of the thermo-optical properties of homogeneously aligned chiral ester liquid crystals of the type ((S)-(-)-2-methylbutyl 4′-(4″-n-alkanoyloxybenzoyloxy) biphenyl-4-carboxylates, where n = 16 or 18. Chiral ester textures are recorded as a function of temperature using POM provided with a hot-stage and a high-resolution colour camera. Temperature-dependent optical parameters, or thermo-optical properties such as optical transmission, degree of polarisation, absorption coefficient and birefringence are computed for chiral esters by analysing the texture of samples using MATLAB software. This is a simple experimental technique for observing how the optical parameters of liquid crystals change with temperature. © 2012 Copyright Taylor and Francis Group, LLC.

Lau L.C.,Jalan University | Mohamad Nor N.,Universiti Sains Malaysia | Lee K.T.,Universiti Sains Malaysia | Mohamed A.R.,Universiti Sains Malaysia
Journal of Environmental Chemical Engineering | Year: 2015

Biogas contains hydrogen sulphide (H2S), which is an acidic gas that would causes severe corrosion to the mechanical parts of combustion engines. Therefore, hydrogen sulphide must be separated from biogas prior to combustion. Among the conventional methods, the use of a cheap adsorbent appears to be one of the most promising methods for H2S removal. CeO2/NaOH/PSAC was successfully synthesized and used to remove H2S from a simulated biogas stream. A better synthesis method was found by applying a soaking method to impregnate cerium oxide into palm shell activated carbon (PSAC). Cerium oxide (CeO2) was obtained via a reaction between cerium nitrate hydrate (Ce(NO3)3·6H2O) and sodium hydroxide (NaOH). The calcination step was crucial for this synthetic route to enhance the H2S adsorption capacity of the adsorbent. Selected adsorbents were characterized using several techniques and provided further information about the surface properties, functional groups, morphologies/composition and chemical states of the selected adsorbents. © 2015 Elsevier Ltd. All rights reserved.

Lee L.H.,Jalan University | Isa D.,University of Nottingham Malaysia Campus
Expert Systems with Applications | Year: 2010

The Naïve Bayes classification approach has been widely implemented in real-world applications due to its simplicity and low cost training and classifying algorithm. As a trade-off to its simplicity, the Naïve Bayes technique has thus been reported to be one of the poorest-performing classification methods around. We have explored and investigated the Naïve Bayes classification approach and found that one of the reasons that causes the low classification accuracy is the mis-classification of documents into several "popular" categories due to the improper organization of the training dataset where the distribution of training documents among categories is highly skewed. In this work, we propose a solution to the problem addressed above, which is the addition of the Automatically Computed Document Dependent (ACDD) weighting factor facility to the Naïve Bayes classifier. The ACDD weighting factors are computed for the purpose of enhancing the classification performance by adjusting the probability values based on the density of classified documents in each available category to minimize the mis-classification rate. © 2010 Elsevier Ltd. All rights reserved.

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